Alumni
Yon Chul Kim
Ph.D. '98.2
Jong-il Choi
Ph.D. '99. 8.
Chemical & Biomolecular Engineering, KAIST
Phone : +82-42-869-5970
Fax : +82-42-869-8800
Details
Education
B.S. : Department of Chemical Engineering, Chungang University, Seoul, Korea (Mar.1989 – Feb. 1993)
M.S. : Department of Chemical Engineering, KAIST, Taejon, Korea (Mar. 1993 – Feb. 1995)
Ph.D.: Department of Chemical Engineering, KAIST, Taejon, Korea (Mar. 1995 – Aug. 1999)
Thesis
M.S. Thesis : Purification of lactic acid using solid catalyzed reaction (Supervised by Won Hi Hong)
Ph.D. Thesis : Development of recombinant Escherichia coli strain and the process for the production of poly(3-hydroxyalkanoate) (Supervised by Sang Yup Lee)
Career
Mar. 1995 - Feb. 1999 : Research and teaching assistant in KAIST
Aug. 1999 – Mar. 2000 : Postdoctoral associater at BioProcess Engineering Research Institute, KAIST
Apr. 2000 – Sep. 2001 : Postdoctoral associater at Department of Microbiology, University of Minnesota
Oct. 2001 – Present : Senior researcher at Samchully Pharmaceutical Co.
Research Work in Ph. D. course
Molecular cloning
Construction of recombinant bacteria
Metabolic engineering
High cell density culture
Production and recovery of biodegradable polymer
Process analysis and economic evaluation
Research Work at Postdoctoral Fellowship
Discovery of new anti-cancer drug
Separation of sponge cells producing bioactive compound from sponge samples
Construction of BAC library to target the PKS pathway
Cloning of novel PKS genes from deep marine bacteria
Discovery of new PKS biosynthesis pathway
Research Work at Postdoctoral Fellowship
production of pyrimidine deoxyribonucleoside by microorganisms
Publications
International Journal: 17 papers
Book Chapter: 4 papers
International Proceeding: 7 papers
Domestic Journal: 7 papers
International Conference: 19
Domestic Conference: 17
International Patent: 1
International Journal
1. Choi, J., Hong W.H., Chang, H.N. 1995. Reaction kinetics of lactic acid with methanol catalyzed by acid resins. Int. J. Chem. Kinetics, 28: 37-41.
2. Choi, J., Lee S.Y. 1997. Process analysis and economic evaluation for poly(3-hydroxybutyrate) production by fermentation. Bioprocess Eng., 17(6): 335-342.
3. Lee, S.Y., Choi, J. 1998. Effect of fermentation of performance on economics of poly(3-hydroxybutyrate) production by Alcaligenes latus. Polymer Degrad. Stabil., 59: 387-393.
4. Choi, J., Lee, S. Y., Han, K. 1998. Cloning of the Alcaligenes latus polyhydroxyalkanoate biosynthesis genes and use of these genes for enhanced production of poly(3-hydroxybutyrate) by recombinant Escherichia coli. Appl. Environ. Microbiol., 64: 4897-4903.
5. Choi, J., Lee, S. Y. 1999. Efficient and economical recovery of poly(3-hydroxybutyrate) from recombinant Escherichia coli by simple digestion with chemicals. Biotechnol. Bioeng., 62(5): 546-553.
6. Lee, S. Y., Choi, J. 1999. Production and degradation of polyhydroxyalkanoates in waste environment. Waste Management, 19: 133-139.
7. Choi, J., Hong, W. H. 1999. Recovery of lactic acid by batch distillation with chemical reactions using ion exchange resin. J. Chemical Eng. Japan, 32(2): 184-189.
8. Choi, J., Lee, S. Y. 1999. Factors affecting the economics of polyhydroxyalkanoates production by bacterial fermentation. Appl. Microbiol. Biotechnol., 51(1): 13-21.
9. Choi, J., Wong, H. H. 1999. Recent advances in polyhydroxyalkanoate production by bacterial fermentation. Intl. J. Biol. Macromol. 25: 31-36.
10. Lee, S. Y., Choi, J., Han, K., Song, J. Y. 1999. Removal of endotoxin during the purification of poly(3-hydroxybutyrate) from gram-negative bacteria. Appl. Environ. Microbiol., 65(6): 2762-2764.
11. Choi, J., Lee, S. Y. 1999. Production of poly(3-hydroxybutyrate) [P(3HB)] with high P(3HB) content by recombinant Escherichia coli harboring the Alcaligenes latus P(3HB) biosynthesis genes and the E. coli ftsZ gene. J. Microbiol. Biotechnol., 9(6):722-725.
12. Wong, H. H., van Wegen R. J., Choi, J., Lee, S. Y., Middelberg, A. P. J. 1999. Metabolic analysis of poly(3-hydroxybutyrate) production by recombinant Escherichia coli. J. Microbiol. Biotechnol., 9(5):593-603.
13. Choi, J., Lee, S. Y. 1999. High level production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by fed-batch culture of recombinant Escherichia coli. Appl. Environ. Microbiol., 65(10): 4363-4368.
14. Lee, S. H., Oh, D. H., Ahn, W. S., Lee, Y., Choi, J., Lee, S. Y. 2000. Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas hydrophila. Biotechnol. Bioeng., Biotechnol. Bioeng., 67(2): 240-244.
15.Choi, J. and Lee, S.Y. 2000. Economic consideration on the production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by bacterial fermentation. Appl. Microbiol. Biotechnol., 53(6): 646-649.
16. Lee, S. Y., Wong, H. H., Choi, J., Lee, S. H., Lee, S. C., Han, C. S. 2000. Production of medium-chain-length polyhydroxyalkanoates by high cell density cultivation of Pseudomonas putida. Biotechnol. Bioeng., 68(4):466-470.
17. Lee, S. Y., Choi, J. 2001. Production of microbial polyester by fermentation of recombinant microorganisms. Adv. Biochem. Eng. Biotechnol., 71:183-207.
Book Chapter
1. Lee, S.Y., Choi, J. 1999. Chapter 51. Polyhydroxyalkanoate: biodegradable polymer. In : Manual of Industrial Microorganisms and Biotechnology, 2nd ed., eds. A. L. Demain and J. E. Davies, American Society for Microbiology, Washington DC. USA, pp. 616-627.
2. Lee, S. Y., Choi, J. 1999. Metabolic engineering strategies for the production of polyhydroxyalkanoates, a family of biodegradable polymers. eds. S. Y. Lee and E. T. Papoutsakis. Marcel Dekker, USA, pp. 113-151.
3. Lee, S.Y., Choi, J. 2000. Polyhydroxyalkanoate production by recombinant Escherichia coli: new genes and new strains, In: ACS symposium series 764, Polymers from renewable resources - Biopolyesters and biocatalysis. eds. C. Scholz, R. A. Gross, American chemical society. Washington DC, USA, pp. 77-88.
4. Lee, S.Y.Choi, J. 2001. Production of microbial polyesters by fermentation of recombinant microorganisms, In: Biopolyesters eds. W. Babel and A. Steinbuchel, Springer Velag, Berlin, Germany pp. 183-207.
International Proceeding
1. Lee, S.Y., Choi, J., Chang, H.N. 1997. Process development and economic evaluation for the production of polyhydroxyalkanoates by Alcaligenes eutrophus. Proceedings of 96 International Symposium on Bacterial Polyhydroxyalkanoates. Swiss, Davos, 127-136.
2. Choi, J., Lee, S.Y. 1997. Development of recombinant Alcaligenes eutrophus for the efficient production of poly(3-hydroxybutyrate). Proceeding of 4th APBioChEC’97, Beijing, China, 626-629.
3.Choi, J., Wang, F., Lee, S.Y. 1997. Production of poly(3-hydroxybutyrate) by filamentation-suppressed recombinant Escherichia coli in defined medium. Proceeding of 4th APBioChEC’97, Beijing, China, 630-633.
4. Lee, S. Y., Choi, J., Wang, F. 1998. Production of poly(3-hydroxybutyrate) by recombinant bacteria. In Science and Technology of Polymers and Advanced Materials. Proceedings of the 4th International conference on Frontiers of Polymers and Advanced Materials, Cairo, Egypt, eds. P. N. Prasad et al., Plenum Press, New York, 463-475.
5. Lee, S.Y., Choi, J. 1998. Metabolic engineering of Escherichia coli for the production of polyhydroxyalkanoates. Proceeding of the 7th International Conference on Computer Application in Biotechnology, Osaka, Japan, 363-377.
6. Lee, S.Y., Choi, J., Lee, S. H. 1999. Production of polyhydroxyalkanoates by fermentation of bacteria. Proceeding of 7th SPSJ International Polymer Conference, Yokohama, Japan.
7. Choi, J., Hong, W. H., Lee, S. Y. 1999. Recovery of poly(3-hydroxybutyrate) from recombinant Escherichia coli. Proceedings of 5th APBioChEC’99. Phuket, Thailand.
Domestic Journal
1. Lee, S.Y., Lee, Y., Choi, J. 1995. Production and application of polyhydroxyalkanoates. Kor. J. Biotechnol. Bioeng., 10(4): 406-420.
2. Choi, J., Lee, S.Y. 1995. Polyhydroxyalkanoates. Recent Advances in Bioprocess Engineering, 3: 3-16.
3.Choi, J., Lee, S. Y. 1996. Production of polyhydroxyalkanoates by recombinant microorganisms: Application of metabolic engineering. Bioindustry News, 9(4): 47-55.
4. Hur, S.S., Choi, J., Lee, S.Y. 1997. Isolation of Poly(3-hydroxybutyrate) [PHB] accumulating bacteria from soil and production of PHB from inexpensive carbon substrates, Kor. J. Biotechnol. Bioeng., 12: 451-458.
5. Choi J., Lee, S.Y. 1997. Development of recombinant Alcaligenes eutrophus for the production of poly(3-hydroxybutyrate). Hwahak Konghak, 35: 684-689.
6. Lee, S. Y., Choi, J., Wong, H. H., Wang, F. 1998. Production of bioproducts by high cell density culture of recombinant Escherichia coli. Biochemical Eng., 12: 3-13.
7.Choi, J., Hong, W. H. 1999. Separation characteristics of lactic acid by batch reactive distillation. Kor. J. Biotechnol. Bioeng., 14(2): 220-224.
International Conference
1. Choi, J., Hong, W.H. Distillation of lactic acid using its ester. 7th Chungnam-Kyushu International Symposium 1994, Kitakyushu, Japan, November (1994).
2. Lee, S.Y., Choi, J. Enhancement of PHB synthesis by suppressing filamentation in recombinant Escherichia coli. International Symposium on Biodegradable Polymers, Tokyo, Japan, November (1995).
3. Lee, S.Y., Choi, J. Characterization of filamentation-suppressed recombinant E. coli. 8th Chungnam-Kyushu International Symposium 1995, Taejon, Korea, December (1995).
4. Lee, S.Y., Choi, J., Chang, H.N. Optimization and economics of polyhydroxyalkanoate production in bacteria. International Symposium on Bacterial Polyhydroxyalkanoates '96, Davos, Switzerland, August (1996).
5. Lee, S. Y., Choi, J., Lee. Y. Polyhydroxyalkanoates synthesis by metabolically engineered Escherichia coli strains. Recombinant DNA Biotechnology IV: Metabolic Engineering, Danover, MA, U.S.A., October (1996).
6. Jeong, K.J., Choi, J., Lee, S.Y. Construction of shuttle vector between Escherichia coli and Alcaligenes sp. 9th Chungnam-Kyushu International Symposium. Miyazaki, Japan, October (1996).
7. Choi, J., Lee, S.Y. Development of recombinant Alcaligenes eutrophus for the efficient production of poly(3-hydroxybutyrate). 4th APBioChEC’97, Beijing, China, October (1997).
8. Choi, J., Wang, F., Lee, S.Y. Production of poly(3-hydroxybutyrate) by filamentation-suppressed recombinant Escherichia coli in defined medium. 4th APBioChEC’97, Beijing, China, October (1997).
9. Choi, J., Wang, F., Lee, S.Y. Production of poly(3-hydroxybutyrate) with high productivity and high P(3HB) content by fed-batch culture of Alcaligenes latus under nitrogen limitation. 10th Chungnam-Kyushu International Symposium. Taejon, Korea, November (1997).
10. Lee, S.Y., Choi, J. Metabolic engineering of Escherichia coli for the production of polyhydroxyalkanoates. 7th International Conference on Computer Application in Biotechnology, Osaka, Japan, June (1998).
11.Choi, J., Lee, S. Y. Cloning and molecular analysis of polyhydroxyalkanoate biosynthesis genes of a gram negative bacterium. 7th Annual Meeting of the Bio/Environmentally degradable Polymer Society, Boston, USA, August (1998).
12.Choi, J., Lee, S. Y. Design and analysis of Process for the production of poly(3-hydroxybutyrate) by recombinant Escherichia coli. 7th Annual Meeting of the Bio/Environmentally degradable Polymer Society, Boston, USA, August (1998).
13.Choi, J., Lee, S. Y. Production of poly(3-hydroxybutyrate) with high productivity by fed-batch culture of recombinant Escherichia coli harboring the Alcaligenes latus polyhydroxyalkanoate biosynthesis genes. 7th Annual Meeting of the Bio/Environmentally degradable Polymer Society, Boston, USA, August (1998).
14. Lee, S. Y., Choi, J., Wong H. H. Poly(3-hydroxybutyrate) production from whey by recombinant Escherichia coli. 7th Annual Meeting of the Bio/Environmentally Degradable Polymer Society, Boston, USA, August (1998).
15. Choi, J., Lee, S. Y. Efficient recovery of poly(3-hydroxybutyrate) from recombinant Escherichia coli by simple digestion with chemicals. International Symposium on Biological Polyhydroxyalkanoates 98, Tokyo, Japan, September (1998).
16. Choi, J. Poly(3-hydroxybutyrate) production from xylose. International Symposium on Biological Polyhydroxyalkanoates 98, Tokyo, Japan, September (1998).
17.Choi, J., Lee, S. Y. Economic recovery of poly(3-hydroxybutyrate) from recombinant Escherichia coli by simple digestion. 12th Chungnam-Kyushu International Symposium. Kongju, Korea, October (1999).
18. Ahn, W. S., Choi, J., Lee, S. Y. Poly(3-hydroxybutyrate) production by recombinant Escherichia coli harboring the Alcaligenes latus polyhydroxyalkanoate biosynthesis genes. 12th Chungnam-Kyushu International Symposium. Kongju, Korea, October (1999).
19. Choi, J., Hong, W. H., Lee, S. Y. Recovery of poly(3-hydroxybutyrate) from recombinant Escherichia coli. Proceedings of 5th APBioChEC’99. Phuket, Thailand.(1999)
Domestic Conference
1. Choi, J., Hong, W.H. Purification of lactic acid by esterification reaction. KIChE Fall Meeting, Chonbuk Univ., October (1994).
2. Midelberg, A.P.J., Lee, S.Y., Choi, J. Study on the poly(3-hydroxybutyric acid) granules produced in recombinant E. coli. Annual Meeting of Korean Society for Applied Microbiology, Seoul National Univ., April (1995).
3. Lee, S.Y., Choi, J. Production of medium chain length poly-(3-hydroxyalkanoates) by Pseudomonas oleovorans. Annual Symposium of KIBB, SunMun Univ., October (1995).
4. Choi, J., Lee, S.Y. Economic evaluation for poly(3-hydroxybutyrate) production by bacterial fermentation. Annual Symposium of KIBB, Pusan National Univ., October (1996).
5. Choi, J., Lee, S. Y. Production of PHB by recombinant Alcaligenes eutrophus. KIChE Spring Meeting, Dongkuk Univ., April (1997).
6. Wang, F., Choi, J., Park, S.J., Lee, S.Y. Production of poly(3-hydroxybutyrate) with high productivity and high P(3HB) content by fed-batch culture of Alcaligenes latus under nitrogen limitation. KIChE Fall Meeting, Chungnam Univ., October (1997).
7. Choi, J., Lee, S.Y. Process analysis and economic evaluation for poly(3-hydroxybutyrate) production by fermentation. Annual Symposium of KIBB, Chonbuk Univ., April (1998).
8. Choi, J., Lee, S.Y., Isolation of poly-3-hydroxybutyrate [P(3HB)] accumulating bacteria from soil and production of P(3HB) from inexpensive carbon substrates, Annual Meeting of Korean Society for Applied Microbiology, Korea Univ., April (1998).
9. Choi, J., Lee, S. Y., Process analysis for polyhydroxyalkanoate production, Annual BPERC Symposium’98, KAIST. September (1998).
10. Choi, J., Lee, S. Y., Production of polyhydroxyalkanoate by new recombinant Escherichia coli, Annual BPERC Symposium’98, KAIST. September (1998).
11. Lee, S. Y., Choi, J., Wong H. H. Poly(3-hydroxybutyrate) production from whey by recombinant Escherichia coli. Annual BPERC Symposium’98, KAIST. September (1998).
12. Choi, J., Lee, S. Y. Cloning of the Alcaligenes latus polyhydroxyalkanoate biosynthesis genes and use of these genes for the enhanced production of poly(3-hydroxybutyrate) in Escherichia coli. Annual Symposium of KIBB, Hanyang Univ., October (1998)
13. Choi, J., Lee, S. Y., Wong H. H. Poly(3-hydroxybutyrate) production from whey by recombinant Escherichia coli. KIChE Fall Meeting, Chosun Univ., October (1998).
14. Choi, J., Lee, S. Y., Chang, H. N. Efficient and economical recovery of poly(3-hydroxybutrate) from recombinant Escherichia coli. Annual Symposium of KIBB, Chonnam Univ., April (1999).
15. Choi, J., Lee, S. Y., Production of Poly(3-Hydroxybutyrate-co-3-Hydroxyvalerate) by Fed-batch Culture of Recombinant Escherichia coli, KIChE Fall Meeting, Kyungnam Univ., October (1999).
16. Choi, J., Lee, S. Y., Endotoxin removal during the recovery of poly(3-hydroxybutyrate), Annual Meeting of Korean Society for Applied Microbiology, Youngnam Univ., October (1999).
17. Choi, J., Park, S.J., and Lee, S.Y.: Production of Poly(3-hydroxybutyrate) with high molecular mass by recombinant Escherichia coli. KJChE meeting, Hanyang Univ., Ansan April (2000).
Zhaohui Xu
Ph.D. '00. 3.
Huazhong Agricultural University
Ki Jun Jeong
Assistant Professor '01. 2.
KAIST, Dept. of Chemical & Biomolecular Engineering, KAIST
Protein Engineering Laboratory
Phone : +82-42-869-5970
Fax : +82-42-869-8800
Details
Research Interest
Protein engineering (protein secretion, protein folding, directed evoloution)
Recombinant protein production
High-cell density cultivation
Proteomics
Education
1990. 3. - 1994. 2. Dept. of Biological Technology, KAIST, Daejeon, Korea (B.S.)
1994. 3. - 1996. 2. Dept. of Biological Sciences, KAIST, Daejeon, Korea (M.S.)
1996. 3. - 2001. 2. Dept. of Chemical Engineering, KAIST, Daejeon, Korea (Ph.D.)
Experience and Academic/Research Activity
Teaching and Research Assistant at the department of Chemical Engineering, KAIST (1996. 9 - 1997. 6)
Member, Korean Society for Applied Microbiology (1997 - present)
Member, The Biochemical Society of the Republic of Korea (2000 - present)
Member, Korea Institute of Biotechnology and Bioengineering (2000 - present)
Senior researcher, Dept. Chemical Engineering KAIST (2001. 3 - 2002. 9.)
Post-doc, Dept. of Chemical Engineering, University of Texas at Austin, USA (2002. 10. - present)
Publications
International Journals
Jeong K. J., Lee P. C., Park I. Y., Kim M. S. and Kim S. C., "Molecular cloning and characterization of an endoxylanase gene of Bacillus sp. in Escherichia coli", Enzyme Microb Technol. 22(7): 599-605 (1998). [Abstract]
Jeong K. J., Park I. Y., Kim M. S. and Kim S. C., "High-level expression of an endoxylanase gene from Bacillus sp. in Bacillus subtilis DB104 for the production of xylobiose from xylan", Appl. Microbiol. Biotechnol. 50(1): 113-118 (1998). [Abstract]
Jeong, K. J., Lee, H. S., Lee, S. Y., and Chang Y. K., "Development of recombinant bacteria for the degradation of dibenzothiophene", Ann. NY Acad. Sci., 864:375-378 (1998).
Jeong. K. J. and Lee, S. Y., "High-level production of human leptin by fed-batch cultivation of recombinant Escherichia coli and its purification", Appl. Environ. Microbiol. 65(7):3027-3032 (1999). [Abstract]
Jeong. K. J. and Lee, S. Y., "Secretory production of human leptin in Escherichia coli", Biotechnol. Bioengin. 67:398-407 (2000). [Abstract]
Choi, J. H., K. J. Jeong, S. C. Kim and S. Y. Lee., "Efficient secretory production of alkaline phosphatase by high cell density culture of recombinant Escherichia coli using the Bacillus sp. endoxylanase signal sequence", Appl. Microbiol. Biotechnol. 53:640-645 (2000). [Abstract]
Jeong, K.J. and Lee, S.Y., "Secretory production of human leptin in Bacillus subtilis??J. Microbiol. Biotechnol. 10(6):753-758 (2000).
Jeong, K. J. and S. Y. Lee, "Secretory production of human granulocyte colony stimulating factor in Escherichia coli", Protein Express. Purif. 23:311-318 (2001).
Lim S. C., K. J. Jeong, H. N. Chang and S. Y. Lee, "High-level secretory production of human granulocyte-colony stimulating factor by fed-batch culture of recombinant Escherichia coli", Bioprocess Biosystems Engineering, 24:249-254 (2001).
Jeong, K.J., and Lee, S.Y.,(2002) "Excretory Production of Human -Endorphin into Culture Medium by Using Outer Membrane Protein F as a Fusion Partner in Recombinant Escherichia coli ", Appl. Environ. Microbiol.,68(10):4979-4985 (2002).
Yoon,S.H., Han, M.J., Lee, S.Y., Jeong, K.J., and Yoo, J.S., "Combined transcriptome and proteome analysis of Escherichia coli during the high cell density culture" Biotechnol. Bioeng., 81(7) : 753-767 (2003).
Jeong, K.J. and Lee, S.Y., "Enhanced production of recombinant proteins in Escherichia coli by filamentation suppression", Appl. Environ. Microbiol. 69(2) : 1295-1298 (2003).
Han, M.J., Jeong, K.J., Yoo, J.S, and Lee. S.Y., "Engineering Escherichia coli for increased production of serine-rich proteins based on proteome profiling", Appl. Environ. Microbiol., 69(10) : 5772-5781 (2003).
Chen, S., Huang, X., Zhou, X., Bai, L., Jing He, Jeong, K. J.,Lee, S.Y., and Deng, Z., Chemistry and Biology, in press
Lee, S.Y. and Jeong, K. J., "Cellular engineering of Escherichia coli for the enhanced protein production by fermentation", in Fermentation Biotechnology (ed. Saha, B.C.), American Chemical Society, Washinton, D.C., USA (2004).
Domestic Journals
Ki Jun Jeong, Hyun Sook Lee, Sang Yup Lee and Yong Keun Chang, "Efficient transformation of Klebsiella oxytoca by electroporation", Biotechnol. Bioprocess Eng., 2. 87-91 (1998).
Ki Jun Jeong, and Sang Yup Lee, "Secretory production of human leptin in Bacillus subtilis", J. Microbiol. Biotechnol., 10(6):753-758 (2000).
Invited Lectures
Jeong, K. J., "Secretory production of proteins in E. coli : focus on excretion to the culture medium", Biochemical Engineering XII, Sonoma, California, USA, June (2001)
International Conferences
Jeong K. J., Choi J. I., and Lee S. Y., "Vector construction, transformation, and gene ampilification in Alcaligenes latus", The 9th Kyushu/Chungnam Symposium on Chemical Engineering, Kushu, Japan (1996).
Jeong K. J. Lee, H. S., Lee S. Y., Chang, Y. K., "Development of recombinant Klebsiella oxytoca for the desulfurization activity", The 10th Kyushu/Chungnam Symposium on Chemical Engineering, Taejon, Korea (1997).
Lee, S. Y., Jeong, K. J., Lee, H. S., and Chang Y. K., "Development of recombinant bacteria for the degradation of dibenxothiophen", Enzyme Engineering XIV CONFERENCE, Beijing, China (1997).
Jeong, K. J. and Lee, S. Y., "Efficient secretion of protein in Escherichia coli using endoxylanase signal sequence of Bacillus subtilis", Metabolic Engineering II, Elmau/Oberbayern, Germany (1998).
Lee, S.Y., and Jeong, K.J., "High level production of human leptin and its purification", The Microfluidics & Microarrays Conference : Small Talk '99 San Diego, CA. USA, June (1999).
Jeong, K. J. and Lee, S. Y., "Secretory production of human leptin in Escherichia coli", The 12th Kyushu/Chungnam Symposium on Chemical Engineering, Kongju Univ, Kongju (1999).
Jeong, K. J. and Lee, S. Y., "Secretory production of leptin in Escherichia coli" The 5th Asia-Pacific Biochemical Engineering Conference 1999 and The 11th Annual Meeting of The Thai Society for Biotechnology, Phuket, Thailand (1999).
Lee, S.Y., and Jeong, K. J., "High level production of human leptin and its purification", Biochemical Engineering XI, Park city, Utah, July (1999)
Lee, S. Y., Yoon, S. H., Han, M. J., Jeong, K.J., "Combined analysis of transcriptome and proteome profiles during the high cell density cultivation of Escherichia coli", Biochemical Engineering XII, Sonoma, California, USA, June (2001)
Han, M.J., Choi, J.H., Jeong, K.J., Yoo, J.S. and Lee, S.Y., "Proteome Analysis of Overproducing Human Leptin System", The 14th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, Chungnam Univ., Taejon , Korea (2001)
Domestic Conferences
Jeong K. J. and Kim S. C., "Molecular cloning and sequencing of an endoxylanase gene from Bacillus sp. and their expression in Bacillus subtilis", at the Autumn Meeting of Korea Society for Applied Microbiology (1995).
Jeong K. J., Lee Sang Yup, and Chang Y. K., "Construction of stable plasmid for the expression of desulfurization gene in E. coli", Annual BPERC Symposium 1996, KAIST, Taejon, Korea (1996).
Nam S. W., Kim J. H., Jeong K. J., Kim S. C., and Kim J. H., "Media optimization for xylanase overproduction by recombinant Bacillus subtilis", at the Autumn Meeting of Korea Society for Applied Microbiology (1996).
Jeong K. J., Lee S. Y., and Chang Y. K., "Construction of stable plasmid for the expression of desulfurization gene in E. coli", at the Spring Meeting of Korea Society for Applied Microbiology (1997).
Wong Heong Ho, Jeong Ki Jun, Lee Sang Yup, "Production of Bioadhesive Protein by Fed-batch culture of Recombinant Escherichia coli", Annual BPERC Symposium 1997, KAIST, Taejon, Korea (1997).
Jeong, K. J, and Lee, S. Y., "Overproduction of recombinant leptin in Escherichia coli", Annual BPERC Symposium 1998, KAIST, Taejon, Korea (1998).
Jeong, K. J., Choi, J. H. and Lee, S. Y., "Efficien secretion of recombinant endoxylanase in Escherichia coli", Annual BPERC Symposium 1998, KAIST, Taejon, Korea (1998).
Jeong, K. J, and Lee, S. Y., "Fed-batch fermentation of a recombinant Escherichia coli overproducing human leptin", at the Autumn Meeting of Korea Society for Applied Microbiology (1998).
Park, S. J., Jeong K. J., Lee, H. S., Lee S. Y., and Chang Y. K., "Development of recombinant bacteria for the degradation of dibenzothiophen", KJChE fall meeting, Chosun Univ., Kwangju (1998).
Choi, J.H., Jeong, K.J., Lee, S.Y., "Construction of secretion Vector containing Endoxylanase Signal Sequence from Bacillus subtilis and Secretory", Production of Alkaline Phosphatase in Escherichia coli", Annual Symposium of Korea Institute of Biotechnology and Bioengineering (KIBB) Chunnam Univ., Kwangju (1999).
Jeong, K. J., Lee, S.Y., "Overproduction of Human Leptin by Fed-Batch Cultivation of Recombinant Escherichia.coli and its purification", At the Spring Meeting of The Korean Society for Applied Microbiology, SeoGang Univ, Seoul (1999).
Jeong, K. J., Lee, S.Y., "Secretory production of human leptin in Escherichia coli", At the Autumn Meeting of The Korean Society for Applied Microbiology, Youngnam Univ, Ulsan (1999).
Jeong, K. J., and Lee, S. Y., "Production of human leptin in Bacillus subtilis", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 535-538. (2000, Apr.)
Jeong, K. J., and Lee, S. Y., "Production of soluble human leptin in periplasmic space of Escherichia coli using DsbA coexpression", Theories and Applications of Chemical Engineering 6(1): 1197-2000 (2000).
Jeong, K. J., and Lee, S. Y., "Production of soluble human leptin in periplasmic space of Escherichia coli using DsbA coexpression KJChE meeting", Hanyang Univ., Ansan April, 2000
Jeong, K. J., Lee, S. Y., "Secretory production of human granulocyte colony stimulation factor in Escherichia coli", Annual Meeting of The Korean Society for Applied Microbiology, Cheon-buk Univ., October, 2000
Lim, S. C., Jeong, K. J., Chang, H. N., Lee, S. Y., "Secretory production of human G-CSF in E. coli by large-scale fermentor", Annual meeting of Korean society for Biotechnology and Bioengineering , Konkuk Univ., Seoul, April (2001)
Yoon, S.H., Han, M.J., Jeong, K. J., Yoo, J.S., Lim, B.K., Lee, S.Y., "Transcriptome and proteome analysis of Escherichia coli during high cell density cultivation", Annual Meeting of Korean Society for Applied Microbiology, Chonan Sangnok Resort, June(2001)
Jeong, K. J., Lee, S. Y., "Secretory production of Human Granulocyte- colony stimulating factor into periplasm of Escherichia coli and its purification, Annual Meeting of Korean Society for Applied Microbiology", Chonan Sangnok Resort, June (2001)
Han, M.J., Choi, J.H., Jeong, K.J., Yoo, J.S. and Lee, S.Y., "Proteome Analysis of Overproduction of Recombinant Protein in Escherichia coli by Fed-Batch Fermentations", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Seoul, November(2001)
Han, M.J., Choi, J.H., Jeong, K.J., Yoo, J.S. and Lee, S.Y., "Proteome Analysis of Overproduction of Human Leptin in Escherichia coli by Fed-Batch Fermentations", KIChE meeting, Taejon , Korea (2001)
Jeong, K.J. and Lee, S.Y., "Excretory production of human β-endorphin into culture medium by recombinant Escherichia coli", KIChE meeting, Taejon , Korea (2001)
Pyung Cheon Lee
Ph.D. '01. 2.
Jin Hwan Do
Ph.D. '02. 2.
Young Lee
Ph.D. '02. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-863-8609
Fax : +82-303-2020-8609
Details
Research Interest
PolyHydroxyAlkanoate(PHA) monomer production/modification/application
Recombinant protein production
Education
1992 (B.S.) Dept. of Chemical Engineering, KAIST, Taejon, Korea
1997 (M.S.) Dept. of Chemical Engineering, KAIST, Taejon, Korea
2002 (Ph.D.) Dept. of Chemical & Biomolecular Engineering, KAIST, Taejon, Korea
Experience and Academic Activity
Researcher, BioProcess Engineering Research Center (1994-2002)
Member, Korean Institute of Chemical Engineers (1995-present)
Member, Korean Society for Biotechnology and Bioengineering (1995-present)
CEO, ChiroBio Inc., Taejon, Korea (2000-present)
Honor/Awards
The First Elmer Garden Award - coauthor, Biotechnology and Bioengineering (John Wiley & Sons, USA) – American Chemical Society (San Francisco National Meeting) (2000.3.27)
Award for Excellent Poster, Korean Society for Biotechnology and Bioengineering (2000.11.10)
SejongDaeWang Award – The Best Patent Award, KIPO (2001.3)
Publications
International Journal
1. Lee, Y. and Lee, S.Y. "Enhanced production of poly(3-hydroxybutyrate) by filamentation-suppressed recombinant Escherichia coli in a defined medium", J. Environ. Polymer Degrad. 4: 131-134 (1996)
2. Lee, Y., Lee, S.Y. and Yang, J. "Production of rhamnolipid biosurfactant by fed-batch culture of Pseudomonas aeruginosa using glucose as a sole carbon source", Biosci. Biotechnol. Biochem. 63(5): 946-947(1999)
3. Lee, S.Y., Lee, Y., and Wang, F. "Chiral compounds from bacterial polyesters: Sugars to plastics to fine chemicals" Biotechnol. Bioeng.. 65:363-368(1999)
4. Lee, Y., Park, S.H., Lim, I.T., Han, K. and Lee, S.Y. "Preparation of alkyl (R)-(-)-3-hydroxybutyrate by acidic alchoholysis of poly-(R)- (-)-3-hydroxybutyrate" Enzyme Microb. Technol. 27:33-36 (2000).
5. Lee, S.H., Oh, D.H., Ahn, W.S., Lee, Y., Choi, J., and Lee, S.Y., "Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas hydrophila" Biotechnol. Bioeng. 67:240-244(2000)
6. Lee, Y., Park, S.H., Lim, I.T., Han, K. and Lee, S.Y., "Preparation of alkyl (R)-(-)-3-hydroxybutyrate by acidic alchoholysis of poly-(R)- (-)-3-hydroxybutyrate" Enzyme Microb. Technol. 27:33-36 (2000).
7. Lee, S.Y. and Lee, Y., "Metabolic engineering of Escheichia coli for production of enantiomenically pure (R)-(-)-hydroxycarboxylic acids", Appl. Environ. Microbiol., 69(6) : 3421-3426 (2003).
8. Park, S.J., Lee, Y., and Lee, S.Y. "Biosynthesis of (R)-3-hydroxyalkanic acid by metabolically engineered E.coli" Appl. Biochem. Biotechnol., In press.
International Proceedings
1. Lee, Y., Lim, I.-T., Han, K., and Lee S.Y. "Preparation of Enatiomerically pure hydroxycarboxylic acid"CD ROM (No. P-IB15) Proceedings of APBioCheC "9, Phuket, Thailand (1999)
Korean Journal
1. Lee, S.Y., Lee, Y., and Choi, J. "Production and application of polyhydroxyalkanoates", Kor. J. Biotechnol. Bioeng., 10(4): 406-420 (1995).
2. Lee, Y., Lee, S.Y., Yang, J.W., and Park, C.H. "Biosurfactants", Biochemical Eng. 10: 53-63 (1996).
3. Lee, Y., Lee, S.H., Lee, S.Y."Fed-batch culture of Aeromonass hydrophila for the production of poly(3-hydroxybutyrate-co-hydroxyhexanoate) using two carbon sources" Biotechnol.Bioproc. Eng. 4:195-198(1999)
Korean Proceedings
1. Lee, S.Y. and Lee, Y. "PHB synthesis by filamentation suppressed recombinant E. coli", Proceedings of BPERC International Symposium '95, p. 181-182 (1995).
2. Lee, S.Y., Lee, Y., and Chang, H.N. "High cell density culture of recombinant E. coli for the production of PHB", Proceedings of BPERC International Symposium '95, p. 183-184 (1995).
3. Lee, Y. and Lee, S.Y. "Enhancement of production of poly(3-hydroxybutyrate) by using filamentation-suppressed recombinant E. coli in a defined medium", Theories and Applications of Chemical Engineering 2(1): 493-496 (1996).
4. Lee, Y. and Lee, S.Y. "Production of Optically Pure Monomer of PHB and It's Methyl-, Ethyl-esters by using Acidic degradation of PHB", proceedings of BPERC International Symposium '97, 149-150 (1997).
5. Lee, Y. and Lee, S.Y. "Production of optically pure[D]-hydroxybutyric acid and it's methyl-, ethyl-esters by chemical depolymerization of PHB", Theories and Applications of Chemical Engineering, 2361-2364 (1997)
6. Lee, Y., Lee, S.Y., Han, K.B., and Lim, I.T. "Production of optically pure methyl (D)-3-hydroxybutyrate by acidic depolymerization of microbial polymer, polyhydroxybutyrate(PHB)", Theories and Applications of Chemical Engineering, 1217-1220 (1998)
7. Lee, Y., Lim, I.T., Han,K.B., Lee, S.Y. " Preparation of optically acive alkyl (R)-(-)-3-hydroxybutyrate by chemical depolymerization of Polyhydroxyalkanoate"Proceedings of Korea Institute of Biotechnology and Bioengineering Symposium, 106-109 (1999)
8. Lee, Y., and Lee, S.Y. "Preparation of enantiomerically pure (R)-3-hydroxybutyrate"Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 579-582 (2000, Apr.)
9. Lee, Y., Kang, K.H. and Lee, S.Y. "Production of enantiomerically pure (R)-3-hydroxybutyric acid using metabolically engineered Escherichia coli" Theories and Applications of Chemical Engineering 7(2): 4039-4042 (2001)
International Conferences
1. Lee, S.Y. , Lee, Y., Chang, Y.K., and Chang, H.N. "Enhanced synthesis of poly(3-hydroxybutyrate) by filamentation-suppressed recombinant E. coli", Pacifichem-95, Honolulu, Hawaii, U.S.A., December (1995).
2. Lee, S.Y., Lee, Y., Park, S., Lee, S.H., "Production of (R)-hydroxycarboxylic acids by bacteria" ISBP/BEDPS 2000, Honolulu, Hawaii, December (2000)
3. Park, S.H., Lee, S.H., Lee, Y., Lee, S.Y., "Preparation of optically active b-amino acids from microbial polymer" 221st National meeting of American Chemical Society" San Diego,CA, USA, April (2001)
Korean Conferences
1. Lee, S.Y., Lee, Y., and Chang, H.N., "Comparison of PHB synthesis depending on the E. coli strain characteristics", '94 BPERC International Symposium, KAIST, September (1994).
2. Lee, S.Y., Lee, Y., and Chang, H.N. "Production of PHB by fed-batch culture of recombinant E. coli in a defined medium containing small amounts of amino acids", Annual Meeting of KIChE, ChunBuk Univ., October (1994).
3. Lee, S.Y., Lee, Y., and Chang, H.N. "High cell density culture and production of PHB by recombinant E. coli using sucrose as a carbon source", Annual Meeting of KIBB, Inha Univ., October (1994).
4. Lee, S.Y., Lee, Y., and Chang, H.N. "Effect of growth temperature and nutrients on the synthesis of poly(3-hydroxybutyric acid) by filamentation-suppressed recombinant E. coli", Annual Meeting of KIBB, KAIST, April (1995).
5. Chung, Y.L., Lee, Y., Yang, J.W., Lee, S.Y., and Park, C.H. "Screening of microorganisms producing emulsifiers", Annual Meeting of Korean Society for Applied Microbiology, Seoul National Univ., April (1995).
6. Lee, Y., Lee, S.Y., and Chang, H.N. "Production of PHB by high cell density cultivation of filamentation-suppressed recombinant E. coli", Annual Meeting of Korean Society for Applied Microbiology, MyungJi University, YongIn, October (1995).
7. Lee, Y. and Lee, S.Y. "Production of PHB by filamentation-suppressed recombinant E. coli", ChungNam-Kyushu International Symposium 1995, ChungNam Univ., Taejon, December (1995).
8. Lee, Y. and Lee, S.Y. "Enhanced production of PHB by filamentation -suppressed recombinant E. coli in a defined medium", Annual Symposium of KIChE, KOEX, Seoul, May (1996).
9. Lee, Y. and Lee, S.Y. "Cloning of Pseudomonas aeruginosa YPJ80 rhamnolipid byosynthesis genes", ibid (1996).
10. Lee, Y. and Lee, S. Y. " Efficient production of biosurfactant by fed-batch culture of Pseudomonas aerusinosas YPJ-80", Annual Symposium of KIBB, MyungJi Univ. Yongin, April (1997)
11. Lee, Y. and Lee, S.Y. "Production of optically pure (D)-hydroxybutyric acid and it's methyl-, ethyl-esters by chemical depolymerization of PHB", Annual Symposium of KIChE, ChungNam Univ., October (1997)
12. Lee, Y., Lee, S.Y. , Han, K.B., and Lim, I.T. "Production of optically pure methyl (D)-3-hydroxybutyrate by acidic depolymerization of microbial polymer, polyhydroxybutyrate(PHB)", Annual Symposium of KIChE, KOEX, Seoul, April (1998)
13. Lee, Y. and Lee, S.Y. "Efficient production of biosurfactant by fed-batch culture of Pseudomonas aeruginosa YPJ-80", A Day's Workshop for New Surfactants, KAIST, Taejon, Korea, July (1998)
14. Lee, Y., Lim, I.-T., Han, K., and Lee, S.Y. "Preparation of optically active alkyl (R)-(-)-3-hydroxybutyrate by chemical depolymerization of Polyhydroxyalkanoate"Annual Symposium of Korea Institute of Biotechnology and Bioengineering (KIBB). Chunnam Univ., Kwangju (1999)
15. Lee, Y., and Lee, S.Y. "Production of Optically active (R)-(-)-Hydroxycarboxylic acid"Annual Meeting of The Korean Society for Applied Microbiology, Youngnam Univ, Taegu (1999).
16. Lee, Y., and Lee, S.Y. "Preparation of enantiomerically pure (R)-3-hydroxybutyrate"Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, KAIST, April (2000)
17. Lee, S.Y., Park, S.H., Lee, Y., and Lee, S.H. "Metabolic engineering for the production of fine chemicals" Annual Meeting of the Korean Chemical Society , Hanyang Univ., April (2001)
18. Lee, S.Y., Park, S.J. and Lee, Y. "Metabolic Engineering of Escherichia coli for the Production of Novel PHA and Chiral Compounds" Annual Meeting of Korean Society for Applied Microbiology, Chonan Sangnok Resort, June(2001)
19. Lee, Y., Kang, K.H. and Lee, S.Y. "Production of enantiomerically pure (R)-3-hydroxybutyric acid using metabolically engineered Escherichia coli" KIChE meeting, Taejon , Korea (2001)
Books
1. Lee, S.Y., Park, S.H., Lee, Y. and Lee, S.H. "Production of chiral and other valuable compounds from microbial polyesters", Biopolymers Vol 3b, Ch 14, 375-387, VCH (2001)
2. Lee, S.Y., Park, S.H., Hong, S.H., Lee, Y. and Lee, S.H. "Fermentative Production of Building Blocks for Chemical Synthesis of Polyesters", Biopolymers Vol 4, Ch 10, 265-325, VCH (2001)
3. Lee, S.Y., Park, S.J., Park, J.P., Lee, Y. and Lee, S.H. "Economic aspects of biopolymer production", Biopolymers Vol 10, Ch 2, VCH in press (2002)
4. Lee, S.Y., Park, S.J., Lee, Y. and Lee, S.H. "Biotechnological processes for the production of monomers for subsequent chemical polymer synthesis", Biopolymers Vol 10, Ch 3, VCH in press (2002)
Sung Ho Yoon
Ph.D. '02. 8
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-863-8609
Fax : +82-303-2020-8609
Details
Professional Experience
2009.3 - present Postdoctorial Fellow, Institute for Systems Biology at Seattle
2009.1 - 2009.3 Senior Research Scientist, Industrial Biotechnology and Bioenergy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea
2008 - present Editorial Advisory Board Member, Recent Patents on Biotechnology, Bentham Science Publishers, USA
2006.9 - 2009.2 Lecturer, Functional Genomics Major, University of Science and Technology (UST), Daejeon, Korea
2004.7 - 2008.12 Senior Research Scientist, Systems Microbiology Research Center, KRIBB2003.7 - 2004.6 Senior Research Scientist, Genome Research Center, KRIBB
2003 - 2006 Committee Member, Korean Society for Bioinformatics (KSBI)
2002.11 - 2003.6 Post. Doc National Center for Genome Informatics, KRIBB
1998. 3 - 2002. 2 Teaching Assistant, Department of Chemical Engineering, Korea Advanced Institute of Science and Technology (KAIST)
ad hoc Reviewer
Biotechnology and Bioengineering / Biotechnology Journal / Process Biochemistry
BMC Genomics / BMC Bioinformatics / Computer Methods and Programs in Biomedicine / Gene
Educational Background
1992 (B.S.) Dept. of Chemical Engineering, KAIST, Taejon, Korea
1997 (M.S.) Dept. of Chemical Engineering, KAIST, Taejon, Korea
2002 (Ph.D.) Dept. of Chemical & Biomolecular Engineering, KAIST, Taejon, Korea
Experience and Academic Activity
1998.3 - 2002.8 Department of Chemical & Biomolecular Engineering, KAIST (Ph.D.)
