Highlighted Papers

High Impact Papers Highlighted by Scientific Journals and Media

708. Kim, J.Y., Lee, J.A., Ahn, J.H., and Lee, S.Y. "High-level succinic acid production by overexpressing a magnesium transporter in Mannheimia succiniciproducens", Proc. Nat. Acad. Sci. (PNAS), 121(37): e2407455121, https://doi.org/10.1073/pnas.2407455121 (2024.9)

707. Wang, F., Jiang, X., Liu, Y., Zhang, G., Zhang, Y., Jin, Y., Shi, S., Men, X., Liu, L., Wang, L., Liao, W., Chen, X., Chen, G., Liu, H., Ahmad, M., Fu, C., Wang, Q., Zhang, H., and Lee, S.Y. "Tobacco as a promising crop for low-carbon biorefinery", The Innovation, 5(5): 100687 (2024.9), https://doi.org/10.1016/j.xinn.2024.100687

702. Li, Y., Yin, D., Lee, S.Y. and Lv, Y., "Engineered polymer nanoparticles as artificial chaperones facilitating the selective refolding of denatured enzymes", Proc. Nat. Acad. Sci. (PNAS), PNAS 2024 Vol. 121 No. 19 e2403049121, https://doi.org/10.1073/pnas.2403049121 (2024.5), 

701. Choi, K.R., Jung, S.Y., and Lee, S.Y. "From sustainable feedstocks to microbial foods", Nature Microbiol., 9: 1167-1175, https://doi.org/10.1038/s41564-024-01671-4 (2024.4), https://doi.org/10.1038/s41564-024-01671-4

698. Choi, K.R., Luo, Z.W., Kim, G.B., Xu, H., Lee, S.Y. "A microbial process for the production of benzyl acetate" Nature Chem. Eng., 1: 216-228, (2024.3), https://doi.org/10.1038/s44286-023-00022-0 

697. Torrente-Murciano, L., Dunn, J.B., Christofides, P.D., Keasling, J.D., Glotzer, S.C., Lee, S.Y., Van Geem, K.M, Tom, J. and He, G. "The forefront of chemical engineering research", Nature Chem. Eng. 1: 18-27 (2024.1), https://doi.org/10.1038/s44286-023-00017-x

693. Choi, S.Y., Lee, Y., Yu, H.E., Cho, I.J., Kang, M. & Lee, S.Y. "Sustainable production and degradation of plastics using microbes", Nature Microbiol., 8: 2253-2276,(2023. 11), https://doi.org/10.1038/s41564-023-01529-1

692. Kim, W.J., Lee, Y., Kim, H.U., Ryu, J.Y., Yang, J.E., and Lee, S.Y. "Genome-wide identification of overexpression and downregulation gene targets based on the sum of covariances of the outgoing reaction fluxes", Cell Systems, 14(15): 990-1001.e5 (2023.11), https://doi.org/10.1016/j.cels.2023.10.005

690. Kim, G.B., Kim, J.Y., Lee, J.A., Norsigian, C.J., Palsson, B.O. & Lee, S.Y. "Functional annotation of enzyme-encoding genes using deep learning with transformer layers", Nature Communications, 14:7370, DOI: 10.1038/s41467-023-43216-z (2023.11),  https://doi.org/10.1038/s41467-023-43216-z

685. Liu, L., Li, J., Gai, Y., Tian, Z., Wang, Y., Wang, T., Liu, P., Yuan, Q., Ma, H., Lee S.Y. & Zhang, D. "Protein engineering and iterative multimodule optimization for vitamin B6 production in Escherichia coli", Nature Comm., 14:5304, DOI: 10.1038/s41467-023-40928-0 (2023), https://doi.org/10.1038/s41467-023-40928-0

684. Kang, Q., Fang, H., Xiangm, M., Xiao, K., Jiang, P., You, C., Lee, S.Y., Zhang, D. "A synthetic cell-free 36-enzyme reaction system for vitamin B12 production", Nature Comm., 14: 5177, DOI: 10.1038/s41467-023-40932-4 (2023), https://doi.org/10.1038/s41467-023-40932-4

681. Choi, K.R., Lee, S.Y., "Systems metabolic engineering of microorganisms for food and cosmetics production", Nature Reviews Bioeng., DOI: 10.1038/s44222-023-00076-y (2023.6), https://doi.org/10.1038/s44222-023-00076-y

677. Cho, J.S., Yang, D., Prabowo, C.P.S., Ghiffary, M.R., Han, T.H., Choi, K.R., Moon, C.W., Zhou, H., Ryu, J.Y., Kim, H.U., and Lee, S.Y., "Targeted and high-throughput gene knockdown in diverse bacteria using synthetic sRNAs", Nature Comm., 12: 173, DOI: 10.1038/s41467-023-38119-y (2023.4), https://doi.org/10.1038/s41467-023-38119-y

675. Lim, J., Choi, S. Y., Lee, J. W., Lee, S. Y. & Lee, H., "Biohybrid CO2 electrolysis for the direct synthesis of polyesters from CO2", Proc. Nat. Acad. Sci. (PNAS), PNAS 2023 Vol. 120 No. 14 e2221438120, https://doi.org/10.1073/pnas.2221438120 (2023.4)

674. Kim, Y., Ryu, J.Y., Kim, H.U. and Lee, S.Y., "Computational prediction of interactions between Paxlovid and prescription drugs", Proc. Nat. Acad. Sci. (PNAS), PNAS 2023 Vol. 120 No. 12 e2221857120, https://doi.org/10.1073/pnas.2221857120 (2023.3)

661. Park, S.Y., Eun, H., Lee, M.H., and Lee, S.Y. "Metabolic engineering of Escherichia coli with electron channelling for the production of natural products", Nature Catalysis, 5, 726-737 (2022) https://doi.org/10.1038/s41929-022-00820-4

660. Zou, X., Xia, X., Mo, Z., Ge, Y., Jiang, X., Huang, R., Li, M., Deng, Z., Chen, S., Wang, L., & Lee, S.Y. "Systematic strategies for developing phage resistant Escherichia coli strains", Nature Comm. 13: 4491 https://doi.org/10.1038/s41467-022-31934-9 (2022. 8)

654. Fu, G., Yue, J., Li, D., Li, Y., Lee, S.Y., and Zhang, D. "An operator-based expression toolkit for Bacillus subtilis enables fine-tuning of gene expression and biosynthetic pathway regulation", Proc. Nat. Acad. Sci. (PNAS), PNAS 2022 Vol. 119 No. 11 e2119980119, https://doi.org/10.1073/pnas.2119980119 (2022.3), 

646. Tong, Y., Jorgensen, T.S., Whitford, C.M., Weber, T., and Lee, S.Y. "A versatile genetic engineering toolkit for E. coli based on CRISPR-prime editing", Nature Comm. 12: 5206 https://doi.org/10.1038/s41467-021-25541-3 (2021. 9)