(Dissertation: Development of Escherichia coli DNA microarray and global gene expression profiling in Escherichia coli. Supervor: Sang Yup Lee)
1996.3 - 1998.2 Department of Chemical Engineering, KAIST (M. S.)
(Dissertation: Development of fermentation strategies for the production of poly (γ-lutamic acid) and insulin-like growth factor I. Supervisor: Sang Yup Lee)
1992.3 - 1996.2 Department of Chemical Engineering, KAIST (B. S.)
Research Interests
Metabolic Engineering / Synthetic Biology
Pathogenomics / Host-Pathogen Interactio
Bioinformatics / Omics Analysis
Systems Microbiology
ad hoc Awards
Award for Excellent Staff, KRIBB (2007.2.1)
Award for Most Excellent Poster, Korean Society for Biotechnology and Bioengineering (2002.4.13)
Media Recognition
2007. 2. 6. Daejonilbo (newspaper), "Scientist opening 21 century - Dr. Sung Ho Yoon"
2006.11.28. MBC TV newstoday, "Development of pathogenicity island database"
2006.11.28. YTN TV "Development of pathogenicity island database"
Publications
20) Yoon SH, Kim SK, and Kim JF "Secretory production of recombinant proteins in Escherichia coli" Recent Patents on Biotechnology (2010) (in press)
19) Barrick JE, Yu D-S, Yoon SH, Jeong H, Oh TK, Schneider D, Lenski RE, and Kim JF "Genome dynamics in a long-term experiment with Escherichia coli" Nature 461:1243-1247 (2009)
18) Jeong H, Barbe V, Lee CH, Vallenet D, Yu D-S, Choi S-H, Couloux A, Lee S-W, Yoon SH, Cattolico L, Hur C-G, Park H-S, Ségurens B, Kim SC, Oh TK, Lenski RE, Studier FW, Daegelen P, and Kim JF "Genome sequences of Escherichia coli B strains REL606 and BL21(DE3)" J. Mol. Biol. (Published online 26 September 2009)
17) Yoon SH, Jeong H, Kwon S-K, and Kim JF "Chapter 1. Genomics, biological features, and biotechnological applications of Escherichia coli B: "Is B for better?!"", pp. 1-17, In: Systems Biology and Biotechnology of E. coli, Lee SY (ed.) Springer, Berlin, Germany (2009. 4)
16) Kim JF, Jeong H, Yu DS, Choi S-H, Hur C-G, Park M-S, Yoon SH, Kim D-W, Ji GE, Park H-S, and Oh TK "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011" J. Bacteriol. 191:678-679 (2009)
15) Jeong H, Yoon SH, Yu D-S, Oh TK, and Kim JF "Recent progress in microbial genome projects of Korea" Biotechnol. J. 3:601-611 (2008)
14) Nam D, Yoon SH, and Kim JF "Ensemble learning of genetic networks from time-series expression data" Bioinformatics 23:3225-3231 (2007)
13) Yoon SH, Park YK, Lee S, Choi D, Oh TK, Hur C-G, and Kim JF "Towards pathogenomics: a web-based resource for pathogenicity islands" Nucleic Acids Res. 35:D395-D400 (2007)
12) Hur C-G, Kim S, Kim CH, Yoon SH, In YH, Kim C, and Cho HG "FASIM: Fragments assembly simulation using biased-sampling model and assembly simulation for microbial genome shotgun sequencing" J. Microbiol.Biotechnol. 16:683-688 (2006)
11) Jiang H, Shang L, Yoon SH, Lee SY, and Yu Z "Optimal production of poly-¥lutamic acid by metabolically engineered Escherichia coli" Biotechnol. Lett. 28:1241-1246 (2006)
10) Jeong H, Yoon SH, Lee HK, Oh TK, and Kim JF "Lessons from the sea: genome sequence of an algicidal marine bacterium Hahella chejuensis (적조 살상 해양 미생물 Hahella chejuensis의 유전체 구조)" Kor. J. Microbiol. Biotechnol. 34:1-6 (2006)
9) Jeong H, Yim JH, Lee C, Choi SH, Park YK, Yoon SH, Hur CG, Kang HY, Kim D, Lee HH, Park KH, Park SH, Park HS, Lee HK, Oh TK, and Kim JF "Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent", Nucleic Acids Res. 33:7066-7073 (2005)
8) Yoon SH, Hur C-G, Kang HY, Kim YH, Oh TK, and Kim JF "A computational approach for identifying pathogenicity islands in prokaryotic genomes" BMC Bioinformatics 6:184 (2005)
7) Yoon SH, Han MJ, Lee SY, Jeong KJ, and Yoo JS "Combined transcriptome and proteome analysis of Escherichia coli during the high cell density culture", Biotechnol. Bioeng. 81:753-767 (2003)
6) Kim JS, Yoon SH, and Lee SY "Development of database systems by integrating heterogeneous metabolic databases", Genome Informatics 13:486-487 (2002)
5) Heo WJ, Yoon SH, and Lee SY "Global gene expression profiling of E. coli and its mutant unable to produce acetate", Genome Informatics 13: 270-271 (2002)
4) Yoon SH and Lee SY "Comparison of transcript levels by DNA microarray and metabolic flux based on flux analysis for the production of poly-γ-glutamic acid in recombinant Escherichia coli", Genome Informatics 13:587-588 (2002)
3) Chung BH, Choi YJ, Yoon SH, Lee SY, and Lee YI "Process development for production of recombinant human insulin-like growth factor-I in Escherichia coli", J. Ind. Microbiol. Biotechnol. 24:94-99 (2000)
2) Yoon SH, Do JH, Lee SY, and Chang HN "Production of poly-γ-glutamic acid by fed-batch culture of Bacillus licheniformis" Biotechnol. Lett. 22:585-588 (2000)
1) Yoon SH, Choi J, and Lee SY "Development of DNA chip microarrayer" J. Microbiol.Biotechnol., 10:21-26 (2000) (The result was presented at Nature Genetics, Microarray Meeting (1999)
Patents
3) Jeong H, Han JH, Yoon SH, Ryu C-M, Kim JF, Oh TK, Jung MH, Yoon SP "Method for Selecting Alcohol Resistant Variants of Microorganism Using Mutagenesis by Proton Beam Irradiation" Korean Patent: appl. 10-2009-0080393 (2009.08.28)
정해영 한지희 윤성호 류충민 김지현 오태광 정명환 윤상필 “양성자 빔 조사에 의한 돌연변이 유도방법을 이용한 알코올 내성 미생물 변이체의 선별 방법” 특허출원번호10-2009-0080393 (2009.08.28)
2) Hong JW, Kim JF, Oh TK, and Yoon SH "A fluidic array system for biological, chemical, and biochemical assessments" PCT/US08/59777 (PCT/US08/59777) (filed on April 9, 2008)
1) Lee SY and Yoon SH "Methods for producing high concentration of poly (gamma-glutamic acid) by fed-batch culture of Bacillus licheniformis" Korean Patent: appl. 97-67605 (12. 10. 1997), registered 250627 (1. 5. 2000)
이상엽, 윤성호 "바실러스 리케니포니스에 의한 폴리글루탐산(g-PGA)의 고효율 생산방법" 특허출원번호 10-1997-0067605 (1997. 12. 10.), 등록번호 1002506270000 (2000. 01. 05)
Program Registration
2) 김지현, 윤성호, 허철구, 오태광. "미생물 유전체 내에서 외래에서 유입된 병원성 유전자군인 pathogenicity island를 예측하는 방법" (등록일자: 2007년 7월 29일; 등록번호: 2007-01-129-3962)
1) 김지현, 윤성호, 허철구, 박영규, 오태광. "미생물 유전체 내에서 외래에서 유입된 병원성 유전자군인 pathogenicity island를 분석, 예측하는 시스템" (등록일자: 2007년 7월 29일; 등록번호: 2007-01-129-3964)
Essays
6) Yoon SH "Systems and Synthetic Biology" In State of the Art Report on Microbial Genomics 미생물유전체 연구동향 분석연구), Ministry of Science and Technology, Korea (2007)
5)Yoon SH “최신 기술동향: Biolog사의 Phenotype Microarray (PM) Technology” 미생물과 산업, 32(2): 28-29, 한국미생물학회 (2006)6)
4) 이승구, 김지현, 정흥채, 송재준, 류충민, 윤성호 “Development of Platform Technologies for Synthetic Biology” (바이오기반 경제구축을 위한 합성생물학 핵심기술 개발), KRIBB, Korea (2006)
3) 김지현, 정해영, 윤성호, 박승환 “시스템 미생물학 : 유전체 해독에서 네트워크 재설계까지”, e-생물산업, 16(3) (2003)
2) Kim JS, Yoon SH, and Lee SY "미생물 게놈 연구", BioZine (http://biozine.kribb.re.kr) (2001.6)
1) Lee SY, Yoon SH, Im GB, and Cho YK "Genomics와 DNA chip" News & Information for Chemical Engineers, 18(3): 307-311 (2000)
Invited talks
14) "Computational identification of pathogenicity islands in prokaryotic genomes" KOGO 2009 Winter Symposium, YongPyung Resort, Gangwon-do, Korea (2009.01.15)
13) "Multi-omics-based Systems Approach Captures the Whole-cellular Features of closely related Escherichia coli B and K-12" International Symposium on Microbiology, Daejeon convention center, Daejeon, Korea (2008. 5.16)
12) "Integrated Omics Analysis of Escherichia coli B and K-12" International Meeting of the Federation of Korean Microbiological Societies, Seoul KyoYuk MunHwa HoeKwan, Seoul, Korea ( 2007.10.12)
11) "In silico identification of pathogenicity islands in pathogenic genomes", BIO KOREA 2007, COEX, Seoul , Korea (2007. 9.13)
10) "General Concepts of Systems Biology", National Institute for Mathematical Sciences (NIMS), Daejeon, Korea (2007. 7.13)
9) "PAIDB: a web-based resource for pathogenicity islands", 신변종 전염병 출현 조기탐지 기반사업 Workshop, Korea Centers for Disease Control and Prevention, Seoul, Korea (2007. 6.22)
8) "Systems Microbiology" Korea Institute of Oriental Medicine, Daejeon , Korea (2007. 5.1)
7) "Computational approach for identifying genomic and pathogenicity islands in prokaryotic genomes", National Institute for Mathematical Sciences (NIMS), Daejeon, Korea (2007. 2.28)
6) "Microarray Experiment and Image Analysis", The Korean Society for Microbiology and Biotechnology. BEXCO Convention Hall, Pusan, Korea (2006. 6. 18)
5) "Systems Microbiology" Korea Maritime University, Division of Civil and Environmental Engineering (Major of Environmental Engineering), Pusan, Korea (2006. 5. 4)
4) "Genome chip analysis workshop" KRIBB Conference - Synthetic and Systems Biology of Escherichia coli, KRIBB, Daejeon, Korea (2006. 4.27)
3) "A Computational Approach for Identifying PathogenicityIslands in Prokaryotic Genomes", The Korean Society for Microbiology and Biotechnology. Korea University, Seoul , Korea (2005. 7. 1)
2) "Genomic Islands & Pathogenicity Islands", International Meeting of the Federation of Korean Microbiological Societies, Seoul , Korea (2005.10.21)
1) "Applications of DNA microarray: transcriptome profiling", The 1st International Symposium on Environmental Biosensors and DNA Microarrays for Environmental Biomonitoring, Kwangju Institute of Science and Technology, Korea (2002.5.20)
Jong Hyun Choi
Ph.D. '03. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-869-5970
Fax :+82-42-869-8800
Details
Research Interest
Protein Technology
Directed evoloution
Cell surface display
Secretion of recombinant proteins from microorganism
Extracellular production of recombinant proteins
Recombinant protein production
High cell density culture
Transcriptome Analysis Metabolic Engineering
Systems Biotechnology
Genomic Engineering
Education
1995 (B.S.) Dept. of Biological Engineering, Inha Univ., Incheon, Korea
1997 (M.S.) Dept. of Biological Sciences, KAIST, Daejeon, Korea
2003 (Ph.D.) Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Activity
International Journals
Choi, J. H., Jun, S. C., Lee, G. M., "Effect of serum concentration on retroviral vector production from the amphotropic ψCRIP murine producer cells", Bioproc. Eng. (1997) 17, 349-353
Lee, G. M., Choi, J. H. Jun, S. C. Passon, B. O., "Temperature significantly affects retroviral vector production and deactivation rates, and thereby determines retroviral titers", Bioproc. Eng. (1998) 19, 343-349
Choi, J.H., Jeong, K.J., Kim, S.C., and Lee, S.Y., "Efficient secretory production of alkaline phosphatase by high cell density culture of recombinant Escherichia coli using the Bacillus sp. Endoxylanase signal sequence", Appl. Microbiol. Biotechnol. 53:640-645 (2000)
Lee, S. Y., Choi, J.H., and Xu, Z., "Microbial cell surface display", Trends Biotechnol. (2003) 12(1): 45-52
Choi, J.H., Lee, S.J., Lee, S.J., and Lee, S.Y., "Enhanced production of IGF-I fusion protein in Escherichia coli by the coexpression of the down -regulated genes identified by transcriptome profiling", Appl. Environ. Microbiol., 69(8): 4737-4742 (2003).
Choi, J.H. and Lee, S.Y., "Secretory and extracellular producion of recombinant proteins using Escherichia coli", Appl. Microbiol. Biotechnol., 64 : 625-635 (2004).
Jeong, K.J., Choi, J.H., Yoo, W.M., Keum, K.C., Yoo, N.C., Lee, S.Y. and Sung, M.-H. "Constitutive Production of Human Leptin by Fed-batch Culture of Recombinant rpoS- Escherichia coli", Protein Exp. Purif. 36 : 150-156 (2004).
Lee, S.H., Choi, J.H., Park, S.H., Choi, J.-I., and Lee, S.Y., "Enantioselective resolution of racemic compounds by cell surface displayed lipase", Enzyme Microbial Technol., 35: 429-436. (2004).
Choi, J.H., Choi, J.I. and Lee, S.Y., " Display of Proteins on the Surface of Escherichia coli by C-Terminal Deletion Fusion to the Salmonella typhimurium OmpC” J. Microbiol. Biotechnol. 15(1):141-146 (2005)
Lee, S.H., Choi, J.-I., Han, M.-J., Choi, J.H., and Lee, S.Y. "Display of lipase on the cell surface of Escherichia coli using OprF as an anchor and its applications to enantioselective resolution in organic solvent", Biotechnol. Bioeng. 90(2):223-230 (2005).
Lee, S.Y., Choi, J.H. and Lee, S.J., "Engineering therapeutic protein production in microbial host cells", in Therapeutic Proteins: Methods and Protocols (ed. Smales C.M. and James D.C.), Humana Press, Totowa, NJ., USA., 308: 31-41 (2005).
Choi, J.H. and Lee, S.Y., "Production of recombinant proteins by high cell density culture of Escherichia coli", Chem. Eng. Sci., 66: 876-885. (2006).
International Proceedings
1. Lee, S.Y., and Choi, J.H., "Secretory Production of recombinant proteins using an artificial signal sequence. Biochemical Engineering XI, Park city", Utah, July (1999)
2. Jeong, K.J., Choi, J.H., Lee, S.Y., "Secretory production of proteins in E.coli : focus on excretion to the culture medium", Biochemical Engineering XII, Sonoma, California, USA, June (2001)
3. Jeong, K.J., Choi, J.H., Lee, S.Y., "Secretory production of proteins in E.coli : focus on excretion to the culture medium", Biochemical Engineering XII, Sonoma, California, USA, June (2001)
4. Choi, J.H., Lee, S.J. and Lee, S.Y., "Transcriptome analysis of Escherichia coli during production of IGF-1 by fed-batch fermentation", Proceeding of GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, p.110, Gyeongju, Korea, July 1-5 (2002)
Patents
1. 국내 특허 출원 9 건
2. 국내 특허 등록 5 건
3. 국제 특허 출원 6 건
4. 국제 특허 등록 1 건
Korean Journals
1. Choi J. H., Chun, S. C and Lee G. M., "Efficient productioin of retroviral vector for gene therapy, Biochemical Engineering, 10, 10-17 (1996)
2. Choi, J.H. and Lee, S.Y., "Secretion of proteins in E.coli", Recent Advances in Bioprocess Engineering 5: 81-94 (1997).
International Conferences
1. Lee, S.Y. and Choi, J.H., "Secretory Production of recombinant proteins using an artificial signal sequence", Biochemical Engineering XI, Park city, Utah, July (1999)
2. Jeong, K.J., Choi, J.H., and Lee, S.Y., "Secretory production of proteins in E.coli: focus on excretion to the culture medium", Biochemical Engineering XII, Sonoma, California, USA, June (2001)
3. Choi, J.H., Lee, S.J. and Lee, S.Y., "Transcriptome analysis of Escherichia coli during production of IGF-1 by fed-batch fermentation", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
4. Choi J.H., Lee, S. J. and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of IGF-1 by transcriptome analysis", Metabolic Engineering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11 (2002)
5. Lee, S. H., Choi J.H., and Lee, S.Y., "Resolution of racemic compounds by genetically immobilized lipase", Metabolic Engineering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11(2002)
6. Choi J.H., Park, J.P., Park, S.J.and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of polyhydroxyalkanoates consisting of short-chain-lenth and medium-chain-length monomers", Metabolic Engineering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11 (2002)
7. Choi, J.H., Lee, S.H., and Lee, S.Y., "Display of polyhistidine and lipase on the surface of Escherichia coli by using the salmonella ompC as an anchoring motif and its application to chemoenzymatic synthesis", Biochemical Engineering (XIII) 2003, Boulder, Colorado, USA July 17-23 (2003)
8. Lee, S.H, Choi, J.H., and Lee, S.Y., "Dynamic kinetic resolution using cell surface displayed biocatalysts", Biochemical Engineering (XIII) 2003, Boulder, Colorado, USA July 17-23 (2003)
9. Choi, J.H, Bang, H.O., and Lee, S.Y., "Display of proteins on the surface of Escherichia coli by C-terminal deletion fusion method", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov - 4 December (2003)
10. Choi, J.H., Heo, W.J., Lee, S.J., and Lee, S.Y., "Global expression profiling of acetyl phosphate-free mutant in Escherichia coli", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov - 4 December (2003)
11. Choi, J.H., Lee, S.H., and Lee, S.Y., "Production of chiral compounds by cell surface displayed lipase", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov - 4 December (2003)
12. Choi, J.H., Han, M.J., Jeong, K.J., and Lee, S.Y., "Using proteomics to engineer improved cell growth and increased production of heterologous proteins in Escherichia coli", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov - 4 December (2003)
13. Lee, S.Y., Lee, S.J., Yoo, S.M., and Choi, J.H., "Protein arrays for protein-protein interactions analysis", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov - 4 December (2003)
14. Lee, S.Y., Bang, H.O., Lee, S.J., and Choi, J.H., "Lycopene overproduction in metabolically engineered Escherichia coli by high cell density culture", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov - 4 December (2003)
15. Park, J.P., Park, T.J., Lee, S.J., Choi, J.H., and Lee, S.Y., "Self-assembly of functional bacterial surface protein around carbon nanotube and its use in nanostructure fabrication", 227th ACS National Meeting, Anaheim, CA, March 28-April 1 (2004)
16. Park, J.H., Kim,B.H., Choi, J.H., Lee, D.Y. and Lee, S.Y., "Identification of growth-associated regulatory circuit of FadR by transcriptome profiling", The 12th International Conference on Intelligent Systems for Molecular Biology (ISMB 2004), Glasgow, UK, July 31-August 4 (2004)
17. Choi, J.H., Woo, H.M., and Lee, S.Y., ”Extracellular production of recombinant proteins in Escherichia coli”, Metabolic Engineering V: Genome to Product, Lake Tohoe, California, USA Sept. 19-23(2004)
18. Choi, J.H., "Systems biotechnological strategies for the enhanced production of recombinant proteins”, 3rd Recombinant Protein Production Meeting, Tavira, Portugal, Nov 11-14 (2004).
19. Lee, S.Y., Park, J.H., Kim, B.H, and Choi, J.H., "Identification of growth-associated expression pattern of FadR-responsive genes by transcriptome profiling”, 3rd Recombinant Protein Production Meeting, Tavira, Portugal, Nov 11-14 (2004).
20. Choi, J.H., Jeong, K.J., Lee, S.Y, and Sung, M.-H., "Constitutive production of recombinant protein by fed-batch culture of rpoS- Escherichia coli”, 3rd Recombinant Protein Production Meeting, Tavira, Portugal, Nov 11-14 (2004).
21. Choi, J.H., Choi, H.S. and Lee, S.Y., "Efficient production of small therapeutic peptides in recombinant Escherichia coli”, 3rd Recombinant Protein Production Meeting, Tavira, Portugal, Nov 11-14 (2004).
22. Choi, J.H., Lee, S.Y., “Efficient Production of Small Therapeutic Peptides in Recombinant Escherichia coli”, Asia Pacific Biochemical Engineering Conference (APBioChEC'05), Lotte Jeju Hotel, Jeju Island, Korea, May 15-19, (2005)
Korean Proceedings
1. Choi, J.H. and Lee, S.Y., "Expression of Recombinant Proteins using pH-inducible Promoter System", Proceedings of BPERC International Symposium '97, 151-152 (1997).
2. Choi, J.H. and Lee, S.Y., "Effect of induction condition on expression of recombinant protein using pH-inducible promotor system", Proceedings of The 10th Daejeon/Chungnam-Kyushu Symposium
3. Jeong, K.J., Choi, J.H., Lee, S.Y., and Kim, S.C., "Efficient secretion of recombinant endoxylanase in Escherichia coli", Proceedings of BPERC International Symposium '98, 173-174 (1998)
4. Choi, J.H. and Lee, S.Y., "Efficient secretion of protein by strong promoters in Escherichia coli", Proceedings of BPERC International Symposium '98, 175-176 (1998)
5. Choi, J.H. and Lee, S.Y., "Efficient secretion of recombinant endoxylanase by strong promoters in Escherichia coli", Proceedings of Korea Institute of Biotechnology and Bioengineering Symposium, 373-374(1998)
6. Choi, J.H., Jeong, K.J., and Lee, S.Y., "Construction of secretion vector containing endoxylanase signal sequence from Bacillus subtilis and secretory production of alkaline phosphatase in Escherichia coli", Proceedings of Korea Institute of Biotechnology and Bioengineering Symposium, 509-512 (1999)
7. Choi, J.H. and Lee, S.Y., "Secretory production of recombinant proteins by high cell density culture of recombinant Escherichia coli using the the Bacillus sp. endoxylanase signal sequence", Proceedings of The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 129-130 (1999)
8. Choi, J.H. and Lee, S.Y., "Secretory production of recombinant proteins by high cell density culture of Escherichia coli", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 329-330 (1999)
9. Choi, J.H., Xu, Z., and Lee, S.Y., "Surface Display of Poly(His)n on the Escherichia coli using OmpC as Surface anchoring Motif", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 523-526 (2000)
10. Han, M.J., Choi, J.H., Jeong, K.J., Yoo, J.S., and Lee, S.Y., "Proteome Analysis of Overproduction of Recombinant Protein in Escherichia coli by Fed-Batch Fermentations", Proceedings of Korean Society for Biotechnology and Bioengineering Symposium,750-753, November (2001)
11. Han, M.J., Choi, J.H., Jeong, K.J., Yoo, J.S., and Lee, S.Y., "Proteome Analysis of Overproduction of Human Leptin in Escherichia coli by Fed-Batch Fermentations", Theories and Applications of Chemical Engineering 7(2): 4075-4078 (2001).
12. Choi, J.H., Lee, S.H., Park, S.H., and Lee, S.Y., "Chiral Resolution by Lipase on the Escherichia coli Cell Surface", Theories and Applications of Chemical Engineering, 7(2): 4027-4030 (2001).
13. Kang, Y.J., Choi, J.H., Lee, S.J., and Lee, S.Y., “High-level expression of silk protein in Escherichia coli”, Proceedings of The 17th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 37 (2004)
Korean Conferences
1. Choi, J.H. and Lee, S.Y., "Secretion of proteins in E. coli", Recent Advances in Bioprocess Engineering, 5: 81-94 (1997).
2. Choi, J.H. and Lee, S.Y., "Expression of recombinant proteins using pH-inducible promoter system", Annual Symposium of KIBB, Taegu Univ., Kyungsan, October (1997)
3. Choi, J.H. and Lee, S.Y., "Effect of induction condition on expression of recombinant protein using pH-inducible promotor system", The 10th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, KAIST, Teajon, November (1997)
4. Jeong, K.J., Choi, J.H., Lee, S.Y., and Kim, S.C., "Efficient secretion of recombinant endoxylanase in Escherichia coli", Annual Symposium of BPERC '98, KAIST, Daejeon, Korea, September (1998)
5. Choi, J.H. and Lee, S.Y., "Efficient secretion of protein by strong promoters in Escherichia coli", Annual Symposium of BPERC '98, KAIST, Daejeon, Korea, September (1998)
6. Choi, J.H. and Lee, S.Y., "Efficient Secretion of Recombinant Endoxylanase by Strong Promoters in Escherichia coli", Proceedings of Korea Institute of Biotechnology and Bioengineering Symposium, 373-374(1998)
7. Choi, J.H., Jeong, K.J., and Lee, S.Y., "Construction of secretion Vector containing Endoxylanase Signal Sequence from Bacillus subtilis and Secretory Production of Alkaline Phosphatase in Escherichia coli", Annual Symposium of Korea Institute of Biotechnology and Bioengineering (KIBB) Chunnam Univ., Kwangju (1999)
8. Choi, J.H. and Lee, S.Y., "Secretory Production of Recombinant proteins by High Cell Density Culture of Recombinant Escherichia coli using the Bacillus sp. Endoxylanase Signal Sequence", The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Kongju Univ., Kongju (1999)
9. Choi, J.H. and Lee, S.Y., "Secretory production of recombinant proteins by high cell density culture of Escherichia coli", Annual Symposium of Korean Society for Biotechnology and Bioengineering, Kangwon University, Chuncheon (1999)
10. Choi, J.H., Xu, Z., and Lee, S.Y., "Surface Display of Poly (His)n on the Escherichia coli using OmpC as Surface anchoring Motif", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, KAIST, April (2000)
11. Choi, J.H., Xu, Z., and Lee, S.Y., "Physiological Study on Recombinant Escherichia coli Displaying Poly-His Peptides", Annual Meeting of The Korean Society for Applied Microbiology, Yonsei Univ., Seoul (2000).
12. Choi, J.H. and Lee, S.Y., "Physiological study on bacteria cell surface display systems using OmpC", Annual Meeting of The Korean Society for Applied Microbiology, Cheon-buk Univ., October (2000)
13. Choi, J.H. and Lee, S.Y., "Surface display of recombinant protein on the Escherichia coli using OmpC", Annual Meeting of Korean Society for Applied Microbiology, Chonan Sangnok Resort, June (2001)
14. Han, M.J., Choi, J.H., Jeong, K.J., Yoo, J.S., and Lee, S.Y., "Proteome Analysis of Overproducing Human Leptin System", The 14th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Chungnam Univ., Daejeon, Korea (2001)
15. Han, M.J., Choi, J.H., Jeong, K.J., Yoo, J.S., and Lee, S.Y., "Proteome Analysis of Overproduction of Recombinant Protein in Escherichia coli by Fed-Batch Fermentations", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, November (2001)
16. Han, M.J., Choi, J.H., Jeong, K.J., Yoo, J.S., and Lee, S.Y., "Proteome Analysis of Overproduction of Human Leptin in Escherichia coli by Fed-Batch Fermentations", KIChE Meeting, Daejeon, Korea (2001)
17. Choi, J.H., Lee, S.H., Park, S.H., and Lee, S.Y., "Chiral Resolution by Lipase on the Escherichia coli Cell Surface", KIChE Meeting, Daejeon, Korea (2001)
18. Choi, J.H., Kang, K.H., and Lee, S.Y., "Efficient production of S-layer protein using Geobacillus sp.", Annual Meeting of Korean society for Biotechnology and Bioengineering Symposium, Chungju, October 12(2002)
19. Park, S. J, Choi, J.H., and Lee, S.Y., "Production of Poly (3-Hydroxybutyrate-co-3-Hydroxyvalerate) by Fed-Batch Culture of Recombinant Escherichia coli in a Pilot Scale Fermentor", Korean Society for Biology and Biotechnology Meeting, Konkuk Univ., October 26 (2002)
20. Choi, J.H., Lee, S.J., and Lee, S.Y., "Increasing of Productivity of Recombinant Proteins by Transcriptome Analysis in Escherichia coli", Korean Society for Biology and Biotechnology Meeting, Konkuk Univ. October 26(2002)
21. Choi, J. H. and Lee, S.Y., "Cell Surface Display on Escherichia coli", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Busan, Korea, April 11-12(2003)
22. Lee, S.H., Choi, J.H., and Lee, S.Y., "Production of chiral compounds by cell surface displayed lipase", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Busan, Korea, April 11-12(2003)
23. Lee, S.H., Choi, J.H., and Lee, S.Y., "Kinetic resolution of beta-lactams by cell surface displayed Lipase", Annual Spring Meeting of KIChE, Soonchun, April 25-26(2003)
24. Kang, K.H., Lee, S.Y., and Choi, J.H., "Efficient Production of S-layer Protein Using Geobacillus sp. And its Characterization", Annual Meeting of Korean Society for Microbiology and Biotechnology Symposium, Muju, Korea, June 24-26(2003)
25. Choi, J.H., and Lee, S.Y., "Enhanced Production of Recombinant Protein in Escherichia coli by the Coexpression of the Down-Regulated Genes Identified by Transcriptome Profiling", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October 22-24(2003)
26. Choi, J.H., Jeong, K.J., and Lee, S.Y., "Enhanced production of recombinant proteins in Escherichia coli by filamentation suppression", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October22-24(2003)
27. Choi, J.H. and Lee, S.Y., "Display of Polyhistidine and Lipase on the Surface of Escherichia coli by using the Salmonella OmpC as an Anchoring Motif and its Application to bioconversion", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October 22-24(2003)
28. Choi, J.H., and Lee, S.Y., "Transcriptome profiling of IGF-I fusion protein production in Escherichia coli", KSBI 2003, KAIST, Daejeon, October 31-November 1(2003)
29. Song, A.J., Park, S.J., Choi, J.H., and Lee, S.Y., "Biosynthesis and characterization of polyhydroxyalkanoates produced by newly screened strain Pseudomonas sp. MBEL 6-19", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
30. Choi, J.H., Jeong, K.J., and Lee, S.Y., "Constitutive production of recombinant proteins by Fed-batch culture of recombinant Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
31. Lee, S.J., Park, S.J., Park, T.J., Choi, J.H., and Lee, S.Y., "Self-assembly of functional bacterial surface protein and its use in nanobiotechnology", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
32. Park, J.H., Kim, B.H., Choi, J.H., and Lee, S.Y., "Growth-associated transcriptome profiling of Escherichia coli fadR mutant", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
33. Park, J.H., Kim, B.H., Choi, J.H., and Lee, S.Y., "Transcriptome profiling of Escherichia coli mutant fadR" Annual Spring Meeting of KIChE, Kongju University, April 23-24(2004)
34. Choi, J.H., Jeong, K.J., Lee, S.Y., and Sung, M.H., “High Level Production of Human Leptin using Constitutive Promoter in rpoS Escherichia coli”, Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Cheongju, Korea, October 13-15 (2004)
35. Park, J.P., Lee, S.J., Choi, J.H., Lee, S.Y., "Self-Assembly of Functional Bacterial Surface Protein around Carbon Nanotubes and Its Application", ISNM, Daejeon, November 3-5 (2004)
36. Kang, Y.J., Choi, J.H., Lee, S.J., and Lee, S.Y., “High-level expression of silk protein in Escherichia coli”, The 17th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, December 4-5 (2004)
37. Choi, J.H., Lee, S.Y., "System approach towards efficient production of therapeutic proteins by recombinant Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, April 15-16 (2005)
38. Kang, Y.J., Choi, J.H., Lee, S.J. and Lee,S.Y., "High-level expression of silk protein in Escherichia coli", Annual Spring Meeting of KIChE, April 22-23 (2005)
39. Choi, J.H., Lee, S.J. and Lee,S.Y., "Peptide chips immobilized with protein layer for protein kinase assay", Annual Spring Meeting of KIChE, April 22-23 (2005)
40. Choi, J.H., Lee, S.H. and Lee, S.Y., Display of Lipase on the Ell Surface of Escherichia coli OprF", Annual Spring Meeting of KIChE, April 22-23 (2005)
41. Park, J.H., Lee, J.W., Kim, B.H., Choi, J.H., and Lee, S.Y., “Global analyses of transcriptomes and proteomes of Escherichia coli fadR mutant”, The 62th Korean Society for Biochemistry and Molecular Biology(KSBMB) annual meeting, Seoul, Korea, May 19-20 (2005)
42. Kang, Y.J., Choi, J.H., Lee, S.J., and Lee, S.Y., “High level production of recombinant silk protein in Escherichia coli”, The 62th Korean Society for Biochemistry and Molecular Biology(KSBMB) annual meeting, Seoul, Korea, May 19-20 (2005)
43. Choi, J.H, and Lee, S.Y., "System approach towards efficient production of therapeutic proteins by recombinant Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, April 15-16 (2005)
44. Kang, Y.J., Choi, J.H., Lee, S.J. and Lee,S.Y., "High-level expression of silk protein in Escherichia coli", Annual Spring Meeting of KIChE, April 22-23 (2005)
45. Choi, J.H., Lee, S.J. and Lee, S.Y., "Peptide chips immobilized with protein layer for protein kinase assay", Annual Spring Meeting of KIChE, April 22-23 (2005)
46. Choi, J.H., Lee, S.H. and Lee, S.Y., Display of Lipase on the Ell Surface of Escherichia coli OprF", Annual Spring Meeting of KIChE, April 22-23 (2005)
47. Park, J.H., Lee, J.W., Kim, B.H., Choi, J.H., and Lee, S.Y., “Global analyses of transcriptomes and proteomes of Escherichia coli fadR mutant”, The 62th Korean Society for Biochemistry and Molecular Biology(KSBMB) annual meeting, Seoul, Korea, May 19-20 (2005)
48. Kang, Y.J., Choi, J.H., Lee, S.J., and Lee, S.Y., “High level production of recombinant silk protein in Escherichia coli”, The 62th Korean Society for Biochemistry and Molecular Biology(KSBMB) annual meeting, Seoul, Korea, May 19-20 (2005)
49. Choi, J.H., Lee, S.Y., “Extracellular Production of Recombinant Proteins in Escherichia coli”, Annual Fall Meeting of KIChE, October 21-22 (2005)
50. Xiao, X.X., Qian, Z.G., Choi, J.H., Yoo, N.C., Lee, S.Y., “Highly Efficient Extracellular Production of Human β-Endorphin in Recombinant Escherichia coli by Using Outer Membrane Protein F as a Fusion Partner”, International Symposium and annual meeting of KSBB, October 27-29 (2005)
Soon Ho Hong
Ph.D. '03. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-869-5970
Fax :+82-42-869-8800
Details
Research Interest
Metabolic engineering
Recombinant protein production
Education
B.S., Dept. of Chemical Engineering, KAIST, Daejeon, Korea (1993. 3. 1.~ 1997. 2. 29.)
M.S., Dept. of Chemical Engineering, KAIST, Daejeon, Korea (1997. 3. 1.~ 1999. 2. 28.)
Ph.D., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea (1999. 3. 1. ~ 2003. 8. 31.)
Honor/Awards
IBM Basic Research Award, Korean Society for Bioinformatics (2002. 11. 16.)
Experience and Academic Activity
International Journal
1. Lee, S.Y. , Chang, H.N., Um, Y.S., and Hong, S.H., "Bacteriorhodopsin production by cell recycle culture of Halobacterium halobium", Biotechnol. Lett., 20(8): 763-765 (1998).
2. Hong, S.H. and Lee, S.Y., "Metabolic Flux distribution in metabolically engineered Escherichia coli strain producing succinic acid", J. Microbiol. Biotechnol., 10(4) : 496-501 (2000).
3. Hong, S.H. and Lee, S.Y., "Metabolic flux analysis for succinic acid production by recombinant Escherichia coli with amplified malic enzyme activity", Biotechnol. Bioeng., 20;74(2):89-95(2001).
4. Hong,S.H. and Lee,S.Y., "Importance of redox balance on the production of succinic acid by metabolically engineered Escherichia coli", Appl. Microbiol. Biotechnol., 58 : 286-290(2002).
5. Lee, P.C., Lee, S.Y., Hong, S.H., and Chang, H.N. "Isolation and characterization of a new succinic acid producing bacterium, Mannheimia succiniciproducens MBEL 55E, from bovine rumen", Appl. Microbiol. Biotechnol., 58 : 663-668 (2002).
6. Lee, S.Y., Hong S.H., and Moon S.Y. "In Silico Metabolic Pathway Analysis and Design: Succinic acid Production by Metabolically Engineered Escherichia coli as an example", Genome Informatics 2002, 13: 214-223 (2002)
7. Lee, P.C., Lee, S.Y, Hong, S.H., and Chang, H.N. "Biological conversion of wood hydrolysate to succinic acid by Anaerobiospirillum succiniciproducens", Biotechnol.Lett., 25: 111-114 (2003)
8. Hong, S.H., Park, S.J., Moon, S.Y., Park, J.P. and Lee, S.Y., "In silico prediction and validation of the importance of Entner-Doudoroff pathway in poly(3-hydroxybutyrate) production by metabolically engineered Echerichia coli", Biotech. Bioeng., 83: 854-863 (2003).
9. Hong, S.H., Moon, S.Y. and Lee, S.Y. "Prediction of the maximum yields of metabolites and optimal pathways for their production by metabolic flux analysis", J. Microbiol. Biotechnol., 13: 571-577 (2003).
10. Lee, P.C., Lee, S.Y., Hong, S.H., and Chang, H.N. "Batch and Continuous cultures of Mannheimia succiniciproducens MBEL55E for the production of succinic acid from whey and corn steep liquor", Bioproc. Biosystems Eng., in press.
11. Hong, S.H. and Lee, S.Y., "Evaluating evolutionary relationships of microorganisms and cellular metabolic pathways based on genome-scale metabolic pathway content", submitted.
12. Hong, S.H., Park, S.J. and Lee, S.Y., "Metabolic flux profiling and clustering: New strategies for identification of microbial metabolic characteristics", submitted.
13. Moon, S.Y., Hong, S.H., and Lee.S.Y., "Production of malic acid by the amplification of Mannheimia succiniproducens phosphoenolpyruvate carboxykinase in Escherichia coli", submitted.
International Proceedings
1. Lee, S.Y. and Hong, S.H., "Engeering of E. coli central metabolic pathways for the production of succinic acid", Proceedings of Pacifichem 2000, Hawaii, pp. 30-38 (2000).
Korean Journal
1. Um, Y.S., Park, J.T., Hong, S.H., Lee, S.Y. and Chang, H.N. "Production of bacteriorhodopsin by Halobacterium halobium in the internal membrane bioreactor", Kor. J. Biotechnol. Bioeng. 13(3): 268-271 (1998)
2. Lee, P.C., Lee, S.Y., Hong, S.H., and Chang, H.N. "Cloning and characterization of Mannheimia succiniciproducens MBEL55E phophoenol pyruvate carboxykinase (pckA) gene", Biotechnol. Bioprocess Eng. 7:95-99 (2002)
Korean Proceedings
1. Hong, S.H., Park, J.T., Lee, S.Y. , and Chang, H.N. "The effects of complex nitrogen sources and initial pH on growth of Halobacterium halobium S9-P", Proceedings of The 10th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 233-234 (1997)
2. Hong, S.H., Lee, S.Y. and Chang, H.N., "Production of succinic acid by recombinant Escherichia coli", Proceedings of BPERC International Symposium '98, 183-184 (1998)
3. Hong, S.H., Park, J.T., Lee, S.Y., and Chang, H.N., "Production of bacteriorhodopsin by Halobacterium halobium S9-P using various nitrogen sources", Proceedings of BPERC International Symposium '98, 185-186 (1998)
4. Hong, S.H. and Lee, S.Y., "Production of succinic acid by recombinant Escherichia coli", Proceedings of The 11th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 155-156 (1998)
5. Hong, S.H., Lee, S.Y., "Production of Succinic Acid by Recombinant Escherichia coli and metabolic flux analysis", Theories and Applications of Chemical Engineering 5(1): 1053-1056 (1999).
6. Hong, S.H., Lee, S.Y., "Production of Succinic acid by recombinant Escherichia coli and Metabolic analysis", Proceedings of The 12th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 127-128 (1999)
7. Hong, S.H., Lee, S.Y., "Succinic acid production by metabolically reoriented Escherichia coli and metabolic flux analysis", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 329-330 (1999)
8. Hong, S.H., and Lee, S.Y., "Effect of fumarase on the production of succinic acid", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 531-534 (2000, Apr.)
9. Hong, S.H., and Lee, S.Y., "Metabolic flux analysis for succinic acid and production by recombinant Escherichia coli with amplified malic enzyme activity", Theories and Applications of Chemical Engineering 6(1): 1253-1256 (2000).
10. Hong, S.H., Lee, S.Y., "Prediction of intracellular metabolites accumulation in succinic acid producing recombinant Escherichia coli by metabolic flux analysis", Theories and Applications of Chemical Engineering 7(1): 1413-1416 (2001).
11. Hong, S.H. and Lee, S.Y., "Identification of metabolic characteristics by metabolic flux analysis", Proceeding of Annual fall meeting of KIChE, 8 (2): 3941-3944 (2002)
International Conferences
1. Lee, S.Y., Hong, S.H., "Metabolic engineering of Escherichia coli for the production of succinic acid and metabolic flux analysis", Annual Meeting of Society for Industrial Microbiology, San Diego, CA, July (2000)
2. Hong, S.H. and Lee, S.Y., "Metabolic engineering of E. coli for the production of succinic acid", Metabolic Engineering III, Colorado Springs, Colorado, USA, October (2000)
3. Lee, S.Y., Hong, S.H., "Metabolic engineering of Escherichia coli for the production of succinic acid", ISBP/BEDPS 2000, Honolulu, Hawaii, December (2000)
4. Hong, S.H. and Lee, S.Y., "Identification of metabolic characteristics by metabolic flux analysis", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
5. Moon, S.Y., Hong, S.H., and Lee, S.Y., "Prediction of the maximum yields of various metabolites and optimal pathways by metabolic flux analysis", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
6. Moon, S.Y., Hong, S.H., and Lee, S.Y., "Metabolic flux analysis for the succinic acid production in Escherichia coli", ChungNam-Kyushu International Symposium, Kumamoto, Japan,December,6 (2002)
7. Lee, S.Y., Hong, S.H., and Moon, S.Y., "In Silico Metabolic Pathway Analysis and Design: Succinic acid Production by Metabolically Engineered Escherichia coli as an example", The 13th International conference on genome informatics GIW2002 meeting, Yebisu garden place, Tokyo, Japan, December 16-18(2002)
8. Lee, S.Y., Hong, S.H., and Moon, S.Y., "Metabolic Engineering of Escherichia coli for the Production of Succinic Acid", Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, Colorado, May 4-7 (2003)
9. Lee, S.Y., Hong, S.H., and Moon, S.Y., "Production of Short-Length and Medium-chain-Length Polyhyroxyalkanote Copolymer by Metabolically Engineered E. coli" , Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, Colorado, May 4-7 (2003)
10. Lee, S.Y., Hong, S.H. , Lee, P.C., and Chang, H.N., "Production of Succinic acid by Anaerobiospirillum succiniproducens from Wood Hydrolysate" , Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, Colorado, May 4-7 (2003)
11. Lee, S.Y., Hong, S.H., Lee, P.C., and Chang, H.N., "Batch and Continuous of Mannheimia succiniciproducens MBEL55E for the production of Succinic Acid from Whey and Corn Steep Liquor" , Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, Colorado, May 4-7 (2003)
Korean Conferences
1. Kim, B.K., Hong, S.H., Lee, S.Y. , Lee, Y.H., and Chung, B.H., "Production of IGF-I by recombinant Escherichia coli", Annual Symposium of KIBB, Chosun Univ., Kwangju, April (1996).
2. Um, Y.S., Park, J.T., Hong, S.H., Lee, S.Y. , and Chang, H.N., "Production of bacteriorhodopsin by Halobacterium halobium R1 using internal and external membrane bioreactor systems", Annual Symposium of KIBB, Taegu Univ., Kyungsan, October (1997)
3. Hong, S.H., Park, J.T., Lee, S.Y. , and Chang, H.N., "The effects of complex nitrogen sources and initial pH on growth of Halobacterium halobium S9-P", The 10th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, KAIST, Teajon, November (1997)
4. Hong, S.H., Lee, S.Y., and Chang, H.N., "Production of succinic acid by recombinant Escherichia coli", Annual Symposium of BPERC '98, KAIST, Taejon, Korea, September (1998)
5. Hong, S.H., Park, J.T., Lee, S.Y., and Chang, H.N., "Production of bacteriorhodopsin by Halobacterium halobium S9-P using various nitrogen sources", Annual Symposium of BPERC '98, KAIST, Taejon, Korea, September (1998)
6. Hong, S.H. and Lee, S.Y., "Production of succinic acid by metabolically engineered Escherichia coli", Annual Symposium of KSAM, KOFST Bldg., Seoul, October (1998)
7. Hong, S.H., Lee, S.Y., "Production of Succinic Acid by Recombinant Escherichia coli and metabolic flux analysis", Annual Symposium of KIChE, SeongKyunKwan Univ. Suwon (1999)
8. Hong, S.H., Lee, S.Y., "Production of Succinic acid by recombinant Escherichia coli and Metabolic analysis", The 12th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, Kongju Univ., Kongju (1999)
9. Hong, S.H., Lee, S.Y., "Succinic acid production by metabolically reoriented Escherichia coli and metabolic flux analysis", Annual Symposium of Korean Society for Biotechnology and Bioengineering, Kangwon University, Chuncheon (1999)
10. Hong, S.H., and Lee, S.Y., "Effect of fumarase on the production of succinic acid", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, KAIST, April (2000)
11. Hong, S.H., and Lee, S.Y., "Metabolic flux analysis for succinic acid and production by recombinant Escherichia coli with amplified malic enzyme activity", KIChE Meeting, Hanyang Univ., Ansan , April (2000)
12. Hong, S.H., Lee, S.Y., "Effect of redox potential on the production of succinic acid by metabolically engineered Escherichia coli", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Chunan, November(2000)
13. Hong, S.H., Lee, S.Y., "Prediction of intracellular metabolites accumulation in succinic acid producing recombinant Escherichia coli by metabolic flux analysis", KIChE meeting, Yonsei Univ., April (2001)
14. Hong, S.H. and Lee, S.Y., "Importance of redox balance on the production of succinic acid by metabolically engineered Escherichia coli”, The 14th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, Chungnam Univ., Taejon , Korea (2001)
15. Hong, S.H. and Lee S.Y., "In Silico Metabolic Pathway Analysis and Design", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Chungju, October 12(2002)
16. Moon, S.Y, Hong. S.H., and Lee, S.Y., "Prediction of the optimal metabolic pathways for the production of metabolites in Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Chungju, October 12(2002)
17. Hong, S.H. and Lee S.Y., "Identification of metabolic characteristics of Mannheimia succiniciproducens MBEL55E", Annual Meeting of Korean Society for Biotechnology and Bioengineering symposium, Chungju, October 12(2002)
18. Hong, S.H. and Lee, S.Y., "Identification of metabolic characteristics by metabolic flux analysis", Annual Fall Meeting of KIChE, Seoul, October 24-26 (2002)
19. Hong, S.H., Park, S.J., Moon, S.Y., Park, J.P. and Lee, S.Y., "In Silico Prediction of the Importance of Enter-Doudoroff Pathway in Poly (3-Hydroxybutyrate) Production", Korean Society for Bicrobiology and Biotechnology Meeting, Konkuk univ., October, 26 (2002)
20. Hong, S. H., Lee, P.C., Chang, H.N. and Lee, S.Y., "Continuous Cultures of Mannheimia succiniciproducens MBEL55E for the Production of Succinic Acid from various carbon substrates", Korean society for Bicrobiology and Biotechnology Meeting, Konkuk Univ., October, 26 (2002)
21. Hong, S.H., Lee, S.Y. and Moon, S.Y., "In silico metabolic network construction and metabolic flux analysis for the production of succinic acid in Escherichia coli", Korean Society For Bioinformatics Annual Meeting, Haeundae, Korea, November,15-16 (2002)
22. Han, M.J., Lee, S.Y., Hong, S. H., and Park, S.J., "Role of Eda in polyhydroxyalkanoate biosynthesis deciphered from proteome analysis and metabolic flux analysis", Korean Society For Bioinformatics Annual Meeting, Haeundae, Korea, November, 15-16 (2002)
23. Lee, S.Y., Jeong, K.J., Yoon, S.H., Han, M.J., Choi, J.H., Park, S.J., and Hong, S.H., "Integrated analysis of the transcriptome and proteome of recombinant E. coli fermentation", 2002 Nanobio International Symposium, Haeundae, Korea, November 22-23 (2002)
24. Hong, S.H., Moon, S.Y.and Lee, S.Y., "“Prediction of the maximum yields of metabolites by metabolic flux analysis", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Busan, Korea, April 11-12(2003)
Books/Book Editing
1. Lee, S.Y. and Hong, S.H., "Engineering of E. coli central metabolic pathways for the production of succinic acid", In:Advances in Biochemical Production Technology(Park, T.H. and Martin, eds.), American Chemical Society, Washington DC, USA, pp.30-38 (2002)
2. Lee S.Y., Hong S.H., Park S.J., van Wegen, R. and Middelberg A.P.J., "Metabolic flux analysis on the prodcution of poly(3-hydroxybutyrate)", Biopolymers Vol 3a, Ch 8, pp.249-262 ,VCH-Wiley, Weinheim, Germany (2001)
3. Lee, S.Y., Park, S.H., Hong, S.H., Lee, Y. and Lee, S.H., "Fermentative Production of Building Blocks for Chemical Synthesis of Polyesters", Biopolymers Vol 3b, Ch 10, pp.265-326, VCH-Wiley, Weinheim, Germany (2001)
Patents
국내 특허 등록 2건, 출원 1건
Si Jae Park
Ph.D. '03. 8.
Senior Scientist / Engineer
LG Chem, Ltd. / Research Park
Phone :+82-42-869-5970
Fax :+82-42-863-7446
Details
Research Interest
Metabolic engineering
Polyhydroxyalkanoate (PHA)
High cell density cultivation
Protein engineering
Education
1993. 3.-1997. 2. Department of Chemical Engineering, Seoul National University, Seoul, Korea, B. S
1997. 3 – 1999. 2. Department of Chemical Engineering, KAIST, Taejon, Korea M. S (M. S. thesis : Cloning of desulfurization genes from Gordona sp. CYKS1 and its expression in Escherichia coli (Advisor: Prof. Sang Yup Lee))
1999. 3 – 2003. 8. Department of Chemical Engineering, KAIST, Taejon, Korea, Ph. D. (Dissertation title: Metabolic engineering for the production of poly(3-hydroxyalkanoate) in recombinane Escherichia coli. (Advisor: Prof. Sang Yup Lee))
Publications
International Journal
1. Park SJ,Lee SY (1998) "Efficient recovery of secretory recombinant protein from protease negative mutant Escherichia coli strains", Biotechnol Techniques 12: 815-818
2. Park SJ,Georgiou G, Lee SY (1999) "Secretory production of recombinant protein by high cell density culture of protease negative mutant Escherichia coli strain", Biotechnol Prog 15: 164-167
3. Ahn WS, Park SJ, Lee SY (2000) "Production of poly(3-hydroxybutyrate) by fed-batch culture of recombinant Escherichia coli with a highly concentrated whey solution", Appl Environ Microbiol 66:3624-3627
4. Park SJ, Ahn WS, Green PR, Lee SY (2001) "High level production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains" Biomacromolecules 2:248-254
5. Park SJ, Ahn WS, Green PR, Lee SY (2001) "Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains¢¢ç", Biotechnol Bioeng 74:82-87
6. Ahn WS, Park SJ, Lee SY (2001) "Production of poly(3-hydroxybutyrate) from whey by cell recycle fed-batch culture of recombinant Escherichia coli" Biotechnol Lett 23:235-240
7. Chen GQ, Zhang G, Park SJ, Lee, SY (2001) "Industrial scale production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)" Appl Microbiol Biotechnol 57: 50-55
8. Park SJ, Park JP, Lee SY (2002) "Production of poly(3-hydroxybutyrate) from whey by fed-batch culture of recombinant Escherichia coli in a pilot-scale fermentor", Biotechnol. Lett., 24:185-189
9. Park SJ, Park JP, Lee SY (2002)" Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates rich in specific monomers", FEMS Microbiol. Lett., 214:217-222.
10. Hong SH, Park SJ, Moon SY, Park JP, Lee SY "In silico prediction and validation of the importance of enter-doudoroff pathway in poly(3-hydroxybutyrate) production by metabolically engineered Escherichia coli" Biotechnol Bioeng, 83: 854-863
11. Park SJ, Park JP, Lee SY, Doi Y "Enrichment of specific monomer in medium-chain-length poly(3-hydroxyalkanoates) by amplification of fadD and fadE genes in recombinant Escherichia coli" Enzyme Microb Technol., 33 : 62-70.
12. Park SJ, Lee I-S, Chang YK, Lee SY "Desulfurization of dibenzothiophene by metabolically engineered Escherichia coli", J. Microbiol. Biotechnol., 13(4):578-583.
13. Park S J and Lee S Y "Identification and characterization of a new enoyl Coenzyme A hydratase involved in the biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant Escherichia coli", J. Bacteriol., 185(18) : 5391-5397.
14. Park, S.J., Lee, Y., and Lee, S.Y., "Biosynthesis of (R)-3-hydroxyalkanic acid by metabolically engineered E.coli", Appl. Biochem. Biotechnol., In press
Domestic Journal
1. Choi J, Lee SY, Shin K, Lee WG, Park SJ, Chang HN, Chang YK (2002) "Pilot scale production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by fed-batch culture of recombinant Escherichia coli", Biotechnol Bioprocess Eng 7: 371-374
Book chapters
1. Lee SY, Park SJ, "Fermentative production of SCL-PHAs", in Biopolymers, Vol. 3a(Steinbuchel A Ed), Wiley-VCH, 263-290.
2. Lee SY, Park SJ, "Biosynthesis and fermentative production of SCL-MCL-PHAs", in Biopolymers, Vol. 3a (Steinbuchel A Ed), Wiley-VCH, 317-336.
3. Lee SY, Hong SH, Park SJ, van Wegen R, Middelberg APJ, "Metabolic flux analysis on the production of poly(3-hydroxybutyrate)" in Biopolymers, Vol. 3a (Steinbuchel A Ed), Wiley-VCH, 249-261.
4. Lee SY, Park SJ, Park JP, Lee Y, Lee SH (2002), "Economic aspects of biopolymer production" in Biopolymers, Vol. 10 (Steinbuchel A Ed), Wiley-VCH, in press.
5. Lee SY, Park SJ, Lee Y, Lee SH (2002), "Biotechnological Processes for the Production of Monomers for Subsequent Chemical Polymer Synthesis", in Biopolymers, Vol. 10 (Steinbuchel A Ed), Wiley-VCH, in press.
Patents: 6 patents were pended.
Domestic Proceedings
1. Park SJ, Lee SY "Production of heterogeneous protein by fed-batch culture of protease negative mutant Escherichia coli", Proceedings of The 10th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 367-368 (1997)
2. Park SJ, Lee SY, Chang YK "Cloning of desulfurization genes from Gordona sp.", Proceedings of BPERC International Symposium '98, 177-178 (1998)
3. Park SJ, Lee SY "Production of secretory recombinant protein by fed-batch culture of protease negative mutant Escherichia coli strain", Proceedings of BPERC International Symposium '98, 179-180 (1998)
4. Park SJ, Lee SY "Development of efficient recovery methods for secretory recombinant protein from protease-negative mutant Escherichia coli strains", Proceedings of BPERC International Symposium '98, 181-182 (1998)
5. Park SJ, Lee SY "Production of heterologous protein by fed-batch culture of protease negative mutant Escherichia coli" Proceedings of The 11th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 149-150 (1998)
6. Park SJ, Lee SY, Chang YK "Cloning of desulfurization genes from newly isolated Gordona sp. CYKS1", Proceedings of Korea Institute of Biotechnology and Bioengineering Symposium, 293-294(1998)
7. Park SJ, Lee SY "Clonig of desulfurization genes from Gordona sp. CYKS1 and development of recombinant Escherichia coli for desulfurization", Theories and Applications of Chemical Engineering 5(1): 1145-1148 (1999).
8. Park SJ, Lee SY "Development of Recombinant Escherichia coli for Biodesulfurization", Proceedings of The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 123-124 (1999)
9. Park SJ, Ahn WS, Lee SY "Production of poly (3-hydroxybutyrate) by high cell density cultivation of recombinant Escherichia coli from whey", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 223-226 (2000. Apr.)
10. Choi J, Park SJ, Lee SY "Production of Poly (3-hydroxybutyrate) with high molecular mass by recombinant Escherichia coli", Theories and Applications of Chemical Engineering 6(1): 1233-1236 (2000).
11. Lee SH, Park SJ, Lee SY, Park SH "Production of Medium-chain-length Polyhydroxyalkanoate from Newly Screened Pseudomonas sp. MBEL21", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 153-156 (2001, Apr.)
12. Park SJ, Ahn WS, Lee SY "Production of poly (3- hydroxybutyrate- co- 3- hydroxyvalerate- co- 3- hydroxyhexanoate by recombinant Escherichia coli strains)", Theories and Applications of Chemical Engineering 7(1): 1425-1428 (2001).
13. Park SJ, Park JP, Lee SY "Biosynthesis of medium-chain-length poly(3-hydroxyalkanoates) by metabolically engineered Escherichia coli strains", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 735-738, November (2001)
14. Park JP, Park SJ, Lee SY "Production and characterization of ultra-high-molecular weight poly (3-hydroxybutyrate) by recombinant Escherichia coli", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 731-734, November (2001)
15. Park SJ, Park JP, Lee SY "Production of poly (3-hydroxybutyrate) by recombinant Escherichia coli strain in pilot-scale fermentor from whey", Theories and Applications of Chemical Engineering 7(2): 3943-3946 (2001)
International Conferences
1. Lee SY, Ahn WS, Park SJ "Production of poly (3-hydroxybutyrate) from whey by fed-batch culture of recombinant Escherichia coli", Annual Meeting of Society for Industrial Microbiology, San Diego, CA, July (2000)
2. Park SJ, Ahn WS, Green PR, Lee SY "Production of poly (3-hydroxybutyrate-co-3- hydroxyhexanoate) by metabolically engineered Escherichia coli strains", The 8th Annual International Symposium on Biological Polyesters, MIT, Masachusetts, USA, September (2000)
3. Park SJ, Ahn WS, Lee SY "Production of poly (3-hydroxybutyrate) by fed-batch culture of recombnant Escherichia coli using highly concentrated whey solution", The 8th Annual International Symposium on Biological Polyesters, MIT, Masachusetts, USA, September (2000)
4. Lee SY, Ahn WS, Park SJ "High level production of poly (3-hydroxybutyrate) from whey by metabolically engineered E. coli", Metabolic Engineering III, Colorado Springs, Colorado, USA, October (2000)
5. Lee SH, Park SJ, Park JP, Lee SY "Biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant Escherichia Coli by engineering ¥â-oxidation pathway", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
6. Park JP, Park SJ, Lee SY "Production of medium-chain–length polyhydroxyalkanoates in metabolically engineered Escherichia Coli strains", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
7. Park SJ, Park JP, Lee SY "Biosynthesis of poly (3-hydroxybutyrate-co-3-hydroxyalkanoate) in metabolically engineered Escherichia Coli strains", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
8. Park JP, Park SJ, Lee SY "Biosynthesis and chataterization of polyhydroxalkanotes in newly screened Pseudomonas sp. MBEL21", International Symposium on Biological Polyesters,Munster, Germany, September 24(2002)
9. Park SJ, Park JP, Lee SY "Biosynthesis of medium-chain-length polyhydroxyalkanotates in recombinant Escherichia coli", International Symposium on Biological Polyesters, Munster, Germany, September 24(2002)
10. Park JP, Park SJ, Lee SY "Biosythesis and chacterization of polyhydroxyalkanotes from newly screened strain from sludge" , International Symposium on Biological Polyesters, Munster, Germany, September 22-26(2002)
11. Park JP, Park SJ, Lee SY "Production of (R)-(-)-3-hydroxybutyric acid by metabolically engineered Escherichia coli" , International Symposium on Biological Polyesters, Munster, Germany, September 22-26(2002)
12. Park JP, Park SJ, Lee SY "Amplification of glycolytic pathway increases the yield of poly(3-hydroxbutyrate) in Esxherichia coli", International Symposium Biological Polyesters, Munster, Germany, September 22-26(2002)
13. Choi JH, Park JP, Park SJ, Lee SY "Metabolic engineering of Escherichia coli for the production of polyhydroxyalkanoates consisting of short-chain–length and medium-chain-length monomers", Metabolic Engneering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11 (2002)
14. Lee SH, Park JP, Park SJ, Lee SY "Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates" Metabolic Engneering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11(2002)
Domestic Conferences
1. Park SJ, Lee SY "Production of heterogeneous protein by fed-batch culture of protease negative mutant Escherichia coli", The 10th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, KAIST, Taejon, November (1997)
2. Park SJ, Lee SY, Chang YK "Cloning of desulfurization genes from Gordona sp.", Annual Symposium of BPERC '98, KAIST, Daejeon, Korea, September (1998)
3. Park SJ, Lee SY "Production of secretory recombinant protein by fed-batch culture of protease negative mutant Escherichia coli strain", Annual Symposium of BPERC '98, KAIST, Daejeon, Korea, September (1998)
4. Park SJ, Lee SY "Development of efficient recovery methods for secretory recombinant protein from protease-negative mutant Escherichia coli strains", Annual Symposium of BPERC '98, KAIST, Daejeon, Korea, September (1998)
5. Park SJ, Lee SY, Chang YK "Cloning of desulfurization genes from newly isolated Gordona sp. CYKS1" Annual Symposium of KIBB, Hanyang Univ., Ansan, October (1998)
6. Park SJ, Jeong KJ, Lee HS, Lee SY, Chang YK "Development of recombinant bacteria for the degradation of dibenzothiophene" Annual Symposium of KIChE, Chosun Univ., Kwangju, October (1998)
7. Park SJ, Lee SY "Clonig of desulfurization genes from Gordona sp. CYKS1 and development of recombinant Escherichia coli for desulfurization", Annual Symposium of KIChE, SeongKyunKwan Univ. Suwon (1999)
8. Park SJ, Lee SY "Development of Recombinant Escherichia coli for Biodesulfurization", The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Kongju Univ., Kongju (1999)
9. Park SJ, Ahn WS, Lee SY "Production of poly (3-hydroxybutyrate) by high cell density cultivation of recombinant Escherichia coli from whey", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, KAIST, April (2000)
10. Park SJ, Ahn WS, Green PR, Lee SY "Production of poly (3-hydroxybutyrate-co-3- hydroxyhexanoate) by high cell density cultivation of recomninant Escherichia coli", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Chunan, November(2000)
11. Lee SH, Park SJ, Lee SY, Park SH " Production of Medium-chain-length Polyhydroxyalkanoate from Newly Screened Pseudomonas sp. MBEL21", Annual meeting of Korean society for Biotechnology and Bioengineering, Konkuk Univ., Seoul, April (2001)
12. Park SJ, Ahn WS, Lee SY "Production of poly (3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate by recombinant Escherichia coli strains), KIChE meeting, Yonsei Univ., April (2001)
13. Lee SY, Park SJ, Lee Y "Metabolic Engineering of Escherichia coli for the Production of Novel PHA and Chiral Compounds", Annual Meeting of Korean Society for Applied Microbiology, Chonan Sangnok Resort, June (2001)
14. Park SJ, Lee SY "Biosynthesis of medium-chain-length poly (3-hydroxyalkanoates) by metabolically engineered Escherichia coli strains", The 14th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Chungnam Univ., Daejeon, Korea (2001)
15. Park JP, Park SJ, Lee SY "Production and characterization of ultra-high-molecular weight poly (3-hydroxybutyrate) by recombinant Escherichia coli", The 14th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Chungnam Univ., Daejeon, Korea (2001)
16. Park SJ, Park JP, Lee SY "Biosynthesis of medium-chain-length poly (3-hydroxyalkanoates) by metabolically engineered Escherichia coli strains", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Seoul, November (2001)
17. Park JP, Park SJ, Lee SY "Production and characterization of ultra-high-molecular weight poly(3-hydroxybutyrate) by recombinant Escherichia coli", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Seoul, November(2001)
18. Park SJ, Park JP, Lee SY "Production of poly (3-hydroxybutyrate) by recombinant Escherichia coli strain in pilot-scale fermentor from whey", KIChE meeting, Daejeon, Korea (2001)
19. Park JP, Park SJ, Lee SY "Molecular cloning of (R)-specific enoyl-CoA hydratase genes from Pseudomonas sp. MBEL21 and their use for polyhydroxyalkanoate synthesis", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium,chungju ,October 12(2002)
20. Park SJ, Park JP, Lee SY "Evaluation of the roles of 3-ketoacyl-ACP reductases in the polyhydroxyalkanoates in recombinant Escherichia coli", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Chungju, October 12(2002)
21. Hong SH, Park SJ, Moon SY, Park JP, Lee SY "In SilicoPrediction of the Importance of Enter-Doudoroff Pathway in Poly (3-Hydroxybutyrate) Production", Korean society for Bicrobiology and Biotechnology meeting, Konkuk univ. October, 26 (2002)
22. Park SJ, Choi J, Lee SY "Production of Poly (3-Hydroxybutyrate-co-3-Hydroxyvalerate) by Fed-Batch Culture of Recombinant Escherichia coli in a Pilot Scale Fermentor", Korean society for Bicrobiology and Biotechnology meeting, Konkuk univ. October, 26 (2002)
23. Park JP, Park SJ, Lee SY " Production of medium-chain-length polyhydroxyalkanoates by a newly isolated strain of Pseudomonas sp. MBEL21", Korean society for Bicrobiology and Biotechnology meeting, Konkuk univ. October, 26 (2002)
24. Park JP, Park SJ, Lee SY "Medium-chain-length polyhydroxyalkanoate biosynthesis and accumulation in metabolic engineered recombinant E. coli" Korean society for Bicrobiology and Biotechnology meeting, Konkuk univ. October, 26(2002)
25. Han MJ, Lee SY, Hong SH, Park SJ "Role of Eda in polyhydroxyalkanoate biosynthesis deciphered from proteome analysis and metabolic flux analysis", Korean Society For Bioinformatics Annual Meeting, Haeundae, Korea, November, 15-16 (2002)
26. Lee SY, Jeong KJ, Yoon SH, Han MJ, Choi JH, Park SJ, Hong SH "Integrated analysis of the transcriptome and proteome of recombinant E. coli fermentation", 2002 Nanobio international symposium, Haeundae, Korea, November, 22-23 (2002)
Dong Yup Lee
Senior Researcher, Ph.D. '04. 2.
Bioinformatics Research Center, KAIST
Phone :+82-42-869-3960
Fax :+82-42-869-3910
Details
Education
PhD., Chemical and Biomolecular Engineering, present, KAIST, Daejeon, Korea. (Thesis Title: Computational and Bioinformatic Analysis of Complex Biochemical Pathways, Thesis Supervisors: Prof. Sunwon Park & Prof. Sang Yup Lee)
MS., Chemical Engineering, Feb. 2000, KAIST, Daejeon, Korea. (Thesis Title: Environmentally Friendly Scheduling for Primary Steelmaking Processes, Thesis Supervisor: Prof. Sunwon Park)
BS., Chemical Engineering, Feb. 1998, Yonsei Univ., Seoul, Korea
Experience and Academic Activity
Internship, Pacific R&D Center, Pacific Corp., July 1997.
Visiting Research Fellow, Social and Environmental Systems Division, National Institute for Environmental Studies (NIES), Tsukuba, Japan (Jan. 2000 - Feb. 2000), supported by JISTEC
Reference: Dr. Yuichi Moriguchi (Host researcher)
Research theme: Environmental Impacts for the Change of World Resource Flows in Fuel Oil Production
Photo
Visiting Research Fellow, Institute for Algorithms and Scientific Computing (SCAI), Fraunhofer-Gesellschaft (FhG), Sankt Augustin, Germany (Jul. 2001 - Oct. 2001), supported by Korean Ministry of Education
Reference: Prof. Ralf Zimmer (Praktische Informatik und Bioinformatik, Institut für Informatik, LMU München)
Research theme: Petri Net Representation and Simulation of Signal Transduction Network
Visiting Research Fellow, Dept. of Chem. Eng., Kansas State University, Manhattan, United State (Jan. 2003 - Apr. 2003), supported by Korean Ministry of Education & Human Resources Development
Reference: Prof. L. T. Fan
Research theme: Synergistic Identification of Multiple Flux Distributions and Multiple Metabolic Pathways
Honor/Awards
Oct. 1990, Bronze medal, The 4th Korean Mathematical Olympiad by Korean Mathematical Society, Test paper
Oct. 1996, 1st Prize, The 2nd Plant Design Contest sponsored by Korean Institute of Chemical Engineers
June 2001, Best paper award, 2001 Korean Society of Supply Chain Management Spring Meeting
2003, Genome Informatics Workshop (GIW) Student Fellowship Award by Japanese Society for Bioinformatics (JSBi)
Software
MetaFluxNetTM: An integrated program for the management of metabolic reaction information and quantitative metabolic flux analysis (MFA)
Version 1.0 (program registration: 29 Mar. 2002) [Registration No.: 2002-01-12-1984]
Version 1.5 (released: 15 Dec. 2002; program registration: 6 Jan. 2003) [Registration No: 2003-01-12-27]
Version 1.6 (released: 10 May 2003)
Version 1.63 (released: 4 Aug. 2003) [Download] [More]
Version 1.7 (program registration: 19 Aug. 2003) [Registration No: 2003-01-12-4370]
Publications
Jin-Kwang Bok, Dong-Yup Lee and Sunwon Park, "Mixed-Integer Programming Model for Scheduling of Steelmaking Processes", J. Control, Automation and Systems Eng., Vol. 5, No. 6, pp. 714-723, 1999. [PDF-Full text in Korean]
Heejin Lim, Dong-Yup Lee and Sunwon Park, "Environmental Analysis and Improvement of PET Production Systems Using Life Cycle Assessment", Korean Journal of LCA., Vol. 2, No. 1, pp. 53-60, 2000. [PDF-Full text in Korean]
Hodong Seo, Dong-Yup Lee, Sunwon Park, Liang-Tseng Fan, Shahram Shafie, Botond Bertók and Ferenc Friedler, "Graph-Theoretical Identification of Pathways for Biochemical Reactions", Biotechnology Letters, Vol. 23, pp. 1551-1557, 2001. [PDF-Full text]
Jehoon Song, Jin-Kwang Bok, Heeman Lee, Hyungjin Park, Dong-Yup Lee and Sunwon Park, "SCM의 개요와 화학공학분야에서의 연구 현황 및 화학 산업의 적용 사례", ICASE Magazine, Vol. 7, No. 4, pp. 7-18, 2001. [PDF-Full text in Korean]
Jehoon Song, Hyungjin Park, Dong-Yup Lee and Sunwon Park, "Scheduling Model for Actual Size Refinery Processes Considering Supply Chain Management", Journal of the Korean Society of Supply Chain Management, Vol. 1, pp. 73-80, 2001. [PDF-Full text in Korean]
Jehoon Song, Dong-Yup Lee and Sunwon Park, "공습사슬 관리(SCM)의 개요와 화학공학분야에서의 연구 현황", News & Information for Chemical Engineers, Vol. 20, No. 3, pp. 289-291, 2002. [PDF-Full text in Korean]
Jehoon Song, Hyungjin Park, Dong-Yup Lee and Sunwon Park, "Scheduling of Actual Size Refinery Processes Considering Environmental Impacts with Multiobjective Optimization", Industrial & Engineering Chemistry Research, Vol. 41, pp. 4794-4806, 2002. [PDF-Full text]
Dong-Yup Lee, Young-gyun Oh, Hongseok Yoon, Sang Yup Lee and Sunwon Park, "Exploring Flux Distribution Profiles for Switching Pathways Using Multiobjective Flux Balance Analysis", Genome Informatics, Vol. 13, pp. 363-364, 2002. [PDF-Full text]
Dong-Yup Lee, Moonyong Lee, Yongho Lee and Sunwon Park, "Mp Criterion Based Multiloop PID Controllers Tuning for Desired Closed Loop Responses", Korean J. Chem. Eng., Vol. 20, pp. 8-13, 2003. [PDF-Full text]
Dong-Yup Lee, Hongseok Yun, Sunwon Park and Sang Yup Lee, "MetaFluxNet: the Management of Metabolic Reaction Information and Quantitative Metabolic Flux Analysis", Bioinformatics, Vol. 19, pp. 2144-2146, 2003. [PDF-Full text]
Dong-Yup Lee, Su Whan Sung, Sang Yup Lee and Sunwon Park, "A Combined Deterministic-Stochastic Approach for Pharmacokinetic Modeling", submitted for Journal publication.
Dong-Yup Lee, L. T. Fan, Sunwon Park, Sang Yup Lee, Shahram Shafie, Botond Bertók and Ferenc Friedler, "Synergistic Identification of Multiple Flux Distributions and Multiple Metabolic Pathways", submitted for Journal publication.
Sungdeuk Moon, Dong-Yup Lee and Sunwon Park, "Scheduling of Primary Steelmaking Processes: Part 1. Mathematical Model", in preparation to be submitted to Industrial & Engineering Chemistry Research.
Dong-Yup Lee, Sungdeuk Moon, Paulo-Miguel Lopes and Sunwon Park, "Scheduling of Primary Steelmaking Processes: Part 2. Environmentally Friendly Scheduling", in preparation to be submitted to Industrial & Engineering Chemistry Research.
Presentations
Jehoon Song, Seokjoon Kim, Dong-Yup Lee and Doohwan Kim, "Simulation for Separation of the MCH-Toluence System", Process S/W and H/W Symposium, pp. 157-167, 1997.
Dong-Yup Lee, Yongho Lee and Sunwon Park, "Application of SISO-DCLR Method for MIMO Systems", Proc. '98 KIChE Fall meeting, Vol. 4, pp. 2337-2340, 1998. [PDF-Full text in Korean]
Dong-Yup Lee, Hodong Seo, Myungwan Han and Sunwon Park, "A Study on Optimization Regions for Complex Column Alterntives", The 11th Kyushu-Chungnam Symposium on Chem. Eng., pp. 339-340, Nov. 1998. [presentation]
Changryol Kim, Dong-Yup Lee and Sunwon Park, "Life Cycle Inventory of Petroleum Products", Proc. '98 KSLCA meeting, pp. 121, 1998.
Dong-Yup Lee, Yongho Lee and Sunwon Park, "Multiloop PID Controller Tuning for Unstable Systems", Proc. '99 KIChE Spring meeting, Vol. 5, pp. 389-392, 1999. [PDF-Full text in Korean]
Jin-Kwang Bok, Dong-Yup Lee and Sunwon Park, "Mixed-Integer Programming Model for Scheduling of Steelmaking Processes", Proc. '99 KIChE Spring meeting, Vol. 5, pp. 513-516, 1999.
Dong-Yup Lee, Jin-Kwang Bok and Sunwon Park, "Mixed-Integer Programming Model for Scheduling of Steelmaking Processes Considering Environmental Impacts", The 2nd Technical Society of Steel Process Control Workshop in Pohang, pp. 52-55, 1999.
Dong-Yup Lee, Jin-Kwang Bok and Sunwon Park, "Scheduling of Steelmaking Processes Considering Environmental Impacts", The 3rd Korea-China Joint Workshop on PSE in Taejon, pp. 127-130, 1999. [PDF-Full text]
Dong-Yup Lee and Sunwon Park, "Approximation Technique for the Generation of the Noninferior Set in Multiobjective Optimization", Proc. '99 KIChE Fall meeting, Vol. 5, pp. 2593-2596, 1999. [PDF-Full text in Korean]
Dong-Yup Lee, Yongho Lee, Jeongseok Lee and Sunwon Park, "Multiloop PID Controller Tuning Method for Open-Loop Unstable Systems", The 12th Chungnam-Kyushu Symposium on Chem. Eng., pp. 385-386, Oct. 1999. [PDF-Full text]
Heejin Lim, Dong-Yup Lee and Sunwon Park, "Application of LCA to PET Process", Proc. '99 KSLCA meeting, pp. 116-122, 1999. [PDF-Full text in Korean]
Sungdeuk Moon, Dong-Yup Lee and Sunwon Park, "Mathematical Model for Scheduling of Primary Steelmaking Processes", The 4th Korea-France Workshop on Simulation, Optimization and Control in PSE in Cheju Island, pp. 123-135, 2000.
Sungdeuk Moon, Dong-Yup Lee and Sunwon Park, "Scheduling of Primary Steelmaking Processes: Part 1. Mathematical Modeling", Proc. '00 KIChE Spring meeting, Vol. 6, pp. 377-380, 2000.
Dong-Yup Lee, Sungdeuk Moon and Sunwon Park, "Scheduling of Primary Steelmaking Processes: Part 2. Environmentally Friendly Scheduling", Proc. '00 KIChE Spring meeting, Vol. 6, pp. 381-384, 2000. [PDF-Full text][presentation]
Hyungjin Park, Sungdeuk Moon, Dong-Yup Lee and Sunwon Park, "Scheduling of Primary Steelmaking Processes with an Optimal Control Approach", Proc. '00 KIChE Spring meeting, Vol. 6, pp. 413-416, 2000.
Heejin Lim, Dong-Yup Lee and Sunwon Park, "Life Cycle Assessment for Two Different PET Production Systems", Proc. '00 KIChE Spring meeting, Vol. 6, pp. 553-556, 2000. [PDF-Full text in Korean]
Dong-Yup Lee, Hyungjin Park, Jehoon Song and Sunwon Park, "Environmental Purchasing for Green Supply Chain Management", Proc. '00 KIChE Fall meeting, Vol. 6, pp. 3033-3036, 2000. [PDF-Full text in Korean][presentation][presentation PDF-file]
Jehoon Song, Hyungjin Park, Dong-Yup Lee and Sunwon Park, "Scheduling Model for Refinery Processes of Actual Size Considering Supply Chain Management", Proc. '01 KIChE Spring meeting, Vol. 7, pp. 565-568, 2001. [PDF-Full text in Korean]
Young-gyun Oh, Heejin Lim, Dong-Yup Lee and Sunwon Park, "Life Cycle Assessment for Sulfuric and Nitric Acid Production Systems", Proc. '01 KIChE Spring meeting, Vol. 7, pp. 649-652, 2001.
Mingu Kang, Heejin Lim, Dong-Yup Lee and Sunwon Park, "Life Cycle Assessment for Phosphoric Acid Production Systems", Proc. '01 KIChE Spring meeting, Vol. 7, pp. 653-656, 2001.
Hodong Seo, Dong-Yup Lee, Sunwon Park, Liang-Tseng Fan, Shahram Shafie, Botond Bertók and Ferenc Friedler, "Graph-Theoretical Identification of Pathways for Biochemical Reactions", PRES'01, Florence, Italy, 2001. [PDF-Full text][presentation]
Jehoon Song, Hyungjin Park, Dong-Yup Lee and Sunwon Park, "Scheduling Model for Actual Size Refinery Processes Considering Supply Chain Management", Proc. 2001 Korean Society of Supply Chain Management Spring meeting, 2001. [PDF-Full text in Korean]
Dong-Yup Lee, Moonyong Lee, Yongho Lee and Sunwon Park, "Multiloop PID Controllers Tuning for Desired Closed Loop Responses", DYCOPS-6, Cheju Island, Korea, June 4 - 6, 2001. [PDF-Full text][presentation]
Hodong Seo, Dong-Yup Lee, Sunwon Park, Liang-Tseng Fan, Shahram Shafie, Botond Bertók and Ferenc Friedler, "An Attempt for the Identification of Stoichiometrically Exact Mechanisms of the Conversion of Glucose to Pyruvate", Proc. '01 KIChE Fall meeting, Vol. 7, pp. 2953-2956, 2001. [PDF-Full text in Korean][presentation]
Jehoon Song, Hyungjin Park, Dong-Yup Lee and Sunwon Park, "Scheduling for Actual Size Refinery Processes Considering Environmental Impacts with Multiobjective Optimization", Proc. '01 KIChE Fall meeting, Vol. 7, pp. 3007-3010, 2001. [PDF-Full text in Korean][presentation]
Young-gyun Oh, Dong-Yup Lee and Sunwon Park, "Pathway Analysis and Dynamic Simulation of Metabolic Pathway in the Human Red Blood Cells", Proc. '02 KIChE Spring meeting, Vol. 8, pp. 357-360, 2002.
Hongseok Yun, Dong-Yup Lee, Sang Yup Lee and Sunwon Park, "MetaFluxNetTM: a program for metabolic flux analysis (MFA)", International Conference on Control, Automation and Systems, 2002.
Young-gyun Oh, Dong-Yup Lee and Sunwon Park, "Multiobjective Linear Programming in Flux Balance Analysis", Proc. '02 KIChE Fall meeting, Vol. 8, pp. 2997-3000, 2002.
Dong-Yup Lee, Ralf Zimmer, Juliane Fluck, Daniel Hanisch and Sunwon Park, "Petri Net Representation and Simulation of Signal Transduction Network", Proc. '02 KIChE Fall meeting, Vol. 8, pp. 2857-2860, 2002.
Dong-Yup Lee, Su Whan Sung, Sang Yup Lee and Sunwon Park, "Development of Pharmacokinetic/Pharmacodynamic Models Considering Physiological Delays and Uncertainties", AIChE Annual Meeting, Indianapolis, USA, November 3 - 8, 2002.
Dong-Yup Lee, Sung Ho Yoon, Hongseok Yun, Sunwon Park and Sang Yup Lee, "Graph-Theoretical Identification of Multiple Flux Distiributions in Metabolic Flux Analysis", Korean Society for Bioinformatics annual meeting, Pusan, 2002.
Dong-Yup Lee, Young-gyun Oh, Hongseok Yun, Sang Yup Lee and Sunwon Park, "Exploring Flux Distribution Profiles for Switching Pathways Using Multiobjective Flux Balance Analysis", 13th International Conference on Genome Informatics (GIW 2002), Tokyo, Japan, December 16 - 18, 2002.
Dong-Yup Lee, Sungdeuk Moon, Paulo-Miguel Lopes and Sunwon Park, "Environmentally Friendly Scheduling of Primary Steelmaking Processes", Proc. Foundations of Computer-Aided Process Operations (FOCAPO 2003), pp. 355-358, Coral Springs, Florida, USA, January 12 - 15, 2003. [PDF-Full text][presentation]
Young-gyun Oh, Hongseok Yun, Dong-Yup Lee, Sang Yup Lee and Sunwon Park, "Development of the Flux Balance Analysis Software Using Multiobjective linear programming", KIChE Spring meeting, Soonchun, 2003.
Hongseok Yun, Dong-Yup Lee, Sang Yup Lee and Sunwon Park, "Development of a Software for Metabolic Flux Analysis (MFA)", KIChE Spring meeting, Soonchun, 2003.
Sang Yup Lee, Dong-Yup Lee, Hongseok Yun and Sunwon Park, "MetaFluxNet: an Integrated Program for the Management of Metabolic Reaction Information and Quntitative Metabolic Flux Analysis", First International E.coli Alliance (IECA) Conference on Systems Biology of E.coli, Tsuruoka, Japan, June 23 - 25, 2003.
Dong-Yup Lee, Hongseok Yun, Sang Yup Lee and Sunwon Park, "Comparative Metabolic Flux Analysis by MetaFluxNet", 11th International Conference on Intelligent Systems for Molecular Biology (ISMB 2003), Brisbane, Australia, June 29 - July 3, 2003.
Young-gyun Oh, Dong-Yup Lee, Hongseok Yun, Sang Yup Lee and Sunwon Park, "Supporting SBML for representation and exchange of biochemical network models in MetaFluxNet", KIChE Fall meeting, Seoul, 2003.
Soon Ho Hong, Dong-Yup Lee, Tae Yong Kim, Sang Yup Lee and Sunwon Park, "Effect of carbon substrate on the intracellular fluxes in succinic acid producing Escherichia coli", 2nd Annual Conference of the Korean Society for Bioinformatics (KSBI 2003), KAIST, Daejeon, October 31 - November 1, 2003.
Dong-Yup Lee, Soon Ho Hong, Tae Yong Kim, Sang Yup Lee and Sunwon Park, "An Integrated Environment for Reconstruction and Analysis of Large-scale Metabolic Pathways", 2nd Annual Conference of the Korean Society for Bioinformatics (KSBI 2003), KAIST, Daejeon, October 31 - November 1, 2003.
Young-Gyun Oh, Dong-Yup Lee, Sang Yup Lee and Sunwon Park, "Communication Between MetaFluxNet and Other Systems Biology Tools", 2nd Annual Conference of the Korean Society for Bioinformatics (KSBI 2003), KAIST, Daejeon, October 31 - November 1, 2003.
Choamun Yun, Jinkuk Kim, Young-Gyun Oh, Dong-Yup Lee, Sunwon Park and Sang Yup Lee, "WebCell: a Web-based Dynamic Simulation Environment for Cellular Network Systems", 2nd Annual Conference of the Korean Society for Bioinformatics (KSBI 2003), KAIST, Daejeon, October 31 - November 1, 2003.
Dong-Yup Lee, L. T. Fan, Sunwon Park, Sang Yup Lee, Shahram Shafie, Botond Bertók and Ferenc Friedler, "Synergistic Identification of Multiple Flux Distributions and Multiple Metabolic Pathways", AIChE Annual Meeting, San Francisco, USA, November 16 - 21, 2003.
Sang Yup Lee, Dong-Yup Lee, Soon Ho Hong, Tae Yong Kim, Hongseok Yun, Young-Gyun Oh and Sunwon Park, "MetaFluxNet, a Program Package for Metabolic Pathway Construction and Analysis, and Its Use in Large-scale Metabolic Flux Analysis of Escherichia coli", 14th International Conference on Genome Informatics (GIW 2003), Yokohama, Japan, December 14 - 17, 2003.
Projects
Project Manager, Korean National LCI Database Construction (National Infra-Industry/Basic Materials), KAIST, Ministry of Environment, 1999-2001.
Development of Platform Technology for In Silico Physiomics: Development of Biotechnology Processes Based on Metabolic Network Modeling and Biological Reaction Simulation System, KAIST, Supported by IMT-2000 Project from the Ministry of Science & Technology and Ministry of Information & Communication, 2002-2004.
Mee-Jung Han
Dongyang Univ., Professor '04. 2.
Phone :+82-42-869-3960
Fax :+82-42-869-3910
Details
Research Interest
Functional Genomics
Proteomics
Systems biology/biotechnology
Metabolic and cellular engineering
Education
B.S., Dept. of Biological Science, Youngnam Univ., Daegu, Korea (1994. 3. 1.-1998. 2. 28)
M.S., Dept. of Chemical Engineering, Youngnam Univ., Daegu, Korea (1998. 3. 1.-2000. 2. 29)
M. S. Thesis: Viability improvement of animal cells by genetic manipulation (Advisor: Prof. Moo Hwan Cho)
Ph.D., Dept. of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea (2000.3.1-2004.2.29)
Ph.D. Thesis: Proteome profiling and its application in developing recombinant Escherichia coli strains (Advisor: Prof. Sang Yup Lee)
Post-doc., Dept. of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea (2004.3-2004.7)
Post-doc., Systems Biology Division, Proteomics Laboratory, The Wistar Institute, University of Pennsylvania, Philadelphia, PA, USA (2004.8-2006.6)
Honor/Awards
A 96' National Transport Phenomena Meeting Awards (1996)
Yeungnam University Scholarship from 1994 to 1998
Election "an outstanding graduate of the KAIST"2004)
Applied Biosystems Young Scientist Award (2004) in KHUPO 4th Annual International Proteomics Conference
Publications
4-1. Research Articles (Published in Peer-reviewed Journals)
1. Han, M.-J., Yoon, S.S., and Lee, S.Y. "Proteome analysis of metabolically engineered Escherichia coli cells producing poly(3-hydroxybutyrate)" J. Bacteriol. 183(1):301-308 (2001).
2. Yoon, S.H., Han, M.-J., Jeong, K.J., Yoo, J.-S., and Lee, S.Y. "Combined transcriptome and proteome analysis of Escherichia coli during the high cell density culture" Biotechnol. Bioeng. 81(7):753-767 (2003). (Accelerated publication article)
3. Han, M.-J., Jeong, K.J., Yoo, J.-S, and Lee. S.Y. "Engineering Escherichia coli for increased production of serine-rich proteins based on proteome profiling" Appl. Environ. Microbiol. 69(10): 5772-5781 (2003).