642. Choi, S.Y., Oh, J., Jung, J.H., Park, Y.K., and Lee, S.Y., "Three-dimensional label-free visualization and quantification of polyhydroxyalkanoates in individual bacterial cell in its native state", Proc. Natl. Acad. Sci. (PNAS), 118(31): e2103956118 (2021. 8), https://doi.org/10.1073/pnas.2103956118

641. Jang, W.D., Jeon, S., Kim, S. and Lee, S.Y., "Drugs repurposed for COVID-19 by virtual screening of 6,218 drugs and cell-based assay", Proc. Natl. Acad. Sci. (PNAS), 118(30): e2024302118 (2021. 7),  https://doi.org/10.1073/pnas.2024302118

640. Yang, D., Park, S.Y., and Lee, S.Y., "Production of rainbow colorants by metabolically engineered Escherichia coli", Adv. Sci., 8(13): 2100743 1-13 (2021. 7), https://doi.org/10.1002/advs.202100743

634. Yang, D., Jang, W.D., and Lee, S.Y., "Production of carminic acid by metabolically engineered Escherichia coli", J. Am. Chem. Soc., 143(14): 5364-5377 (2021. 4), https://doi.org/10.1021/jacs.0c12406

631. Kim, G.B., Gao, Y., Palsson, B.E. and Lee, S.Y. "DeepTFactor: A deep learning-based tool for the prediction of transcription factors", Proc. Natl. Acad. Sci. (PNAS), 118(2): e2021171118 (2021. 1), https://doi.org/10.1073/pnas.2021171118

630. Davis, B., Backus, K., Winter, G., Chica, R., Li, D., Lee, S.Y., He, C., Weeks, A., Overall, C., Hagihara, S., Thuronyi, B., Kamat, S., Chen, L.-L., Guerrero, R.H., Yao, S., Mahal, L.K., Voigt, C., Woo, C., Strauss, E., Kikuchi, K., Dore, T., dford, S., Li, X.D., Heo, W.D., Superti-Furga, G., Deans, T., Belousov, V., Matthews, M., Jackson, C., Malek, S., Waldmann, H., Rising, A., Jewett, M., Stamou, D., Parker, E., Murakami, M., Polizzi, K., Hamachi, I., Erb, T., Joo, C., Uesugi, M., Prinjha, R., Rechavi, G., Solano, R., Schulman, B., Yael David, Y., Oslund, R., "Voices of chemical biology", feature, Nature Chem. Biol., 17: 1-4 (2021. 1), https://doi.org/10.1038/s41589-020-00714-1

626. Choi, Y., Lee, S.Y., "Biosynthesis of inorganic nanomaterials using microbial cells and bacteriophages", Nature Reviews Chemistry, 4(12): 638–656, https://doi.org/10.1038/s41570-020-00221-w (2020. 12)

624. Han, T., Kim, G.B., and Lee, S.Y. "Glutaric acid production by systems metabolic engineering of an L-lysine–overproducing Corynebacterium glutamicum", Proc. Natl. Acad. Sci. (PNAS), 117(48): 30328-30334 (2020. 12), https://doi.org/doi.org/10.1073/pnas.2017483117

619. Bang, J., Hwang, C.H., Ahn, J.H., Lee, J.A., and Lee, S.Y."Escherichia coli is engineered to grow on CO2 and formic acid", Nature Microbiol., 5: 1459-1463, https://doi.org/10.1038/s41564-020-00793-9 (2020. 9), https://doi.org/10.1038/s41564-020-00793-9

618. Wei, S.-P., Qian, Z.-G., Hu, C.-F., Pan, F., Chen, M.-T., Lee, S.Y. and Xia, X.-X. "Formation and functionalization of membraneless compartments in Escherichia coli", Nature Chemical Biology, 16(10): 1143-1148 (2020. 10), https://doi.org/10.1038/s41589-020-0579-9

617. Choi, S.Y., Cho, I.J., Lee, Y., Kim, Y.-J., Kim, K.-J., and Lee, S.Y. "Microbial polyhydroxyalkanoates and non-natural polyesters", Adv. Mat., 32(35): 1907138, 1-37 (2020. 9), https://doi.org/10.1002/adma.201907138

615. Ko, Y.-S., Kim, J.W., Lee, J.A., Han, T., Kim, G.B., Park, J.E. and Lee, S.Y., "Tools and strategies of systems metabolic engineering for the development of microbial cell factories for chemical production", Chem. Soc. Rev., 49: 4615-4636 (2020. 7), https://doi.org/10.1039/d0cs00155d

614. Tong, Y., Whitford, C.M., Blin, K. Jorgensen, T.S., Weber, T., and Lee, S.Y. "CRISPR–Cas9, CRISPRi and CRISPR-BEST-mediated genetic manipulation in streptomycetes", Nature Protocols, 15: 2470-2502 (2020.7) (https://doi.org/10.1038/s41596-020-0339-z)

608. Ahn, J.H., Seo, H., Park, W., Seok, J., Lee, J.A., Kim, W.J., Kim, G.B., Kim, K.-J. & Lee, S.Y., "Enhanced succinic acid production by Mannheimia employing optimal malate dehydrogenase", Nature Comm., 11: 1970, DOI: 10.1038/s41467-020-15839-z (2020. 4), https://doi.org/10.1038/s41467-020-15839-z

603. Lieven, C., Beber, M.E., Olivier, B.G., Bergmann, F.T., Ataman, M., Babaei, P., Bartell, J.A., Blank, L.M., Chauhan, S., Correia, K., Diener, C., Dräger, A., Ebert, B.E., Edirisinghe, J.N., Faria, J.P., Feist, A.M., Fengos, G., Fleming, R.M.T., García-Jiménez, B., Hatzimanikatis, V., Helvoirt, W.V., Henry, C.S., Hermjakob, H., Herrgård. M.J., Kaafarani, A., Kim, H.U., King, Z., Klamt, S., Klipp, E., Koehorst, J.J., König, M., Lakshmanan, M., Lee, D.-Y., Lee, S.Y., Lee, S., Lewis, N.E., Liu, F., Ma, H., Machado, D., Mahadevan, R., Maia, P., Mardinoglu, A., Medlock, G.L., Monk, J.M., Nielsen, J., Nielsen, L.K., Nogales, J., Nookaew, I., Palsson, B.O., Papin, J.A., Patil, K.R., Poolman, M., Price, N.D., Resendis-Antonio, O., Richelle, A., Rocha, I., Sánchez, B.J., Schaap, P.J., Sheriff, R.S.M., Shoaie, S., Sonnenschein, N., Teusink, B., Vilaça, P., Vik, J.O., Wodke, J.A.H., Xavier, J.C., Yuan, Q., Zakhartsev, M., and Zhang, C. "MEMOTE for standardized genome-scale metabolic model testing", Nature Biotechnol., 1-5 (2020.03), https://doi.org/10.1038/s41587-020-0446-y