4. Han, M.-J., and Lee, S.Y. "Proteome profiling and its use in metabolic and cellular engineering" Proteomics 3:2317-2324 (2003).
5. Han, M.-J., Park, S.J., Park, T.J., and Lee, S.Y. "Roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli" Biotechnol. Bioeng. 88(4): 426-436 (2004). (Cover article)
6. Lee, S.H., Choi, J.-I., Han, M.-J., Choi, J.H., and Lee, S.Y. "Display of lipase on the cell surface of Escherichia coli using OprF as an anchor and its applications to enantioselective resolution in organic solvent" Biotechnol. Bioeng. 90(2):223-230 (2005).
7. Park, S.J., Lee, S.Y., Cho, J., Kim, T.Y., Lee, J.W., Park, J.H., and Han, M.-J. "Global physiological understanding and metabolic engineering of microorganisms based on omics studies" Appl. Microbiol. Biotechnol. 23:1-13 (2005).
8. Han, M.-J., Lee, J.W., and Lee, S.Y. "Enhanced Proteome Profiling by Inhibiting Proteolysis with Small Heat Shock Proteins" J. Proteome Res. 4:2429-2434 (2005).
9. Han, M.-J., Park, S.J., Lee, J.W., Min, B.H., Lee, S.Y., Kim, S.-J., and Yoo, J.-S. "Analysis of poly(3-hydroxybutyrate) granule-associated proteome in recombinant Escherichia coli" J. Microbiol. Biotechnol. 16:901-910 (2006).
10. Han, M.-J., and Lee, S.Y. "The Escherichia coli Proteome: Past, Present, and Future Prospects" Microbiol. Mol. Biol. Rev. 70: 362-439 (2006).
11. Lee, Y.T., Han, M.-J., Lim, S.H., Park, S.H., Suh, H.S., Park, J.B., Kim, Y.I., and Lee, J.W. "Effect of Antibiotics on the Survival of Human Hepatocellular Carcinoma Cells under Hypoxic Conditions" J Korean surgical society 071(01): 31-38 (2006).
12. Han, M.-J., Herlyn, M., Fisher, A.B., and Speicher, D.W. "Microscale solution IEF combined with 2-D DIGE substantially enhances analysis depth of complex proteomes such as mammalian cell and tissue extracts", Electrophoresis, 29(3):695-705 (2008).
13. Han, M.-J., Lee, J.W., Lee, S.Y. and Yoo, J.-S. "Proteome-level responses of Escherichia coli to long-chain fatty acids and use of fatty acid inducible promoter in protein production", J. Biomedicine Biotechnol. 2008:1-12 (2008).
14. Xia, X.-X., Han, M.-J., Lee, J.W., Lee, S.Y. and Yoo, J.-S. "Comparison of the extracellular proteomes of Escherichia coli B and K-12 strains during high cell density cultivation", Proteomics 8:2089-2103 (2008).
15. Han, M.-J., Yun H., and Lee, S.Y. “Microbial small heat shock proteins and their use in biotechnology”, Biotechnol. Adv. in press (2008).
4-2. Books
1. Lee, J.W, Han, M.-J., and Lee, S.Y., "Chapter 4. Improved 2-Dimensional Electrophoresis by Inhibiting Proteolysis with Small Heat Shock Proteins" Methods in Proteomics, The Korean Human Proteome Organization (KHUPO), 71-79 (2007)
2. Han, M.-J., and. Speicher D.W. "Microscale Isoelectric Focusing in Solution: A Method for More Comprehensive and Quantitative Proteome Analysis Using 1-D and 2-D DIGE Combined with MicroSol IEF Prefractionation", in Methods Molecular Biology: 2D PAGE: Sample Preparation and Fractionation (Posch, A., ed.), Humana, Totowa, NJ, 424:241-256 (2008)
3. Han, M.-J. and Lee, S. Y., "Chapter 6.5, The Escherichia coli Proteome: Past, Present, and Future Prospects", In A. Böck, R. Curtiss III, J. B. Kaper, F. C. Neidhardt, T. Nyström, J. M. Slauch, and C. L. Squires (ed.), EcoSal—Escherichia coli and Salmonella: cellular and molecular biology. http://www.ecosal.org. ASM Press, Washington, D.C. (18 October 2007, posting date)
4. Jang, S.H., Han, M.-J., Lee, S.Y., Choi, J.H., Xia, X.-X. “Genome-wide technologies: DNA microarrays, phenotypic microarrays, and proteomics” in Metabolic Pathway Engineering Handbook, in press
4-3. Proceedings
1. Han, M.-J., You, J.S., and Lee, S.Y. "Variation of proteome expression during the high cell density cultivation of Escherichia coli" Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 483-486 (2001).
2. Yoon, S.H., Han, M.-J., Lim, K.B., and Lee, S.Y. "Combined analysis of transcriptome and proteome for high cell density cultivation of Escherichia coli" Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 845-848 (2001).
3. Han, M.-J., Choi, J.H., Jeong, K.J., Yoo, J.-S., and Lee, S.Y. "Proteome Analysis of Overproduction of Recombinant Protein in Escherichia coli by Fed-Batch Fermentations" Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 750-753 (2001).
4. Han, M.-J., Choi, J.H., Jeong, K.J., Yoo, J.-S., and Lee, S.Y. "Proteome Analysis of Overproduction of Human Leptin in Escherichia coli by Fed-Batch Fermentations" Theories and Applications of Chemical Engineering 7(2): 4075-4078 (2001).
5. Lee, J.W., Han, M.-J., and Lee, S.Y. "Proteomic analysis of oleic acid stimulon in Escherichia coli and its application" Proceedings of the 17th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering 21 (2004).
6. Han, M.-J., Lee, J.W., Lee, S.Y., and Yoo, J.-S. "Proteomic Signature of a Response to Long-Chain Fatty Acid in Escherichia coli and Its Application in Biotechnology" Frontiers in the Convergence of Bioscience and Information Technologies 2007, Ramada Plaza Jeju, Jeju-do, Oct 11-13 (2007).
4-4. Patents
- 8 Applications of International Patent
- 6 Applications of Domestic Patent
Presentations
5-1. Proceedings
1. Lee, S.Y., Yoon, S. H., Han, M.-J., and Jeong, K.J. "Combined analysis of transcriptome and proteome profiles during the high cell density cultivation of Escherichia coli" Biochemical Engineering XII, Sonoma, California, USA, June (2001).
2. Han, M.-J., Yoon, S. H., and Lee, S.Y. "Transcriptome profile analysis of Escherichia coli during high cell density cultivation using DNA microarray" Biochemical Engineering XII, Sonoma, California, USA, June (2001).
3. Lee, S.Y., Yoon, S.H., Han, M.-J., Yoo, J.-S., and Lim, G. "Transcriptome and proteome analysis of Escherichia coli during high cell density cultivation" The 9th International Symposium on Intelligent Systems for Molecular Biology, Copenhagen, Denmark, July (2001).
4. Lee, S.Y. and Han, M.-J. "Analysis of serum proteome profiles in leukemia patients" Inaugural Symposium of AOHUOP & 2nd Annual Meeting of KHUPO, Seoul, Korea, March 26-27 (2002).
5. Han, M.-J., Jeong, K.J., Yoo, J. -S., and Lee, S.Y. "Improvement of Recombinant Protein Productivity through Proteome Analysis" ChungNam-Kyushu International Symposium, Kumamoto, Japan, December, 6 (2002).
6. Lee, S.Y., and Han, M. -J. "Proteome Profiling and Its use in Metabolic and Cellular Engineering" KHUPO, Seoul National University, Seoul, Korea, March 27-28(2003).
7. Han, M.-J., Jeong, K.J., and Lee, S.Y. "Improvement of recombinant protein productivity through proteome analysis" Biochemical Engineering (XIII) 2003, Boulder, Colorado, USA, July 17-23 (2003)
8. Choi, J.H., Han, M.-J., Jeong, K.J., and Lee, S.Y. "Using proteomics to engineer improved cell growth and increased production of heterologous proteins in Escherichia coli" APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, Nov 30 - Dec 4 (2003).
9. Han, M.-J., Park, S.J., Lee, J.W., Yoo, J.-S., and Lee, S.Y. "Analyses of poly(3-hydroxybutyrate) granule-associated proteins in recombinant Escherichia coli" KHUPO 4th Annual International Proteomics Conference, March, 25-26 (2004).
10. Han, M.-J., Park, S.J., Park, T.J., Lee, J.W., and Lee, S.Y. "Essential roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli" KHUPO 4th Annual International Proteomics Conference, March, 25-26 (2004).-Poster award
11. Han, M.-J., Park, S.J. Park, T.J. Lee, D.Y. and Lee, S.Y. "Importance of small heat shock proteins in engineering recombinant protein production as revealed by proteome profiling" The 12th International Conference on Intelligent Systems for Molecular Biology (ISMB 2004), Glasgow, UK, July 31-August 4 (2004).
12. Lee, S.Y., Han, H.-J., Park, S.J., and Park, T.J. "Essential roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli" Metabolic Engineering V: Genome to Product, Lake Tohoe, California, USA, Sept. 19-23 (2004).
13. Park, J.P., Han, M.-J., Park, T.J., Lee, S.J., and Lee, S.Y. "Metabolic engineering of Escherichia coli for the production of polyamide" Metabolic Engineering V: Genome to Product, Lake Tohoe, California, USA, Sept. 19-23 (2004).
14. Lee, S.Y., Han, M.-J., Park, S.J, and Lee, J.W. "Roles and applications of small heat shock proteins for the production of recombinant proteins in Escherichia coli" 3rd Recombinant Protein Production Meeting, Tavira, Portugal, Nov 11-14 (2004).
15. Lee, J.W., Han, M.-J., Yoo, J.-S., and Lee, S.Y. "Proteomic analysis of Escherichia coli cultured in oleic acid and its application" KHUPO 5th International Proteomics Conference AOHUPO Workshop/Symposium, April 27-29 (2005).- Poster award
16. Han, M.-J., Park, S.J., Lee, J.W., Yoo, J.-S., and Lee, S.Y. "Analysis of poly(3-Hydroxybutyrate) granule-associated proteome in recombinant Escherichia coli" KHUPO 5th International Proteomics Conference AOHUPO Workshop/Symposium, April 27-29 (2005).
17. Speicher, D.W., Tang, H.-Y., Han M.-J., Wang, H., Ali-Khan, N., Echan, L.A., Tan, G., Musselman, I., and Joo, W.A. "The Multi-dimensional Approach to Cellular and Plasma Proteomics and Its Application to Human Cancers" The Association of Biomolecular Resource Facilities (ABRF) meeting, Long Beach, California, USA, Feb. 11-14 (2006).
18. Lee, J.W., Han, M-.J., and Lee, S.Y., "Improved proteome profiling method by inhibiting proteolysis with small heat shock proteins" The 3rd International E. coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3).
19. Lee, J.W., Han, M.-J., Yoo, J.-S., and Lee, S.Y. "Mining Low Abundance Proteins by Inhibiting Proteolysis with Small Heat Shock Proteins" KHUPO 7th International Proteomics Conference Workshop, March 29-30 (2007).
20. Han, M.-J., Lee, J.W., Yoo, J.-S., and Lee, S.Y. "Enhanced proteome profiling by inhibiting proteolysis with small heat shock proteins in two-dimensional gel electrophoresis" HUPO 6th Annual World Congress 2007, Coex, Seoul, Korea, Oct. 6-10 (2007).
21. Han, M.-J., Lee, J.W., Yoo, J.-S., and Lee, S.Y. "Proteomic signature of a response to long-chain fatty acid in Escherichia coli and its application in biotechnology" HUPO 6th Annual World Congress 2007, Coex, Seoul, Korea, Oct. 6-10 (2007).
22. Xia, X.-X., Han, M.-J., Lee, S.Y., and Yoo, J.-S. "Proteomic analysis of selectively released proteins from Escherichia coli B and K-12 strains grown in high cell density cultivation" HUPO 6th Annual World Congress 2007, Coex, Seoul, Korea, Oct. 6-10 (2007).
23. Han, M.-J., Echan, L.A., Fisher, A.B., and Speicher, D.W. "A method for comprehensive and quantitative proteome analysis using microscale solution IEF combined with 2-D DIGE" HUPO 6th Annual World Congress 2007, Coex, Seoul, Korea, Oct. 6-10 (2007).
24. Han, M.-J., Echan, L.A., Tang, H.-Y., Herlyn, M., and Speicher, D.W. "Identification of proteins and their pathways associated with increased metastatic potential of human melanoma cells using in depth three-dimensional protein profiling" HUPO 6th Annual World Congress 2007, Coex, Seoul, Korea, Oct. 6-10 (2007).
25. Han, M.-J., Lee, J.W., Lee, S.Y., and Yoo, J.-S. "Proteomic Signature of a Response to Long-Chain Fatty Acid in Escherichia coli and Its Application in Biotechnology" Frontiers in the Convergence of Bioscience and Information Technologies 2007, Ramada Plaza Jeju, Jeju-do, Oct 11-13 (2007).
5-2. Korean Conferences
1. Han, M.-J., Cho, M.H., and Lee, J.W. "Antibiotics geneticin (G418) makes a hepatocellular cell line, HepG2, more resistant to hypoxia by efficient utilization of glucose" The Korean Society for Molecular Biology (1999).
2. Han, M.-J., Cho, M.H., and Lee, J.W., "Improvement of metabolism under hypoxia by antibiotics geneticin (G418)" The Korean Society for Microbiology (1999).
3. Han, M.-J., Yoon, S.S., and Lee, S.Y. "Proteome analysis of metabolically engineered Escherichia coli producing poly(3-hydroxybutyrate)" Annual Meeting of The Korean Society for Applied Microbiology, Cheon-buk Univ., October (2000).
4. Han, M.-J., You, J.S., and Lee, S.Y. "Variation of proteome expression during the high cell density cultivation of Escherichia coli" Annual meeting of Korean society for Biotechnology and Bioengineering, Konkuk Univ., Seoul, April (2001).
5. Yoon, S.H., Han, M.-J., Jeong, K.J., Yoo, J.-S., Lim, B.K., and Lee, S.Y. "Transcriptome and proteome analysis of Escherichia coli during high cell density cultivation" Annual Meeting of Korean Society for Applied Microbiology, Chonan Sangnok Resort, June (2001).
6. Han, M.-J., Choi, J.H., Jeong, K.J., Yoo, J.-S., and Lee, S.Y. "Proteome Analysis of Overproducing Human Leptin System" The 14th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Chungnam Univ., Daejeon (2001).
7. Yoon, S.H., Han, M.-J., Lim, K.B., and Lee, S.Y. "Combined analysis of transcriptome and proteome for high cell density cultivation of Escherichia coli" Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, November (2001).
8. Han, M.-J., Choi, J.H., Jeong, K.J., Yoo, J.-S., and Lee, S.Y. "Proteome Analysis of Overproduction of Recombinant Protein in Escherichia coli by Fed-Batch Fermentations" Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, November (2001).
9. Han, M.-J., Choi, J.H., Jeong, K.J., Yoo, J.-S., and Lee, S.Y. "Proteome Analysis of Overproduction of Human Leptin in Escherichia coli by Fed-Batch Fermentations" KIChE Meeting, Daejeon (2001).
10. Lee, S.Y., Han, M.-J., and Yoon, S.S. "Proteome Analysis of Metabolically Engineered Escherichia coli Producing Poly (3-Hydroxybutyrate)" Korean Society of Medical Biochemistry and Molecular Biology, Seoul (2001).
11. Han, M .-J., Jeong, K. J., Yoo, J.-S., and Lee S Y. "Improvement of Recombinant Protein Productivity through Proteome Analysis" Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Chungju, October 12 (2002).
12. Han, M.-J., Jeong, K.J., Yoo, J.-S., and Lee, S.Y. "Proteome analysis of recombinant Escherichia coli producing heterologous proteins" Korean Society for Bioinformatics Annual Meeting (KSBI 2002), Haeundae, Korea, November 15-16 (2002).
13. Han, M.-J., Lee, S.Y., Hong, S. H., and Park, S.J. "Role of Eda in polyhydroxyalkanoate biosynthesis deciphered from proteome analysis and metabolic flux analysis" Korean Society for Bioinformatics Annual Meeting (KSBI 2002), Haeundae, Busan, November, 15-16 (2002).
14. Han, M.-J., Jeong, K.J., Yoo, J.-S. and Lee,S.Y. "Rational design for improving cell growth and protein production of a recombinant Escherichia coli strain using a proteomic approach" Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Busan, April 11-12 (2003).
15. Han, M.-J., Jeong, K.J., Yoo, J.-S., and Lee, S.Y. "Using Proteomics to Engineer Improved Cell Growth and Increased Production of Serine-Rich Heterologous Proteins in Escherichia coli." Annual meeting of Korean Society for Microbiology and Biotechnology Symposium (KMB 2003), Muju, June 24-26 (2003).
16. Han, M.-J., Jeong, K.J., Yoo, J.-S., and Lee, S.Y. "Engineering Escherichia coli for Increased Productivity of Serine-Rich Proteins Based on Proteome Profiling" Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, October 22-24 (2003).
17. Bang, H.O., Han, M.-J., Park, S.J., and Lee, S.Y. "Roles of the Escherichia coli small heat shock proteins IbpA and IbpB in recombinant proteins productionin recombinant proteins production" Annual fall meeting of KIChE, Seoul, October 24-25 (2003).
18. Han, M.-J., and Lee, S.Y. "A Proteomic Approach for Engineer Improved Cell Growth and Increased Productivity of Serine-Rich Protein" KSBI 2003, KAIST, Daejeon, October 31-November 1 (2003).
19. Han, M.-J., Park, S.J., Park, T.J., and Lee, S.Y. "Essential roles and applications of the Escherichia coli small heat shock proteins IbpA and IbpB in the production of recombinant proteins" Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, April 16-17 (2004).
20. Han, M.-J. "Microbial proteomics: Enhanced recombinant protein production by E. coli engineered based on proteome profiling" 2004 International Meeting of the Microbiological Society of Korea, Sangnok Resort Convention Center, Cheonan, May 13-14 (2004).
21. Han, M.-J., Park, S.J., Lee, J.W., Yoo, J.-S., and Lee, S.Y. "Proteome Analysis of Poly(3-Hydroxybutyrate) Granule-Associated Proteins in Recombinant Escherichia coli" Annual Meeting of Korean Society for Microbiology and Biotechnology Symposium, Deagu, June 21-23 (2004).
22. Han, M.-J., Park, S.J., Lee, J.W., Park, T.J., and Lee, S.Y. "Functions of small Heat Shock Proteins in the Production of Recombinant Proteins in Escherichia coli and its Applications" Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Cheongju, October 13-15 (2004).
23. Lee, J.W., Han, M.-J., and Lee, S.Y. "Proteomic analysis of oleic acid stimulon in Escherichia coli and its application" The 17th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, December 4-5 (2004).
24. Han, M.-J., Park, S.J., Lee, J.W. and Lee, S.Y. "Use of small heat shock proteins in the production of recombinant proteins in Escherichia coli and its applications" Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, April 15-16 (2005).
25. Lee, J.W., Han, M.-J., Yoo, J.-S., and Lee, S.Y. "Proteomic analysis of Escherichia coli cultured in oleic acid and its application" Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, April 15-16 (2005).
26. Lee, J.W., Han, M-.J., Yoo, J.-S. and Lee, S.Y. "Proteomic signature of a response to long chain fatty acid in Escherichia coli and its application" The 62th Korean Society for Biochemistry and Molecular Biology (KSBMB) annual meeting, Seoul, May 19-20 (2005).
27. Lee, J.W., Han, M.-J., Yoo, J.-S., and Lee, S.Y. "Proteomic Signature of a Response to Long Chain Fatty Acid in Escherichia coli and Its Application" Annual Meeting & International Symposium of the Korea Society for Microbiology and Biotechnology (KMB), June 30 - July 1 (2005).
28. Han, M.-J., and Lee, S.Y., "Metabolic Engineering for Strain Improvement Based on Proteome Profiling" 2006 Annual Fall Meeting of Korean Society for Biotechnology and Bioengineering Symposium, September 7-8 (2006)
29. Lee, J.W., Han, M-.J., and Lee, S.Y., "Improved Proteome Profiling Method Using Small Heat Shock Proteins by Inhibiting Proteolysis" 2006 International Meeting of the Federation of Korean Microbiological Societies, October 19-20 (2006)
30. Han, M.-J., Lee, J.W., and Lee, S.Y., "General improvement of proteome profiling by inhibiting proteolysis with small heat shock proteins" Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, April 27 (2007)
31. Han, M.-J., Lee, J.W., Lee, S.Y., Yoo, J.S., "Proteomic response to a long-chain fatty acid in Escherichia coli and its application in the production of recombinant proteins" The Korean Society for Microbiology and Biotechnology, COEX Grand Ballroom, Seoul, June 28-29 (2007)
5-3. Invited Talk
1. Han, M.-J. "The Escherichia coli Proteome: Past, Present, and Future Prospects" Symposium on Pathogen & Proteome, Korea Centers for Disease Control and Prevention, National Institute of Health, July 28 (2006).
2. Han, M.-J. "Systems-level analysis for the metabolic engineering of microorganism by proteome analysis"Korean Society for Mass Spectrometry, Phoenix Park, Gangwon-do, Aug 23-25 (2006).
3. Han, M.-J. "Metabolic Engineering for Strain Improvement Based on Proteome Profiling"The Korean Society for Biotechnology and Bioengineering, COEX, Seoul, Sept 7-8 (2006).
4. Han, M.-J. "프로테오믹스 (Proteomics)의 이해와 생명과학 연구에서의 활용" University of Yeungnam University, School of Display & Chemical Engineering, an autumn seminar 2006, Sept 15 (2006).
5. Han, M.-J. "The Multi-dimensional Approach to Cellular and Plasma Proteomics and Its Application to Human Cancers"Kyungpook National University, School of Medicine, BK21 Program Seminar, Sept 19 (2006).
6. Han, M.-J. "The Escherichia coli Proteome: Past, Present, and Future Prospects" Department of Biotechnology, Daegu University, Nov 16 (2006).
Seung Hwan Lee
Ph.D. '04. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-869-5970
Fax :+82-42-869-8800
Details
Research Interest
Biocatalysts
Kinetic resolution
Enantiomerically pure compound
Education
1998 (B.S.) Dept. of Biological Science, KAIST, Taejon, Korea
2000 (M.S.) Dept. of Biological Science, KAIST, Taejon, Korea
2004. 8(Ph. D) Department of Chemical Engineering, KAIST, Taejon, Korea
Sissertation title
M.S. Thesis : Development of fed-batch culture for the production of Medium-chain-length Polyhydroxyalkanoate by Pseudomonas (Advisor: Professor Sang Yup Lee)
Ph.D. Thesis : Synthesis of enantiomerically pure compounds by biocatalysis (Advisor: Professor Sang Yup Lee)
Publications
International Journals
1. Lee, S.H., Oh, D.H., Ahn, W.S., Lee, Y., Choi, J., and Lee, S.Y. , “Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas hydrophila”, Biotechnol. Bioeng. 67:240-244(2000)
2. Lee, S.Y. , Choi, J., and Lee, S.H. “Production of polyhydroxyalkanoates by fermentation of bacteria”Macromol. Symp. 159:259-266(2000)
3. Lee, S.Y. , Wong, H.H., Choi, J., Lee, S.H., Lee, S.C., and Han, C.S., “Production of medium-chain-length polyhydroxyalkanoates by high cell density cultivation of Peudomonas putida under phosphorus limitation”, Biotechnol. Bioeng., 68:466-470(2000)
4. Park, S.H., Lee, S.H., and Lee, S.Y., "Preparation of optically active beta-amino acids from microbial polyester polyhydroxyalkanoates", J. Chem. Reseach (S), 498-499(2001)
5. Lee, S.Y., Hong, S.H., Lee, S.H., Park, S.J. "Fermentative Production of Chemicals That Can Be Used for Polymer Synthesis", Macromolecular Bioscience, 4 : 157-164 (2004).
6. Lee, S. H., Choi, J., Park, S. J., Lee, S.Y., Park, B. C. " Display of bacterial lipase on the Escherichia coli cell surface by using FadL as an anchoring motif and its use in enantioselective biocatalysis", Appl. Environ. Microbiol. 70(9) : 5074-5080 (2004).
7. Lee, S. H., Choi, J.H., Park, S.H., Choi, J.-I., and Lee, S.Y., "Enantioselective resolution of racemic compounds by cell surface displayed lipase", Enzyme Microbial Technol., 35 : 429-436 (2004).
8. Lee, S.H., Choi, J.-I., Han, M.-J., Choi, J.H., and Lee, S.Y. "Display of lipase on the cell surface of Escherichia coli using OprF as an anchor and its applications to enantioselective resolution in organic solvent", Biotechnol. Bioeng. in press(2004).
Korean Journals
1. Lee, Y., Lee, S.H., Lee, S.Y. “Fed-batch culture of Aeromonass hydrophila for the production of poly(3-hydroxybutyrate-co-hydroxyhexanoate) using two carbon sources”, Biotechnol.Bioproc. Eng. 4:195-198(1999)
2. Choi, J.-I., Lee, S.H., and Lee, S.Y., "Isolation and characteristics of polyhydroxyalkanoates producing Pseudomonas sp. MBEL21", Kor. J. Microbiol. Biotechnol. 32(2) : 123-127 (2004).
Korean Proceedings
1. Lee, S.H., Choi, J, and Lee, S.Y. “Economical recovery of poly(3-hydroxybutyrate)from recombinant Escherichia coli by simple digestion” Proceedings of The 12th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 331-332 (1999)
2. Lee, S.H., and Lee, S.Y. “Production of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas Hydrophila” Proceedings of The 12th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 325-326 (1999)
3. Lee, S.H., and Lee, S.Y. “Production of medium-chain-length polyhydroxyalkanoates by the fed-batch culture of Pseudomonas putida” Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 329-330 (1999) Kangwon University.
4. Lee, S.H., Park, S.J., Lee, S.Y., and Park, S.H. “ Production of Medium-chain-length Polyhydroxyalkanoate from Newly Screened Pseudomonas sp. MBEL21”, Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 153-156 (2001, Apr.)
5. Choi, J.H., Lee, S.H., Park, S.H. and Lee, S.Y. “Chiral Resolution by Lipase on the Eshcherichia coli Cell Surface”, Theories and Applications of Chemical Engineering 7(2): 4027-4030 (2001).
International Conferences
1. Lee, S.Y., Lee, Y., Park, S., Lee, S.H., “Production of (R)-hydroxycarboxylic acids by bacteria”, ISBP/BEDPS 2000, Honolulu, Hawaii, December (2000)
2. Park, S.H., Lee, S.H., Lee, Y., Lee, S.Y., “Preparation of optically active β-amino acids from microbial polymer”, 221st National meeting of American Chemical Society”, San Diego,CA, USA, April (2001)
3. Lee, S. H., Choi, J.H., and Lee, S.Y., "Resolution of racemic compounds by genetically immobilized lipase", Metabolic Engineering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11(2002)
4. Lee, S. H., Park, J.P., Park, S.J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates", Metabolic Engineering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11(2002)
5. Choi, J.H., Lee, S.H., and Lee, S.Y., "Display of polyhistidine and lipase on the surface of Escherichia coli by using the salmonella ompC as an anchoring motif and its application to chemoenzymatic synthesis", Biochemical Engineering (XIII) 2003, Boulder, Colorado, USA July 17-23 (2003)
6. Lee, S.H., Choi, J.H., and Lee, S.Y., "Dynamic kinetic resolution using cell surface displayed biocatalysts", Biochemical Engineering (XIII) 2003, Boulder, Colorado, USA July 17-23 (2003)
7. Choi, J.H., Lee, S.H., and Lee, S.Y., "Production of chiral compounds by cell surface displayed lipase", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov - 4 December (2003)
Korean Conferences
1. Lee, S.H., and Lee, S.Y. “Production of medium-chain-length polyhydroxyalkanoates by the fed-batch culture of Pseudomonas putida” Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 329-330 (1999) Kangwon University.
2. Lee, S.H. and Lee, S.Y., "Production of Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas Hydrophila", The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Kongju Univ., Kongju (1999)
3. Lee, S.H., Choi, J., and Lee, S.Y., "Economical recovery of poly (3-hydroxybutyrate) from recombinant Escherichia coli by simple digestion", The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Kongju Univ., Kongju (1999)
4. Lee, S.H., Park, S.J., Lee, S.Y., Park, S.H. “ Production of Medium-chain-length Polyhydroxyalkanoate from Newly Screened Pseudomonas sp. MBEL21”, Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 153-156 (2001, Apr.)
5. Choi, J.H., Lee, S.H., Park, S.H. and Lee, S.Y. “Chiral Resolution by Lipase on the Eshcherichia coli Cell Surface”, Theories and Applications of Chemical Engineering 7(2): 4027-4030 (2001).
6. Lee, S.H., Choi, J.H., and Lee, S.Y., "Production of chiral compounds by cell surface displayed lipase", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Busan, Korea, April 11-12(2003)
7. Lee, S.H., Choi, J.H., and Lee, S.Y., "Kinetic resolution of beta-lactams by cell surface displayed Lipase", Annual Spring Meeting of KIChE, Soonchun, April 25-26(2003)
8. Lee, S.H., and Lee, S.Y., "Dynamic kinetic resolution of styrene oxide by metabolically engineered Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October 22-24(2003)
9. Lee, S.H., and Lee, S.Y., "Kinetic resolution of epoxides by metabolically engineered Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October 22-24(2003)
10. Lee, S.H. and Lee, S.Y., "Cell surface display of lipase using Escherichia coli FadL as an anchoring motif", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
Book chapter
1. Lee, S. Y., Choi, J., Lee, S. H., “Production of polyhydroxyalkanoates by fermentation of bacteria”, pp. 259-266 In: Polymer Science and Industrial Research in the Fast-changing Age (Kajiyama, T. ed) Wiley-VCH, Germany (2000)
2. Lee S.Y., Park S.H., Lee Y., Lee S.H., "Production of chiral and other valuable compounds from microbial polyesters", Biopolymers Vol 4, Ch.14.pp.375-388, VCH-Wiley, Weinheim, Germany (2001)
3. Lee, S.Y., Park, S.H., Hong, S.H., Lee, Y., Lee, S.H., "Fermentative Production of Building Blocks for Chemical Synthesis of Polyesters", Biopolymers Vol 3b, Ch 10, pp.265-326, VCH-Wiley, Weinheim, Germany (2001)
4. Lee, S.Y., Park, S.J., Park, J.P., Lee, Y., Lee, S.H., "Economic aspects of biopolymer production", Biopolymers Vol.10,Ch.10, pp.307-337, VCH-Wiley, Weinheim Germany (2003)
5. Lee, S.Y., Park, S.J., Lee, Y., Lee, S.H., "Biotechnological process for production of monomers for subsequent chemical polymer synthesis", Biopolymers Vol.10,Ch.9, pp.281-305, VCH-Wiley, Weinheim, Germany (2003)
Jong Pil Park
Ph.D. '04. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-869-5970
Fax :+82-42-869-8800
Details
Research Interest
NANOBIOTECHNOLOGY
Cell, Protein Patterning and Surface Modification
Protein Electrochemistry
Biosensor/Biochip
Functionalization of Carbon Nanotube
Synthesis of Nanoparticle/Nanowire/Nanocarrier
Biofuel Cell
BIOCATALYSIS AND BIOTRANSFORMATION
PROTEIN CHEMISTRY AND ENGINEERING
TISSUE ENGINEERING
Education
1991.3~1998.3 Department of Biotechnology, Daegu University (BS), B.S. in Biotechnology, February 1998, Advisor: Professor Jong Won Yun
1998.3~ 2000.2 MS in Department of Biotechnology, Daegu University (MS), M.S. in Biotechnology, Advisor: Professor Jong Won Yun, Thesis: Production of fructooligosaccharides (FOS) from a novel transfructosylating enzyme from Bacillus sp.
2001.9 ~2004.8 Department of Chemical Engineering, KAIST, Ph. D course, Ph.D. in Chemical & Biomolecular Engineering, Advisor: Professor Sang Yup Lee, Thesis: Development of nanobiosensors for biotechnological and environmental applications
Additional Experience
REPUBLIC OF KOREA Marine Corps (ROKMC), Kimpo, Korea
Corporal, June 10, 1992- September 10, 1994
Awards
The 1st Excellent R&D Award, Graduate School of Daegu University (2000)
Best Paper in Poster Section, KSBB (2005)
Publications
1)Papers:
M.S. course (March 1, 1998~Fubruary, 2001):
1. Park, J.P., Kim, D.H., Kim, D.S., and Yun, J.W.: Enzymatic production of inulo-oligosaccharides from chicory juice. Biotechnol Lett, 20(4) 385~388 (1998)
2. Park JP, Bae JT, and Yun JW : Critical effect of ammonium ions on the enzymatic reaction of a novel transfructosylating enzyme for fructooligosaccharide formation from sucrose. Biotechnol Lett, 21(10) (1999)
3. Park JP, Bae JT, You DJ, Kim BW and Yun JW: Production of inulooligosaccharides from inulin by a novel endoinulinase from Xanthomonas sp. Biotechnol Lett, 21(12) (1999)
4. Yun JW, Park JP, Song CH, Lee CY, Kim JH, and Song SK : Continuous production of inulo-oligosaccharides from chicory juice by immobilized endoinulinase. Bioprocess Eng, 22(3) 189~194 (2000)
5. Kim BW, Kwon HJ, Park YH, Nam SW, Park JP and Yun JW : Production of a novel transfructosylating enzyme from Bacillus macerans EG-6. Bioprocess Eng, 23(1) 11~16 (2000)
6. JT Bae, J Sinha, JP Park, CH Song, and JW Yun : Optimization of submerged culture conditions for exo-biopolymer production by Paecilomyces japonica. J Microbiol Biotechnol, 10 (4) 482~487 (2000)
7. Kim YM, Park JP, Sinha J, Lim KH, Yun JW : Acceptor reaction of a novel transfructosylating enzyme from Bacillus sp.. Biotechnol Lett, 23(1) 13~16 (2001)
8. Cho YJ, Sinha J, Park JP, Yun JW : Production of inulooligosaccharides from chicory extract by endoinulinase from Xanthomonas oryzae No.5. Enzyme Microb Technol, 28(4-5), 439~445 (2001)
9. JT Bae, JP Park, J Sinha, CH Song and JW Yun: Effect of carbon source on the mycelial growth and exo-biopolymer production by submerged culture of Paecilomyces japonica. J Biosci Bioeng, 91(5) 522~524 (2001)
10. Park JP, Yun JW : Utilization of chicory roots for microbial endoinulinase production. Lett Appl Microbiol, 33(3) 183~187 (2001)
11. JP Park, TG Oh, JW Yun : Purification and characterization of a novel fructosyltransferase by Bacillus macerans EG-6. Process Biochem, 37, 471~476 (2001)
12. Park JP, SW Kim, HJ Hwang and JW Yun :Optimization of submerged culture conditions for the mycelial growth and exo-biopolymer production by Cordyceps millitaris. Lett Appl Microbiol, 32, 1~6 (2001)
13. J. Sinha, JT Bae, JP Park, KH Kim, CH Song, and JW Yun: Changes in morphology of Paecilomyces japonica and its effect on broth rheology during production of exo-biopolymer. Appl Microbiol Biotechnol, 56, 88~92 (2001)
14. YJ Cho, J. Sinha, JP Park, JW Yun: Production of inulooligosaccharides from a dual endoinulinase system of Xanthomonas sp. and Pseudomonas sp. Enzyme Microb Technol, 29, 428~433 (2001)
15. J Sinha, JT Bae, JP Park, JW Yun: Effect of substrate concentration on broth rheology and fungal morphology during exo-biopolymer production by Paecilomyces japonica in a bioreactor. Enzyme Microb Technol, 29, 392~399 (2001)
16. JP Park, CH Song, JW Yun : Stimulatory effect of plant oils and fatty acids on the exo-biopolymer production in Cordyceps militaris. Enzyme Microb Technol. 31, 250-255 (2002)
17. JP Park, YM Kim, SW Kim, HJ Hwang, YJ Cho, YS Lee, CH Song, JW Yun : Effect of agitation intensity on the exo-biopolymer production and mycelial morphology in Cordyceps militaris. Lett Appl Microbiol. 34(6), 433~438 (2002)
18. YJ Cho, JP Park, HJ Hwang, SW Kim, JW Choi, JW Yun: Production of red pigment by submerged culture of Paecilomyces sinclairii. Lett Appl Microbiol. 35(3) , 195-202 (2002)
19. SW Kim, HJ Hwang, JP Park, YJ Cho, CH Song,, JW Yun : Mycelial growth and exo-biopolymer production by submerged culture of various edible mushrooms under different media. Lett Appl Microbiol. 34(1) 56~61 (2002)
20. JP Park, YM Kim, SW Kim, HJ Hwang, YJ Cho, YS Lee, CH Song, JW Yun : Effect of aeration rate on the mycelial morphology and exo-biopolymer production in Cordyceps militaris. Process Biochem. 37, 1257~1262 (2002).
Ph.D course (September 1, 2001~)
21. Park SJ, Park JP, Lee SY : Production of poly(3-hydroxybutyrate) from whey by fed-batch culture of recombinant Escherichia coli in a pilot-scale fermentor. Biotechnol Lett 24(3), 185-189 (2002)
22. Park, S.J, Park, J.P, Lee, S.Y. " Metabolic engineering of Escherichia coli for the production of medium -chain-length polyhydroxyalkaroates rich in specific monomers", FEMS Microbiol. Lett. 214:217-222 (2002)
23. Park, S.J., Park, J.P., Lee, S.Y., and Doi, Y., "Enrichment of specific monomer in medium-chain-length poly (3-hydroxyalkanoates) by amplification of fadD and fadE genes in recombinant Escherichia coli ", Enzyme Microbial Technol., 33 : 62-70 (2003)
24. Hong SH, Park S J, Moon S Y, Park J P and Lee SY . In Silico prediction of the importance of Enter-Doudoroff pathway in poly(3-hydroxybutyrate) production. Biotechnol Bioeng. 83(7) : 854-863 (2003)
25. Jong Pil Park, Seok Jae Lee, Tae Jung Park, Kyung-Bok Lee, Insung S. Choi, Sang Yup Lee, Min-Gon Kim and Bong Hyun Chung. Microcontact printing of biotin for selective immobilization of streptavidin-fused proteins and SPR analysis. BBE 9:137-142 (2004)
26. Park, T.J., Lee, K.-B., Lee, S.J., Park, J.P., Lee, Z.-W., Lee, S.Y., and Choi, I.S. "Micropatterns of spores displaying heterologous proteins", J. Am. Chem. Soc., 126(34):10512-10513 (2004).
27. Jong Pil Park, Seok Jae Lee, Tae Jung Park, Kyung-Bok Lee, Insung S. Choi, Min Gon Kim, Bong Hyun Chung, Zee-Won Lee, and Sang Yup Lee: Micropatterning proteins on polyhydroxyalkanoate substrates by using the substrate binding domain as a fusion partner. Biotechnol. Bioeng, In Press (2005)
28. S.J. Lee, J.P. Park, T. J. Park. S.N. Lee, J.K. Park, S.Y. Lee. Visual detection of specific protein-protein interaction via PHB microsphere using substrate binding domain. in preparation , Anal. Chem, being revised (2005)
2) Book chapter:
1. Lee, S.Y., Park, S.J., Park, J.P., Lee, Y. and Lee, S.H. "Economic aspects of biopolymer production", Biopolymers Vol.10, Ch.10, pp.307-337, VCH-Wiley, Weinheim Germany (2003)
2. Polyhydroxyalkanoates in nanobiotechnology: application to protein-protein interaction studies, Horizon Scientific Prss, Submitted (2005).
Presentation
1) Domestic Conference
M.S. Course (March 1, 1998 ~ February, 2001) :
1. JP Park, DH Kim and JW Yun : Inulo-oligosaccharide production using chicory juice from Pseudomonas sp. Annual Meeting of the Korean Society for Biotechnology and Bioengineering, (1998.4)
2. JP Park, JW Yun : Enzymatic production of inulo-oligosaccharide from chicory juice by endoinulinase immobilized on carrier materials. Annual Meeting of the Korean Society for Biotechnology and Bioengineering, (1998.10)
3. JH Kim, JP Park, JW Yun and SK Song : Continuous production of inulooligosaccharides from chicory juice by immobilized endoinulinase. Annual Meeting of the Korean Society for Biotechnology and Bioengineering,(1999.4)
4. JP Park, BC Oh, TK Oh and JW Yun : Purification and characterization of a novel transfructosylating enzyme from Bacillus sp. Annual Meeting of the Korean Society for Applied Microbiology, (1999.4)
5. JP Park, JW Yun : Production of inulooligosaccharides from inulin by Xanthomonas sp." Annual Meeting of the Korean Society for Applied Microbiology, (1999. 10).
6. JP Park, JT Bae, JW Yun : Critical effects of ammonium ions on the enzymatic reaction of a novel transfructosylating enzyme for fructooligosaccharide production from sucrose. Annual Meeting of the Korean Society for Applied Microbiology (1999.10)
7. JT Bae, J Sinha, JP Park and JW Yun : Optimization of culture conditions for exo-biopolymer production by Paecilomyces japonica. Annual Meeting of the Korean Society for Biotechnology and Bioengineering (2000.4)
8. JP Park, J Sinha and JW Yun : Utilization of chicory roots as a carbon source for endoinulinase production in Xanthomonas sp. Annual Meeting of the Korean Society for Applied Microbiology, (2000.4)
9. JP Park, JT Bae and JW Yun : Inulo-oligosaccharide production using chicory juice from Xanthomonas sp. Annual Meeting of the Korean Society for Applied Microbiology, (2000.4)
10. YJ Cho, JP Park, J Sinha and JW Yun : Inulo-oligosaccharide production using chicory juice from Xanthomonas sp. Annual Meeting of the Korean Society of Food Science and Technology (2000.5)
11. JT Bae, J Sinha, JP Park, CH Song and JW Yun : Application of rotating simplex method for optimization of the physical parameters for exo-biololymer production by Paecilomyces japonica in batch bioreactor. Annual Meeting of the Korean Society for Applied Microbiology, (2000. 10)
12. JP Park, J Sinha, CH Song and JW Yun : Optimization of submerged culture conditions for the mycelial growth and exo-biopolymer production by Cordyceps millitaris. Annual Meeting of the Korean Society for Applied Microbiology (2000.11)
13. YM Kim, JP Park and JW Yun : Acceptor reactions of a novel transfructosylating enzyme from Bacillus sp. Annual Meeting of the Korean Society for Biotechnology and Bioengineering (2000.11)
14. YJ Cho, JP Park, J Sinha and JW Yun : Production of inulooligosaccharides from inulin by a dual endoinulinase system. Annual Meeting of the Korean Society for Biotechnology and Bioengineering (2000.11)
15. YJ Cho, JP Park, JW Yun: Production of the water-soluble red pigment from mycelial culture of Paecilomyces sinclairii. Annual Meeting of the Korean Society for Applied Microbiology, (2001. 6.20-22)
16. YM Kim, JP Park, JW Yun: Optimization of submerged culture conditions for the mycelial growth and exo-biopolymer production. Annual Meeting of the Korean Society for Applied Microbiology, (2001.6.20-22)
17. HJ Hwang, SW Kim, JP Park, JW Yun: A comparative study of effects of synthetic medium for mycelial growth and exo-biopolymer production by edible mushrooms. Annual Meeting of the Korean Society for Applied Microbiology, (2001.6.20-22)
18. SW Kim, HJ Hwang, JP Park, JW Yun: Production of exo-biopolymers by submerged culture of various insect-born fungi. Annual Meeting of the Korean Society for Applied Microbiology, (2001.6.20-22)
Ph.D Course (September 1, 2001 ~)
19. Park, J.P., Park, S.J. and Lee, S.Y. : Production and characterization of ultra-high-molecular weight poly(3-hydroxybutyrate) by recombinant Escherichia coli, Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Seoul, November(2001)
20. Park, S.J., Park, J.P. and Lee, S.Y. : Biosynthesis of medium-chain-length poly(3-hydroxyalkanoates) by metabolically engineered Escherichia coli strains, Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Seoul, November(2001)
21. Park, S.J., Park, J.P. and Lee, S.Y. : Production of poly(3-hydroxybutyrate) by recombinant Escherichia coli strain in pilot-scale fermentor from whey, KIChE meeting, Taejon , Korea (2001)
22. Park,.J.P., Park, S.J., and Lee, S.Y. : Characterization of (R)-specific enoyl-CoA hydratase genes from Pseudomonas sp. MBEL21 and their use for polyhydroxyalkanoate synthesis, Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Chungju , October 10-12(2002)
23. Park.S.J, Park,J.P., and Lee, S.Y. : Evaluation of the roles of 3-ketoacyl-ACP reductases in the polyhydroxyalkanoates in recombinant Escherichia coli, Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Chungju , October 10-12(2002)
24. Park, J.P., Park, S.J., and Lee S.Y. : Production of medium-chain-length polyhydroxyalkanoates by a newly isolated strain of Pseudomonas sp. MBEL21, KMB Meeting, Gyunbook Univ., October,26(2002)
25. Park,J.P., Park, S.J., and Lee, S.Y. : Medium-chain-length polyhydroxyalkanoate biosynthesis and accumulation in metabolic engineered recombinant E.coli, KMB meeting,Gyunbook univ., October,26(2002)
26. Hong SH, Park S J, Moon S Y, Park J P and Lee SY . : In Silico prediction of the importance of Enter-Doudoroff pathway in poly(3-hydroxybutyrate) production, KMB meeting,Gyunbook univ., October,26(2002)
27. AJ Song, SJ Park, JP Park, SY Lee. : Newly screened Pseudomonas sp. producing polyhydroxyalkanoates consisting of SCL and MCL monomers, Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Pukyong Univ, April 11-12, Pusan
28. JP Park, SJ Lee, SY Lee. : Preliminary study of an efficient secretory system of recombinant fusion protein in Escherichia coli using the PHB depolymerase signal sequence, Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Pukyong Univ, April 11-12, Pusan
29. J. P. Park, S. J. Lee, T. J. Park, S. Y. Lee, H. S. Lee, H. T. Jung, : Enzyme-based Biomolecular Engineering of Single-Walled Carbon Nanotubes (SWNTs) by Transglycosylation Reaction, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, October 22-24, Seoul, Korea (2003)
30. Tae Jung Park, Jong Pil Park, Seok Jae Lee, and Sang Yup Lee, : Recombinant Protein Secretion in Escherichia coli using Several Leader Peptides, Annual Meeting of the Korean Society for Biotechnology and Bioengineering (2003)
31. Seok Jae Lee, Jong Pil Park, Tae Jung Park, Kyung-Bok Lee, Insung Choi, and Sang Yup Lee, : Patterning of Proteins Fabricated by Microcontact Printing (μCP) Method for Site-Specific Immobilization and Protein-Protein Interaction Assay, Annual Meeting of the Korean Society for Biotechnology and Bioengineering (2003)
32. Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee, : Visual Detection of Specific Protein-Protein Interaction using PHB Microsphere of Substrate Binding Domain from Alcaligenes faecalis, Annual Meeting of the Korean Society for Microbiology and Biotechnology(2003)
33. Seok Jae Lee, Jong Pil Park, Tae Jung Park, and Sang Yup Lee, : Enzyme-based Biomolecular Engineering of Single-Walled Carbon Nanotubes (SWNTs) by Transglycosylation Reaction, Annual Meeting of the Korean Institute of Chemical Engineers (2003)
34. Seok Jae Lee, Tae Jung Park, Jong Pil Park and Sang Yup Lee, : Novel PHB-based Protein Microarray using Extracellular Depolymerase Substrate Binding Domain for Site-Directed Capture Ligand to Detect Protein-Protein Interaction, Annual Meeting of the Korean Institute of Chemical Engineers (2003)
35. Park, J.P., Park, T.J., Lee, S.J., and Lee, S.Y., “Polyhydroxyalkanoates(PHAs) in Nanobiotechnology”, Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Cheongju, Korea, October 13-15 (2004)
36. Park, J.P., Lee, S.J., Park, T.J., Lee, K.B., Choi, I.S., and Lee, S.Y., "Microcontact printing of biotin for selective immobilization of streptavidin-fused proteins and SPR analysis", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
37. Lee, S.J., Park, S.J., Park, T.J., Choi, J.H., and Lee, S.Y., "Self-assembly of functional bacterial surface protein and its use in nanobiotechnology", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
38. Lee, S.J., Park, S.J., Park, T.J., and Lee, S.Y., "Bioactivation of poly(3-hydroxybutyrate) microsphere and its application in a bead-based assay", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
39. Park, T.J., Park, J.P., Lee, S.J., and Lee, S.Y., "Artificial surface display system in Escherichia coli using exosporal agent", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
40. Kang, Y.J., Park, J.P. and Lee, S.Y., "Micropattern Generation of Proteins on Gold Surface using Fusion Protein Strategy and Microcontact Printing", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, April 15-16 (2005)
41. Park, J.P., Jung, D.H., Kang, Y.J., Ko, Y.K, Jung, H.T. and Lee, S.Y., "Controlled Networks of Single-Walled Carbon Nanotubes(SWNTs) Arrays by Functionalized Magnetic Microbeads under Ultra-Low Magnetic Field", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, April 15-16 (2005)
2). International Conferences
M.S. Course (March 1, 1998 ~ February, 2001) :
1. Park JP and Yun JW : Continuous production of inulo-oligosaccharides from chicory juice by immobilized endoinulinase. 9th European Congress on Biotechnology (ECB9), Brussels, Belgium (1999.7)
2. Bae JT, J Sinha, Park JP, and Yun JW : Optimization of submerged culture conditions for exo-biopolymer production by Paecilomyces japonica. Asian Mycological Congress 2000, Hong Kong (2000.7)
3. Cho YJ, JP Park, JT Bae, JW Yun: Production of inulooligosaccharide from chicory extract by dual endoinulinase system of Pseudomonas spp. and Xanthomonas spp. Biotechnology 2000, The World Congress on Biotechnology, 3-8 September, Berlin, Germany (2000)
4. JP Park, HJ Hwang, JT Bae, J Sinha and JW Yun: Production of biopolymers with biological activities by submerged culture of mushrooms. 11th World Congress of Food Science and Technology. April 22-27, 2001, Seoul
5. YJ Cho, YM Kim, JP Park, J Sinha and JW Yun: Production of high-content oligosaccharides from inulin by two types of endoinulinase preparations from Xanthomonas sp. and Pseudomonas sp. 11th World Congress of Food Science and Technology. April 22-27, 2001, Seoul
6. HJ Hwang, SW Kim, JP Park, CH Song, JW Yun: Effect of substrate concentration on broth rheology and fungal morphology during exo-biopolymer production by P. japonica in a batch bioreactor. 6th World Congress of Chemical Engineering. Sep 23-27, 2001, Melbourne
7. SW Kim, HJ Hwang, JP Park, JW Yun: Optimization of submerged culture conditions for the mycelial growth and exo-biopolymer production by C. militaris. 6th World Congress of Chemical Engineering. Sep 23-27, 2001, Melbourne
Ph.D Course (September 1, 2001 ~) :
8. Seung Hwan Lee, Jong Pil Park, Si Jae Park, Sang Yup Lee : Biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant E. coli by engineering beta-oxidation pathway. 9th International Symposium on the genetics of industrial microorganism. July1-5, 2002, Gyeongju, Korea
9. Jong Pil Park, Si Jae Park, San Yup Lee : Production of the medium-chain-length polyhydrxoyalkanoates in methabolically engineered E. coli strains. 9th International Symposium on the genetics of industrial microorganism. July1-5, 2002, Gyeongju, Korea
10. Si Jae Park, Jong Pil Park, Sang Yup Lee : Biosynthesis of poly(3-hydroxybutyrate-co-hydroxyalkanoate) in metabolically engineered E. coli strains. 9th International Symposium on the genetics of industrial microorganism. July1-5, 2002, Gyeongju, Korea
11. JP Park, SJ Park, SY Lee: Biosynthesis and characterization of polyhydroxyalkanoates in newly screened Pseudomonas sp. MBEL21. ISBP, Sep 22-26, Germany (Oral)
12. SJ Park, JP Park, SY Lee: Biosynthesis and characterization of polyhydroxyalkanostes from newly screened strain from sludge. ISBP, Sep 22-26, Germany
13. SJ Park, JP Park, SY Lee: Amplification of glycolytic pathway increases the yield of poly(3-hydroxybutyric acid ) in E. coli. ISBP, Sep 22-26, Germany
14. SJ Park, JP Park, SY Lee: Production of (R)-(-)-3-hydroxybutyric acid by metabolically engineered E.coli. ISBP, Sep 22-26, Germany
15. JH Choi, JP Park, Si Jae Park, Sang Yup Lee : Metabolic engineering of Escherichia coli for the production of polyhydroxyalkanoates consisting of short-chain-length and medium-chain-length monomers. Metabolic Engineering IV: Applied System Biology, October 6-11, 2002, Italy
16. Seung Hwan Lee, Si Jae Park, Jong Pil Park, Sang Yup Lee: Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates. Metabolic Engineering IV: Applied System Biology, October 6-11, 2002, Italy
17. Jong Pil Park, SJ Lee, TJ Park, SY Lee: Visual detection of specific protein-protein interaction using PHB microsphere of substrate binding domain from Acaligenes faecalis. 2003 Annual meeting and international symposium of the KMB, June 24-26, Muju, Korea
18. SJ Lee, JP Park, SY Lee: Selective immobilization of proteins on phb-based microarray using extracellular depolymerase substrate binding domain for site-directed capture ligand to detect protein-protein interaction. BioChE-03, July 19-23, 2003, Boulder, Colorado, USA
19. Seok Jae Lee, Jong Pil Park, Tae Jung Park, and Sang Yup Lee, : Selective Immobilization of Proteins on PHB-Based Microarray using Extracellular Depolymerase Substrate Binding Domain for Studying Protein-Protein Interaction, BioChE-03. Biochemical Engineering (XIII) Conference (2003)
20. Jong Pil Park, Seok Jae Lee, Tae Jung Park, Kyung-bok Lee, Insung S Choi, and Sang Yup Lee, : Patterning of Poly(3-hydroxybutyrate) for Site-Selective Protein Immobilization and Studying Protein-Protein Interaction, The 2nd KAIST International Symposium on Frontier Issues in NBI Technologies (2003)
21. Seok Jae Lee, Jong Pil Park, Tae Jung Park, Kyung-bok Lee, Insung S Choi, and Sang Yup Lee, "Patterning of Proteins by Microcontact Printing", The 2nd KAIST International Symposium on Frontier Issues in NBI Technologies (2003)
22. Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee, "The Structural Basis for Catalysis and Specificity of the Substrate Binding Domain of PHB Depolymerase from Bacteria" Enzyme Engineering XVII (2003)
23. Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee, "Bead-Based System for Studying Protein-Protein Interactions using PHB Microsphere with Substrate Binding Domain", Enzyme Engineering XVII ( 2003)
24. Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee, "Microbial Polyamide Production by Recombinant Escherichia coli", Enzyme Engineering XVII, (2003)
25. Lee, S. J., Park, J. P., Park, T. J., Lee, S. Y., "Peptide arrays Improvedby the Protein layer for Protein Kinase Assay", 227th ACS National Meeting, Anaheim, CA, March 28-April 1 (2004)
26. Park, J. P., Park, T. J., Lee, S. J., Choi, J. H., and Lee, S. Y., "Self-assembly of functional bacterial surface protein around carbon nanotube and its use in nanostructure fabrication", 227th ACS National Meeting, Anaheim, CA, March 28-April 1 (2004)
27. Park, T. J., Park, J. P., Lee, S. J., Lee, K.-B., Choi, I. S., and Lee, S. Y., "Patterning of polyhydroxyalkanoates for selective protein immobilization and studying protein-protein interaction", 227th ACS National Meeting, Anaheim, CA, March 28-April 1 (2004)
28. S.J. Lee, J.P. Park, T.J. Park, K.-B. Lee, I.S. Choi, S.Y Lee. Microcontact printing of biotin for selective immobilization of streptavidin-fused proteins and its application for biosensor using SPR analysis. Biosensor 2004, Spain (2004)
29. J.P. Park, S.J. Lee, T.J. Park, S.M. Yoo, D. Lee, S.Y. Lee. Systematic detection of pathogenic bacteria using carbohydrate-encapsulated quantum dot. Biosensor 2004, Spain (2004)
30. Jae Shin Lee, Do Hyun Kim, Seok Jae Lee, Jong Pil Park, Tae Jung Park, Sang Yup Lee, Dae-Hwan Jung, Hee-Tae Jung, Jin Hee Kim, and Seong Ku Kwon. Eltrical detection of kinase assay using multi walled-carbon nanotube(mwcnt) nanoelectrode. microTAS 2004 Malmo Sweden. 26-30 Sep.
31. Jong Pil Park, Seok Jae Lee, Kwang Suk Yang, Yong Beom Shin, Bong Hyun Chung, Do Hyun Kim, and Sang Yup Lee. Fabrication of Gold Binding Protein Fusion Protein Arrays for Surface Plasmon Resonance Imaging Studies of Protein-Protein and DNA Hybridization Assays. ISNM, Daejeon, KAIST (2004.11.3)
32. Park, J.P., Lee, S.J., Choi, J.H., Lee, S.Y., "Self-Assembly of Functional Bacterial Surface Protein around Carbon Nanotubes and Its Application", ISNM, Daejeon, Korea (2004)
33. Park, J.P., Lee, S.J., Lee, K.B., Choi, I.S., Kim, M.G., Chung, B.H., Lee, S.Y., "Microcontact Printing and SPR Analysis of Biotin for Selective Immobilization of Streptavidin-fused Proteins". ISNM, Daejeon, Korea (2004)
34. Park, J.P., S.J., Lee., Hong, H.J., Lee, S.Y., “Fabrication of Polyhydroxyalkanoate (PHA) Chip for Studying Protein-Protein Interactions”, Yonsei University, December 3, Korea (2004)
Seok-Jae Lee
Senior Manager '04. 8.
Samsung Engineering Co., LTD.(SECL), R&D Center
Phone :+82-31-260-6040
Fax :+82-31-260-6008
Details
Research Interest
Nanobiotechnology
Protein chip and microarray
Microfluidic chip (MEMS)
Recombinant protein technology
Biosensor
Education
B.S., Dept. of Chemical Engineering, Hanyang University, Korea, 1997
M.S., Dept. of Chemical Engineering, Hanyang University, Korea, 1999
Ph.D. Candidate, Department of Chemical Engineering, KAIST, Daejeon, Korea, 2004
Experience and Academic Activity
Research Scientist, Korea Greencross Life Science Corp., General Research Institute (1998-2001)
Member, Korean Institute of Chemical Engineers (2002-present)
Student member, Korean Institute of Biotech. & Bioeng. (2002-present)
Student member, The microbiological society of Korea (2002-present)
Publications
International Journal
Chun Yeon Lee, Seok Jae Lee, Kyung Hwan Jung, Shigeo Katoh, and Eun Kyu Lee, "High dissolved oxygen tension enhances heterologous protein expression by recombinant Pichia pastoris", Process Biochemistry, 38, 1147-1154 (2003)
Jong Hyun Choi, Sang Jun Lee, Seok Jae Lee, and Sang Yup Lee, "Enhanced Production of IGF-1 Fusion Protein in Escherichia coli by the Coexpression of the Down-Regulated Genes Identified by Trascriptome Profiling", Appl. Environ. Microbiol., 68, 4737-4742 (2003)
Seok Jae Lee and Sang Yup Lee, "Micro total analysis system (μ-TAS) in biotechnology", Appl. Microbiol. Biotechnol., in press. (2004)
Seok Jae Lee and Sang Yup Lee, "Microarrays of peptides elevated on the protein layer for efficient protein kinase assay", Anal. Biochem., in press (2004)
Jong Pil Park, Seok Jae Lee, Tae Jung Park, Kyung-bok Lee, Insung S. Choi, Sang Yup Lee, Min-Gon Kim, Bong Hyun Jun : Microcontact Printing of Biotin for Selective Immobilization of Streptavidin-Fused Proteins and SPR Analysis, Biotechnol. Bioprocess Eng., 9, 137-142 (2004)
* These authors equally contributed to this work.
Domestic Journal
Sang Yup Lee, Seok Jae Lee, and Hee-Tae Jung, "Protein Microarrays and Chips", J. Ind. Eng. Chem., 9(1) : 9-15 (2003)
Essays
Lee, S.Y., Park, H.G., Jung, H.T., Lee, S.J., Lee, J.H., "Development of process-on-a-chip system for high-throughput screening of medical and biological samples", News & Information for Chemical Engineers vol.21(6) : 735-738 (2003)
Domestic Conferences
S. J., Lee, S. Y., Lee : High-Level Production of Spider Silk Protein by Fed-Batch Cultivation of Recombinant Escherichia coli and Its Purification, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, November 7-9, COEX, Korea (2001)
S. J., Lee, S. Y., Lee : Chip-based microenzymeassay for kinase using antibody, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, April 12-13, Kwangju, Korea (2002)
J. H., Choi, S. J., Lee, K. J., Jeong, S. Y., Lee : Transcriptome Analysis of Escherichia coli during Overproduction of Recombinant Protein by Fed-batch Fermentation, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, April 12-13, Kwangju, Korea (2002)
S. J., Lee, S. Y., Lee : Efficient High-Level Production of Spider Silk Protein by Fed-Batch Cultivation of Recombinant Escherichia coli and Its Purification, KIChE meeting, October 24-26, Seoul, Korea (2002)
S. J., Lee, S. M., Yoo, S. Y., Lee : Protein Microchips for Protein-Protein Interaction, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, October 10-12, Chungju, Korea (2002)
Choi, J.H., Lee, S.J., and Lee, S.Y., "Increasing of Productivity of Recombinant Proteins by Transcriptome Analysis in Escherichia coli", Korean Society for Bicrobiology and Biotechnology Meeting, Konkuk Univ. October, 26 (2002)
S. J., Lee, S. Y., Lee : Peptide chips immobilized with protein layer using fluorescence labeled antibody detection systems for protein kinase assay, KIChE meeting, April 25-26, Soonchun, Korea (2003)
S. J., Lee, S. Y., Lee : High-Level Production of Spider Silk Protein by Fed-Batch Cultivation of Recombinant Escherichia coli and Its Purification, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, April 11-12, Busan, Korea (2003)
J. P., Park, S. J., Lee, S. Y., Lee : Preliminary study of an efficient secretory system of recombinant fusion protein in Escherichia coli using the PHB depolymerase signal sequence, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, April 11-12, Pusan, Korea (2003)
S. H., Chae, S. J., Lee, S. Y., Lee : Genetically engineering of synthetic spider silk proteins, high-level production of spider silk protein by fed-batch cultivation of recombinant Escherichia coli and its purification, GIM2003 10th international Symposium on the Genetics of Industrial Microorganisms, Muju, Korea, June 24-26 (2003)
J. P., Park, S. J., Lee, T. J., Park, S. Y., Lee : Visual detection of specific protein-protein interaction using PHB microsphere of substrate binding domain from Alcaligenes faecalis, GIM2003 10th international Symposium on the Genetics of Industrial Microorganisms, Muju, Korea, June 24-26 (2003)
Lee, S. J., and Lee, S.Y., "Development of reaction motif for embodiment of process on a chip", Center for Ultramicrochemical Process Systems Workshop, Youngpeong, Gangwondo, Korea, June 26-27 (2003)
Seok Jae Lee, Jong Pil Park, Tae Jung Park and Sang Yup Lee : Selective immobilization of proteins on PHB-based microarray using extracellular depolymerase substrate binding domain for site-directed capture ligand to detect protein-protein interaction. KIChE meeting, October 24-25, Seoul, Korea (2003)
S. H., Chae, S. J., Lee, and S. Y., Lee : High-level production of spider silk protein by fed-batch cultivation of recombinant Escherichia coli coexpressing E. coli dead gene and its purification, KIChE meeting, October 24-25, Seoul, Korea (2003)
Tae Jung Park, Jong Pil Parke, Seok Jae Lee, and Sang Yup Lee : Recombinant Protein Secretion in Escherichia coli using several leader peptides, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, October 22-24, Seoul, Korea (2003)
Tae Jung Park, Seok Jae Lee, Jong Pil Park and Sang Yup Lee : Selective Immobilization and Diagnosis Protein Chips on PHB-Based Microarray Using
Extracellular Depolymerase Substrate Binding Domain for Site-Directed Capturinge Ligand to Detect Protein-Protein and Antigen-Antibody Interactions, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, October 22-24, Seoul, Korea (2003)
Jong Pil Park, Seok Jae Lee, Tae Jung Park, Sang Yup Lee, Hae Sung Lee, Hee Tae Jung : Enzyme-based Biomolecular Engineering of Single-Walled Carbon Nanotubes (SWNTs) by Transglycosylation Reaction, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, October 22-24, Seoul, Korea (2003)
Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee : Visual detection of specific protein-protein interaction using PHB microsphere of substrate binding domain from Alcaligenes faecalis, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, October 22-24, Seoul, Korea (2003)
Seok Jae Lee and Sang Yup Lee : Chip-based microenzymeassay for kinase using antibody, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, October 22-24, Seoul, Korea (2003)
Seok Jae Lee, Jong Pil Park, Tae Jung Park, Kyung-Bok Lee, Insung S. Choi and Sang Yup Lee : Patterning of Proteins Fabricated by Microcontact Printing method for site-specific immobilization and protein-protein interaction assay, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, October 22-24, Seoul, Korea (2003)
Seok Jae Lee, Jong Pil Park, Tae Jung Park and Sang Yup Lee : Bioactivation of poly(3-hydroxybutyrate) microsphere and its application in a bead-based assay, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, April 17-18, Daegu, Korea (2004)
Jong Pil Park, Seok Jae Lee, Tae Jung Park, Kyung-Bok Lee, Insung S. Choi, Sang Yup Lee : Microcontact printing of biotin for selective immobilization of streptavidin-fused proteins and SPR analysis, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, April 17-18, Daegu, Korea (2004)
Tae Jung Park, Jong Pil Park, Seok Jae Lee, and Sang Yup Lee : Artificial surface display system in Escherichia coli using exosporal agent, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, April 17-18, Daegu, Korea (2004)
Seok Jae Lee, Jong Pil Park, Tae Jung Park, Jong Hyun Choi, and Sang Yup Lee : Self-assembly of functional bacterial surface protein and its use in nanobiotechnology, Annual Meeting of the Korean Society for Biotechnology and Bioengineering, April 17-18, Daegu, Korea (2004)
Yang, K.S., Park, T.J., Park, J.P., Lee, S.J., Kim, D.H., and Lee, S.Y., "Dynamic Concentration and Separation by Isoelectric Focusing in Microfluidic Channel", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, April 16-17, Daegu, Korea (2004)
Korean Proceedings
S. J., Lee, E. K., Lee, K. H., Jung and K. Y., Kim, "Use of Oxygen Enriching Gas Separation Membrane System for High Cell density Fermentation", Theories and Application of Chemical Eng., 4: 3045-3048 (1998)
S. J., Lee, E. K., Lee, "Oxygen Enriching Gas Separation Membrane System As a new Means of Supplying Oxygen to a Fermentor", Proceeding of Korean Institute of Biotechnology and Bioengineering, 37-41 (1998)
S. J., Lee, S. Y., Lee, "Efficient High-Level Production of Spider Silk Protein by Fed-Batch Cultivation of Recombinant Escherichia coli and Its Purification", Proceedings of The 14th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 325-326 (2001)
Lee, S.Y., Lee, S.J., Park, J.P., and Park, T.J., "Novel Plaform Technologies for Protein chip Development", Peoceeding of 1stAnnual Symposium of the Korea Society of Microsystem on life Science and Chemistry & 1st Korea-Japan Symposium on Microsystem for Life Science and Chemistry, 67-68(2003)
International Conferences
Choi, J.H., Lee, S.J., and Lee, S.Y., "Transcriptome analysis of Escherichia coli during production of IGF-1 by fed-batch fermentation", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
Jong Hyun Choi, Seok Jae Lee, and Sang Yup Lee, "Metabolic engineering of Escherichia coli for the production of IGF-1 by transcriptome analysis", Metabolic Engineering IV - Applied System Biology (United Engineering Foundation Conference), October 6-11, Il Ciocco, Castelvecchio Pascoli (Tuscany), Italy (2002)
Lee, S. J. and Lee, S. Y., "Chip-based microenzymeassay for kinase using antibody", ChungNam-Kyushu International Symposium, Kumamoto, Japan, Dec 6, (2002)
Sang Yup Lee and Seok Jae Lee, "Development of novel protein chip system for detecting interactions between the protein kinases and their substrates", 2002 Nanobio International Symposium, Haeundae Hotel, Korea, November, 22-23 (2002)
Seok Jae Lee, Jong Pil Park, Tae Jung Park, and Sang Yup Lee, "Selective immobilization of proteins on PHB-based microarray using extracellular depolymerase substrate binding domain for site-directed capture ligand to detect protein-protein interaction", Biochemical Engineering (XIII), Boulder, Colorado, USA, Jul 19-24 (2003)
Seok Jae Lee, Jong Pil Park, Tae Jung Park, Kyung-Bok Lee, Zee-Won Lee, Insung S. Choi, and Sang Yup Lee, "Patterning of Proteins Fabricated by Microcontact Printing method for site-specific immobilization", 2ndKAIST International Symposium on Frontier Issues in NBI Technologies, September 22-24, Daejeon Korea (2003)
Jong Pil Park, Seok Jae Lee, Tae Jung Park, Kyung-Bok Lee, Insung S. Choi and Sang Yup Lee, "Patterned of poly(3-hydroxybutyrate) for site-selective protein recognition substrate", 2nd KAIST International Symposium on Frontier Issues in NBI Technologies, September 22-24, Daejeon Korea (2003)
Jong Pil Park, Seok Jae Lee, Tae Jung Park, Sang Yup Lee, "Bead-based system for studying protein-protein interaction using PHB microsphere with substrate binding domain", Enzyme Engineering XVII, Santafe, New Maxico, USA, Nov 9-14 (2003)
Jong Pil Park, Seok Jae Lee, and Sang Yup Lee, "The structural basis for catalysis and specificity of the substrate binding domain of PHB depolymerase form bacteria", Enzyme Engineering XVII, Santafe, New Maxico, USA, Nov 9-14 (2003)
Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee, "Microbial polyamide production by recombinant E. coli", Enzyme Engineering XVII, Santafe, New Maxico, USA, Nov 9-14 (2003)
Sang Yup Lee, Seok Jae Lee, Seung Min Yoo, and Jong Hyun Choi, "Protein arrays for Protein-Protein Interactions Analysis", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov - 4 December (2003)
Seok Jae Lee, Jongpil P. Park, Taejung P. Park, and Sang Yup Lee, "Peptide arrays improvedby the protein layer for protein kinase assay", 227th ACS National Meeting, Anaheim, CA, March 28-April 1 (2004)
Jongpil P. Park, Taejung P. Park, Seok Jae Lee, and Sang Yup Lee, "Self-assembly of functional bacterial surface protein around carbon nanotube and its use in nanostructure fabrication", 227th ACS National Meeting, Anaheim, CA, March 28-April 1 (2004)
Taejung P. Park, Jongpil P. Park, Seok Jae Lee, Kyung-Bok Lee, Insung S. Choi, and Sang Yup Lee, "Patterning of polyhydroxyalkanoates for selective protein immobilization and studying protein-protein interaction", 227th ACS National Meeting, Anaheim, CA, March 28-April 1 (2004)
Seok Jae Lee, Jong Pil Park, Tae Jung Park, Kyung-Bok Lee, Insung S. Choi, Sang Yup Lee, and Doheon Lee, "Microcontact printing of biotin for selective immobilization of streptavidin-fused proteins and its application for biosensor using SPR analys", The 8th world congress on biosensors, Granada, Spain, May 24-26 (2004)
Jong Pil Park, Seok Jae Lee, Tae Jung Park, Seung Min Yoo, Sang Yup Lee, Doheon Lee, "Optical nanobiosensor for the detection of pathogenic bacteria using carbohydrate-encapsulated quantum dots", The 8th world congress on biosensors, Granada, Spain, May 24-26 (2004)
Seok Jae Lee and Sang Yup Lee, "Efficient High-Level Production of Spider Silk Protein by Fed-Batch Cultivation of Recombinant Escherichia coli and Its Purification", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
Patents
국내 특허 출원 8건, 등록 1건, 국제 특허 출원 3건
Tae Jung Park
Assistant Professor '04. 8.
Department of Chemistry, Chung-Ang University
Phone :+82-02-820-5220
Fax :+82-02-825-4736
Details
Research Interest
Biomimetics Using Nanomaterials
BioSensors & BioChips
Protein Engineering
Electrochemical Engineering
Professional Experience
2012. 09. - present. Assistant Professor, Chung-Ang University, Seoul, Korea
2012. 07. - present. Editorial Board Member, Graphene, Irvine, CA, USA
2012. 05. - present Technical Adviser, Thinker Route, Korea
2011. 05. - 2012. 08. Vice Director/Senior Researcher, Center for Nanobio Integration & Convergence Engineering, National Nanofab Center, Korea
2011. 11. - 2012. 01. Scientific Advisory Board, SPL Lifesciences, Korea
2011. 05. - 2012. 08. Adjunct Professor, BioProcess Engineering Research Center, KAIST, Korea
2011. 04. - 2012. 03. Scientific Advisory Board, Teltron Co. Ltd., Korea
2011. 01. - present. Editorial Board Member, American Journal of Analytical Chemistry, Irvine, CA, USA
2010. 04. - present. Scientific Advisory Board, Fumate Co. Ltd., Korea
2009. 12. - 2012. 03. Scientific Advisory Board, Chungho ComNet Co. Ltd., Korea
2009. 04. - 2011. 05. Research Professor, BioProcess Engineering Research Center, KAIST, Korea
2009. 04. - present. Scientific Advisory Board, Mecasys Co. Ltd., Korea
2009. 02. - 2011. 05. Senior Researcher, Center for Systems & Synthetic Biotechnology, and Institute for the BioCentury, KAIST, Korea
2008. 10. - present. Ordinary Member, Korean Society for Biotechnology & Bioengineering, Korea
2008. 08. - present. Regular Member, Korean BioChip Society, Korea
2008. 07. - present. Scientific Advisory Board, NanoMedicine Research Co. Ltd., Korea
2004. 07. - 2009. 03. Senior Researcher, BioProcess Engineering Research Center, KAIST, Korea
2001. 11. - present. Corporation Supervisor, ChiroBio Incorporation, Daejeon, Korea
2000. 06. - 2003. 05. Researcher, R&D center, GenoFocus Incorporation, Korea
1999. 12. - 2000. 06. Researcher, R&D center, Daewoong Pharmceutical Company, Korea
Certificate Pass
Patent Specification and Claim Analysis, International Intellectual Property Training Institute, Korean Intellectual Property Office (KIPO), Daejeon, Korea (2000. 04.)
KIPONET Online Application Training Course, Korean Intellectual Property Office (KIPO), Daejeon, Korea (2000. 04.)
Fermentor Qualification and Fermentation Process Scale-Up, Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea (2000. 05.)
Bio- & Chem-informatics Training Course, Soongsil University, Seoul, Korea (2001. 11.)
Teaching Training Course for Specific Education of Geniuses in Science, Gifted Children's Education Institute, Seoul, Korea (2004.12.)
CFC-ACE+ Basic Training Course, KyungWon Tech Co. Ltd., Seongnam, Korea (2007.12.)
Awards/Honors
"Undergraduate Student Fellowship at Chungnam National University" (1996.-1997.)
"University Graduate Student Fellowship at Chungnam National Universigy" (1998.-2000.)
"Best Poster Award" - Jong Pil Park, Tae Jung Park, Seok Jae Lee, and Sang Yup Lee. "Polyhydroxyalkanoates (PHAs) in nanobiotechnology", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Cheongju, Korea (2004.10.15)
"Graduate Student Fellowship at KAIST" (2003-.2008.)
"Best Research Poster Award" - Tae Jung Park, Seung Min Yoo, and Sang Yup Lee. "Polyhydroxyalkanoate microarray for immunodiagnostics and pathogen detections using immobilization of fusion proteins", 2006 Korean BioChip Conference, Seoul, Korea (2006.23)
"Best Research Award" - Tae Jung Park, Eun Zoo Lee, Sang Yup Lee, and Won Hi Hong. "Fully integrated microfluidic applications for the biosensors", 2008 Korean BioChip Conference, Daejeon, Korea (2008.06.13)
"Best Patent Award/Honor" - Sang Yup Lee, and Tae Jung Park. "Method for preparing metal nanoparticle using metal binding protein", Korea Intellectual Property Service Center (KIPS) 2009 Patent Valuation (2009.06.)
"Best Research Award" - Do-Kyun Kim, Tae Jung Park, and Sang Yup Lee. "Analysis of antibody-antigen interaction using LSPR-based optical biosensor", 2009 Korean BioChip Conference, Daejeon, Korea (2009.06.05)
"Best Poster Award" - Min Ho Yang, Bong Gill Choi, Tae Jung Park, and Sang Yup Lee. "Electrical characterization of the exfoliated graphene/nafion hybrid as a biosensing platform", The 10th IEEE International Conference on Nanotechnology (IEEE Nano), Goyang, Korea (2010.08.20)
"High Impact Journal Paper of People Glorifying Korea", Biological Research Information Center (BRIC) - Tae Jung Park and Sang Yup Lee (2010.08)
"Research Highlight" for Nanotechnology in NPG Asia Materials - "Biofactories for nanoparticles" (Tae Jung Park and Sang Yup Lee) (2010.10.18)
"Best Research Award" - Tae Jung Park. "Site-specific immobilization of organophosphrous hydrolase on graphene-based nanohybrids for electrochemical detection of paraoxon", 2011 Annual Meeting of Korean Society for Biotechnology and Bioengineering, Jeju, Korea (2011.04.16)
"Best Poster Award" - Byeong Il Kim, Kyoung G. Lee, Tae Jae Lee, Gle Park, Tae Jung Park, and Seok Jae Lee. "Microfluidic device for the synthesis of bioactive core-shell microcapsules", IEEE NMDC 2011 IEEE Nanotechnology Materials and Devices Conference, Jeju, Korea (2011.10.26)
"High Impact Journal Paper of People Glorifying Korea", Biological Research Information Center (BRIC) - Jae Hwan Jung, Tae Jung Park, Sang Yup Lee, and Tae Seok Seo (2012.04.)
"Best Scientist Award from Daejeon Metropolitan City - Tae Jung Park [YTN TV] [YTN Science24] [Joongang.co.kr] [Chungcheong TV] [Money Today] [News1] [NEWSIS] [DTNEWS24] [NEWS ZUM] [BZeroNews] [CND News] [CCDN] [CC Today] [Daejeon Ilbo] [DJ Post] [Jeju Ilbo] [Shina Ilbo] [Sejong nTV] [Sisamaeil] (2012.05.10)
"High Impact Journal Paper of People Glorifying Korea", Biological Research Information Center (BRIC) - Kyoung G. Lee, Seok Jae Lee and Tae Jung Park (2012.07.)