591. Seo, H., Cho, I.J., Joo, S., Son, H.F., Sagong, H.-Y., Choi, S.Y., Lee, S.Y., & Kim, K.-J., "Reply to "Conformational fitting of a flexible oligomeric substrate does not explain the enzymatic PET degradation" Nature Comm., 10:5582, 1-2, DOI: 10.1038/s41467-019-13492-9 (2019.12), https://doi.org/10.1038/s41467-019-13492-9

590. Tong, Y., Whitford, C.M., Robertsen, H.L., Blin, K., Jørgensen, T.S., Klitgaard, A.K., Gren, T., Jiang, X., Weber, T., and Lee, S.Y., "Highly efficient DSB-free base editing for streptomycetes with CRISPR-BEST", Proc. Natl. Acad. Sci. (PNAS), 116 (41): 20366-20375, (https://doi.org/10.1073/pnas.1913493116) (2019. 10), https://doi.org/10.1073/pnas.1913493116

589. Gwon, H., Park, K., Chung, S.-C., Kim, R.-H., Kang, J.K., Ji, S.M., Nag-Jong Kim, Lee, S., Ku, J.-H., Do, E.C., Park, S., Kim, M., Shim, W.Y., Rhee, H.S., Kim, J.-Y., Kim, J., Kim, T.Y., Yamaguchi, Y., Iwamuro, R., Saito, S., Kim, G., Jung, I.-S., Park, H., Lee, C., Lee, S., Jeon, W.S., Jang, W.D., Kim, H.U., Lee, S.Y., Im, D., Doo, S.-G., Lee, S.Y., Lee, H.C. and Park, J.H., "A safe and sustainable bacterial cellulose nanofiber separator for lithium rechargeable batteries", Proc. Natl. Acad. Sci. (PNAS), 116 (37): 19288-19293, (https://doi.org/10.1073/pnas.1905527116) (2019. 9), https://doi.org/10.1073/pnas.1905527116

583. Kim, H.M., Chae, T.U., Choi, S.Y., Kim, W.J. and Lee, S.Y., "Engineering of an oleaginous bacterium for the production of fatty acids and fuels", Nature Chem. Biol., 15, 721-729 (https://doi.org/10.1038/s41589-019-0295-5) (2019.6), https://doi.org/10.1038/s41589-019-0295-5

582. Ryu, J.Y., Kim, H.U. and Lee, S.Y., "Deep learning enables high-quality and high-throughput prediction of enzyme commission numbers", Proc. Natl. Acad. Sci. (PNAS), 116 (28): 13996-14001 (https://doi.org/10.1073/pnas.1821905116) (2019.7), https://doi.org/10.1073/pnas.1821905116

581. Luo, Z.W., Cho, J.S., Lee, S.Y. "Microbial production of methyl anthranilate, a grape flavor compound", Proc. Natl. Acad. Sci. (PNAS), 116 (22): 10749-10756 (https://doi.org/10.1073/pnas.1903875116) (2019.5), https://doi.org/10.1073/pnas.1903875116

565. Lee, S.Y., Kim, H.U., Chae, T.U., Cho, J.S., Kim, J.W., Shin, J.H., Kim, D.I., Ko, Y.-S., Jang, W.D. and Jang, Y.-S., "A comprehensive metabolic map for production of bio-based chemicals" Nature Catalysis, 2:18-33 (2019), https://doi.org/10.1038/s41929-018-0212-4

561. Yang, J.E., Park, S.J., Kim, W.J., Kim, H.J., Kim, B.J., Lee, H., Shin, J., & Lee, S.Y., "One-step fermentative production of aromatic polyesters from glucose by metabolically engineered Escherichia coli strains", Nature Comm., 9:79, DOI: 10.1038/s41467-017-02498-w (2018.1), https://doi.org/10.1038/s41467-017-02498-w

551. Yang, D., Kim, W.J., Yoo, S.M., Choi, J.H., Ha, S.H., Lee, M.H., and Lee, S.Y. "Repurposing type III polyketide synthase as a malonyl-CoA biosensor for metabolic engineering in bacteria", Proc. Natl. Acad. Sci. (PNAS), 115 (40) 9835-9844 (2018.10.2), https://doi.org/10.1073/pnas.1808567115

549. Bang, J., Lee, S.Y. "Assimilation of formic acid and CO2 by engineered Escherichia coli equipped with reconstructed one-carbon assimilation pathways", Proc. Nat. Acad. Sci. (PNAS), 115 (40) E9271-E9279 (2018.10.2), https://doi.org/10.1073/pnas.1810386115

548. Zhao, X.R., Choi, K.R., and Lee, S.Y. "Metabolic engineering of Escherichia coli for secretory production of free haem", Nature Catalysis, 1:720–728 (2018), https://doi.org/10.1038/s41929-018-0126-1

544. Choi, Y., Park, T.J., Lee, D.C., and Lee, S.Y. "Recombinant Escherichia coli as a biofactory for various single- and multi-element nanomaterials", Proc. Nat. Acad. Sci. (PNAS), 115(23): 5944-5949 (2018.6), https://doi.org/10.1073/pnas.1804543115

542. Ryu, J.Y., Kim, H.U., and Lee, S.Y. "Deep learning improves prediction of drug–drug and drug–food interactions", Proc. Nat. Acad. Sci. (PNAS), 201803294: 1-8 (2018. 4), https://doi.org/10.1073/pnas.1803294115

539. Tong, T., Chen, S., Wang, L., Tang, Y., Ryu, J.Y., Jiang, S., Wu, X., Chen, C., Luo, J., Deng, Z., Li, Z., Lee, S.Y., and Chen, S. "Occurrence, evolution, and functions of DNA phosphorothioate epigenetics in bacteria", Proc. Nat. Acad. Sci. (PNAS),  115(13): E2988-E2996 (2018. 3), https://doi.org/10.1073/pnas.1721916115

533. Joo, S., Cho, I.J., Seo, H., Son, H.F., Sagong, H.-Y., Shin, T.J., Choi, S.Y., Lee, S.Y. & Kim, K.J., "Structural insight into molecular mechanism of poly (ethylene terephthalate) degradation", Nature Comm., 9:382, DOI: 10.1038/s41467-018-02881-1 (2018.1), https://doi.org/10.1038/s41467-018-02881-1

512. Jo, Y., Park, S., Jung, J., Yoon, J., Joo, H., Kim, M.-H., Kang, S.-J., Choi, M.C., Lee, S.Y., and Park, Y. "Holographic deep learning for rapid optical screening of anthrax spores", Sci. Adv. 2017;3: e1700606 (4 August 2017), http://doi.org/10.1126/sciadv.1700606

507. Jiang, X., Ellabaan, M.M.H., Charusanti, P., Munck, C., Blin, K., Tong, Y., Weber, T., Sommer, M.O.A., & Lee, S.Y. "Dissemination of antibiotic resistance genes from antibiotic producers to pathogens", Nature Comm. 8:15784, DOI: 10.1038/ncomms15784 (Jun 7, 2017), http://doi.org/10.1038/ncomms15784

506. Luo, Z.W. and Lee, S.Y. "Biotransformation of p-xylene into terephthalic acid by engineered Escherichia coli", Nature Comm. 8:15689, DOI: 10.1038/ncomms15689 (May 31, 2017), http://doi.org/10.1038/ncomms15689

476. Choi, S.Y., Park, S.J., Kim, W.J., Yang, J.E., Lee, H., Shin, J., and Lee, S.Y. "One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli", Nature Biotechnol., 34(4): 435-440 (2016. 4), http://dx.doi.org/10.1038/nbt.3485

461. Lee, S.Y., Kim, H.U., "Systems strategies for developing industrial microbial strains", Nature Biotechnol., 33(10): 1061–1072 (2015. 10), http://dx.doi.org/10.1038/nbt.3365

459. Kim, S., Jang, Y.-S., Ha, S.-C., Ahn, J.-W., Kim, E.-J., Lim, J.H., Cho, C., Ryu, Y.S., Lee, S.K., Lee, S.Y. and Kim, K.-J. "Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum", Nature Communications, 6:8410, http://dx.doi.org/10.1038/ncomms9410

446. Kim, H.U., Ryu, J.Y., Lee, J.O. and Lee, S.Y., "A systems approach to traditional oriental medicine", Nature Biotechnol. 33:264-268 (2015. 3), http://dx.doi.org/10.1038/nbt.3167

445. Pronk, J.T., Lee, S.Y., Lievense, J., Pierce, J., Palsson, B., Uhlen, M. and Nielsen, J., "How to set up collaborations between academia and industrial biotech companies", Nature Biotechnol. 33:237-240 (2015. 3), https://doi.org/10.1038/nbt.3171

428. Park, S.H., Kim, H.U., Kim, T.Y., Park, J.S., Kim, S.-S. and Lee, S.Y., "Metabolic engineering of Corynebacterium glutamicum for L-arginine production", Nature Commun., 5: 4618, http://dx.doi.org/10.1038/ncomms5618

420. Nielsen, J., Fussenegger, M., Keasling, J., Lee, S.Y., Liao, J.C., Prather, K. and Palsson, B., "Engineering synergy in biotechnology", Nature Chem. Biol., 10(5): 319-322 (2014. 5), http://dx.doi.org/10.1038/nchembio.1519

416. Na, D., Yoo, S.M., Chung, H., Park, H., Park, J.H., and Lee, S.Y., "Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs", Nature Biotechnol., 31(2): 170-174 (2013. 2), http://dx.doi.org/10.1038/nbt.2461

410. Choi, Y.J., Lee, S.Y., "Microbial production of short-chain alkanes", Nature, 502(7472): 571-574 (2013. 10), http://dx.doi.org/10.1038/nature12536

402. Yoo, S.M., Na, D., Lee, S.Y., "Design and use of synthetic regulatory small RNAs to control gene expression in Escherichia coli", Nature Protocols, 8(9): 1694-1707 (2013. 8), http://dx.doi.org/10.1038/nprot.2013.105

367. Lee, J.W., Na, D., Park, J.M., Lee, J., Choi, S., and Lee, S.Y. "Systems metabolic engineering of microorganisms for natural and non-natural chemicals", Nature Chem. Biol. 8(6): 536-546 (2012. 6), http://dx.doi.org/10.1038/nchembio.970

338. Yim, H., Haselbeck, R., Niu, W., Pujol-Baxley, C., Burgard, A., Boldt, J., Khandurina, J., Trawick, J.D., Osterhout, R.E., Stephen, R., Estadilla, J., Teisan, S., Schreyer, H.B., Andrae, S., Yang, T.H., Lee, S.Y. , Burk, M.J., and Van Dien, S. "Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol", Nature Chem. Biol., 7(7): 445-452 (2011. 7), http://dx.doi.org/10.1038/nchembio.580

- Multiple authors including Lee, S.Y., "What's in a name?", Nature Biotechnology, 27(12): 1071-1073 (2009. 12), http://dx.doi.org/10.1038/nbt1209-1071

187. Lee, S.Y., "Deciphering bioplastic production", Nature Biotechnol. 24 (10): 1227-1229 (2006. 10.), https://doi.org/10.1038/nbt1006-1227

147. Hong, S. H.,  Kim, J.S.,  Lee, S.Y., In, Y.H., Choi, S.S., Rih, J.K., Kim, C. H.,  Jeong, H., Hur, C. G., and Kim, J.J., "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens", Nature Biotechnology 22(10): 1275-1281 (2004. 10.), https://doi.org/10.1038/nbt1010

32.  Lee, S.Y.,  "E. coli moves into the plastic age", Nature Biotechnol., 15: 17-18 (1997. 1.) , https://doi.org/10.1038/nbt0197-17b

[Papers selected by Faculty of 1000]

[Alkanes paper]  - 410. Choi, Y.J., Lee, S.Y., "Microbial production of short-chain alkanes", Nature, In press. http://dx.doi.org/10.1038/nature12536

[Systems metabolic engineering paper]  - 194. Park, J.H., Lee, K.H., Kim, T.Y., and Lee, S.Y, "Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation", Proc. Nature Acad. Sci. (PNAS), 104 (19): 7797-7802 (2007. 4.) , http://dx.doi.org/10.1073/pnas.0702609104 

[Proteome paper]  - 164. Han, M.-J., Lee, J.W., and Lee, S.Y., "Enhanced Proteome Profiling by Inhibiting Proteolysis with Small Heat Shock Proteins", J. Proteome Res., 4(6): 2429-2434 (2005. 12.), https://doi.org/10.1021/pr050259m

[Systems biology paper]  - 135. Hong, S.H., Kim, T.Y., and Lee, S.Y., "Phylogenetic analysis based on genome-scale metabolic pathway reaction content", Appl. Microbiol. Biotechnol., 65: 203-210 (2004.8), https://doi.org/10.1007/s00253-004-1641-3

354. Park, S.J., Lee, S.Y., Kim, T.W., Jung, Y.K., and Yang, T.H., "Biosynthesis of lactate containing polyesters by metabolically engineered bacteria", Biotechnol. J., 7(2): 199-212 (2012. 2), http://dx.doi.org/10.1002/biot.201100070