Research Activity (as of July 2012)
International Journal Publications - [PubMed] & [Google Scholar] Link (by Tae Jung Park)
1. Jie-Wan Kim, Tae Jung Park, Dewey E. Y. Ryu, and Jeong-Yoon Kim, "High cell density culture of recombinant Yarrowia lipolytica using a one-step feeding", Biotechnol. Prog., 16(4):657-660 (2000) [Abstract]
2. Jong Pil Park+, Seok Jae Lee+, Tae Jung Park+, Kyung-Bok Lee, Insung S. Choi, Min-Gon Kim, Bong Hyun Chung, and Sang Yup Lee, "Microcontact printing of biotin for selective immobilization of streptavidin-fused proteins and SPR analysis", Biotechnol. Bioprocess Eng., 9(2):137-142 (2004) +Equally contributed. [Abstract]
3. Mee-Jung Han, Si Jae Park, Tae Jung Park, and Sang Yup Lee, "Roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli", Biotechnol. Bioeng., 88(4):426-436 (2004) ("Cover Article") [Abstract]
4. Tae Jung Park, Kyung-Bok Lee, Seok Jae Lee, Jong Pil Park, Zee-Won Lee, Soo-Keun Choi, Heung-Chae Jung, Jae-Gu Pan, Sang Yup Lee, and Insung S. Choi. "Micropatterns of spores displaying heterologous proteins", J. Am. Chem. Soc., 126(34):10512-10513 (2004) [Abstract] [chosun.com] [KVN] [DIGITALTIMES] [Food Today]
5. Seok Jae Lee, Jong Pil Park, Tae Jung Park, Sang Yup Lee, Seongnam Lee, and Jung-Ki Park. "Selective immobilization of fusion proteins on polyhydroxyalkanoate microbeads", Anal. Chem., 77(17):5755-5759 (2005) [Abstract]
6. Jong Pil Park, Kyung-Bok Lee, Seok Jae Lee, Tae Jung Park, Min-Gon Kim, Bong Hyun Chung, Zee-Won Lee, Insung S. Choi, and Sang Yup Lee. "Micropatterning proteins on polyhydroxyalkanoate substrates by using the substrate binding domain as a fusion partner", Biotechnol. Bioeng., 92(2):160-165 (2005) [Abstract]
7. Tae Jung Park, Jong Pil Park, Seok Jae Lee, Hyo Jeong Hong, and Sang Yup Lee. "Polyhydroxyalkanoate chip for the specific immobilization of recombinant proteins and its applications in immunodiagnostics", Biotechnol. Bioprocess Eng., 11(2):173-177 (2006) [Abstract]
8. Tae Jung Park, Jong Pil Park, Gwi-Moon Seo, Young Gyu Chai, and Sang Yup Lee. "Rapid and accurate detection of Bacillus anthracis spores using peptide-quantum dot conjugates", J. Microbiol. Biotechnol., 16(11):1713-1719 (2006)
9. Tae Jung Park, Sang Yup Lee, Seok Jae Lee, Jong Pil Park, Kwang Suk Yang, Kyung-Bok Lee, Sungho Ko, Jong Bae Park, Taekeun Kim, Seong Kyu Kim, Yong Bum Shin, Bong Hyun Chung, Su-Jin Ku, Do Hyun Kim, and Insung S. Choi. "Protein nanopatterns and biosensors using gold binding polypeptide as a fusion partner", Anal. Chem., 78(20):7197-7205 (2006) [Abstract]
10. Yun Suk Huh, Jong Hyun Choi, Tae Jung Park, Yeon Ki Hong, Won Hi Hong, and Sang Yup Lee. "Microfluidic cell disruption system employing a magnetically actuated diaphragm", Electrophoresis, 28(24):4748-4757 (2007) [Abstract]
11. Eun Zoo Lee, Yun Suk Huh, Hyo Jin Won, Yeon Ki Hong, Tae Jung Park, Sang Yup Lee, and Won Hi Hong. "Removal of bovine serum albumin using solid-phase extraction with in-situ polymerized stationary phase in a microfluidic device", J. Chromatogr. A, 1187(1-2):11-17 (2008) [Abstract]
12. Tae Jung Park, Yun Suk Huh, Eun Zoo Lee, Seok Jae Lee, Shun Zheng, Kwang Seok Yang, Sang Yup Lee, Won Hi Hong, Do Hyun Kim and Sungho Ko. "An active mixing microfluidic system for the colorimetric analysis of intracellular enzymes", BioChip J., 2(1):33-38 (2008) [Abstract]
13. Yun Suk Huh+, Tae Jung Park+, Eun Zoo Lee, Won Hi Hong, and Sang Yup Lee. "Development of a fully integrated microfluidic system for sensing infectious viral disease", Electrophoresis, 29(14):2960-2969 (2008) +Equally contributed. [Abstract]
14. Yun Suk Huh, Tae Jung Park, Kwang Suk Yang, Eun Zoo Lee, Yeon Ki Hong, Sang Yup Lee, Do Hyun Kim, and Won Hi Hong. "Advanced cleanup process of the free-flow microfluidic device for protein analysis", Ultramicroscopy, 108(10):1365-1370 (2008) [Abstract]
15. Bong Gil Choi, HoSeok Park, Tae Jung Park, Dong Hyun Kim, Sang Yup Lee, and Won Hi Hong. "Development of the electrochemical biosensor for organophosphate chemicals using CNT/ionic liquid bucky gel electrode", Electrochem. Commun., 11(3):672-675 (2009) [Abstract]
16. Tae Jung Park, Seung Min Yoo, Ki Chang Keum, and Sang Yup Lee. "Microarray of DNA-protein complexes on poly-3-hydroxybutyrate surface for pathogen detection", Anal. Bioanal. Chem., 393(6-7):1639-1647 (2009) [Abstract]
17. Tae Jung Park, Shun Zheng, Yeon Jae Kang, and Sang Yup Lee. "Development of whole cell biosensor by cell surface display of gold binding polypeptide on the gold surface", FEMS Microbiol. Lett., 293(1):141-147 (2009) [Abstract]
18. Sungho Ko, Tae Jung Park, Hyo-Sop Kim, Jae-Ho Kim, and Yong-Jin Cho. "Directed self-assembly of gold binding polypeptide-protein A fusion proteins for development of gold nanoparticle-based SPR immunosensors", Biosens. Bioelectron., 24(8):2592-2597 (2009) [Abstract]
19. Tae Jung Park, Soo-Keun Choi, Heung-Chae Jung, Sang Yup Lee, and Jae-Gu Pan. "Spore display using Bacillus thuringiensis exosporium protein InhA", J. Microbiol. Biotechnol., 19(5):495-501 (2009) [Abstract]
20. Sungho Kim, Jae-Hyuk Ahn, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "A biomolecular detection method based on charge pumping in a nanogap embedded field-effect-transistor biosensor", Appl. Phys. Lett., 94(24):243903 (2009) [Abstract]
- Specially selected in Virtual Journal of Nanoscale Science & Technology, Vol. 19, Issue 26, p.109 [Link]
- Specially selected in Virtual Journal of Biological Physics Research, Vol. 18, Issue 1, p.198 [Link]
21. Tae Jung Park, Moon Seop Hyun, Hye Jin Lee, Sang Yup Lee, and Sungho Ko. "A self-assembled fusion protein-based surface plasmon resonance biosensor for rapid diagnosis of severe acute respiratory syndrome", Talanta, 79(2):295-301 (2009) [Abstract]
22. Kwang Suk Yang, Phylip Clementz, Tae Jung Park, Seok Jae Lee, Jong Pil Park, Do Hyun Kim, and Sang Yup Lee. "Free-flow isoelectric focusing microfluidic device with glass coating by sol-gel methods", Curr. Appl. Phys., 9(2):e66-e70 (2009) [Abstract]
23. Bonsang Gu, Tae Jung Park, Jae-Hyuk Ahn, Xing-Jiu Huang, Sang Yup Lee, and Yang-Kyu Choi. "Nanogap field-effect transistor biosensor for electrical detection of avian influenza", Small, 5(21):2407-2412 (2009) [Abstract]
24. Kwang-Won Lee, Sung-Jin Choi, Jae-Hyuk Ahn, Dong-Il Moon, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "An underlap field-effect transistor for electrical detection of influenza", Appl. Phys. Lett., 96(3):033703 (2010) [Abstract]
- Specially selected in Virtual Journal of Biological Physics Research, Vol. 19, Issue 3, p.156 [Link]
25. Yun Suk Huh, Chang-Moon Jeong, Ho Nam Chang, Sang Yup Lee, Won Hi Hong, and Tae Jung Park*. "Rapid separation of bacteriorhodopsin using a laminar-flow extraction system in a microfluidic device", Biomicrofluidics, 4:014103 (2010) [Abstract]
- Specially selected in Virtual Journal of Biological Physics Research, Vol. 19, Issue 3, p.157 [Link]
26. Sungho Kim, Jae-Hyuk Ahn, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "Charge pumping technique to analyze the effect of intrinsically retained charges and extrinsically trapped charges in biomolecules by use of a nanogap embedded biotransistor", Appl. Phys. Lett., 96(5):053702 (2010) [Abstract]
- Specially selected in Virtual Journal of Nanoscale Science & Technology, Vol. 21, Issue 7, p.98 [Link]
- Specially selected in Virtual Journal of Biological Physics Research, Vol. 19, Issue 4, p.99 [Link]
27. So Young Yoo+, Do-Kyun Kim+, Tae Jung Park+, Eung Kweon Kim, Eiichi Tamiya, and Sang Yup Lee. "Detection of most common corneal dystrophies caused by BIGH3 gene point mutations using multi-spot gold-capped nanoparticle array chip", Anal. Chem., 82(4):1349-1357 (2010) +Equally contributed. [Abstract]
28. Min Ho Yang, Bong Gill Choi, HoSeok Park, Won Hi Hong, Sang Yup Lee, and Tae Jung Park*. "Development of the glucose biosensor using advanced electrode modified by nanohybrid composing chemically modified graphene and ionic liquid", Electroanal., 22(11):1223-1228 (2010) [Abstract]
29. Bong Gill Choi, HoSeok Park, Tae Jung Park, Min Ho Yang, Joon Sung Kim, Sung-Yeon Jang, Nam Su Heo, Sang Yup Lee, Jing Kong, and Won Hi Hong. "Solution chemistry of self-assembled graphene nanohybrids for high performance flexible biosensors", ACS Nano, 4(5):2910-2918 (2010) [Abstract]
30. Sungho Kim, Jae-Hyuk Ahn, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "Comprehensive study of a detection mechanism & optimization strategies to improve sensitivity in a nanogap-embedded biotransistor", J. Appl. Phys. 107(11):114705 (2010) [Abstract]
- Specially selected in Virtual Journal of Biological Physics Research, Vol. 19, Issue 12, p.188 [Link
31. Shun Zheng, Do-Kyun Kim, Tae Jung Park*, Seok Jae Lee, and Sang Yup Lee. "Label-free optical diagnosis of hepatitis B virus with genetically engineered fusion proteins", Talanta, 82(2):803-809 (2010) [Abstract
32. Kyoung G. Lee, Rinbok Wi, Muhammad Imran, Tae Jung Park*, Jaebeom Lee, Sang Yup Lee, and Do Hyun Kim. "Functionalization effects of single-walled carbon nanotubes as templates for the synthesis of silica nanorods and study of growing mechanism of silica", ACS Nano, 4(7):3933-3942 (2010) [Abstract]
33. Jae-Hyuk Ahn, Sung-Jin Choi, Jin-Woo Han, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "Double-gate nanowire field effect transistor for a biosensor", Nano Lett., 10(8):2934-2938 (2010) [Abstract]
34. HoSeok Park, Tae Jung Park*, Yun Suk Huh, Bong Gil Choi, Sungho Ko, Sang Yup Lee, and Won Hi Hong. "Immobilization of genetically-engineered fusion proteins on gold-decorated carbon nanotube hybrid films for the fabrication of biosensor platforms", J. Colloid Interf. Sci., 350(2):453-458 (2010) [Abstract]
35. Kyoung G. Lee, Rinbok Wi, Tae Jung Park, Sun Hong Yoon, Jae Beom Lee, Seok Jae Lee, and Do Hyun Kim. "Synthesis and characterization of gold-deposited red, green and blue fluorescent silica nanoparticles for biosensor application", Chem. Commun., 46(34):6374-6376 (2010) [Abstract
36. Sungho Kim, Jee-Yeon Kim, Jae-Hyuk Ahn, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "A charge pumping technique to identify biomolecular charge polarity using a nanogap embedded bio-transistor", Appl. Phys. Lett., 97(7):073702 (2010) [Abstract]
- Specially selected in Virtual Journal of Nanoscale Science & Technology, Vol. 22, Issue 9, p.76 [Link]
37. Tae Jung Park, Sang Yup Lee, Nam Su Heo, and Tae Seok Seo. "In vivo synthesis of diverse metal nanoparticles by recombinant Escherichia coli", Angew. Chem. Int. Ed., 49(39):7019-7024 (2010) [Abstract]
- Specially selected for "Hot Paper" by Editor
- Specially selected for "Highlight" [Nature Asia Materials]
- Specially selected for "Spotlight" [Nanowerk] - "Bacteria as environmentally friendly nanoparticle factories"
[NRF_1] [NRF_2] [HelloDD.com] [hankyung.com] [Newsis] [daejonilbo.com] [etimes] [Financial News] [Geumgang-ilbo] [Daum] [MSN] [Paran] [Unitel]
38. Kyoung G. Lee, Tae Jung Park, Song Young Soo, Kye Won Wang, Byeong IL Kim, Jae Hong Park, Chang-Soo Lee, Do Hyun Kim, and Seok Jae Lee. "Synthesis and utilization of E. coli-encapsulated PEG-based microdroplet using a microfluidic chip for biological application", Biotechnol. Bioeng., 107(4):747-751 (2010) [Abstract]
39. Kyung Min Choi, Seok Jae Lee, Jung Hun Choi, Tae Jung Park, Jong Wan Park, Weon Ho Shin, and Jeung Ku Kang. "Facile fabrication of networked patterns and their superior application to realize the virus immobilized networked pattern circuit", Chem. Commun., 46(45):8609-8611 (2010) [Abstract]
40. Bong Gill Choi, HoSeok Park, Min Ho Yang, Young Mee Jung, Jung Youn Park, Sang Yup Lee, Won Hi Hong, and Tae Jung Park*. "Microwave-assisted synthesis of highly water-soluble graphene towards electrical DNA sensor", Nanoscale, 12(2):2692-2697 (2010) [Abstract]
41. Maesoon Im, Jae-Hyuk Ahn, Jin-Woo Han, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "Development of a point-of-care testing platform with a nanogap-embedded separated double-gate field effect transistor array and its readout system for detection of avian influenza", IEEE Sens. J., 11(2):351-360 (2011) [Abstract]
42. Tae Jung Park, Seok Jae Lee, Jong Pil Park, Min Ho Yang, Jong Hyun Choi, and Sang Yup Lee. "Characterization of a bacterial self-assembly surface layer protein and its application as an electrical nanobiosensor", J. Nanosci. Nanotechnol., 11(1):402-407 (2011) [Abstract]
43. Tae Jung Park, Seung-Kon Lee, Seung Min Yoo, Seung-Man Yang, and Sang Yup Lee. "Development of reflective biosensor using fabrication of functionalized photonic nanocrystals", J. Nanosci. Nanotechnol., 11(1):632-637 (2011) [Abstract]
44. Tae Jung Park, Jong Pil Park, Seok Jae Lee, and Sang Yup Lee. "Quantitative studies of carbohydrate-protein interaction using functionalized bacterial spores in solution and on chips", Biotechnol. Bioproc. Eng., 16(1):190-195 (2011) [Abstract]
45. MinHo Yang, Bong Gill Choi, HoSeok Park, Tae Jung Park*, Won Hi Hong, and Sang Yup Lee. "Directed self-assembly of gold nanoparticles on graphene-ionic liquid hybrid for enhancing electrocatalytic activity", Electroanalysis, 23(4):850-857 (2011) [Abstract]
46. Do-Kyun Kim, Tae Jung Park, Eiichi Tamiya, and Sang Yup Lee. "Label-free detection of leptin antibody-antigen interaction by using LSPR-based optical biosensor", J. Nanosci. Nanotechnol., 11(5):4188-4193 (2011) [Abstract]
47. Tae Jung Park, Jong Pil Park, Seok Jae Lee, Dae-Hwan Jung, Young Koan Ko, Hee-Tae Jung, and Sang Yup Lee. "Alignment of SWNTs by protein-ligand interaction of functionalized magnetic particles under low magnetic fields", J. Nanosci. Nanotechnol., 11(5):4540-4545 (2011) [Abstract]
48. Fei Liu, Ki Seok Choi, Tae Jung Park, Sang Yup Lee, and Tae Seok Seo. "Graphene-based electochemical biosensor for pathogenic virus detection", BioChip J., 5(2):123-128 (2011) [Abstract]
49. MinHo Yang, Bong Gill Choi, Tae Jung Park*, Nam Su Heo, Won Hi Hong, and Sang Yup Lee. "Site-specific immobilization of gold binding polypeptide on gold nanoparticle-coated graphene sheet for biosensor application", Nanoscale, 3(7):2950-2956 (2011) [Abstract]
50. Seong Cheol Hong, Hongxia Chen, Jaewook Lee, Hye-Kyung Park, Young Sik Kim, Hyun-Chul Shin, Cheol-Min Kim, Tae Jung Park, Seok Jae Lee, Kwangnak Koh, Hwa-Jung Kim, Chulhun L. Chang, and Jaebeom Lee. "Ultrasensitive immunosensing of tuberculosis CFP-10 based on SPR spectroscopy", Sensor. Actuat. B-Chem., 156(1):271-275 (2011) [Abstract]
51. Bong Gill Choi, MinHo Yang, Tae Jung Park, Yun Suk Huh, Sang Yup Lee, Won Hi Hong, and HoSeok Park. "Programmable peptide-directed two dimentional arrays of various nanoparticles on graphene sheets", Nanoscale, 3(8):3208-3213 (2011) [Abstract]
52. Do-Kyun Kim, Seung Min Yoo, Tae Jung Park*, Hiroyuki Yoshikawa, Eiichi Tamiya, Jung Youn Park, and Sang Yup Lee. "Plasmonic properties of multispot copper-capped nanoparticle array chip and its application to optical biosensor for pathogen detection of multiplex DNAs", Anal. Chem., 83(16):6215-6222 (2011) [Abstract]
53. Gle Park, Kyung G. Lee, Seok Jae Lee, Tae Jung Park, Rinbok Wi, and Do Hyun Kim. "Synthesis of graphene-gold nanocomposites via sonochemical reduction", J. Nanosci. Nanotechnol., 11(7):6095-6101 (2011) [Abstract]
54. Gle Park, Kyung G. Lee, Seok Jae Lee, Tae Jung Park, Ringbok Wi, Kye Won Wang, and Do Hyun Kim. "Ultrasound-aided formation of gold nanoparticles on multi-walled carbon nanotubes functionalized with mercaptobenzene moieties", J. Nanosci. Nanotechnol., 11(7):6227-6232 (2011) [Abstract]
55. Tae Jung Park, Seok Jae Lee, Jae-Gu Pan, Heung-Chae Jung, Jung Youn Park, Jong Pil Park, and Sang Yup Lee. "DNA capturing machinery through spore-displayed proteins", Lett. Appl. Microbiol., 53(4):445-451 (2011) [Abstract]
56. Sunray Lee, Jihoon Kim, Tae Jung Park, Youngmin Shin, Sang Yup Lee, Yong-Mahn Han, Seongman Kang, and Hyun-Sook Park. "The effects of the physical properties of culture substrates on the growth and differentiation of human embryonic stem cells", Biomaterials, 32(34):8816-8829 (2011) [Abstract]
57. Jae-Hyuk Ahn, Sung-Jin Choi, Jin-Woo Han, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "Investigation of size dependence on sensitivity for nanowire FET biosensors", IEEE Transact. Nanotechnol., 10(6):1405-1411 (2011) [Abstract]
58. Kye Won Wang, Kyoung G. Lee, Tae Jung Park, Young Chul Lee, Ji Won Yang, Do Hyun Kim, and Seok Jae Lee. "Organoclay-assisted interfacial polymerization for microfluidic production of monodisperse peg-microdroplets and in situ encapsulation of E. coli", Biotechnol. Bioeng., 109(1):289-294 (2012) [Abstract]
59. Tae Jung Park, Seok Jae Lee, Do-Kyun Kim, Nam Su Heo, Jung Youn Park, and Sang Yup Lee. "Development of label-free optical diagnosis for sensitive detection of influenza virus with genetically engineered fusion protein", Talanta, 89:246-252 (2012) [Abstract]
60. Jee-Yeon Kim, Jae-Hyuk Ahn, Dong-Il Moon, Sungho Kim, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "A dual-gate field-effect transistor for label-free electrical detection of avian influenza", BioNanoScience, 2(1):35-41 (2012) [Abstract]
61. Jee-Yeon Kim, Jae-Hyuk Ahn, Sung-Jin Choi, Maesoon Im, Sungho Kim, Chang-Hoon Kim, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "An underlap channel-embedded field-effect transistor for biosensor application in watery and dry environment", IEEE Transact. Nanotechnol., 11(2):390-394 (2012) [Abstract]
62. Hongjian Zhoua, Jaewook Lee, Tae Jung Park, Seok Jae Lee, Jung Youn Park, and Jaebeom Lee. "Ultrasensitive DNA monitoring by Au-Fe3O4 nanocomplex", Sensor. Actuat. B-Chem., 163(1):224-232 (2012) [Abstract]
63. Myeong-Lok Seol, Sung-Jin Choi, David J. Baek, Tae Jung Park, Jae-Hyuk Ahn, Sang Yup Lee, and Yang-Kyu Choi. "Nanoforest for practical surface-enhanced raman scattering (SERS) substrate", Nanotechnol., 23(9):095301 (2012) [Abstract]
64. Kwang Suk Yang, Ji Sun Yun, Jin Chul Kim, Jungsun Min, Tae Jung Park, Jeong Keun Ahn, and Do Hyun Kim. "Polydiacetylene single-walled carbon nanotubes nano-hybrid for cellular imaging applications", J. Nanosci. Nanotechnol., 12(1):377-385 (2012) [Abstract]
65. Moon-Keun Lee, Seok Jin Cho, Youngdeok Jo, Haiwon Lee and Tae Jung Park. "Hierarchical gold micro-nanostructures based on three-dimensional networks of carbon nanotubes fabricated by using electrochemical deposition", J. Kor. Phys. Soc., 60(7):1135-1139 (2012)
66. Jae Hwan Jung+, Tae Jung Park+, Sang Yup Lee and Tae Seok Seo. "Homogeneous biogenic paramagnetic nanoparticle synthesis based on a microfluidic droplet generator", Angew. Chem. Int. Ed., 51(23):5634-5637 (2012) +Equally contributed. [Abstract] ("Cover Article")
- Specially selected for "Hot Topic" by Wiley
67. Gle Park, Leian Bartolome, Kyoung G. Lee, Seok Jae Lee, Do Hyun Kim and Tae Jung Park*. "One-step sonochemical synthesis of graphene oxide-manganese oxide nanocomposite for catalytic glycolysis of poly(ethylene terephthalate)", Nanoscale, 4(13):3879-3885 (2012) [Abstract] ("Cover Article")
68. Nam Su Heo, Shun Zheng, MinHo Yang, Seok Jae Lee, Sang Yup Lee, Hwa-Jung Kim, Chang-Soo Lee, and Tae Jung Park*. "Label-free electrochemical diagnosis of viral antigens with genetically engineered fusion protein", Sensors, 12(8):10097-10108 (2012) [Abstract]
69. Byoung Il Kim, Soon Woo Jeong, Kyoung G. Lee, Tae Jung Park, Jung Youn Park, Jae Jun Song, Seok Jae Lee, and Chang-Soo Lee. "Synthesis of bioactive microcapsules using microfluidic device", Sensors, 12(8):10136-10147 (2012) [Abstract]
70. Kyoung G. Lee, Tae Jae Lee, Soon Woo Jeong, Ho Woon Choi, Nam Su Heo, Jung Youn Park, Tae Jung Park*, and Seok Jae Lee*. "Development of plastic-based microfluidic immunosensor chip for detection of H1N1 influenza", Sensors, 12(8):10810-10819 (2012) [Abstract]
71. Jae-Hyuk Ahn, Jee-Yeon Kim, Kyungyong Choi, Dong-Il Kim, Chang-Hoon Kim, Myeong-Lok Seol, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "Nanowire FET biosensors on a bulk silicon substrate", IEEE Transact. Electron. Dev., in press (2012)
72. Kyoung G. Lee, Jongin Hong, Kye Won Wang, Nam Su Heo, Do Hyun Kim, Sang Yup Lee, Seok Jae Lee, and Tae Jung Park*. "In vitro biosynthesis of metal nanoparticles in microdroplets", ACS Nano, in press (2012) [etnews]
73. Byoung-Hwa Kwon, Kyoung G. Lee, Tae Jung Park, Hyunki Kim, Tae Jae Lee, Seok Jae Lee, and Duk Young Jeon. "Continuous in situ synthesis of ZnSe/ZnS core/shell quantum dots in a microfluidic reaction system and its application for light-emitting diodes", Small, in press (2012)
74. Jee-Yeon Kim, Kyungyong Choi, Dong-Il Moon, Jae-Hyuk Ahn, Tae Jung Park, Sang Yup Lee, and Yang-Kyu Choi. "Surface engineering for enhancement of sensitivity in an underlap-FET biosensor by control of wettability", Biosens. Bioelectron., in press (2012)
75. Chang-Hoon Kim, Jae-Hyuk Ahn, Jee-Yeon Kim, Ji-Min Choi, Tae Jung Park, Nam Su Heo, Hee Gu Lee, Jong-Wan Kim, and Yang-Kyu Choi. "CRP detection from serum for chip-based point-of-care testing system", Biosens. Bioelectron., in press (2012)
Domestic Journal Publications
1. Tae Jung Park, and Sang Yup Lee. "A research and application of polyhydroxyalkanoates in biosensor chip", Korean J. Biotechnol. Bioeng., Special issue for 'Biochip and Biosensor', 22(6):371-377 (2007)
2. Do-Kyun Kim, Tae Jung Park, and Sang Yup Lee. "Fabrication of label-free biochips based on localized surface plasmon resonance (LSPR) and its application to biosensors", Korean Soc. Biotechnol. Bioeng. J., 24(1):1-8 (2009)
3. Tae Jung Park, Min Ho Yang, Sang Yup Lee, and Soo Hyun Kim. "Biosensor system for the detection of agrichemicals and its applications", Korean Soc. Biotechnol. Bioeng. J., 24(3):227-238 (2009)
4. Tae Jung Park, and Seok Jae Lee. "Development of biochip by bioengineering technology ", Special Issue, Korean Biochip Soc. News Lett., 6(2):6-8 (2011)
International Proceedings
1. Sang Yup Lee, Seok Jae Lee, Jong Pil Park, and Tae Jung Park. "Novel platform technologies for protein chip development", Proceeding of 1st Annual Symposium of the Korea Society of Microsystem on life Science and Chemistry & 1st Korea-Japan Symposium on Microsystem for Life Science and Chemistry, 67-68 (2003)
2. Jae Shin Lee, Do Hyun Kim, Seok Jae Lee, Jong Pil Park, Tae Jung Park, Sang Yup Lee, Dae-Hwan Jung, Hee-Tae Jung, Jin Hee Kim, and Seong Ku Kwon. "Electrical detection of kinase assay using multi walled-carbon nanotube (MWCNT) nanoelectrode", Micro Total Analysis Systems 2004, 2:124-126 (2004)
3. Kwansuk Yang, Philippe Clementz, Seok Jae Lee, Tae Jung Park, Jong Pil Park, Do Hyun Kim, and Sang Yup Lee. "Microfluidic device for protein concentration and separation using IEF", The 17th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 343-344 (2004)
4. Tae Jung Park, Yeon Jae Kang, Su-Jin Ku, and Sang Yup Lee. "Immobilization of cells displaying recombinant protein onto the gold surface for whole cell biosensor", The Korean Sensors Society, 17(1):130-133 (2006)
5. Seung-Kon Lee, Tae Jung Park, Soyoung Kim, Gi-Ra Yi, Sang Yup Lee, and Seung-Man Yang. "Photonic crystal based centrifugal microfluidic biosensors", Optoelectronic Materials and Devices, 6352:635207-1-635207-9 (2006)
6. Tae Jung Park, Seung Min Yoo, and Sang Yup Lee. "Polyhydroxybutyrate microarray using immobilization of fusion proteins for immunodiagnostics and pathogen detections", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), I0126 (2007)
7. Tae Jung Park, Byung-Seon Kong, Hee-Tae Jung, and Sang Yup Lee. "Label-free electrochemical biosensor in highly conductive carbon nanotube and gold nanocomplexes", Micro Total Analysis Systems 2009, 1:195-197 (2009)
8. Byeong Il Kim, Eun Kyung Yang, Jae Hong Park, Kyung Min Kim, Hee Yeoun Kim, Chi Won Ahn, Seok Jae Lee, Kyung Sik Kim, Tae Jung Park, Moon Il Kim, Hyun Gyu Park, and Chang-Soo Lee. "Microfluidic hybrid method for droplet based cross-linking of enzyme aggregates (CLEA) microencapsulation using peg and its application", Micro Total Analysis Systems 2009, 1:764-766 (2009)
9. Tae Jung Park, Hee Yeoun Kim, Jaebeom Lee, Byeong Il Kim, Jae Hong Park, Kyung Min Kim, Eun Kyung Yang, Chi Won Ahn, Sang Yup Lee, and Seok Jae Lee. "Imprinted microfluidic device for bioinspired detection of avian influenza virus using nanowires and gold nanohybrids", Micro Total Analysis Systems 2009, 1:866-868 (2009)
10. Do-Kyun Kim, Tae Jung Park, Eiichi Tamiya, and Sang Yup Lee. "Label-free optical biosensors based on LSPR properties by using gold-capped nanostructure materials", Micro Total Analysis Systems 2009, 1:989-991 (2009)
11. Tae Jung Park, MinHo Yang, Bong Gill Choi, Nam Su Heo, Seok Jae Lee, Won Hi Hong, and Sang Yup Lee. "Label-free electrochemical biosensor based on graphene/ionic liquid nanocomposite for the detection of organophosphate pesticides", Materials Research Society, 2010 Fall Meeting, (2010)
Invited Essays
1. Tae Jung Park. "Research project introduction", Dept. of Chemical & Biomolecular Engineering CHEMBIO NEWS, 2007 fall, 22-23 (2007)
2. Tae Jung Park, and Sang Yup Lee. "Patterning and Biosensor - in vitro synthetic biotechnology", See-KAIST 2007, Oct 30 - Nov 1 (2007)
Patents Pended
· 33 Applications of International Patent
· 35 Applications of Domestic Patent
· Publicated Patent
1. Kwon, S.J., Choi, S.K., Jung, H.C., Pan, J.G., Chang, J.S., Park, T.J. "Stabilized biocatalysts and methods of bioconversion using the same", PCT patent publication. PCT/KR02/00617 (2002.04.09), WO03/102203 (2003.12.11
2. Lee, S.Y., Park, T.J., Park, J.P., Lee, S.J. "Method for whole surrounding surface display of target proteins using exosporium of Bacillus cereus group", Korean patent appl. KR 10-2003-0064998 (2003.09.19), Registered KR 0518953 (2005.09.27)
3. Lee, S.Y., Jeong, H.T., Lee, S.J., Park, J.P., Park, T.J., Jeong, D.H. "Method for wrapping carbon nanotubes with carbohydrates", Korean patent appl. KR 10-2003-0036532 (2003.06.05), Registered KR 0549105 (2006.01.26)
4. Lee, S.Y., Jung, H.T., Lee, S.J., Park, J.P., Park, T.J., Choi, J.H. "Method for producing a carbon nanotubes wrapped with self-assembly materials", Korean patent appl. KR 10-2003-0084888 (2003.11.27), Registered KR 10-0557338 (2006.02.24)
5. Lee, S.Y., Jeong, H.T., Lee, S.J., Park, J.P., Park, T.J., Jeong, D.H. "Method for carbon nanotubes array using magnetic material" Korean patent appl. KR 10-2004-0032278 (2004.05.07), Registered KR 10-0680132 (2007.02.01)
6. Lee, S.Y., Park, T.J., Park, J.P., Lee, S.J., "Method for whole surrounding surface display of target proteins using bacterial exosporium", PCT patent publication. (2003.09.19) PCT/KR03/02882 (2003.12.30), WO05/028654 (2005. 03.31)
7. Lee, S.Y., Park, T.J., Lee, S.J., Kang, Y.J., Park, J.P., Choi, J.H., Lee, J.H., Yu, K-.S., Lim, I-.S. "Bio-metal chip using metal binding protein and method for fabricating the same", Korean patent appl. KR 10-2005-0104830 (2005.11.03), Registered KR 10-0718207 (2007.05.08), Licensed Out
8. Lee, S.Y., Park, T.J., Heo, N.S. "Method for cell surface displaying of target proteins using Bacillus anthracis exosporium", PCT patent publication. PCT/KR06/05886 (2006.12.29), WO07/078127 (2007.07.12)
9. Lee, S.Y., Park, T.J. "Method for preparing metal nanoparticle using metal binding protein", Korean patent appl. KR 10-2006-0045455 (2006.05.22), Registered KR 10-0755746 (2007.08.30)
10. Lee, S.Y., Jung, H.T., Lee, S.J., Park, J.P., Park, T.J., Choi, J.H. "Method for preparing a water-soluble carbon nanotube wrapped with self-assembly materials", Chinese patent appl. CN 1356260 A (2004.08.19), Registered ZL 200410064123.8 (2007.04.18)
11. Kwon, S.J., Choi, S.K., Jung, H.C., Pan, J.G., Chang, J.S., Park, T.J. "Stabilized biocatalysts and methods of bioconversion using the same", Korean patent appl. KR 10-2004-7016115 (2004.10.08), Registered KR 10-0758209 (2007.09.12)
12. Lee, S.Y., Park, T.J. "Method for preparing metal nanoparticle using metal binding protein", PCT patent publication. WO 2007/136174 (2007.11.29)
13. Lee, S.Y., Park, T.J., Heo, N.S. "Method for cell surface displaying of target proteins using Bacillus anthracis exosporium", Korean patent appl. KR 10-2006-0000187 (2006.01.02), Registered KR 10-0784261 (2007.12.04)
14. Lee, S.Y., Park, T.J., "Peptides specifically binding to Bacillus anthracis spore and method for detecting or separating using thereof", Korean patent appl. KR 10-2007-0077190 (2007.07.31), Registered KR 10-0898624 (2009.05.13)
15. Hong, W.H., Lee, S.Y., Kim, D.H., Hong, Y.K., Huh, Y.S., Park, T.J., Yang, K.S., Lee, E.Z., "A micro-mixing device of samples and a lab-on-a-chip comprising said device", Korean patent appl. KR 10-2007-0062941 (2007.06.26), Registered KR 10-0901467 (2009.06.01)
16. Hong, W.H., Lee, S.Y., Kim, D.H., Hong, Y.K., Huh, Y.S., Park, T.J., Yang, K.S., Lee, E.Z., "A microelectro-desalting device of protein sample, a lab-on-a-chip comprising said device and an application method thereof", Korean patent appl. KR 10-2007-0062935 (2007.06.26), Registered KR 10-0924514 (2009.10.26)
17. Lee, S.Y., Jung, H.T., Lee, S.J., Park, J.P., Park, T.J., Choi, J.H. "Method for producing a carbon nanotubes wrapped with self-assembly materials", Japanese patent appl. JP 2004-226211 (2004.08.02), Registered JP 4024785 (2010.03.15)
18. Lee, S.Y., Park, T.J., Zheng, S., "Recombinant vector containing ptsL promoter and method for producing exogeneous protein using the same", Korean patent appl. KR 10-2007-0082686 (2007.08.17), Registered KR 10-0963302 (2010.06.04)
19. Ko, S., Park, T.J., Cho, Y.J., "Recombinant fusion protein, Biosensor using the same, and Immuno-detecting method for target material with the same", Korean patent appl. KR 10-2007-0124593 (2007.12.03), Registered KR 10-0965480 (2010.06.15)
20. Lee, S.Y., Park, T.J., Choi, Y.-K., Gu, B., Ahn, J.-H., "Bio-silica chip using silica binding protein and method for fabricating the same", Korean patent appl. KR 10-2008-0026803 (2008.03.24), Registered KR 10-0979282 (2010.08.25)
21. Lee, S.Y., Park, T.J., Kim, D.-K., "Metal-capped porous anodic aluminum biochip and method for preparing thereof", Korean patent appl. KR 10-2009-0059184 (2009.06.30), Registered KR 10-1029115 (2011.04.06)
22. Lee, S.Y., Yoo, S.Y., Kim, D.-K., Park, T.J., Yoon, J.K., Lee, J., "Multi-spot metal-capped nanostructure array nucleic acid chip for diagnosis of corneal dystrophy and preparing method thereof", Korean patent appl. KR 10-2009-0076300 (2009.08.18), Registered KR 10-1039282 (2011.05.02)
23. Lee, S.Y., Park, T.J., Park, J.P., Lee, S.J., "Method for whole surrounding surface display of target proteins using exosporium of Bacillus cereus group", US patent appl. US 10/572224 (2007.04.18) Registered US 8030064 B2 (2011.10.04)
24. Lee, S.Y., Kim, D.-K., Park, T.J., Yoo, S.M., "Copper-capped nanoparticle array biochip based on LSPR optical properties and use thereof", KR patent appl. KR 10-2009-0099702 (2009.10.20) Registered KR 10-1093203 (2011.12.06)
25. Lee, S.Y., Park, T.J., "Method for preparing metal nanoparticle using metal binding protein", India patent appl. 6384/DHENP/2008 (2007.04.17) Registered IN 249926 (2011.11.23)
26. Lee, S.Y., Park, T.J., Lee, H.J., Lee, S.J., "Biochip with metal-protein grating pattern and method for preparing thereof", KR patent appl. KR 10-2008-0066987 (2008.07.10) Registered KR 10-1102454 (2011.12.28)
27. Lee, S.Y., Park, T.J., Heo, N.S., "Organophosphorus hydrolase variants and method for preparing the same", KR patent appl. KR 10-2009-0047553 (2009.05.29) Registered KR 10-1103022 (2011.12.29), Licensed Out
Oral Presentations (Seminar, Workshop, Invited Lecture)
1. Tae Jung Park, Seok Jae Lee, Jong Pil Park, and Sang Yup Lee. "Selective immobilization and diagnosis protein chips on PHB-based microarray using extracellular depolymerase substrate binding domain for site-directed capturing ligand to detect protein-protein and antigen-antibody interaction", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, Oct 22-24 (2003)
2. Tae Jung Park, Seok Jae Lee, Jong Pil Park, and Sang Yup Lee. "Development of biosensor using nanobiotechnology", 6th workshop of Center for Ultramicrochemical Process Systems, Hoengseong, Korea, Aug 19 (2004)
3. Tae Jung Park, Jong Hyun Choi, and Sang Yup Lee. "Development of biosensor using nanobiotechnology: Novel platform technologies for protein chip development", 8th workshop of Center for Ultramicrochemical Process Systems, Cheonan, Korea, Aug 22-23 (2005)
4. Tae Jung Park, and Sang Yup Lee. "Development of biosensor using nanobiotechnology: Novel platform technologies for protein chip development", 9th workshop of Center for Ultramicrochemical Process Systems, Seoul, Korea, Jan 16 (2006)
5. Tae Jung Park, and Sang Yup Lee. "Development of biosensor using nanobiotechnology: Novel platform technologies for patho-diagnosis", 10th workshop of Center for Ultramicrochemical Process Systems, Chungju, Korea, Aug 18-19 (2006)
6. Tae Jung Park, Yeon Jae Kang, Su-Jin Ku, and Sang Yup Lee. "Immobilization of cells displaying recombinant protein onto the gold surface for whole cell biosensor", Korea Sensors Conference 2006, Seoul, Korea, Nov 10-11 (2006)
7. Tae Jung Park, Jong Hyun Choi, Hee-Tae Jung, and Sang Yup Lee. "Method for preparing a water-soluble carbon nanotube wrapped with self-assembly materials", 2006 Patent Circulation Festival, Seoul, Korea, Nov 21-23 (2006)
8. Tae Jung Park, and Sang Yup Lee. "Development of biosensor using nanobiotechnology: Protein nanopatterns and biosensors using gold binding polypeptide", 11th workshop of Center for Ultramicrochemical Process Systems, Seoul, Korea, Jan 29 (2007)
9. Tae Jung Park, and Sang Yup Lee. "Novel platform technologies for nanobiosensor", 1st workshop of Fusion Pioneer project, Daejeon, Korea, Jan 30 (2007)
10. Tae Jung Park, and Sang Yup Lee. "Platform technologies for nanobiosensor", 1st workshop of IT Fusion Sensor project, Muju, Korea, Apr 13 (2007)
11. Tae Jung Park, and Sang Yup Lee. "High-throughput detection against Anthrax using peptide conjugated magnetic beads", A joint symposium of 6th US-Korea workshop on nanostructured materials & 4th US-Korea workshop on nanoelectronics, Seoul, Korea, Jun 4-5 (2007)
12. Tae Jung Park. "Polyhydroxyalkanoate-based biosensors: applications to immunodiagnostics and pathogen detections", Invited seminar at Korea Basic Science Institute (KBSI), Daejeon, Korea, Jun 21 (2007)
13. Tae Jung Park, Yun Suk Huh, Won Hi Hong, and Sang Yup Lee. "Development of biosensor using nanobiotechnology: Development of active micro-mixer and fully integrated microfluidic system for the detection of infectios viral disease", 12th workshop of Center for Ultramicrochemical Process Systems, Seoul, Korea, Aug 20 (2007)
14. Tae Jung Park. " DNA chip and its applications" Special invited lecture at Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea, Oct 8 (2007)
15. Tae Jung Park, and Sang Yup Lee. "Novel platform technologies for biosensor", 13th workshop of Center for Ultramicrochemical Process Systems, Seoul, Korea, Jan 31 (2008)
16. Tae Jung Park. "Nanobio-fabrications and biosensors based on protein engineering", Invited lecture at Catholic University, Bucheon, Korea, Oct 28 (2008)
17. Tae Jung Park. "Bio-nano/micro platform technology for biosensors", Invited seminar of IT Fusion Sensor project, Daejeon, Korea, Dec 17 (2008)
18. Tae Jung Park, and Sang Yup Lee. "Novel platform technologies for biosensor", 15th workshop of Center for Ultramicrochemical Process Systems, Seoul, Korea, Jan 16 (2009)
19. Tae Jung Park. "Nanobio-platform technologies and biosensors based on protein engineering", Invited seminar at National Nanofab Center (NNFC), Daejeon, Korea, Jul 16 (2009)
20. Tae Jung Park, and Sang Yup Lee. "Development of portable biochemical sensor for the detection of residual agrichemicals", IT-fusion technology workshop of ITSA, Daejeon, Korea, Sep 8 (2009)
21. Tae Jung Park. "Nanobio-platform technologies and biosensors", Invited seminar at Chungnam National University, Daejeon, Korea, Sep 17 (2009)
22. Tae Jung Park, and Sang Yup Lee. "Diagnosis enabled by nanobiotechnology", 1st Joint Workshop of KAIST Nano-Bio WCU, Songli Mountain, Korea, Sep 24 (2009)
23. Tae Jung Park, and Sang Yup Lee. "Development of the advanced electrochemical biosensor for organophosphate chemicals using carbon materials", 16th workshop of Center for Ultramicrochemical Process Systems, Seoul, Korea, Sep 25 (2009)
24. Tae Jung Park. "Fabrication of the carbon-based materials using nanobio-platform technologies and bioengineering", Invited seminar at National Nanofab Center (NNFC), Daejeon, Korea, Oct 22 (2009)
25. Tae Jung Park. "Nanobio-platform technologies based on protein engineering", Invited seminar at Korea Institute of Science and Technology (KIST), Seoul, Korea, Oct 29 (2009)
26. Tae Jung Park. "Nanobio-platform technologies and biosensors based on protein engineering", Invited seminar at Kyoungwon University, Seongnam, Korea, Nov 23 (2009)
27. Tae Jung Park. "Nanobio-platform technologies and biosensors based on protein engineering", Invited seminar at Department of Electrical Engineering, KAIST, Daejeon, Korea, Jan 19 (2010)
28. Tae Jung Park, and Sang Yup Lee. "Novel platform technologies for biosensor", 17th workshop of Center for Ultramicrochemical Process Systems, Jeju, Korea, Jan 29 (2010)
29. Tae Jung Park. "Agrichemical detection sensor system", Workshop for Promising Business Models using IT-based Convergence Technology from the Ministry of Knowledge Economy through ETRI, Seoul, Korea, Feb 11 (2010)
30. Tae Jung Park. "Electrical biosensor using field-effect transistor, functional electrode with nanocomposite and metal-patterned electrode", Invited seminar at National Nanofab Center (NNFC), Daejeon, Korea, April 27 (2010)
31. Tae Jung Park. "Nanobio-platform technologies and biosensors based on protein engineering", Invited seminar at Korean Research Institute of Standards and Science (KRISS), Daejeon, Korea, Jun 11 (2010)
32. Tae Jung Park. "Label-free diagnosis of infectious viral diseases with genetically engineered fusion proteins", Invited seminar at Korea Institute of Science and Technology (KIST), Seoul, Korea, Jun 22 (2010)
33. Tae Jung Park. "Trends in Biosensors and Biochips", Invited lecture at National Nanofab Center (NNFC), Daejeon, Korea, Jan 20 (2011)
34. Tae Jung Park. "Mass formation of metal nanoparticles by biogenic components in microfluidic droplets", 2011 MMB (Microtechnologies in Medicine and Biology) Conference, Lucerne, Switzerland, May 4-6 (2011)
35. Tae Jung Park. "Diagnostics of infectious viral diseases with genetically engineered fusion proteins", Invited session at 2011 International Symposium & Annual Meeting of the Korean Society for Microbiology and Biotechnology (KSMB) "Translational Research in Microbiology and Biotechnology", Kyungju, Korea, Jun 22 (2011)
36. Tae Jung Park. "Biosynthesis of metal nanoparticles based on bio-engineering", Invited session at 2011 WCU Workshop in China, Weihai, China, Jul 15-17 (2011)
37. Tae Jung Park and Nam Su Heo. "Plasma generation system based on high-pressure gas for antimicrobial treatment", Invited session at 2011 Microwave & Radio Wave Conference, Jeongseon, Kangwon-Do, Korea, Sep 23 (2011)
38. Tae Jung Park. "Nanobio-platform technologies and biosensors based on protein engineering", Invited seminar at Korea Institute of Science and Technology (KIST), Seoul, Korea, Nov 23 (2011)
39. Tae Jung Park. "Nanobio-technologies based on bio-engineering", Invited seminar at Kangwon National University, Korea, Feb 24 (2012)
40. Tae Jung Park. "Plasma generation for sterilization of microorganisms", Invited seminar at LG Electronics, Changwon, Korea, May 29 (2012)
41. Tae Jung Park. "Nanobio-technologies based on bio-engineering", Invited seminar at Chungang University, Korea, Jun 14 (2012)
International Conferences
1. Suk-Joon Kwon, Tae-Jung Park, Heung-Chae Chung, Soo-Keun Choi and Jae-Gu Pan. "Microbial spore-displayed enzymes for rugged biocatalysis", International Symposium on the Genetics of the Industrial Microorganisms, Gyeongju, Korea, Jul 1-5 (2002)
2. Seok Jae Lee, Jong Pil Park, Tae Jung Park, and Sang Yup Lee. "Selective immobilization of proteins on PHB-based microarray using extracellular depolymerase substrate binding domain for studying protein-protein interaction", BioChE-03. Biochemical Engineering (XIII) Conference, Boulder, CO, USA, Jul 17-23 (2003)
3. Jongpil P. Park, Seok Jae Lee, Tae Jung Park, Kyung-bok Lee, Insung S Choi, and Sang Yup Lee. "Patterning of poly(3-hydroxybutyrate) for site-selective protein immobilization and studying protein-protein interaction", The 2nd KAIST International Symposium on Frontier Issues in NBI Technologies, KAIST, Daejeon, Korea, Oct 29-30 (2003)
4. Seok Jae Lee, Jongpil P. Park, Tae Jung Park, Kyung-bok Lee, Insung S Choi, and Sang Yup Lee. "Patterning of proteins by microcontact printing", The 2nd KAIST International Symposium on Frontier Issues in NBI Technologies, KAIST, Daejeon, Korea, Oct 29-30 (2003)
5. Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee. "The structural basis for catalysis and specificity of the substrate binding domain of PHB depolymerase from bacteria", Enzyme Engineering XVII, Santa Fe, NM, USA, Nov 9-14 (2003)
6. Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee. "Bead-based system for studying protein-protein interactions using PHB microsphere with substrate binding domain", Enzyme Engineering XVII, Santa Fe, NM, USA, Nov 9-14 ( 2003)
7. Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee. "Microbial polyamide production by recombinant Escherichia coli", Enzyme Engineering XVII, Santa Fe, NM, USA, Nov 9-14 (2003)
8. Taejung P. Park, Jongpil P. Park, Seokjae J. Lee, Kyung-Bok Lee, Insung S. Choi, and Sang Yup Lee. "Patterning of polyhydroxyalkanoates for selective protein immobilization and studying protein-protein interaction", 227th ACS National Meeting, Anaheim, CA, USA, Mar 28 - Apr 1 (2004)
9. Seokjae J. Lee, Jongpil P. Park, Taejung P. Park, and Sang Yup Lee. "Peptide arrays improved by the protein layer for protein kinase assay", 227th ACS National Meeting, Anaheim, CA, USA, Mar 28 - Apr 1 (2004)
10. Jongpil P. Park, Taejung P. Park, Seokjae J. Lee, and Sang Yup Lee. "Self-assembly of functional bacterial surface protein around carbon nanotube and its use in nanostructure fabrication", 227th ACS National Meeting, Anaheim, CA, USA, Mar 28 - Apr 1 (2004)
11. Seok Jae Lee, Jong Pil Park, Tae Jung Park, Kyung-Bok Lee, Insung S. Choi, Sang Yup Lee. "Microcontact printing of biotin for selective immobilization of streptavidin-fused proteins and its application for biosensor using SPR analysis", Biosensors 2004, Granada, Spain, May 24-26 (2004)
12. Jong Pil Park, Seok Jae Lee, Tae Jung Park, Seung Min Yoo, Doheon Lee, Sang Yup Lee. "Systematic detection of pathogenic bacteria using carbohydrate-encapsulated quantum dot", Biosensors 2004, Granada, Spain, May 24-26 (2004)
13. Mee-Jung Han, Si Jae Park, Tae Jung Park, Dong-Yup Lee, and Sang Yup Lee. "Importance of small heat shock proteins in engineering recombinant protein production as revealed by proteome profiling", 12th Inteligent Systems for Molecular Biology, Scotland, UK, Jul 31 - Aug 4 (2004)
14. Tae Jung Park, Seok Jae Lee, Jong Pil Park, and Sang Yup Lee. "Protease deficient Bacillus thuringiensis strain for industrial production of recombinant proteins", Metabolic Engineering V: Genome to Product, Lake Tohoe, CA, USA, Sep 19-23 (2004)
15. Jong Pil Park, Mee Jung Han, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee. "Metabolic engineering of Escherichia coli for the production of polyamide", Metabolic Engineering V: Genome to Product, Lake Tohoe, CA, USA, Sep 19-23 (2004)
16. Mee Jung Han, Si Jae Park, Tae Jung Park, and Sang Yup Lee. "Essential roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli", Metabolic Engineering V: Genome to Product, Lake Tohoe, CA, USA, Sep 19-23 (2004)