314. Kim, H.U., Kim, S.Y., Jeong, H., Kim, T.Y., Kim, J.J., Choy, H.E., Yi, K.Y., Rhee, J.H., Lee, S.Y., "Integrative genome-scale metabolic analysis of Vibrio vulnificus for drug targeting and discovery", Molecular Systems Biology, 7(460): 1-15 (2011. 1), http://dx.doi.org/10.1038/msb.2010.115

302. Park, T.J., Lee, S.Y., Heo, N.S., and Seo, T.S., "In vivo synthesis of diverse metal nanoparticles by recombinant Escherichia coli", Angew. Chem. Int. Ed., 49(39): 7019-7024 (2010.9), http://dx.doi.org/10.1002/anie.201001524

300. Xia, X.-X., Qian, Z.-G., Ki, C.S., Park, Y.H., Kaplan, D.L., and Lee, S.Y., "Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber" Proc. Nature Acad. Sci. (PNAS) 107(32): 14059-14063 (2010. 8), http://dx.doi.org/10.1073/pnas.1003366107

298. Park, J.M., Kim, T.Y., and Lee, S.Y. "Prediction of metabolic fluxes by incorporating genomic context and flux-converging pattern analyses", Proc. Nature Acad. Sci. (PNAS), 107(33): 14931-14936 (2010.8), http://dx.doi.org/10.1073/pnas.1003366107

292. Sohn, S.B., Graf, A.B., Kim, T.Y., Gasser, B., Maurer, M., Ferrer, P., Mattanovich, D., and Lee, S.Y. "Genome-scale metabolic model of methylotrophic yeast Pichia pastoris and its use for in silico analysis of heterologous protein production", Biotechnol. J. 5(7): 705-715 (2010.7), http://dx.doi.org/10.1002/biot.201000078

287. Choi, H.S., Lee, S.Y., Kim, T.Y., and Woo, H.M. "In silico identification of gene amplification targets for improving lycopene production", Appl. Environ. Microbiol. 76(10): 3097-3105 (2010.5), http://dx.doi.org/10.1128/AEM.00115-10

282. Kang, T., Yoo, S.M., Yoon, I., Lee, S.Y., and Kim, B. "Patterned multiplex pathogen DNA detection by Au particle-on-wire SERS sensor", Nano Lett. 10(4): 1189-1193 (2010.4), http://dx.doi.org/10.1021/nl1000086

274. Kim, S., Ahn, J.-H., Park, T.J., Lee, S.Y., and Choi, Y.-K., "Charge pumping technique to analyze the effect of intrinsically retained charges and extrinsically trapped charges in biomolecules by use of a nanogap embedded bio-transistor", Appl. Phys. Lett., 96(5): 053702, 1-3 (2010.2.), http://dx.doi.org/10.1063/1.3300838

269. Kim, H.U., Kim, T.Y., and Lee, S.Y., "Genome-scale metabolic network analysis and drug targeting of multi-drug resistant pathogen Acinetobacter baumannii AYE", Mol. Biosyst., 6: 339-348 (2010. 2.), http://dx.doi.org/10.1039/b916446d

266. Jung, Y.K., Kim, T.Y., Park, S.J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers", Biotechnol. Bioeng., 105(1): 161- 171 (2010.1). http://dx.doi.org/10.1002/bit.22548

258. Qian, Z.-G., Xia, X.-X., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of putrescine, a four carbon diamine", Biotechnol. Bioeng. 104(4): 651-662 (2009. 11) Selected as Research Highlights by Nature (Sept 3, 2009) , http://dx.doi.org/10.1002/bit.22502

255. Lee, J.Y., Jang, Y.-S., Lee, J., Papoutsakis, E.T., and Lee, S.Y., "Metabolic engineering of Clostridium acetobutylicum M5 for highly selective butanol production", Biotechnol. J. 4(10): 1432-1440 (2009.10), http://dx.doi.org/10.1002/biot.200900142

212. Hyeon, B.-H., Kim, H.-Y., Lee, C.M., Moon, S.-H., Kim, E.-S., and Lee, S.Y. "Bio-Vision 2016: The second national framework plan for biotechnology promotion in Korea", Biotechnol. J. 3:591-600 (2008. 5.), http://dx.doi.org/10.1002/biot.200700248

202. Lee, K.H., Park, J.H., Kim, T.Y., Kim, H.U., and Lee, S.Y., " Systems metabolic engineering of Escherichia coli for L-threonine production", Molecular systems biology, 3(149): 1-8 (2007. 12.), http://dx.doi.org/10.1038/msb4100196

199. Kim, P.J., Lee, D.Y., Kim, T.Y., Lee, K.H., Joeong, H.W., Lee, S.Y., Park, S.W., "Metabolite essentiality elucidates robustness of  Escherichia coli metabolism", Proc. Nature Acad. Sci. (PNAS), 104 (34): 13638-13642 (2007. 8.), http://dx.doi.org/10.1073/pnas.0703262104

197. Yun, H., Lee, J. W., Jeong, J., Chung, J., Park, J. M., Myoung, H. N., and Lee, S.Y., "EcoProDB: the Escherichia coli protein database", Bioinformatics, 23(18): 2501-2503 (2007. 9.), http://dx.doi.org/10.1093/bioinformatics/btm351

194. Park, J.H., Lee, K.H., Kim, T.Y., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation", Proc. Nature Acad. Sci. (PNAS), 104 (19): 7797-7802 (2007. 4.), http://dx.doi.org/10.1073/pnas.0702609104

193. Kim, T.Y., Kim, H.U., Park, J.M., Song, H., Kim, J.S. and Lee, S.Y., "Genome-scale analysis of Mannheimia succiniciproducens metabolism", Biotechnol. Bioeng. (Accelerated Publication), 97(4): 657-671 (2007. 7.), http://dx.doi.org/10.1002/bit.21433

206. Yoo, S.Y., Kim, T.-I., Lee, S.Y., Kim, E.K., Keum, K.C., Yoo, N.C., and Yoo, W.M. "Development of DNA chip for the diagnosis of most common corneal dystrophies caused by mutations in the bigh3 gene", British J. Opththalmol. 91: 722-727 (2007. 6.), http://dx.doi.org/10.1136/bjo.2006.111070

176. Lee, D.-Y., Yun, C., Cho, A., Hou, B.K., Park, S. and Lee, S.Y., "WebCell: a web-based environment for kinetic modeling and dynamic simulation of cellular networks", Bioinformatics, 22(9): 1150-1151 (2006. 4. 1.), http://dx.doi.org/10.1093/bioinformatics/btl091

175. Han, M.-J. and Lee, S.Y., "The Escherichia coli Proteome: Past, Present, and Future Prospects", Microbiol. Mol. Biol. Reviews, 70(2): 362-439 (2006. 6.), http://dx.doi.org/10.1128/MMBR.00036-05

171. Lee, S.J., Song, H. and Lee, S.Y., "Genome-based metabolic engineering of Mannheimia succiniciproducens for succinic acid production", Appl. Environ. Microbiol. 72(3): 1939-1948 (2006. 3.), http://dx.doi.org/10.1128/AEM.72.3.1939?1948.2006

164. Han, M.-J., Lee, J.W., and Lee, S.Y., "Enhanced Proteome Profiling by Inhibiting Proteolysis with Small Heat Shock Proteins", J. Proteome Res., 4(6): 2429-2434 (2005. 12.), https://doi.org/10.1021/pr050259m

157. Yun, H., Lee, D.-Y., Jeong, J., Lee, S., and Lee, S.Y., "MFAML: a standard data structure for representing and exchanging metabolic flux models", Bioinformatics, 21(15): 3329-3330 (2005. 8. 1.), https://doi.org/10.1093/bioinformatics/bti502

147. Hong, S. H.,  Kim, J.S.,  Lee, S.Y., In, Y.H., Choi, S.S., Rih, J.K., Kim, C. H.,  Jeong, H., Hur, C. G., and Kim, J.J., "The genome sequence of the capnophilic rumen bacterium Mannheimia succiniciproducens", Nature Biotechnology 22(10): 1275-1281 (2004. 10.), https://doi.org/10.1038/nbt1010

140. Hou, B.K., Kim, J.S., Jun, J.H., Lee, D.-Y., Kim, Y.W., Chae, S., Roh, M., In, Y.-H., and Lee, S.Y., "BioSilico: an integrated metabolic database system", Bioinformatics, 20(17) : 3270-3272 (2004. 11. 22.), http://dx.doi.org/10.1093/bioinformatics/bth363

137. Han, M.-J., Park, S.J., Park, T.J., and Lee, S.Y., "Roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli", Biotechnol. Bioeng. 88(4): 426-436 (2004.11.20.), https://doi.org/10.1002/bit.20227

131. Lee, S.J. and Lee, S.Y., "Microarrays of peptides elevated on the protein layer for efficient protein kinase assay", Analytical Biochemistry, 330:311-316 (2004. 7. 15.), https://doi.org/10.1016/j.ab.2004.04.008

107. Yoon,S.H., Han, M.J., Lee, S.Y., Jeong, K.J., and Yoo, J.S., "Combined transcriptome and proteome analysis of Escherichia coli during high cell density culture", Biotechnol. Bioeng., 81(7) : 753-767 (2003. 3. 30.), https://doi.org/10.1002/bit.10626

114. Lee, D.Y, Yun, H. S, Lee, S.Y. and Park, S.W., "MetaFluxNet: the management of metabolic reaction information and quantitative metabolic fluxanalysis", Bioinformatics, 19(16) : 2144-2146 (2003. 11. 1.),  https://doi.org/10.1093/bioinformatics/btg271



Journal Cover Papers

55.Choi, K.R., Luo, Z.W., Kim, G.B., Xu, H., Lee, S.Y. "A microbial process for the production of benzyl acetate" Nature Chem. Eng., 1: 216-228, https://doi.org/10.1038/s44286-023-00022-0 (2024.3), https://doi.org/10.1038/s44286-023-00022-0

54.Lee, J.A., Kim, J.Y., Ahn, J.H., Ahn, Y.-J., and Lee, S.Y. "Current advancements in the bio-based production of polyamides", Trends Chem. 5(12): 873-891 (2023.12), http://dx.doi.org/10.1038/nprot.2013.105

53.Hu, B., Yu, H., Zhou, J., Li, J., Chen, J., Du, G., Lee, S.Y., and Zhao, X. "Whole-Cell P450 Biocatalysis using engineered Escherichia coli with fine-tuned heme biosynthesis", Adv. Sci., 10(6): 2205580 1-16, https://doi.org/10.1002/advs.202205580 (2023.2), https://doi.org/10.1002/advs.202205580

52. Koh, S., Choi, Y., Lee, I., Kim, G.-M., Kim, J., Park, Y.-S., Lee, S.Y., and Lee, D.C., "Light-Driven Ammonia Production by Azotobacter vinelandii Cultured in Medium Containing Colloidal Quantum Dots", J. Am. Chem. Soc., 144(24): 10798-10808 (2022.6), https://doi.org/10.1021/jacs.2c01886

51. Prabowo, C.P.S., Eun, H., Yang, D., Huccetogullari, D., Jegadeesh, R., Kim, S.J. and Lee, S.Y. "Production of natural colorants by metabolically engineered microorganisms", Trends Chem., 4(7): 608-626 (2022.7), https://doi.org/10.1016/j.trechm.2022.04.009

50. Kim, M.I., Park, C.Y., Seo, J.M., Kang, K.S., Park, K.S., Kang, J., Hong, K.S., Choi, Y., Lee, S.Y., Park, J.P., Park, H.G., and Park, T.J. "In situ biosynthesis of a metal nanoparticle encapsulated in alginate gel for imageable drug-delivery system", ACS Appl. Mater. Interfaces, 13(31): 36697-36708 (2021. 7), https://doi.org/10.1021/acsami.1c02286

49. Yang, D., Park, S.Y., and Lee, S.Y., "Production of rainbow colorants by metabolically engineered Escherichia coli", Adv. Sci., 8(13): 2100743 1-13 (2021. 7), https://doi.org/10.1002/advs.202100743

48. Choi, S.Y., Cho, I.J., Lee, Y., Kim, Y.-J., Kim, K.-J., and Lee, S.Y. "Microbial polyhydroxyalkanoates and non-natural polyesters", Adv. Mat., 32(35): 1907138, 1-37 (2020. 9), https://doi.org/10.1002/adma.201907138

47. Yang, D., Park, S.Y., Park, Y.S., Eun, H., and Lee, S.Y. "Metabolic engineering of E. coli for natural products biosynthesis", Trends Biotechnol., 38(7): 745-765 (2020. 7), https://doi.org/10.1016/j.tibtech.2019.11.007

46. Lee, J.A., Ahn, J.H., Kim, I., Li, S., and Lee, S.Y. "Synthesis, characterization, and application of fully bio-based and biodegradable nylon-4,4 and -5,4", ACS Sustain. Chem. Eng., 8(14): 5604-5614 (2020. 4), https://doi.org/10.1021/acssuschemeng.0c00007

45. Lee, J.A., Ahn, J.H., Kim, I., Li, S., and Lee, S.Y. "Separation and purification of three, four, and five carbon diamines from fermentation broth", Chem. Eng. Sci., 196: 324-332 (2019. 3), https://doi.org/10.1016/j.ces.2018.11.018