17. Tae Jung Park, Jong Pil Park, Seok Jae Lee, Kyung-Bok Lee, Insung S. Choi, Min-Gon Kim, Bong Hyun Chung, and Sang Yup Lee. "Patterning of proteins by microcontact printing", The 2nd International Symposium on Nanomanufacturing, KAIST, Daejeon, Korea, Nov 3-5 (2004)
18. Jae Shin Lee, Do Hyun Kim, Seok Jae Lee, Jong Pil Park, Tae Jung Park, Sang Yup Lee, Dae-Hwan Jung, Hee-Tae Jung, Jin Hee Kim, and Sung Ku Kwon. "Electrical detection of biosensor using MWCNT nanoelectrode", The 2nd International Symposium on Nanomanufacturing, KAIST, Daejeon, Korea, Nov 3-5 (2004)
19. Kwansuk Yang, Philippe Clementz, Seok Hwan Hong, Tae Jung Park, Jong Pil Park, Seok Jae Lee, Do Hyun Kim, and Sang Yup Lee. "Dynamic concentration of fluorescent protein by isoelectric focusing in microfluidic channel", The 17th Symposium on Chemical Engineering DaeJeon-Chungnam (Korea) - Kyushu (Japan), Kagoshima, Japan, Dec 4-5 (2004)
20. Sang Yup Lee, Meehee Kim, Min Hae Choi, Tae Jung Park, Seok Jae Lee, and Jong Pil Park. "Immunoassays using polyhydroxyalkanoates microbeads", The 1st International Symposium of Research Center for Environment Friendly Polymers (IS-RCEFP-I), Kwansei Gakuin University, Nishinomiya, Japan, Oct 24-25 (2005)
21. Seung-Kon Lee, Tae Jung Park, Soyoung Kim, Gi-Ra Yi, Sang Yup Lee, and Seung-Man Yang. "High-speed fabrication of patterned colloidal photonic structures in centrifugal microfluidic chips", SPIE Optics and Photonics in San Diego, USA, Aug 13-17 (2006)
22. Seung-Kon Lee, Tae Jung Park, Soyoung Kim, Gi-Ra Yi, Sang Yup Lee, and Seung-Man Yang. "Photonic crystal based centrifugal microfluidic biosensors", SPIE Asia Pacific Optical Communications, Gwang-ju, Korea, Sep 3-7 (2006)
23. Tae Jung Park, Nam Su Heo, Jong Pil Park, Jong Hyun Choi, and Sang Yup Lee. "Production of cyanophycin in metabolic engineered Escherichia coli", Metabolic Engineering VI : From recDNA towards Engineering Biological Systems, NH Leeuwenhorst, Noordwijkerhout, Netherlands, Oct 1-5 (2006)
24. Tae Jung Park, Yun Suk Huh, Won Hi Hong, and Sang Yup Lee. "Active micro-mixer for selective protein immobilization and studying electrobiochemical sensors", 233th ACS National Meeting, Chicago, IL, USA, Mar 25-29 (2007)
25. Yun Suk Huh, Tae Jung Park, Eun Zoo Lee, Sang Yup Lee, and Won Hi Hong. "Electric field analysis using the protein preparation process in microfluidic device", 2007 International Scanning Probe Microscopy (ISPM) Conference, Jeju, Korea, Jun 10-14 (2007)
26. Tae Jung Park, Yun Suk Huh, Sang Yup Lee, and Won Hi Hong. "SPR sensor by the immobilization of recombinant proteins onto the gold surface", Biochemical Engineering XV, Quebec City, Canada, Jul 15-19 (2007)
27. Tae Jung Park, Jong Pil Park, Seong Ho Yang, Dae-Hwan Jung, Jeung Ku Kang, Hee-Tae Jung, and Sang Yup Lee. "Alignment of single-walled nanotubes by biological interaction of functionalized magnetic particles using low magnetic fields", Frontiers in the Convergence of Bioscience and Information Technologies 2007, Ramada Plaza Jeju, Jeju-do, Korea, Oct 11-13 (2007)
28. Tae Jung Park, Seung Min Yoo, and Sang Yup Lee. "Polyhydroxybutyrate microarray using immobilization of fusion proteins for immunodiagnostics and pathogen detections", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei International Convention Center, Taiwan, Nov 4-7 (2007)
29. Ho Seok Park, Tae Jung Park, Shun Zheng, Byung Gil Choi, Won Hi Hong, and Sang Yup Lee. "Synthesis of organophosphorus hydrolase immobilized gamma-alumina nanoparticles for enzymatic reaction", 22nd International Liquid Crystal Conference, Jeju, Jun 29 - Jul 4 (2008)
30. Ho Seok Park, Tae Jung Park, Shun Zheng, Byung Gil Choi, Won Hi Hong, and Sang Yup Lee. "Immobilization of organophosphorus hydrolase on carbon nanotube/ionic liquid bucky gel electrode for biosensor", 22nd International Liquid Crystal Conference, Jeju, Jun 29 - Jul 4 (2008)
31. Tae Jung Park, Seung-Kon Lee, Seung. Min Yoo, Gi-Ra Yi, Seung-Man Yang, and Sang Yup Lee. "Fabrication for the photonic-fluidic biosensor using functionalized photonic nanocrystals", 22nd International Liquid Crystal Conference, Jeju, Jun 29 - Jul 4 (2008)
32. Shun Zheng, Tae Jung Park, Seok Jae Lee, Won Min Park, Won Hi Hong, and Sang Yup Lee. "Ultrasensitive detection of C-reactive protein using colloidal gold nanoparticles", 22nd International Liquid Crystal Conference, Jeju, Jun 29 - Jul 4 (2008)
33. Kwang Seok Yang, P. Clementz, Tae Jung Park, Seok Jae Lee, Jong Pil Park, and Do Hyun Kim. "Free-flow isoelectric focusing microfluidic device with glass coating by sol-gel methods" Nano Korea 2008, Goyang, Aug 27-29 (2008)
34. Do-Kyun Kim, Shun Zheng, Tae-Jung Park, and Sang-Yup Lee. "Analysis of optical properties on surface of nano-plasmonics materials for application to biochip", Biotronics 2008, Jeju, Oct 8 (2008)
35. Tae Jung Park, Seok Jae Lee, Do-Kyun Kim, and Sang Yup Lee. "Real time monitoring for the detection of avian influenza virus on the optical biosensor chips", Biotronics 2008, Jeju, Oct 8 (2008)
36. Tae Jung Park, Sungho Ko, Moon Seop Hyun, and Sang Yup Lee. "SPR sensor chip for the detection of severe acute respiratory syndrome using real time molecular interaction", Synthetic Biology 4.0, Hong Kong, Oct 10-12 (2008)
37. Do-Kyun Kim, Shun Zheng, Hee-Yon Kim, Tae-Jung Park, Eiichi Tamiya, and Sang-Yup Lee. "Fabrication of gold-capped nanoparticle array chip and application to label-free optical biosensors", NanoBio-Seoul 2008, Seoul, Oct 30-31 (2008)
38. Tae Jung Park, Do-Kyun Kim, Seok Jae Lee, and Sang Yup Lee. "Optical monitoring for the detection of avian influenza virus", NanoBio-Seoul 2008, Seoul, Oct 30-31 (2008)
39. Byung Il Kim, Seok Jae Lee, Kyung Min Kim, Chi-Won Ahn, Wook Jung Hwang, Chang-Hyung Choi, Chang-Soo Lee, and Tae Jung Park. "Microfluidic synthesis of micro core-shell and its application for bioreactor of spore germination", NanoBio-Seoul 2008, Seoul, Oct 30-31 (2008)
40. Seok Jae Lee, Byung Il Kim, Kyung Min Kim, Wook-Jung Hwang, Chang-Hyung Choi, Tae Jung Park, Chang-Soo Lee, and Chi Won Ahn. "Microfluidic device of cyclic-olefin-copolymer for the synthesis of bioactive core-shell microcapsules", 2008 International Conference on Nano Science and Nano Technology, Gwangju, Nov 6-7 (2008)
41. Tae Jung Park, Jong Pil Park, Seok Jae Lee, Dae-Hwan Jung, Hee-Tae Jung, and Sang Yup Lee. "Alignment of SWNTs by protein-ligand interaction on functionalized magnetic particles under low magnetic fields", The 20th International Conference on Molecular Electronics & Devices, Seoul, May 22-23 (2009)
42. Do-Kyun Kim, Tae Jung Park, Eiichi Tamiya, and Sang Yup Lee. "Label-free detection of leptin antibody-antigen interaction by using LSPR-based optical biosensor", The 20th International Conference on Molecular Electronics & Devices, Seoul, May 22-23 (2009)
43. Tae Jung Park, HoSeok Park, Yun Suk Huh, Won Hi Hong, and Sang Yup Lee. "Nanocomplexes based on carbon nanotubes and genetically engineered gold-binding polypeptides for electrochemical biosensor", BioChemical Engineering XVI, Burlington, Vermont, USA, Jul 5-9 (2009)
44. Tae Jung Park, Do-Kyun Kim, Heeyon Kim, Seok Jae Lee, and Sang Yup Lee. "Label-free optical biosensors for food safety using multi-spot nanoparticle array chip and genetically engineered fusion proteins", ACS National Meeting, Washington, DC, USA, Aug 16-20 (2009)
45. Tae Jung Park, HoSeok Park, Yun Suk Huh, Bong Gil Choi, Won Hi Hong, and Sang Yup Lee. "Label-free electrochemical biosensor using nanocomplexes by carbon nanotubes and genetically engineered fusion proteins", ACS National Meeting, Washington, DC, USA, Aug 16-20 (2009)
46. Sang Yup Lee, Tae Jung Park, and Seung Min Yoo. "Polyhydroxybutyrate microarray for immunodiagnostics and pathogen detections by immobilizing fusion proteins", 14th European Congress on Biotechnology, Barcelona, Spain, Sep 13-16 (2009)
47. Tae Jung Park, Byung-Seon Kong, Hee-Tae Jung, and Sang Yup Lee. "Label-free electrochemical biosensor in highly conductive carbon nanotube and gold nanocomplexes", Micro Total Analysis Systems 2009, Jeju, Korea, Nov 1-5 (2009)
48. Do-Kyun Kim, Tae Jung Park, Eiichi Tamiya, and Sang Yup Lee. "Label-free optical biosensors based on LSPR properties by using gold-capped nanostructure materials", Micro Total Analysis Systems 2009, Jeju, Korea, Nov 1-5 (2009)
49. Byeong Il Kim, Eun Kyung Yang, Jae Hong Park, Kyung Min Kim, Hee Yeoun Kim, Chi Won Ahn, Seok Jae Lee, Kyung Sik Kim, Tae Jung Park, Moon Il Kim, Hyun Gyu Park, and Chang-Soo Lee. "Microfluidic hybrid method for droplet based cross-linking of enzyme aggregates (CLEA) microencapsulation using peg and its application", Micro Total Analysis Systems 2009, Jeju, Korea, Nov 1-5 (2009)
50. Tae Jung Park, Hee Yeoun Kim, Jaebeom Lee, Byeong Il Kim, Jae Hong Park, Kyung Min Kim, Eun Kyung Yang, Chi Won Ahn, Sang Yup Lee, and Seok Jae Lee. "Imprinted microfluidic device for bioinspired detection of avian influenza virus using nanowires and gold nanohybrids", Micro Total Analysis Systems 2009, Jeju, Korea, Nov 1-5 (2009)
51. Sang Yup Lee, Tae Jung Park, Do-Kyun Kim, Heeyon Kim, Nam Su Heo, Young Mi Sim, and Seok Jae Lee. "Label-free optical biosensors for the detection of food toxin and pathogen using multi-spot nanoparticle array chip and fusion proteins", Asia Pacific Biochemical Engineering Conference (APBioChEC'09), Kobe, Japan, Nov 24-28 (2009), J. Bios. Bioeng., 108(1):S159 (2009) [Link]
52. Tae Jung Park, Nam Su Heo, Byung-Seon Kong, Young Mi Sim, Hee-Tae Jung, and Sang Yup Lee. "Label-free electrochemical biosensor in highly conductive carbon nanotube and gold nanocomplexes", Asia Pacific Biochemical Engineering Conference (APBioChEC'09), Kobe, Japan, Nov 24-28 (2009)
53. Yu-Sin Jang, Min Ho Yang, Bong Gil Choi, Tae Jung Park, Won Hi Hong, and Sang Yup Lee. "Functionalization of graphene oxide using ionic liquids for glucose biosensing", International Conference on Cellular and Molecular Bioengineering 2 (ICCMB2), Singapore, Aug 2-4 (2010)
54. Tae Jung Park, Min Ho Yang, Bong Gil Choi, Nam Su Heo, Seok Jae Lee, Won Hi Hong, and Sang Yup Lee. "Label-free electochemical biosensor based on graphene/ionic liquid nanocomposite for the detection of organophosphate pesticides", 2010 MRS (Materials Research Society) Fall Meeting, Boston, Massachusetts, Nov 29-Dec 3 (2010)
55. Sangyong Lee, Seungjun Kim, Tae Jung Park, and Keonjae Lee. "Highly sensitive plastic based FET biosensors", 2010 MRS (Materials Research Society) Fall Meeting, Boston, Massachusetts, Nov 29-Dec 3 (2010)
56. Kyoung G. Lee, Rinbok Wi, Tae Jung Park, Jae Beom Lee, Seok Jae Lee, and Do Hyun Kim. "Study of synthesis of gold-deposited fluorescent silica nanoparticles for biosensor application", 2010 MRS (Materials Research Society) Fall Meeting, Boston, Massachusetts, Nov 29-Dec 3 (2010)
57. Kyoung G. Lee, Jong In Hong, Kyeon Won Wang, Tae Jung Park, Do Hyun Kim, Sang Yup Lee, and Seok Jae Lee. "Artificial cells for mass production of metal nanoparticles using the combination of cell extracts and droplets in microfluidic device", 2011 MRS (Materials Research Society) Spring Meeting, San Francisco, CA, Apr 25-29 (2011)
58. Tae Jung Park, Kyoung G. Lee, Tae Jae Lee, Do Hyun Kim, Sang Yup Lee, and Seok Jae Lee. "Mass formation of metal nanoparticles by biogenic components in microfluidic droplets", 2011 MMB (Microtechnologies in Medicine and Biology) Conference, Lucerne, Switzerland, May 4-6 (2011)
59. Kyoung G. Lee, Tae Jung Park, Tae Jae Lee, and Seok Jae Lee. "Synthesis of Bacillus spore encapsulated microdroplet using a microfluidic chip for biological application", 2011 MMB (Microtechnologies in Medicine and Biology) Conference, Lucerne, Switzerland, May 4-6 (2011)
60. Kyoung G. Lee, Tae Jung Park, Seok Jae Lee, and Do Hyun Kim. "Artificial biofactory for mass production of metal nanoparticles using the combination of cell extracts and droplets in a microfluidic device", The 6th Korean-Australian Rheology Conference 2011, Daejeonu, Korea, Sep 25-27 (2011)
61. Byeong Il Kim, Kyoung G. Lee, Tae Jae Lee, Gle Park, Tae Jung Park, and Seok Jae Lee. "Microfluidic device for the synthesis of bioactive core-shell microcapsules", IEEE NMDC 2011 IEEE Nanotechnology Materials and Devices Conference, Jeju, Korea, Oct 18-21 (2011)
62. Tae Jung Park, Kyoung G. Lee, Tae Jae Lee, Byeong Il Kim, nd Seok Jae Lee. "Imprinted microfluidics for detecting influenza virus using nanowires and gold nanohybrids", The 10th International Conference on NNT 2011, Jeju, Korea, Oct 19-21 (2011)
63. Tae Jung Park, Sunray Lee, Jong Pil Park, Seok Jae Lee, and Hyun-Sook Park. "Characterization of enhancing the self-renewal of human embryonic stem cells by using porous membranes with a defined pore density", 11th US-Japan Symposium on Drug Delivery Systems, Maui, Hawaii, USA, Dec 16-20 (2011)
Domestic Conferences
1. Taejung Park, Ho-Myeung Ryu, Min-Young Kim, and Jeong-Yoon Kim. "Enhancement of secreted human tissue inhibitor of metalloProteinase-2 production in the recombinant yeast Yarrowia lipolytica by using fed-batch fermentation", Annual Meeting of the Korean Society for Microbiology and Biotechnology, Seoul, Apr 23-24 (1999)
2. Heung-Chae Chung, Han-Seung Lee, Eui-Joong Kim, Jae-Seung Yang, Tae-Jung Park, Jun-Sung Chang, Kuk-Ki Hong, and Jae-Gu Pan. "Directed protein evolution for desired biological functions", Annual Meeting of the Korean Society for Molecular and Cellular Biology (KSMCB), Seoul, Oct 17-18 (2002)
3. Eui-Joong Kim, Heung-Chae Chung, Soo-Keun Choi, Han-Seung Lee, Tae-Jung Park, Jae-Seung Yang, Jun-Sung Chang, Kuk-Ki Hong, and Jae-Gu Pan. "Microbial display technologies as the multi-purpose platform for vaccine, protein engineering, and high-throughput screening", 14th Annual Meeting of the Korean Society for Molecular and Cellular Biology (KSMCB), Seoul, Oct 17-18 (2002)
4. Jong Pil Park, Seok Jae Lee, Tae Jung Park, and Sang Yup Lee. "Visual detection of specific protein-protein interaction using PHB microsphere of substrate binding domain from Alcaligenes faecalis", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Oct 22-24 (2003)
5. Tae Jung Park, Jong Pil Park, Seok Jae Lee, and Sang Yup Lee. "Recombinant protein secretion in Escherichia coli using several leader peptides", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Oct 22-24 (2003)
6. Seok Jae Lee, Jong Pil Park, Tae Jung Park, Kyung-Bok Lee, Insung S. Choi, and Sang Yup Lee. "Patterning of proteins fabricated by microcontact printing method for site-specific immobilization and protein-protein interaction assay", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Oct 22-24 (2003)
7. Tae Jung Park, Seok Jae Lee, Jong Pil Park, and Sang Yup Lee. "Depolymerase substrate binding domain for site-directed capturing ligand to detect protein-protein and antigen-antibody interactions", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Oct 22-24 (2003)
8. Seok Jae Lee, Jong Pil Park, Tae Jung Park, and Sang Yup Lee. "Enzyme-based biomolecular engineering of single-walled carbon nanotubes (SWNTs) by transglycosylation reaction", Annual Fall Meeting of KIChE, Seoul, Oct 24-25 (2003)
9. Seok Jae Lee, Tae Jung Park, Jong Pil Park and Sang Yup Lee. "Novel PHB-based protein microarray using extracellular depolymerase substrate binding domain for site-directed capture ligand to detect protein-protein interaction", Annual Fall Meeting of KIChE, Seoul, Oct 24-25 (2003)
10. Seok Jae Lee, Jong Pil Park, Tae Jung Park, Jong Hyun Choi, and Sang Yup Lee. "Self-assembly of functional bacterial surface protein and its use in nanobiotechnology", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Apr 16-17 (2004)
11. Tae Jung Park, Jong Pil Park, Seok Jae Lee, and Sang Yup Lee. "Artificial surface display system in Escherichia coli using exosporal agent", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Apr 16-17 (2004)
12. Jong Pil Park, Seok Jae Lee, Tae Jung Park, Kyung-Bok Lee, Insung S. Choi, and Sang Yup Lee. "Microcontact printing of biotin for selective immobilization of streptavidin-fused proteins and SPR analysis", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Apr 16-17 (2004)
13. Seok Jae Lee, Jong Pil Park, Tae Jung Park, and Sang Yup Lee. "Bioactivation of poly(3-hydroxybutyrate) microsphere and its application in a bead-based assay", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Apr 16-17 (2004)
14. Mee-Jung Han, Si Jae Park, Tae Jung Park, and Sang Yup Lee. "Essential roles and applications of the Escherichia coli small heat shock proteins IbpA and IbpB in the production of recombinant proteins", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Apr 16-17 (2004)
15. Kwang Seok Yang, Pilippe Clementz, Tae Jung Park, Jong Pil Park, Seok Jae Lee, and Sang Yup Lee. "Dynamic concentration and separation by isoelectric focusing in microfluidic channel", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Apr 16-17 (2004)
16. Kwangsuk Yang, Philippe Clementz, Tae Jung Park, Jong Pil Park, Seok Jae Lee, Do Hyun Kim, and Sang Yup Lee. "Dynamic concentration and separation by isoelectric focusing in microfluidic channel", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Kongju, Apr 23-24 (2004)
17. Tae Jung Park, Sang Yup Lee, Insung S. Choi, and Kyung-Bok Lee. "Pattern generation of biomolecules and cells", 27th Conference of the Korean Vaccum Society, Daegu, Aug 20 (2004)
18. Kyung-Bok Lee, Tae Jung Park, Sang Yup Lee and Insung S. Choi. "2D cell patterns toward cell-based sensors", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Cheongju, Oct 13-15 (2004)
19. Jong Pil Park, Tae Jung Park, Seok Jae Lee and Sang Yup Lee. "Polyhydroxyalkanoates (PHAs) in nanobiotechnology", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Cheongju, Oct 13-15 (2004)
20. Mee-Jung Han, Si Jae Park, Jeong-Wook Lee, Tae Jung Park and Sang Yup Lee. "Functions of small heat shock proteins in the production of recombinant proteins in Escherichia coli and its applications", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Cheongju, Oct 13-15 (2004)
21. Tae Jung Park and Sang Yup Lee. "Platform technology using polyhydroxyalkanoates (PHAs) for protein immobilization and its nanobiotechnological applications", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jinju, Oct 27-29 (2005)
22. Tae Jung Park, Seok Jae Lee, Jong Pil Park, Sungho Ko, Sang Yup Lee, Su-Jin Ku. "Development of the gold binding polypeptide-mediated surface plasmon resonance sensor chip", Annual Spring Meeting of KIChE, Daegu, Apr 20-21 (2006)
23. Tae Jung Park and Sang Yup Lee. "Rapid and accurate detection of Bacillus anthracis spores using peptide-quantum dot conjugates", Annual Meeting of Korean Society for Biotechnology and Bioengineering, Cheongju, May 10-12 (2006)
24. Tae Jung Park, Seok Jae Lee, Kwang Suk Yang, Jong Bae Park, Sungho Ko, Taekeun Kim, Seong Kyu Kim, Yong Bum Shin, Bong Hyun Chung, Do Hyun Kim, Su-Jin Ku, and Sang Yup Lee. "The gold binding peptide-mediated chip for biosensor application", Annual Meeting of Korean Society for Biotechnology and Bioengineering, Cheongju, May 10-12 (2006)
25. Tae Jung Park, and Sang Yup Lee. "Detection of Bacillus anthracis spores using peptide-quantum dot conjugates", 2006 Annual Meeting of the Korean Society for Microbiology and Biotechnology, Busan, Jun 18-20 (2006)
26. Tae Jung Park, Seung Min Yoo, and Sang Yup Lee. "Polyhydroxyalkanoate microarray for immunodiagnostics and pathogen detections using immobilization of fusion proteins", 2006 Korean BioChip Conference, Seoul, Jun 23 (2006)
27. Tae Jung Park, Seok Jae Lee, Sungho Ko, Su-Jin Ku, and Sang Yup Lee. "Nanopatterns and biosensors using gold binding polypeptide", 2006 Korean BioChip Conference, Seoul, Jun 23 (2006)
28. Tae Jung Park, Seok Jae Lee, Kwang Suk Yang, Sungho Ko, Do Hyun Kim, Su-Jin Ku, and Sang Yup Lee. "Protein patterns and biosensors using gold binding polypeptide (GBP)", 2006 Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Sep 7-8 (2006)
29. Tae Jung Park, Seung Min Yoo, and Sang Yup Lee. "Polyhydroxyalkanoate-based protein chip for the detection of viral diseases and pathogens", BK21 Tech Fair 2007, Daejeon, Feb 27 (2007)
30. Tae Jung Park, Yun Suk Huh, Sang Yup Lee, Sungho Ko, and Won Hi Hong. "SPR sensor by the immobilization of recombinant proteins onto the gold surface", 2007 Korean BioChip Conference, Seoul, Mar 30 (2007)
31. Tae Jung Park, Sang Yup Lee, Kyung-Bok Lee, and Sol Choi. "Microcontact printing of biotin for selective immobilization of streptavidin-fused proteins and cells", Annual Spring Meeting of KIChE, Ulsan, Apr 19-20 (2007)
32. Yun Suk Huh, En Joo Lee, Won Hi Hong, Sang Yup Lee, Jong Hyun Choi, and Tae Jung Park. "Microfluidic sample preparation system for integration of micro mixer and solid phase extraction", Annual Spring Meeting of KIChE, Ulsan, Apr 19-20 (2007)
33. Shun Zheng, Tae Jung Park, and Sang Yup Lee. "Immobilization of recombinant proteins onto the gold surface for cell biosensor", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, Apr 26-28 (2007)
34. Tae Jung Park, Yun Suk Huh, En Joo Lee, Sang Yup Lee, and Won Hi Hong. "Fully integrated microfluidic system for the detection of infectious viral disease ", 2007 Korean BioChip Conference, Seongnam, Oct 4-5 (2007)
35. Tae Jung Park, Sang Yup Lee, and Kyung-Bok Lee. "Biotin patterning for selective immobilization of recombinant cells and streptavidin-fusion proteins", 2007 Korean BioChip Conference, Seongnam, Oct 4-5 (2007)
36. Tae Jung Park, Yun Suk Huh, Won Hi Hong, Sang Yup Lee, and Sungho Ko. "Active micro-mixer system for studying electrobiochemical sensors", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Oct 18-19 (2007)
37. Tae Jung Park, Yun Suk Huh, Won Hi Hong, and Sang Yup Lee. "Biosensor using active micro-mixer in lab-on-a-chip" Annual Fall Meeting of KIChE, Daejeon, Oct 26-27 (2007)
38. Shun Zheng, Tae Jung Park, Xiao Xia Xia, Hyun Uk Kim, and Sang Yup Lee. "Novel stationary phase expression system in Escherichia coli for the production of recombinant protein", Annual Meeting of Korean Society for Biotechnology and Bioengineering, Jeonju, Apr 18-19 (2008)
39. Tae Jung Park, Sungho Ko, Moon Seop Hyun, Hyun Uk Kim, and Sang Yup Lee. "SPR sensor chip for the detection of severe acute respiratory syndrome using real time molecular interaction", Annual Meeting of Korean Society for Biotechnology and Bioengineering, Jeonju, Apr 18-19 (2008)
40. Sang Yup Lee, Shun Zheng, Tae Jung Park. "C-Reactive Protein detection based on surface plasmon resonance and electrochemical analysis", Annual Spring Meeting of KIChE, Jeju, Apr 23-25 (2008)
41. Sang Yup Lee, Tae Jung Park, Yun Suk Huh, Chang-Moon Jeong, Won Hi Hong, Ho Nam Chang. "Development of microfluidic separation technology for the analysis of bacteriorhodopsin", Annual Spring Meeting of KIChE, Jeju, Apr 23-25 (2008)
42. Won Min Park, Tae Jung Park, Young Mee Jung, Ho Seok Park, Won Hi Hong, Sang Yup Lee. "The specific binding interaction between poly(3-hydroxybutyrate) and the substrate binding domain of poly(3-hydroxybutyrate) depolymerase probed by two-dimensional infrared correlation spectroscopy", Annual Spring Meeting of Polymer Science and Technology, Daejeon, Apr 10-11 (2008)
43. Tae Jung Park, Eun Zoo Lee, Sang Yup Lee, and Won Hi Hong. "Fully integrated microfluidic applications for the biosensors", 2008 Korean BioChip Conference, Daejeon, Jun 12-13 (2008)
44. Won Min Park, Tae Jung Park, Won Hi Hong, and Sang Yup Lee. "Fabrication of gold nanorod molecular probe using gold binding polypeptide for plasmonic biosensors", 2008 Korean BioChip Conference, Daejeon, Jun 12-13 (2008)
45. Tae Jung Park, Seok Jae Lee, Do-Kyun Kim, Sang Yup Lee. "SPR sensor chip for the detection of avian influenza virus using real time molecular interaction", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jeju, Oct 6-7 (2008)
46. Do-Kyun Kim, Shun Zheng, Tae-Jung Park, and Sang-Yup Lee. "Label free optical biosensor based on nano-plasmonics materials for detection of DNA-protein interaction", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jeju, Oct 6-7 (2008)
47. Tae Jung Park, Seok Jae Lee, and Sang Yup Lee. "Label-free detection of avian influenza virus based on optical analysis", Annual Fall Meeting of KIChE, Busan, Oct 22-24 (2008)
48. Shun Zheng, Tae Jung Park, and Sang Yup Lee. "HBsAg detection based on SPR and electrochemical assay", Annual Fall Meeting of KIChE, Busan, Oct 22-24 (2008)
49. Chi Won Ahn, Seok Jae Lee, Jong Wan Park, Kyung Min Kim, Byung Il Kim, Hee Yeoun Kim, Jae Hong Park, and Tae Jung Park. "Amorphous SiN thin film, Si nanowire, and membrane based field effect biosensor", 11th Korean MEMS Conference, Jeju, Apr 2-4 (2009)
50. Seok Jae Lee, Byeong Il Kim, Kyung Min Kim, Hee Yeoun Kim, Jae Hong Park, Chi Won Ahn, Tae Jung Park, Chang-Hyung Cho, and Chang-Soo Lee. "Microfluidic device for droplet based spore microencapsulation using PEG and its application", 11th Korean MEMS Conference, Jeju, Apr 2-4 (2009)
51. Tae Jung Park, Bong Gil Choi, HoSeok Park, Won Hi Hong, and Sang Yup Lee. "Agrichemical biosensor by immobilization of organophosphorus hydrolase on carbon nanotube/ionic liquid bucky gel electrode", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Pohang, Apr 9-11 (2009)
52. Tae Jung Park, Do-Kyun Kim, Heeyon Kim, and Sang Yup Lee. "Development of label-free optical biosensors for food safety using multi-spot nanoparticle array chip", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Pohang, Apr 9-11 (2009)
53. Tae Jung Park, Shun Zheng, and Sang Yup Lee. "HBsAg detection based on SPR and electrochemical assay", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Pohang, Apr 9-11 (2009)
54. Tae Jung Park, Byung-Seon Kong, Min Ho Yang, Nam Su Heo, Hee-Tae Jung, and Sang Yup Lee. "Label-free electrochemical biosensor on the highly conductive carbon nanotube film and gold nanocomplexes", 2009 Korean BioChip Conference, Daejeon, Jun 4-5 (2009)
55. Tae Jung Park, HoSeok Park, Yun Suk Huh, Bong Gil Choi, Won Hi Hong, and Sang Yup Lee. "Electrochemical biosensor using nanocomplexes based on carbon nanotubes and genetically engineered fusion proteins", 2009 Korean BioChip Conference, Daejeon, Jun 4-5 (2009
56. Shun Zheng, Tae Jung Park, and Sang Yup Lee. "Detection of HBV surface antigen based on genetic-engineered fusion protein", 2009 Korean BioChip Conference, Daejeon, Jun 4-5 (2009)
57. Do-Kyun Kim, Tae Jung Park, and Sang Yup Lee. "Analysis of antibody-antigen interaction using LSPR-based optical biosensor", 2009 Korean BioChip Conference, Daejeon, Jun 4-5 (2009)
58. Chi Won Ahn, Seok Jae Lee, Jong Wan Park, Kyung Min Kim, Byung Il Kim, Hee Yeoun Kim, Jae Hong Park, Tae Jung Park. "Nano-discovery platform for nano-bio sensors", 2009 Korean BioChip Conference, Daejeon, Jun 4-5 (2009)
59. Eun Kyung Yang, Byeong Il Kim, Kyung Min Kim, Hee Yeoun Kim, Jae Hong Park, Chi Won Ahn, Tae Jung Park, Chang-Soo Lee, Seok Jae Lee. "Microbial spore encapsulation in a microdroplet using COC microfluidic device and its application", 2009 Korean BioChip Conference, Daejeon, Jun 4-5 (2009)
60. Tae Jung Park, Jong Pil Park, Seok Jae Lee, Jong Hyun Choi, and Sang Yup Lee. "Characterization of a bacterial self-assembly surface layer protein and its application as an electrochemical nanobiosensor", Nano Korea 2009, Goyang, Aug 26-28 (2009)
61. Tae Jung Park, Seung-Kon Lee, Seung Min Yoo, Gi-Ra Yi, Seung-Man Yang, and Sang Yup Lee. "Development of reflective biosensor using fabrication of functionalized photonic nanocrystals", Nano Korea 2009, Goyang, Aug 26-28 (2009)
62. Tae Jung Park, Bonsang Gu, Jae-Hyuk Ahn, Yang-Kyu Choi, and Sang Yup Lee. "Electrical biosensor for detecting avian influenza using nanogap field-effect transistor and genetically engineered fusion protein", 2009 Korean BioChip Conference, Daejeon, Oct 8-9 (2009)
63. Do-Kyun Kim, Tae Jung Park, and Sang Yup Lee. "Development of label-free optical biosensor via LSPR-interferometry properties by aptamer-thrombin interaction", 2009 Korean BioChip Conference, Daejeon, Oct 8-9 (2009)
64. Min Ho Yang, Bong Gil Choi, Tae Jung Park, Won Hi Hong, and Sang Yup Lee. "Development of an exfoliated graphene/nafion electrode and electrochemical characteristics of glucose biosensor", 2009 Fall meeting of the Polymer Society of Korea, Oct 7-10 (2009)
65. Bong Gil Choi, Min Ho Yang, Tae Jung Park, Sang Yup Lee, and Won Hi Hong. "Electrochemical biosensor based on graphene/ionic liquid composite electrode for amperometric detection of organophosphate pesticides", 2009 Fall meeting of the Polymer Society of Korea, Oct 7-10 (2009)
66. Min Ho Yang, Bong Gil Choi, Tae Jung Park, Won Hi Hong, and Sang Yup Lee. "Peptide-wrapped single-walled carbon nanotubes as an ultrathin platform for biosensor", 2009 The Korean Society of Industrial and Engineering Chemistry, Seoul, Oct 15-16 (2009)
67. Bong Gil Choi, Min Ho Yang, Tae Jung Park, Won Hi Hong, and Sang Yup Lee. "Advanced electrode based on carbon materials for biosensor", 2009 The Korean Society of Industrial and Engineering Chemistry, Seoul, Oct 15-16 (2009)
68. Bong Gil Choi, HoSeok Park, Min Ho Yang, Tae Jung Park, Sang Yup Lee, and Won Hi Hong. "Flexible and conductive films based on graphene/nafion composites for high-performance biosensors", 2009 Fall Symposium of KIChE, Ilsan, Oct 21-23 (2009)
69. Tae Jung Park, Do-Kyun Kim, and Sang Yup Lee. "Fabrication of label-free LSPR based multi-spot gold-capped nanoparticle array biochip and detection of DNA point mutations in BIGH3 gene causing corneal dystrophies", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daejeon, Nov 2-3 (2009)
70. Tae Jung Park, Byung-Seon Kong, Min Ho Yang, Nam Su Heo, Hee-Tae Jung, and Sang Yup Lee. "Electrochemical biosensor for agrichemical detection on the highly conductive carbon nanotube film and gold nanocomplexes", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daejeon, Nov 2-3 (2009)
71. Tae Jung Park, Min Ho Yang, Bong Gil Choi, Won Hi Hong, and Sang Yup Lee. "Electrochemical biosensor based on exfoliated graphene/nafion electrode for detection of glucose", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daejeon, Nov 2-3 (2009)
72. Do-Kyun Kim, Tae Jung Park, and Sang Yup Lee. "Development of gold-capped nanostructure biochips based on plasmonic properties for label-free optical biosensors", Annual Meeting of Korean Society for Biotechnology and Bioengineering Spring Meeting, Seongnam, Apr 15-16 (2010)
73. Min Ho Yang, Bong Gil Choi, Tae Jung Park, Won Hi Hong, and Sang Yup Lee. "Supramolecular assembly of single-walled carbon nanotubes with peptides towards amperometric glucose biosensor", Annual Meeting of Korean Society for Biotechnology and Bioengineering Spring Meeting, Seongnam, Apr 15-16 (2010)
74. Do-Kyun Kim, Tae Jung Park, and Sang Yup Lee. "LSPR-based detection of the BIGH3 gene mutations by using multispot gold-capped nanoparticle array biochip", 2010 Korean BioChip Conference, Seongnam, May 13-14 (2010)
75. Min Ho Yang, Bong Gill Choi, Tae Jung Park, Won Hi Hong, and Sang Yup Lee. "Organophosphorus hydrolase on graphene-based electrode for the detection of organophosphate pesticides", 2010 The Korean Society of Industrial and Engineering Chemistry, Busan, May 13-14 (2010)
76. Min Ho Yang, Bong Gill Choi, Tae Jung Park, and Sang Yup Lee. "Electrical characterization of the exfoliated graphene/nafion hybrid as a biosensing platform", Nano Korea 2010, Goyang, Aug 17-20 (2010)
77. Bong Gill Choi, HoSeok Park, Tae Jung Park, Sang Yup Lee, and Won Hi Hong. "Entrapping organophosphorus hydrolase in gamma-alumina/ionic liquid nanohybrids for enzymatic reaction", Nano Korea 2010, Goyang, Aug 17-20 (2010)
78. Tae Jung Park, Min Ho Yang, Bong Gill Choi, Won Hi Hong, and Sang Yup Lee. "Ionic liquid-associated preparation of gold nanoparticle/graphene nanohybrids and their applications in glucose biosensor", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, Oct 7-9 (2010)
79. Tae Jung Park, Do-Kyun Kim, and Sang Yup Lee. "Label-free detection of aptamer-protein interaction using optical biosensors based on LSPR-interferometry properties ", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, Oct 7-9 (2010)
80. Do-Kyun Kim, Min Ho Yang, Tae Jung Park, and Sang Yup Lee. "Label-free detection of the BIGH3 gene mutations by using optical biosensor based on LSPR properties ", 2010 Fall Symposium of KIChE, Daejeon, Oct 20-22 (2010)
81. Min Ho Yang, Bong Gil Choi, Tae Jung Park, Won Hi Hong, and Sang Yup Lee. "Graphene-based electrode utilized with fusion protein for detection of organophosphate pesticides ", 2010 Fall Symposium of KIChE, Daejeon, Oct 20-22 (2010)
82. Kyung G. Lee, Tae Jung Park, Kye Won Wang, Seok Jae Lee, and Do Hyun Kim. "Microfluidic hybrid method for preparation of E. coli encapsulated PEG-based hydrogel microbeads ", 2010 Fall Symposium of KIChE, Daejeon, Oct 20-22 (2010)
83. Kyung G. Lee, Rinbok Wi, Seok Jae Lee, Tae Jung Park, Jae Beom Lee, and Do Hyun Kim. "Synthesis of gold-deposited fluorescent silica nanoparticles for biosensor application ", 2010 Fall Symposium of KIChE, Daejeon, Oct 20-22 (2010)
84. Kye Won Wang, Kyoung G. Lee, Tae Jung Park, Young Chul Lee, Ji Won Yang, Do Hyun Kim, and Seok Jae Lee. "Preparation of monodisperse PEG-hydrogel particles using the combination of organoclay-microfluidic device for E. coli encapsulation ", 2011 KMEMS, Jeju, Apr 7-9 (2011)
85. Tae Jung Park, Do-Kyun Kim, and Sang Yup Lee. "Label-free optical detection of CRP antibody-antigen interaction on gold-capped PAA layer chip ", 2011 Spring Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jeju, Apr 14-16 (2011)
86. Tae Jung Park, MinHo Yang, Bong Gill Choi, Won Hi Hong, and Sang Yup Lee. "Site-specific immobilization of organophosphrous hydrolase on graphene-based nanohybrids for electrochemical detection of paraoxon ", 2011 Spring Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jeju, Apr 14-16 (2011)
87. Bong Gill Choi, Min Ho Yang, Tae Jung Park, and Sang Yup Lee. "Programmable peptide-directed one dimensional array of gold nanoparticles on single-walled carbon nanotubes for biosensor ", 2011 Spring Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jeju, Apr 14-16 (2011)
88. Seok Jae Lee, Kyoung G. Lee, Kye Won Wang, and Tae Jung Park. "Microdroplets as a new challenging platform technology for applied microbiology ", 2011 Microbiology Society of Korea (MSK) Conference, Gwangju, May 12 (2011)
89. Do-Kyun Kim, Tae Jung Park, and Sang Yup Lee. "Label-free detection of protein interaction based on nano-plasmonics ", 2011 Korean BioChip Conference, Seoul, Jun 2-4 (2011)
90. Kyoung Suk Kang, Nam Su Heo, Seok Jae Lee, and Tae Jung Park, and Sang Yup Lee. "Detection of agrichemicals using fluorescence assay by variant luciferase from Renilla renifomis ", 2011 Korean BioChip Conference, Ulsan, Nov 2-4 (2011)
91. Nam Su Heo, Kyoung Suk Kang, Seok Jae Lee, Sang Yup Lee and Tae Jung Park. "SPR sensor of ifluenza virus by the immobilization of recombinant proteins onto the gold surface ", 2011 Korean BioChip Conference, Ulsan, Nov 2-4 (2011)
92. Kyoung G. Lee, Tae Jae Lee, Soon Woo Jeong, Gle Park, Tae Jung Park, and Seok Jae Lee. "Plastic-based microfluidic immunosensor chip for diagnosis of human influenza A", 2011 Korean BioChip Conference, Ulsan, Nov 2-4 (2011)
93. Kyoung Suk Kang, Seok Jae Lee, and Tae Jung Park. "Detection of agrichemicals and bacteria using fluorescence and luminescence assay by luciferase", 2012 Korean BioChip Conference, Ansan, May 23-24 (2012)
94. Gi Wook Kim, Sang Yup Lee, Seok Jae Lee, and Tae Jung Park. "Development of biosensor system for human cardiac troponin I by using quantum dots", 2012 Korean BioChip Conference, Ansan, May 23-24 (2012
95. Nam Su Heo, Kyoung Suk Kang, Seok Jae Lee, Sang Yup Lee, and Tae Jung Park. "Sterilization against microorganisms and elimination of agrichemicals by using high-frequency atmospheric plasma system", 2012 Korean BioChip Conference, Ansan, May 23-24 (2012
Jin Sik Kim
Ph.D. '06. 8.
PLUS International Patent Law Office
Phone :+82-42-869-8867
Fax :+82-42-869-8800 or 3910
Details
Research Interest
Genome Analysis
Bioinformatics
Education
B.Sc. ChE (Minor: CS), KAIST, Korea, 1995.3.- 2000.2.
M.Eng. CBE, KAIST, Korea, 2000.3.- 2002.2.
Ph.D. CBE, KAIST, Korea, 2002.3.- 2006.8.
Experience and Academic Activity
RResearch Assistant, KAIST (Mar. 2000 - Aug. 2006)
Teaching Assistant, KAIST (Sep. 2002 - Jun. 2003; Sep. 2004 - Dec. 2004)
Postdoc., Applied Science Research Institute, KAIST, Daejeon, Korea (Sep. 2006 – present)
Publications
5 international journals, 2 domestic journals published
1 international proceedings, 2 book chapters
So Young Yoo
Ph.D. '07. 2
Univ. of California, Berkeley, Post-doc
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Research Interest
Liver Regeneration, Carcinogenesis, Liver Gene Therapy
Cellular Signal Transduction, Mechnical Signal Transduction, Contact Guidance
Lab-On-a-Chip, Tissue Engineering
Microarray, Fuctional Genomics, Bioinformatics
Development of Diagnostic Device and Method
Alternative Splicing and Its Relevance to Human Life
Education
March, 1991 – February, 1995.2 (B.S in Molecular Biology)
Department of Molecular Biology, Pusan National University, Pusan, Korea
Advisor: Prof. Ho Seong Kang
March, 1995 – February, 1997 (M.S. in Molecular Cellular Biology)
Department of Molecular Biology, Pusan National University, Pusan, Korea
Advisor Prof. Kyu Won Kim
(Thesis: Study on Proliferation of Rat Hepatocyte under Ex Vivo Conditions)
March, 1998 – February, 2001 (M.A. in Professional Ministry)
Department of Missiology, Chongshin University, Seoul, Korea
Advisor: Prof. Seong Uk Kim
(Thesis: Study on Female Specialist Manpower in The Korean Specialists Missionaries)
September, 2002 – Fabruary, 2007 (Ph.D. Course in Chemical & Biomocelular Engineering)
Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Advisor: Prof. Sang Yup Lee
Experience and Academic Activity
2007-present, Visiting Research associate (postdoc) at Metabolic & Biomolecular Engineering Lab., KAIST, Daejeon, S. Korea
2002-present, Team Manager, Medigenes Co., Ltd, Seoul, S. Korea
2001-2002, Research Scientist, Microarray and Functional Genomics Team, BioCS Co., Ltd, Seoul, S. Korea
2001-2001, Team Manager, Digital Bio Technology Co., Ltd., Seoul, Korea
1999-2001, Research Scientist, Institute of Advanced Machinery and Design, Seoul, National, University, Seoul, S. Korea
1999-2000, Special Researcher, Medical Science Research Institute, Dong-A University, Pusan, S. Korea
1999-1999, Special Researcher, Life Science Research Institute, Dong-A University, Pusan, S. Korea
1996-1999, Research Assistant, Life Science Research Institute, Dong-A University, Pusan, S. Korea
1994-1996, Research Scientist, Department of Pharmacology, College of Medicine, Dong-A University, Pusan, S. Korea
Memberships
The Korean Society for Molecular and Cellular Biology
Korean Society for Bioinformatics
Korean Society for Genomic
The Korean Society for Biotechnology and Bioengineering
Award
Pusan Nation University Scholarship from 1991 to 1994
The President Award, The General Assembly of Presbyterian Church in Korea (Feb. 15, 2001)
Chongshin University Scholarship from 1999 to 2000
Graduated first on the list from Chongshin Univ. (Feb. 15, 2001)
Poster Award, 42nd ICAAC(Interscience Conference on Antimicrobial Agents and Chemotherapy),San Diego, California, USA, September 27-30, 2002
Medigenes Scholarship from 2002 to 2006
Publications
Journal publications
1. Yoo, S.Y., Lee, S.Y. and Yoo, N.C. "Cytokine Expression and Cancer Detection", Med. Sci. Monit. 15 (2): in press (2009. 2)
2. Kim, W. K., Yoo, S. Y., Ha, B. J., Kim, S. W., Lee, S. Y., Kim, T-I., Cho, J. Y. and Kim, E. K. : Evaluation of Sensitivity and Specificity of DNA Chip for Diagnosis of Granular Corneal Dystrophy II. J. Korean Ophthalmol. Soc. 49 (8): 1220-1225 (2008. 8) (DOI: 10.3341/jkos 2008.49.8.1220)
3. Ganesan, R*., Yoo, S. Y.*, Choi, J.-H., Lee, S. Y. and Kim, J. B. : Simple micropatterning of biomolecules on a diazoketo functionalized photoresist. J. Mater. Chem. 18(6): 703–709 (2008. 1) (DOI:10.1039/b709774c) (*These authors contributed equally to this work)
4. Yoo, S.Y., Kim, T.-I., Lee, S.Y., Kim, E.K., Keum, K.C., Yoo, N.C., and Yoo, W.M. : Development of DNA chip for the diagnosis of most common corneal dystrophies caused by mutations in the bigh3 gene. British J. Opththalmol. 91: 722-727 (2007. 6) (Online First, published on January 10, 2007 as 10.1136/bjo.2006.111070)
5. Kim, J.-B., Ganesan, R., Yoo, S.Y., Choi, J.-H., and Lee, S.Y. : Simple patterning of cells on a biocompatible nonchemically amplified resist. Macromol. Rapid Comm. 27: 1442-1445 (2006. 9)
6. So Young Yoo*, Chanil Chung, Jung Kyung Kim, Jun Keun Chang : Perinuclear translocation of hsp27 in shear stress exposed human endothelial cells. Biotechnol. letters 27(6):443-448 (2005. 3)
7. Yoo, S.M., Keum, K.C., Yoo, S.Y., Choi, J.Y., Chang, K.H., Yoo, N.C., Yoo, W.M., Kim, J.M., Lee Duke, and Lee, S.Y. : Development of DNA Microarray for Pathogen Detection. Biotechnol. Bioprocess Eng. 9(2):93-99 (2004. 3)
8. So Young Yoo, Hyeong Jun An, Doheon Lee and Sang Yup Lee : Development of Efficient Designing Method for Target Specific Probe Sets. Genome Informatics 14:476-477 (2003. 12)
9. So Young Yoo, Kyung Hee Chang, Seung Min Yoo, Sun Young Park, Nae Choon Yoo, Ki Chang Keum, Won Min Yoo, June Myung Kim and Sang Yup Lee : Design of ITS and 23S rDNA-targeted probes and its usefulness for the identification of bacterial pathogens. Genome Informatics 13:589-590. (2002. 12)
10. So-Young Yoo, Chan-YoungPark, Seok Chung, Dong-Ik Kim, Byung-Boong Lee, Se-Ho Huh, Dong-Chul Han and Jun-Keun Chang : Measurement of Smooth Muscle Cell Migration On the Micromachined Groove Topology. J. Korean Vasc. Surg. Soc. 18 (2): 251-258 (2002. 11)
11. So-Young Yoo, Dong-Ik Kim, Byung-Boong Lee and Jun-Keun Chang : Expression of Heat Shock Protein 70 in Vein Endothelial Cells Induced by Shear Stress. J. Korean Vasc. Surg. Soc. 17 (2): 185-191 (2001. 11)
12. Chanil Chung, Dong Ik Kim, So Young Yoo, ChaYoungPark, Byung Boong Lee and Jun Keun Chang : The Response of Human Umbilical Vein Endothelial Cells Under Complicated Flow Conditions. J. Korean Vasc. Surg. Soc. 17 (1): 16-23 (2001. 4)
13. So-Young Yoo, Kyu-Won Kim, Hye-Jeong Lee and Yong-Chun Choi : In Vitro Regeneration of Carcinogen Thioacetamide Treated Rat Hepatocytes. Korean J. of Pharmacology 32: 399-406 (1996)
14. Hye-Jeong Lee, So-Young Yoo and Yong-Chun Choi : Relative irreversibility of nucleolar hypertrophy induced with thioacetamide in rat hepatocytes. Korean J. of Pharmacology 32: 104 (1996)
15. Hye-Jeong Lee, So-Young Yoo, Mi-Ryun Lee and Yong-Chun Choi : Thioacetamide activates the translocation of nucleolus specific 37 kDa and 39 kDa MAP kinase. Korean J. of Pharmacology 31: 130 (1995
Proceedings
1. Yoo, S.Y., Kim, T.-I., Lee, S.Y., Kim, E.K., Keum, K.C.,Yoo,N.C., and Yoo, W.M. : A Simple DNA chip for Diagnosis of Most Common Corneal Dystrophies Caused by Bigh3 Gene Mutations. Proceedings of the FBIT International Conference (Frontiers in the Convergence of Bioscience and Information Technologies) IEEE Computer Society, 69-74 (2007) (doi: 10.1109/FBIT.2007.118)
2. Jin-Baek Kim, Ramakrishnan Ganesan, So Young Yoo, Jae-Hak Choi and Sang Yup Lee : Patterning of biomolecules on a biocompatible nonchemically amplified resist. Advances in Resist Materials and Processing Technology XXIV, edited by Qinghuang Lin. Proc. of SPIE 6519: 65191L-6L (2007) (doi: 10.1117/12.712102)
3. Yoo, S.Y., Kim, T.-I., Lee, S.Y., Kim, E.K., Keum, K.C.,Yoo,N.C., and Yoo, W.M.: Rapid Diagnosis of Most Common Bigh3 Gene Associated Corneal Dystrophies by DNA Chip. Theories and Applications of Chem. Eng.13(1): 455( 2007)
4. So Young Yoo, Hyeong Jun An, Doheon Lee and Sang Yup Lee: Efficient Designing Method for Target Specific Probe Sets. Genome Informatics 14:476-477 (2003).