44. Kim, H.T., Baritugo, K.-A., Hyun, S.M., Khang, T.U., Sohn, Y.J., Kang, K.H., Jo, S.Y., Song, B.K., Park, K., Kim, I.-K., Hwang, Y.T., Lee, S.Y., Park, S.J., and Joo, J.C. "Development of metabolically engineered Corynebacterium glutamicum for enhanced production of cadaverine and its use for the synthesis of bio-polyamide 510", ACS Sustain. Chem. Eng., 8(1): 129−138 (2020. 1), https://doi.org/10.1021/acssuschemeng.9b04693

43. Choi, K.R., Jang, W.D., Yang, D., Cho, J.S., Park, D., and Lee, S.Y. "Systems Metabolic Engineering Strategies: Integrating Systems and Synthetic Biology with Metabolic Engineering", Trends Biotechnol., 37(8): 817-837 (2019.8), https://doi.org/10.1016/j.tibtech.2019.01.003

42. Lee, Y., Cho, I.J., Choi, S.Y., and Lee, S.Y. "Systems metabolic engineering strategies for non-natural microbial polyester production", Biotechnol. J., 1800426: 1-12 (2019. 3), https://doi.org/10.1002/biot.201800426

41.Lee, S.Y., Kim, H.U., Chae, T.U., Cho, J.S., Kim, J.W., Shin, J.H., Kim, D.I., Ko, Y.-S., Jang, W.D. and Jang, Y.-S., "A comprehensive metabolic map for production of bio-based chemicals" Nature Catalysis, 2:18-33 (2019), https://doi.org/10.1038/s41929-018-0212-4

40. Choi, S.Y., Kim, W.J., Yu, S.J., Park, S.J., Im, S.G., and Lee, S.Y. "Engineering the xylose-catabolizing Dahms pathway for production of poly(D-lactate-co-glycolate) and poly(D-lactate-co-glycolate-co- D-2-hydroxybutyrate) in Escherichia coli", Microbial Biotechnol., 10(6): 1353-1364 (2017.11), http://dx.doi.org/10.1111/1751-7915.12721

39. Musiol-Kroll, E.M., Zubeil, F., Schafhauser, T., Hartner, T., Kulik, A., McArthur, J., Koryakina, I., Wohlleben, W., Grond, S., Williams, G.J., Lee, S.Y., and Weber, T., "Polyketide bio-derivatization using the promiscuous acyltransferase KirCII", ACS Syn. Biol., 6(3): 421-427 (2017. 3), http://dx.doi.org/10.1021/acssynbio.6b00341

38. Kim, J.E., Kim, Y-J., Choi, S.Y., Lee, S.Y., Kim, K-J., "Crystal structure of Ralstonia eutropha polyhydroxyalkanoate synthase C-terminal domain and reaction mechanisms", Biotechnol. J., 12(1):  1-12 (2017. 1), http://dx.doi.org/10.1002/biot.201600648

37. Kim, Y-J., Choi, S.Y., Kim, J.E., Jin, K.S., Lee, S.Y., Kim, K-J., "Structure and function of the N-terminal domain of Ralstonia eutropha polyhydroxyalkanoate synthase, and the proposed structure and mechanisms of the whole enzyme", Biotechnol. J., 12(1):  1-12 (2017. 1), http://dx.doi.org/10.1002/biot.201600649

36. Yang, J.E., Kim, J.W., Oh, Y.H., Choi, S.Y., Lee, H., Park, A.-R., Shin, J., Park, S.J., and Lee, S.Y. "Biosynthesis of poly(2-hydroxyisovalerate-co-lactate) by metabolically engineered Escherichia coli", Biotechnol. J. , 11(12): 1572-1585 (2016. 12), http://dx.doi.org/10.1002/biot.201600420

35. Song, C.W., Kim, J.W., Cho, I.J., and Lee, S.Y. "Metabolic engineering of Escherichia coli for the production of 3-hydroxypropionic acid and malonic acid through beta-alanine route", ACS Syn. Biol., 5(11): 1182-1183 (2016. 11), http://dx.doi.org/10.1021/acssynbio.6b00327

34. Lee, S.Y., "Systems Metabolic Engineering for Biorefineries", APBN, 20(1): 32-34 (2016.1)

33.  Jang, Y.-S. and Lee, S.Y. "Recent advances in biobutanol production", Industrial Biotechnol., 11(6): 316-321 (2015. 12),  http://dx.doi.org/10.1089/ind.2015.0023

32. Tong, Y., Charusanti, P., Zhang, L., Weber, T., and Lee, S.Y., "CRISPR-Cas9 based engineering of actinomycetal genomes", ACS Synth. Biol., 4(9): 1020-1029 (2015. 9),  http://dx.doi.org/10.1021/acssynbio.5b00038

31. Song, C.W., Lee, J., and Lee, S.Y., "Genome engineering and gene expression control for bacterial strain development", Biotechnol. J., 10: 48-60 (2015. 1),  http://dx.doi.org/10.1002/biot.201400057

30. Weber, T., Charusanti, P., Musiol-Kroll, E.-W., Jiang, X., Tong, Y., Kim, H.U., and Lee, S.Y., "Metabolic engineering of antibiotic factories: new tools for antibiotic production in actinomycetes", Trends Biotechnol., 33(1): 15-26 (2015. 1),  http://dx.doi.org/10.1016/j.tibtech.2014.10.009

29. Choi, Y.J., Lee, J., Jang, Y.-S., and Lee, S.Y., "Metabolic engineering of microorganisms for the production of higher alcohols", mBio, 5(5): e01524-14, doi: 10.1128/mBio.01524-14  (2014. 9),  http://dx.doi.org/10.1128/mBio.01524-14

28. Choi, Y.J., Lee, S.Y., "Microbial production of short-chain alkanes", Nature, 502(7472): 571-574 (2013. 10),  http://dx.doi.org/10.1038/nature12536

27. Yoo, S.M., Na, D., Lee, S.Y., "Design and use of synthetic regulatory small RNAs to control gene expression in Escherichia coli", Nature Protocols, 8(9): 1694-1707 (2013. 8), https://www.nature.com/articles/nprot.2013.105

26. Song, C.W. and Lee, S.Y., "Rapid one-step inactivation of single or multiple genes in Escherichia coli", Biotechnol. J., 8(7): 776-784 (2013. 7),  http://dx.doi.org/10.1002/biot.201300153

25. Song, C.W., Kim, D.I., Choi, S., Jang, J.W., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of fumaric acid", Biotechnol. Bioeng., 110(7): 2025-2034 (2013. 7),  https://doi.org/10.1002/bit.24868

24. Na, D., Yoo, S.M., Chung, H., Park, H., Park, J.H., and Lee, S.Y., "Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs", Nature Biotechnol., 31(2): 170-174 (2013. 2),  https://doi.org/10.1038/nbt.2461

23. Park, J.H., Oh, J.E., Lee, K.H., Kim, J.Y., and Lee, S.Y., "Rational Design of Escherichia coli for L-isoleucine Production", ACS Synthetic Biol., 1(11): 532-540 (2012.11), https://doi.org/10.1021/sb300071a

22. Jang, Y.-S., Lee, J.Y., Lee, J., Park, J.H., Im, J.A., Eom, M.-H., Lee, J., Lee, S.-H., Song, H., Cho, J.-H., Seung, D.Y., and Lee, S.Y., "Enhanced Butanol Production Obtained by Reinforcing the Direct Butanol-Forming Route in Clostridium acetobutylicum", mBio, 3(5): 1-9 (2012. 10), https://doi.org/10.1128/mbio.00314-12

21. Jang, Y.-S., Kim, B., Shin, J.H., Choi, Y.J., Choi, S., Song, C.W., Lee, J., Park, H.G., Lee, S.Y. "Bio-based production of C2-C6 platform chemicals", Biotechnol. Bioeng., 109(10): 2437-2459(2012. 10), https://doi.org/10.1002/bit.24599

20. Jung, J.H., Park, T.J., Lee, S.Y., and Seo, T.S., "Homogeneous biogenic paramagnetic nanoparticle synthesis based on a microfluidic droplet generator", Angewandte Chemie., 51(23): 5634-5637 (2012. 6), https://doi.org/10.1002/anie.201108977

19. Park, S.J., Kim, M.K., and Lee, S.Y., "One-step fermentative production of polylactic acid (PLA)", Chem. Eng. Prog., 108(5): 51-55 (2012. 5), https://doi.org/10.1002/adma.201804690

18. Park, S.J., Kim, M.K., Lee, S.Y., "Microbial metabolic engineering for the production of polyesters", Biotech international, 24: 11-13 (2012. 3)

17. Kim, H.U., Sohn, S.B., and Lee, S.Y., "Metabolic network modeling and simulation for drug targeting and discovery", Biotechnol. J., 7(3): 330-342 (2012. 3), https://doi.org/10.1002/biot.201100159

16. Jang, Y.-S., Lee, J., Malaviya, A., Seung, D.Y., Cho, J.H., and Lee, S.Y., "Butanol production from renewable biomass: rediscovery of metabolic pathways and metabolic engineering", Biotechnol. J., 7(2): 186-198 (2012. 2), https://doi.org/10.1002/biot.201100059

15. Lee, S.Y., Sohn, S.B., Park, J.M., Lee, J.W., "Biorefinery Research in Korea"., Asia Pacific Biotech News, 15(12): 15-21 (2011. 12), https://doi.org/10.1142/S0219030311000723

14. Yoo, S.M., Kang, T., Lee, S.Y., and Kim, B., "Combining Nanowire SERRS Sensor and Target Recycling Reaction for Ultrasensitive and Multiplex Identification of Pathogenic Fungi" Small, 7(23): 3371-3376 (2011. 12), https://doi.org/10.1002/smll.201100633

13. Yim, H., Haselbeck, R., Niu, W., Pujol-Baxley, C., Burgard, A., Boldt, J., Khandurina, J., Trawick, J.D., Osterhout, R.E., Stephen, R., Estadilla, J., Teisan, S., Schreyer, H.B., Andrae, S., Yang, T.H., Lee, S.Y., Burk, M.J., and Van Dien, S. "Metabolic engineering of Escherichia coli for direct production of 1,4-butanediol", Nature Chem. Biol., 7(7): 445-452 (2011. 7), https://doi.org/10.1038/nchembio.580

12. Lee, J.W., Kim, T.Y., Jang, Y.S., Choi, S., and Lee, S.Y. "Systems metabolic engineering for chemicals and materials", Trends Biotechnol. 29(8): 370-378 (2011. 8), https://doi.org/10.1016/j.tibtech.2011.04.001

11. Sohn, S.B., Kim, T.Y., Park, J.M., and Lee, S.Y. "In silico genome-scale metabolic analysis of Pseudomonas putida KT2440 for polyhydroxyalkanoate synthesis, degradation of aromatics, and anaerobic survival", Biotechnol. J. 5(7): 739-750 (2010.7), https://doi.org/10.1002/biot.201000124

10. Yoo, S.M. and Lee, S.Y., "DNA microarray for the identification of pathogens causing bloodstream infections", Expert Reviews of Molecular Diagnostics, 10(3): 263-268 (2010. 4), https://doi.org/10.1586/erm.10.23

9. Kim, T.Y., Kim, H.U., and Lee, S.Y., "Data integration and analysis of biological networks", Curr. Opin. Biotechnol. 21: 78-84 (2010.2), https://doi.org/10.1016/j.copbio.2010.01.003

8. Kim, H.U., Kim, T.Y., and Lee, S.Y., "Genome-scale metabolic network analysis and drug targeting of multi-drug resistant pathogen Acinetobacter baumannii AYE", Mol. Biosyst., 6: 339-348 (2010. 2.), https://doi.org/10.1039/B916446D

7. Jung, Y.K., Kim, T.Y., Park, S.J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers", Biotechnol. Bioeng., 105(1): 161- 171 (2010.1), https://doi.org/10.1002/bit.22548

6. Qian, Z.-G., Xia, X.-X., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of putrescine, a four carbon diamine", Biotechnol. Bioeng. 104(4): 651-662 (2009. 11), https://doi.org/10.1002/bit.22502

5. Park, J.H. and Lee, S.Y. "Towards systems metabolic engineering of microorganisms for amino acid production", Curr. Opin. Biotechnol. 19(5): 454-460 (2008. 10), https://doi.org/10.1016/j.copbio.2008.08.007

4. Park, J.H., Lee, S.Y., Kim, T.Y., and Kim, H.U., "Application of systems biology for bioprocess development", Trends Biotechnol., 26(8), 404-412 (2008. 8.), https://doi.org/10.1016/j.tibtech.2008.05.001

3. Hyeon, B.-H., Kim, H.-Y., Lee, C.M., Moon, S.-H., Kim, E.-S., and Lee, S.Y. "Bio-Vision 2016: The second national framework plan for biotechnology promotion in Korea", Biotechnol. J. 3:591-600 (2008. 5.), https://doi.org/10.1002/biot.200700248

2. Kim, T.Y., Kim, H.U., Park, J.M., Song, H., Kim, J.S. and Lee, S.Y., "Genome-scale analysis of Mannheimia succiniciproducens metabolism", Biotechnol. Bioeng. (Accelerated Publication), 97(4): 657-671 (2007. 7.), https://doi.org/10.1002/adma.201804690

1.Han, M.-J., Park, S.J., Park, T.J., and Lee, S.Y., "Roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli", Biotechnol. Bioeng. 88(4): 426-436 (2004.11.20.), https://doi.org/10.1002/cphc.201402810

Other Worldwide Recognitions