5. So Young Yoo, Kyung Hee Chang, Seung Min Yoo, Sun Young Park, Nae Choon Yoo, Ki Chang Keum, Won Min Yoo, June Myung Kim and Sang Yup Lee : Design of ITS and 23S rDNA-targeted probes and its usefulness for the identification of bacterial pathogens. Geome Informatics 13:589-590 (2002).
6. Jun-Keun Chang, So-Young Yoo, Sang-Ho Suh and Sang-Sin Yoo : Behavior of Hsp27 in polymerization of actin microfilaments of shear stress exposed human endothelial cells. Proceedings of ICMMB-11: International Conference on Mechanics in Medicine and Biology, 251-254 (2000)
7. Hye-Jeong Lee, So-Young Yoo, Hee-Sook Lee, Seung-Jin Lee and Yong C. Choi : Study of nucleolar signaltransduction I.Induction of p38 MAP kinase in rat liver nucleoli. Proc. Mol. Biol. & Genet. 13: 385-386 (1998)
8. Hye-Jeong Lee, So-Young Yoo, Seung-Jin Lee, Hee-Sook Lee and Yong C. Choi : Study of nucleolar signal transduction II. Structural characterization of nucleolar p38 MAP kinase. Proc. Mol. Biol. & Genet. 13: 387-388 (1998)
9. Hye-Jeong Lee, So-Young Yoo, Seung-Jin Lee and Yong C. Choi : Study of nucleolar signal transduction. I. Composition definition of nucleolar oncoprotein networking. Proc. Mol. Biol. & Genet. 12: 377-378 (1997)
10. Hye-Jeong Lee, So-Young Yoo, Seung-Jin Lee and Yong C. Choi : Study of nucleolar signal transduction. II. Metabolism of nucleolar signal transduction system. Proc. Mol. Biol. & Genet. 12: 379-380 (1997)
Conferences
1. Yoo, S.Y., Lee, S.Y. and Kim, E.K., "Simple and Rapid Diagnosis of Granular Corneal Dystrophy II by DNA chip: A Perfect Substitute for Conventional Diagnosis", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jeju, Korea, October 6-7, 2008.
2. Yoo, S.Y., Kim, T.-I., Lee, S.Y., Kim, E.K., Keum, K.C., Yoo, N.C., and Yoo, W.M., "A Smiple DNA Chip for diagnosis of most common corneal dystrophies caused by Bigh3 gene mutations", Frontiers in the Convergence of Bioscience and Information Technologies (FBIT), Jeju, Korea, October 11-13, 2007.
3. Yoo, S.Y., Kim, T.-I., Lee, S.Y., Kim, E.K., Keum, K.C., Yoo, N.C., and Yoo, W.M., "Rapid diagnosis of most common Bigh3 gene mutations associated corneal dystrophies by DNA chip" , Biochemical Engineering XV, Quebec, Canada, July 15-19, 2007.
4. Yoo, S.Y., Ganesan, R., Kim, J.-B., Choi, J.-H. and Lee, S.Y., " Simple patterning of cells on a biocompatible nonchemically amplified resist", Biochemical Engineering XV, Quebec, Canada, July 15-19, 2007.
5. Yoo, S.Y., Kim, T.Y., Lee, S.Y., Kim, E.K., Keum, K.C., Yoo, N.C., and Yoo, W.M., "DNA chip based diagnosis of most common beta-igh3 mutation", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, April.27, 2007.
6. Yoo. S.Y., Ganesan, R., Kim, J.B., and Lee, S.Y., "Simple patterning of cells by using a biocompatible nonchemically amplified resist", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, April. 27, 2007.
7. Yoo, S.Y., Kim, T., Lee, S.Y., Kim, E.K., Keum, K.C.,Yoo,N.C., and Yoo, W.M., "Rapid Diagnosis of Most Common Bigh3 Gene Associated Corneal Dystrophies by DNA Chip", Annual Spring Meeting of KIChE, April 19-20, 2007.
8. Yoo, S.Y., Ganesan, R., Kim, J., and Lee, S.Y., "Lithogarphic Application of a Novel Photoresist for Patterning of Cells", Annual Spring Meeting of KIChE, April 19-20, 2007.
9. Yoo, S.Y., Kim, E and Lee, S.Y., "Development of DNA Chip for Diagnosis of Most Common CDs in Korea", 2006 Annual Meeting and International Symposium(KMB), June 18-20, 2006.
10. Yoo. S.Y., Kim, E., Lee, S.Y., "Rapid Diagnosis Of Most Common TGFBI by DNA Chip", Annual Meeting & International Symposium of the Korea Scociety for Microbiology and Biotechnology (KMB), May 10-12, 2006.
11. JS Lee, D Kim, SY Yoo, SY Lee. Utilization of MWCNT for the detection of antigen-antibody reaction in cancer diagnosis. Sixth International Conference on the Science and Application of Nanotubes, Gothenburg, Sweden, June 21-July 1, 2005.
12. Yoo, S. Y., and Lee, S. Y., " Study on Differentially Expressed Genes in Cancer Cells using Oligonucleotide Microarray.", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Cheongju, Korea, October 13-15, 2004.
13. Yoo, S.Y., Ahn, H.J., Lee, D.H., and Lee, S.Y., "A Fast Algorithm for Designing Target Specific Probe Sets", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17, 2004.
14. Yoo, S.M., Chang, K.H., Yoo, S.Y., Yoo, N.C, Keum, K.C., Yoo, W.M., Kim, J.M., and Lee, S.Y., "Development of a Diagnostic Microbial Microarray for Infectious Disease", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17, 2004.
15. So Young Yoo, Hyeong Jun An, Doheon Lee and Sang Yup Lee : Efficient Designing Method for Target Specific Probe Sets. The 13th International conference on genome informatics GIW2003 meeting, yebisu garden place, Tokyo, Japan, December 14-17, 2003.
16. Yoo, S.M., Yoo, S.Y., Chang, K.H., Yoo, N.C., Keum, K. C., Yoo, W.M. ,Kim, J.M., and Lee, S.Y., "Microarray Based Identification of Pathogens of Infectious Disease", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October 22-24, 2003.
17. So Young Yoo, Seung Min Yoo, Kyung Hee Chang and Sang Yup Lee : Pathochip facilitates diagnosis of pathogens for infectious diseases with accuracy and high –throughput manner. Biochemical Engineering (XIII) Conference on Novel Devices and Materials, Boulder,Colorado, USA, July 19-24, 2003.
18. Yoo,S.Y.,Chang,K.H.Yoo,S.M.,Im,J.H.,Yoo,N.C.,Km,K.C.,Yoo,W.M.,Kim.J.M. and Lee S.Y. : Identificaation of Microbial pathogens by Microarray-Based Assay, Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Busan, Korea, April 11-12, 2003.
19. So Young Yoo, Kyung Hee Chang, Seung Min Yoo, Sun Young Park, Nae Choon Yoo, Ki Chang Keum, Won Min Yoo, June Myung Kim and Sang Yup Lee : Design of ITS and 23S rDNA-targeted probes and its usefulness for the identification of bacterial pathogens. The 13th International conference on genome informatics GIW2002 meeting, yebisu garden place, Tokyo, Japan, December 16-18, 2002.
20. So Young Yoo, Kyung Hee Chang, Sun Young Park, Seung Min Yoo, Nae Choon Yoo, Ki Chang Keum, Won Min Yoo, June Myung Kim and Sang Yup Lee : Development of bacterial patho-chip by designing of species-specific probes, Korean Society for Bioinformatics annual meeting, Pusan, Korea, November 15-16, 2002.
21. K.H.Chang, S.Y.Lee, S.Y.Yoo, S.M.Yoo, S.Y.Park, D.E.Yong, K.W.Lee, J.Y.Choi, K.S.Lee, A.Huh, J.S.Yeom, Y.S.Song, J.M.Kim : Rapid Identification of Bacterial Pathogens by Amplifying 23S Ribosomal DNA and ITS for Application on Oligonucleotide Microarray, The 42nd ICAAC(Interscience Conference on Antimicrobial Agents and Chemotherapy), San Diego, California, USA, September 27-30, 2002.
22. Kyung Hee Chang, Sang Yup Lee, Seung Min Yoo, Dong Eun Yong, Kyu Won Lee,SunYoungPark, So young Yoo, Jun Yong Choi, Kkot Sil Lee, Aejung Huh, Jun Sup Yeom, Young Goo Song and Jun Myung Kim : Development of a Novel DNA Chip for the Identification of Bacterial Pathogens, Korean Society for Chemotherapy, June 10, 2002.
23. Dong-Ik Kim, Ji-Eun Kim, So-Young Yoo, Jun-Keun Chang and Byung-Boong Lee : Differentially Expressed Vascular Smooth Muscle Cell's mRNAs and Heparin Effect on The Intimal Hyperplasia in Arterialized Vein. The 13th Annual Meeting of the Korean Society for Molecular Biology,Seoul, Korea, October 11-12, 2001.
24. Jun-Keun Chang, So-Young Yoo, Sang-Ho Suh and Sang-Sin Yoo : Behavior of Hsp27 in polymerization of actin microfilaments of shear stress exposed human endothelial cells. International Conference on Mechanics in Medicine and Biology, Maui,Hawaii, USA, April 2-5, 2000.
25. Chan-Young Park, So-Young Yoo and Jun-Keun Chang : Measurement of smooth muscle cell migration on the micromachined groove topology. The Keystone Symposia on Molecular and Cellular Biology,Keystone,Colorado, USA, February 3-9, 2000.
26. So-Young Yoo and Jun-Keun Chang : Behavior of hsp27 and hsp70 in actin polymerization of human umbilical vein endothelial cells (HUVECs) during shear stress exposure. The Keystone Symposia on Molecular and Cellular Biology,Keystone,Colorado,USA, February 3-9, 2000.
27. So-Young Yoo, Dong-Ik Kim,Chan-Young Parkand Jun-Keun Chang : Inhibitory Effects of In Vitro Smooth Muscle Cell and Endothelial Cell Migration and Proliferation by Low Molecular Heparin. The 12th Annual Meeting of the Korean Society for Molecular Biology, Seoul,Korea, October 12-13, 2000.
28. So-Young Yoo and Jun-Keun Chang : Hsp27 translocates into perinuclear region in HUVECs during shear stress. The 11th Annual Meeting of the Korean Society for Molecular Biology, October 25-26, 1999.
29. Hye-Jeong Lee, So-Young Yoo, Seung-Jin Lee, Hee-Sook Lee and Yong C. Choi : Study of nucleolar signal transduction II. Structural characterization of nucleolar p38 MAP kinase. The 10th Annual Meeting of the Korean Society for Molecular Biology, Seoul, Korea, October 22-24, 1998.
30. Hye-Jeong Lee, So-Young Yoo, Hee-Sook Lee, Seung-Jin Lee and Yong C. Choi : Study of nucleolar signal transduction I. Induction of p38 MAP kinase in rat liver nucleoli. The 10th Annual Meeting of the Korean Society for Molecular Biology, Seoul,Korea, October 22-24, 1998.
31. Hye-Jeong Lee, So-Young Yoo, Seung-Jin Lee and Yong C. Choi : Study of nucleolar signal transduction. II. Metabolism of nucleolar signal transduction system. The 9th Annual Meeting of the Korean Society for Molecular Biology, Seoul, Korea, October 16-18, 1997.
32. Hye-Jeong Lee, So-Young Yoo, Seung-Jin Lee and Yong C. Choi : Study of nucleolar signal transduction. I. Composition definition of nucleolar oncoprotein networking. The 9th Annual Meeting of the Korean Society for Molecular Biology, Seoul, Korea, October 16-18, 1997.
33. Hye-Jeong Lee, So-Young Yoo and Yong-Chun Choi : Relative irreversibility of nucleolar hypertrophy induced with thioacetamide in rat hepatocytes. The 48th Korean Society of Pharmacology, Seoul, Korea, November 1, 1996.
34. Hye-Jeong Lee, So-Young Yoo, Mi-Ryun Lee and Yong-Chun Choi : Effect of thioacetamide on nucleolar translocation of signalling molecules of rat liver. The 4th Federation Meeting of Korean Basic Medical Scientists, Seoul, Korea, April 24-25, 1996.
35. Hye-Jeong Lee, So-Young Yoo, Mi-Ryun Lee and Yong-Chun Choi : Thioacetamide activates the translocation of nucleolus specific 37 kDa and 39 kDa MAP kinase. The 47th Korean Society of Pharmacology, Gyeongju, Korea, November 3, 1995.
Patents
47 application including 11 international patent (30 registered)
Hyung Seok Choi
Ph.D. '07. 8
Hanwha
Phone :+82-42-869-8867
Fax :+82-42-869-8800
Details
Research Interest
Systems Biology (Metabolic Engineering)
Metabolic Flux Analysis
Strain Optimization for Enhanced Biochemical Production
Education
2001.2., (B.S.) Dept. of Genetic engineering, Sungkyunkwan Univ., Suwon, Korea
2003.2., (M.S.) Dept. of Life Science, POSTECH, Pohang, Korea
2003.2.~2003.8., (Researcher) MBEL, Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2003.9.~2007.8, (PhD.) MBEL, Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Award
Best Paper Award, The 3rd Asia Pacific Bioinformatics Conference, Singapore (2005. 1. 17-21)
Experience and Academic Activity
International Journals
Lee, S.Y., Woo, H.M., Lee, D.-Y., Choi, H.S., Kim, T.Y., and Yun, H. "Systems-level analysis of genome-scale microbial metabolisms under the integrated software environment" Biotechnol. Bioproc. Eng. 10(5): 425-431 (2005. 9~10).
Kim, J.S., Yun, H., Kim, H.U., Choi, H.S., Kim, T.Y., Woo, H.M., and Lee, S.Y. "Resources for systems biology research" J. Microbiol. Biotechnol. 16 (7): 1139-1143 (2006).
International Conferences
Choi, J.H., Choi, H.S. and Lee, S.Y., "Efficient production of small therapeutic peptides in recombinant Escherichia coli?? 3rd Recombinant Protein Production Meeting, Tavira, Portugal, Nov 11-14 (2004).
Lee, S.Y., Choi, H.S., Kim, T.Y., Lee, D.Y., ?�Constrains-based flux analysis: Exploring internal flux patterns further constrained by split ratio determinant?? The Third Asia-Pacific Bioinformatics Conference, Singapore, January 17-21 (2005)
Lee, S.Y., Woo, H.M., and Lee, D.Y., Choi, H.S., Kim, T.Y., Yun, H.S., ?�Metabolic Analysis of In Silico Genome-Scale Models Using MetaFluxNet?? BioInfo 2005, Busan, Korea, Sep 22-24 (2005)
Choi, H.S., Kim, T.Y., Lee, D.Y., Lee, S.Y., ?�Split Ratio Determinant: Newly Efficient Constraint Exploring Internal Flux Distribution?? BioInfo 2005, Busan, Korea, September 22-24 (2005)
Choi, H.S., Woo, H.M., and Lee, S.Y., ?�Metabolically new approach as the strategy in enhanced metabolite production?? GIM 2006, Prague, Czech Republic, June 24-28 (2006)
Domestic Conferences
Choi, H.S., Kim, T.Y., Hong, S.H., and Lee, S.Y., "Systemic quantification of flux distribution in acetate utilization of Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
Choi, H.S., Kim, T.Y., Lee, D.Y., and Lee, S.Y., ?�Internal Flux Distribution Further Constrained by Flux Ratio Profiling using GC-MS?? Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Cheongju, Korea, October 13-15 (2004)
Kim, S.H., Oh, Y.G., Choi, H.S., Kim, T.Y., Lee, D.Y., Lee, S.Y., and Park, S.W., ?�Determining mass distributions considering natural isotopes?? Annual Fall Meeting of Korean Institute of Chemical Engineering, Asan, Korea, October 29-30 (2004)
Oh, Y.G., Choi, H.S., Kim, T.Y., Lee, D.Y., Lee, S.Y., and Park, S.W., ?�Calculation of the intracellular metabolic flux distribution using split ratio of diverging pathway?? Annual Fall Meeting of Korean Institute of Chemical Engineering, Asan, Korea, October 29-30 (2004)
Choi, H.S., Kim, T.Y., Lee, D.Y., and Lee, S.Y., ?�Exploring international flux patterns further constrained by split ratio determinant in constrains-based flux analysis?? The 3rd Annual Conference of The Korean Society for Bioinformatics, Seoul. November 4 -5 (2004).
Kim, S,H, Oh, Y.G., Choi, H.S., Kim, T.Y., Lee, D.Y., Lee, S.Y., and Park, S.W., ?�Development of the mass isotope correction module for metabolic flux analysis?? The 17th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, December 4-5 (2004)
Woo, H.M., Choi, H.S. and Lee, S.Y., "Enhanced lycopene production of Escherichia coli using gene amplification", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, April 15-16 (2005)
Choi, H.S., Kim, T.Y., Woo, H.M., Lee, D.Y. and Lee, S.Y., "Gene targets prediction for products biosynthesis by system biotechnology", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, April 15-16 (2005)
Woo, H.M., Choi, H.S. and Lee, S.Y., "Bilevel Optimization of gene amplification for enhanced lycopene production of Escherichia coli using metabolic flux analysis", Annual Spring Meeting of KIChE, April 22-23 (2005)
Choi, H.S., Kim, T.Y., Woo, H.M., Lee, D.Y. and Lee,S.Y., "Expecting of gene targets for system biotechnology of various products biosynthesis", Annual Spring Meeting of KIChE, April 22-23 (2005)
Woo, H.M., Lee, D.Y., Choi H.S., Kim, T.Y., Yun, H.S., Lee, S.Y., ?�Platform for In silico Metabolic Flux Analysis?? International Meeting of the Federation of Koeran Microbiological Societies, Seoul, Korea, October 13-14 (2005)
Woo, H.M., Choi, H.S., Kim, T.Y., Lee, S.Y., ?�Integration of Flux Balance Analysis and GC/MS-Based Flux Analysis through Data Reconciliation?? Annual Fall Meeting of KIChE, October 21-22 (2005)
Woo, H.M., Lee, S.Y., Lee, D.Y., Choi, H.S., Kim, T.Y., Yoon, H.S., ?�MetaFluxNet for the Metabolic Analysis of In Silico Genome-Scale Models?? Annual Fall Meeting of KIChE, October 21-22 (2005)
Woo, H.M., Lee, D.Y., Choi, H.S., Kim, T.Y., Yoon, H.S., Lee, S.Y., ?�MetaFluxNet: Platform for in silico metabolic flux analysis?? International Symposium and annual meeting of KSBB, October 27-29 (2005)
Choi, H.S., Kim, T.Y., Lee, D.Y., Lee, S.Y., ?�Metabolic flux analysis cooperated with 13C labeling experiment and constraint-based flux analysis?? International Symposium and annual meeting of KSBB, October 27-29 (2005)
Kim, H.U., Choi, H.S. and Lee, S.Y. ?�Contribution of the amino acids of complex medium to the proteinogenic amino acids for in vivo metabolic flux analysis.?? International Symposium and annual meeting of KSBB, May 10-12 (2006)
Patents : �?��?�허 출원 1�? �?�� ?�허 1�?/font>
5. Media recognitions
Dongailbo, 2005.2.4, HelloDD, 2005.2.4, Newswire, 2005.2.4, Inews, 2005.2.4, Yeonhap News, 2005.2.4, Sciencetimes, JunjaSinmun, 2005.2.4, Unews, 2005.2.4, Jongdoilbo, 2005.2.4, Sciencesinmun, 2005.2.4, KOSEFNews, 2005.2.4, Deajunilbo, 2005.2.4, DigitalTimes, 2005.2.4, Munhwailbo, 2005.2.4. ?�The Best Poster Award of Asia Pacific Bioinformatics Conference??/font>
Jin Hwan Park
Ph.D. '07. 8
Samsung Advanced Institute of Technology
Phone :+82-42-350-8814
Fax :+82-42-350-8800
Details
Research Interest
Metabolic engineering
White biotechnology
Amino acid production system
Global regulatory circuit
Systems biotechnology
Synthetic biotechnology
Education
Dept. of Genetic Engineering, Korea University, Seoul, Korea 1990. 3 -1995. 8 (B.S.)
Dept. of Genetic Engineering, Korea University, Seoul, Korea 1995. 9 -1997. 8 (M.S.)
Advisor: Professor Hyo Ihl Chang Thesis: Cloning of replication origin of Enterococcal plasmid p703/5 and construction of a promoter probe vector for Enterococcus faecalis
Dept. of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea 2003.9 – 2007. 8 (Ph.D.)
Advisor: Professor Sang Yup Lee Thesis: Metabolic engineering of Escherichia coli for the production of L-valine based on systems biotechnology
Professional Experience
LG Chem LTD, Biotech Institute II, Research Scientist (1998. 6 – 2001. 4)
LG CI (Chem Investment) LTD, Biotech Institute II, Research Scientist (2001. 4 – 2002. 8)
LG Life Sciences LTD, Biotech Institute, Research Scientist (2002. 8 – 2003. 8)
KAIST, BioProcess Engineering Research Center, Senior Researcher (2007. 8. 18 – 10. 31)
KAIST, BioProcess Engineering Research Center, Research Professor (2007. 11. 1 - present)
KAIST, BioProcess Engineering Research Center, Vice Director (2008. 8. 1 - present)
Membership
Domestic Member
Korean Institute of Chemical Engineers
The Korean Society for Biotechnology and Bioengineering
The Korean Society for Microbiology and Biotechnology
Awards and Honors
Student Fellowship Award, Biochemical Engineering XIV, Bancouver, Canada (2005. 7. 10)
FEMS Young Scientist Meeting Grant Award, GIM 2006, Prague, Czech Republic (2006. 6. 23)
Best Paper Award, IECA (International E. coli Alliance) 2006, Jeju ICC, Jeju, Korea (2006. 10. 31-11. 3)
Lee KH, Park JH, Kim TY, Lee SY, "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis"
"People glorifying Korea", Biological Research Information Center, BRIC (2007. 4)
Major Advances, Faculty of 1000 Biology (2007. 5)
Best Poster Award, Asia Pacific Biochemical Engineering Conference 2007 (APBioChEC'07), Taipei International Convention Center, Taiwan (2007. 11. 4-7)
Park JH, Lee KH, Kim TY, Lee SY, "Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation"
Oral Presentations
International Conference
1. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, and Sang Yup Lee, "Systems Metabolic Engineering of Escherichia coli", International E. coli Alliance (IECA) 2008, Wellcome Trust Conference Centre, Hinxton, UK (Sept. 24-27, 2008). (Invited Talk) (Program)
2. Jin Hwan Park, "Systems Metabolic Engineering of Escherichia coli for amino acid production", METABOLIC ENGINEERING VIII: Metabolic Engineering for Green Growth, June 13-17, 2010, Jeju Island, Korea (Invited Talk) (Program) (Photo)
Domestic Conference
1. Jin Hwan Park, Kwang Ho Lee, and Sang Yup Lee, "Metabolic engineering of Escherichia coli for L-valine production", Annual Fall Meeting of KIChE, Korea Univ., Seoul, Korea, Oct. 27-28 (2006)
2. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, and Sang Yup Lee, "Metabolic engineering of Escherichia coli for L-valine production based on systems biotechnology", Annual Fall Meeting of KSBB, Young Scientist Special Symposium, Hotel Inter-Burgo, Daegu, Korea, Oct. 18-19 (2007)
BRIC VOD Service
3. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, and Sang Yup Lee, "Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation", Annual Fall Meeting of KIChE, KAIST, Daejeon, Korea, Oct. 26-27 (2007)
4. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, and Sang Yup Lee, "Systems Metabolic Engineering: Its Application to Escherichia coli for L-valine Production", Annual Meeting of The Korean Society for Microbiology and Biotechnology Symposium, Young Scientist Presentation, Seoul Kyoyuk Munhwa HoeKwan, Seoul, Korea, June 26-27 (2008)
5. Jin Hwan Park, "Systems metabolic engineering: Strategies and applications for chemicals and fuels", Annual Spring Meeting of KIChE, Biorefinery Special Symposium, EXCO, Daegu, Korea, Apr. 23 (2010) (Invited Talk) (Program)
Invited Seminar
1. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, and Sang Yup Lee, "Systems Metabolic Engineering of Escherichia coli: Strategy and applications", Korea Yakult Company Ltd., R&D Center, Yongin, Gyeonggi-do, Korea (Mar. 5, 2009)
2. Jin Hwan Park, "Systems Microbiology and Biotechnology: Strategy and Environmental Applications", Dept. of Environmental Science and Engineering, Gwangju Institute of Science and Technology (GIST), Gwangju, Korea (Mar. 30, 2009)
3. Jin Hwan Park, "Systems metabolic engineering for the production of chemicals and fuels", POSTECH Bioenergy Workshop, Biotech Center, Postech, Pohang, Korea (Feb. 24, 2010) (program)
4. Jin Hwan Park, "Biorefinery", KAIST EEWS Executive Program, KAIST Business School, KAIST Seoul Campus (March 17, 2010)
5. Jin Hwan Park, "Systems and synthetic biotechnology", National Academy of Agricultural Science, Rural Development Administration (RDA), Suwon, Korea (Sept. 16, 2010)
6. Jin Hwan Park, "Biorefinery", KAIST EEWS Executive Program (3rd), KAIST Business School, KAIST Seoul Campus (October 6, 2010)
Public Lecture
1. 금요일에 과학터치 (2009. 4. 17) (전남일보 보도내용)
Publications
International Journal
1. Song, J.S., Park, J.H., Kim, C.W., Kim, Y.W., Lim, W.J., Kim, I.U., and Chang, H.I., "Characterization of the replication Region of the Enterococcus faecalis Plasmid p703/5", J. Microbiol. Biotechnol. , 9(1) : 91-97 (1999)
2. Park, S.J., Lee, S.Y., Cho, J., Kim, T.Y., Lee, J.W., Park, J.H., and Han, M.-J., "Global physiological understanding and metabolic engineering of microorganisms based on omics studies", Appl. Microbiol. Biotechnol., 68:567-579 (2005. 9) [doi link]
3. Park, J.H., Lee, K.H., Kim, T.Y., and Lee, S.Y. "Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation", Proc. Nat. Acad. Sci. (PNAS), 104 (19): 7797-7802 (2007) [doi link] [suppl]
4. Lee, K.H., Park, J.H., Kim, T.Y., Kim, H.U., and Lee, S.Y., "Systems metabolic engineering of Escherichia coli for L-threonine production", Molecular systems biology 3: 149 (2007) [doi link] [suppl]
5. Park, J.H., Lee, S.Y., Kim, T.Y., and Kim, H.U., "Application of systems biology for bioprocess development", Trends Biotechnol., 26(8), 404-412 (2008. 8)
6. Lee, S.Y., Park, J.H., Jang, S.H., Nielsen, L.K., Kim, J., and Jung, K. S. " Fermentative butanol production by clostridia", Biotechnol. Bioeng., 101(2), 209-228 (2008. 10.)
7. Park, J.H. and Lee, S.Y. "Towards systems metabolic engineering of microorganisms for amino acid production", Curr. Opin. Biotechnol. 19(5): 454-460 (2008. 10) Journal cover paper
8. Lee, S.Y., Kim, H.U., Park, J.H., Park, J.M., and Kim, T.Y. "Metabolic engineering of microorganisms: general strategies and drug production", Drug Discovery Today, 14(1/2): 78-88 (2009. 1)
9. Park, J.H. and Lee, S.Y. “Fermentative production of branched chain amino acids: a focus on metabolic engineering”, Appl. Microbiol. Biotechnol. 85(3): 491-506 (2010.1)
10. Lee, S.Y. and Park, J.H. "Integration of systems biology with bioprocess engineering - L-threonine production by systems metabolic engineering of E. coli ", Adv. Biochem. Eng. Biotechnol. 120:1-19 (2010.2)
11. Cho, A., Yun, H., Park, J.H., Lee, S.Y., and Park, S. "Prediction of novel synthetic pathways for the production of desired chemicals", BMC Systems Biol. 4:35 (2010. 3)
12. Park, J.H., and Lee, S.Y. "Metabolic pathways and fermentative production of L-aspartate family amino acids", Biotechnol. J. 5: 560-577 (2010. 6)
13. Lee, J.W., Choi, S., Park, J.H.*, Vickers, C.E., Nielsen, L.K., and Lee, S.Y.* "Development of sucrose-utilizing Escherichia coli K-12 strain by cloning β-fructofuranosidases and its application for L-threonine production", Appl. Microbiol. Biotechnol. 88(4): 905-913 (2010. 10) (*co-corresponding author)
14. Archer, C.T., Kim, J.F., Jeong, H., Park, J.H., Vickers, C.E., Lee, S.Y., and Nielsen, L.K. "The genome sequence of E. coli W ATCC 9637: comparative genome analysis and an improved genome-scale reconstruction of E. coli", BMC Genomics, 12(9): 1-20 (2011. 1)
15. Park, J.H., Kim, T.Y., Lee, K.H., and Lee, S.Y., "Fed-batch culture of Escherichia coli for L-valine production based on in silico flux response analysis", Biotechnol. Bioeng. 108(4): 934-946 (2011. 4)
16. Park, J.H., Jang, Y.S., Lee, J.W., and Lee, S.Y. "Escherichia coli W as a new platform strain for the enhanced production of L-valine by systems metabolic engineering", Biotechnol. Bioeng. 108(5):1140-1147 (2011. 5)
17. Choi, Y.J., Park, J.H., Kim, T.Y., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of 1-propanol", Metabol. Eng., 14(5): 477-486 (2012. 9)
18. Jang, Y.-S., Lee, J.Y., Lee, J., Park, J.H., Im, J.A., Eom, M.-H., Lee, J., Lee, S.-H., Song, H., Cho, J.-H., Seung, D.Y., and Lee, S.Y., "Enhanced Butanol Production Obtained by Reinforcing the Direct Butanol-Forming Route in Clostridium acetobutylicum", mBio, 3(5): 1-9 (2012. 10)[doi link] Featured Cover Paper (1, 2, 3, contens)
19. Park, J.H., Oh, J.E., Lee, K.H., Kim, J.Y., and Lee, S.Y., "Rational design of Escherichia coli for L-isoleucine production", ACS Synthetic Biol., 1(11): 532-540 (2012.11)[doi link] [Editorial] Journal cover paper (cover) In this issue, About the author-Jin Hwan Park
20. Choi, S.J., Lee, J., Jang, Y.S., Park, J.H., Lee, S.Y., and Kim, I.H., "Effects of nutritional enrichment on the production of acetone-butanol-ethanol (ABE) by Clostridium acetobutylicum", J. Microbiol., 50(6): 1063-1066 (2012.12)[doi link]
21. Na, D., Yoo, S.M., Chung, H., Park, H., Park, J.H., and Lee, S.Y., "Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs", Nature Biotechnol., 31(1): 1-7 (2013. 1)[doi link]
Book Chapter
1. Lee, S.Y. and Park, J.H., "Chapter 20. Systems Metabolic Engineering of E. coli", pp. 441-453, in Systems Biology and Biotechnology of E. coli (Lee SY Ed.) Springer, Germany (2009. 4)
International Conference
1. Park, J.H., Kim, B.H., Choi, J.H., Lee, D.Y. and Lee, S.Y., "Identification of growth-associated regulatory circuit of FadR by transcriptome profiling", The 12th International Conference on Intelligent Systems for Molecular Biology (ISMB 2004), Glasgow, UK, July 31-August 4 (2004).
2. Lee, S.Y., Park, J.H., Kim, B.H, and Choi, J.H., "Identification of growth-associated expression pattern of FadR-responsive genes by transcriptome profiling", 3rd Recombinant Protein Production Meeting, Tavira, Portugal, Nov 11-14 (2004).
3. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, "Construction of valine-producing strain and its transcriptome/fluxome analysis", Biochemical Engineering XIV, Bancouver, Canada (2005. 7).
4. Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Improvement of E. coli L-valine production strain based on transcriptome analysis", GIM 2006, Prague, Czech Republic (2006. 6).
5. Kwang Ho Lee, Tae Yong Kim, Jin Hwan Park, Sang Yup Lee "Transcriptome and fluxome analysis of a metabolically engineered E. coli L-threonine production strain", Biochemical Engineering XIV, Bancouver, Canada (2005. 7)
6. Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim, Sang Yup Lee, "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis", GIM 2006, Prague, Czech Republic (2006. 6).
7. Jin Hwan Park, Yu Kyung Jung, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, " Metabolic engineering of E. coli for the production of L-valine", Metabolic Engineering VI, Noordwijkerhout, The Netherlands (2006. 10).
8. Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Metabolic engineering of E. coli for L-valine production and its transcriptome analysis", IECA 2006, Jeju, Korea (2006. 11).
9. Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim, Sang Yup Lee, "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis", IECA 2006, Jeju, Korea (2006. 11).
10. Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Metabolic engineering of E. coli for L-valine production" The 29th Symposium on Biotechnology for Fuels and Chemicals, Denver, USA (2007. 4)
11. Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim, Sang Yup Lee, "Construction of L-threonine Producing Strain based on in silico Simulation and Comparative Transcriptome Analysis" The 29th Symposium on Biotechnology for Fuels and Chemicals, Denver, USA (2007. 4.)
12. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, " Metabolic engineering of Escherichia coli for the production of L-valine based on combined transcriptome analysis and in silico gene knockout simulation ", Biochemical Engineering XV, Quebec City, Canada (2007. 7)
13. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, " Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation ", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei International Convention Center, Taiwan, Nov 4-7 (2007)
14. Lee, S.Y., Park, J.H., Lee, K.H., Kim. T.Y., "L-valine production by systematically engineered Escherichia coli", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
15. Lee, S.Y., Lee, K.H., Park, J.H., Kim, T.Y., "Metabolic engineering of Escherichia coli for L-threonine production based on systems biology", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
16. Park, J.H., Lee, K.H., Kim. T.Y., Jang Y.S., Lee, S.Y., " Systems-level analysis and engineering of Escherichia coli for the production of L-valine" The 30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, LA, USA (May 4-7, 2008)
17. Lee, K.H., Park, J.H., Kim. T.Y., Jang Y.S., Lee, S.Y., " Systems metabolic engineering of Escherichia coli for L-threonine production" The 30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, LA, USA (May 4-7, 2008)
Domestic Conference
1. Park, J.H., Kim, Y.W., Jeon, Y.W., and Chang, H.I., "Cloning of replication origin of Enterococcal plasmid p703/5 and construction of promoter probe vector for Enterococcus faecalis", Annual Spring Meeting of Korean Society for Microbiology and Biotechnology Symposium, Seoul Nat'l Univ., Seoul, Korea, April 25-26 (1997)
2. Park, J.H., Kim, B.H., Choi, J.H., and Lee, S.Y., "Growth-associated transcriptome profiling of Escherichia coli fadR mutant", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17 (2004)
3. Park, J.H., Kim, B.H., Choi, J.H., and Lee, S.Y., "Transcriptome profiling of Escherichia coli fadR mutant", Annual Spring Meeting of KIChE, Kongju Nat'l University, April 23-24 (2004)
4. Kim, J., Park, J.H., and Lee, S.Y., "Genome wide transcriptional analysis of Escherichia coli during dual phase fermentation", Annual Meeting of Korean Society for Microbiology and Biotechnology Symposium, Daegu, Korea, June 21-23 (2004)
5. Kim, J., Park, J.H., and Lee, S.Y., "Transcriptome patterns of amino acid metabolism in anaerobic batch fermentation of Escherichia coli" Annual Fall Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Chungbuk Nat'l Univ., Cheongju, Korea, October 13-15 (2004)
6. Park, J.H., Lee, J.W., Kim, B.H., Choi, J.H., and Lee, S.Y., "Combined transcriptome and proteome profiling of Escherichia coli fadR mutant", Annual Spring Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Kangwon Nat'l Univ., Korea, April 15-16 (2005)
7. Park, J.H., Lee, J.W., Kim, B.H., Choi, J.H., and Lee, S.Y., "Global analyses of transcriptomes and proteomes of Escherichia coli fadR mutant", The 62th Korean Society for Biochemistry and Molecular Biology (KSBMB) annual meeting, Seoul, Korea, May 19-20 (2005)
8. Park, J.H., Lee, J.W., and Lee, S.Y., "Combined Global Transcriptome and Proteome Analysis of Escherichia coli fadR Mutant", International Meeting of the Federation of Korea Microbiological Societies, Seoul Kyoyuk Munhwa HoeKwan, Korea, Oct. 13-14 (2005)
9. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, "Metabolic engineering of E. coli for the production of L-valine and its transcriptome/fluxome analysis ", International Meeting of the Federation of Korea Microbiological Societies, Seoul Kyoyuk Munhwa HoeKwan, Korea, Oct. 13-14 (2005)
10. Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim, Sang Yup Lee, "Construction of L-threonine producing Escherichia coli and its transcriptome and fluxome analysis", International Meeting of the Federation of Korea Microbiological Societies, Seoul Kyoyuk Munhwa HoeKwan, Korea, Oct. 13-14 (2005)
11. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, "Metabolic engineering of E. coli for the production of L-valine and its transcriptome/fluxome analysis ", Annual Fall Meeting of KIChE, Oct. 21-22 (2005)
12. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, "Metabolic Engineering of L-Valine Production Escherichia coli W3110 and Its Combined Transcriptome and Fluxome Analysis", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jinju, Korea, Oct. 27-29 (2005)
13. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, "Construction of Escherichia coli L-valine production strain by rational design and its transcriptome analysis", Annual Spring Meeting of KIChE, Daegu, Korea, Apr. 20-21 (2006)
14. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, "Metabolic Engineering of Escherichia coli for the Production of L-Valine", Annual Spring Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Chungbuk Nat'l Univ., Korea, May 10-12 (2006)
15. Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim, Sang Yup Lee, "Construction of L-threonine producing strain based on in silico simulation and comparative transcriptome analysis", Annual Spring Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Chungbuk Nat¡¯l Univ., Korea, May 10-12 (2006)
16. Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, "Metabolic Engineering of Escherichia coli for L-Valine Production" , Annual Meeting of Korean Society for Microbiology and Biotechnology Symposium, BEXCO, Busan, Korea, June 18-20 (2006)
17. Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Metabolic engineering of Escherichia coli for L-valine production based on transcriptome analysis", Annual Fall Meeting of Korean Society for Biotechnology and Bioengineering Symposium, COEX, Seoul, Korea, Sept. 7-8 (2006)
18. Kwang Ho Lee, Jin Hwan Park, Sang Yup Lee, "Metabolic engineering of Escherichia coli for the production of L-threonine", Annual Fall Meeting of Korean Society for Biotechnology and Bioengineering Symposium, COEX, Seoul, Korea, Sept. 7-8 (2006)
19. Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Metabolic engineering of E. coli for the enhanced production of L-valine based on comparative transcriptome analysis", Annual Spring Meeting of KIChE, Ulsan, Korea, Apr. 19-20 (2007)
20. Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Transcriptome analysis of E. coli L-valine production strain and its application to strain improvement", Annual Spring Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, Korea, Apr. 26-28 (2007)
21. Park, J.H., Lee, K.H., Kim, T.Y., Lee, S.Y., "Systems metabolic engineering of Escherichia coli for L-valine production", 2008 Spring KSBB Meeting and International Symposium, Chonbuk National University, Jeonju, April 18-19 (2008)
22. Lee S.Y., Park, J.H., Lee, K.H., Kim, T.Y., "Systems metabolic engineering of Escherichia coli for L-valine and L-threonine production", Annual Spring Meeting of KIChE, Hyatt Regency Jeju, Jeju, April 23-25 (2008)
23. Park, J.H., Lee, K.H., Kim, T.Y., Lee, S.Y., "Systems metabolic engineering of Escherichia coli for L-valine production", The 48th Annual Meeting of The Microbiological Society of Korea, Daejeon Convention Center, Daejeon, Korea, May 15-16 (2008)
Patents - 4건 (PCT)
Kwang Ho Lee
Ph.D. '07. 8
Dept. of Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-869-5970
Fax :+82-42-869-8800
Details
Research Interest
metabolic engineering
strain development for amino acids, vitamins, nucleotides, and trehalose
systems biotechnology
Education
B.S., Dept. of Agricultural chemistry, Korea University, Seoul, Korea (1986. 3 ~ 1990. 2)
M.S., Dept. of Agricultural chemistry, Korea University, Seoul, Korea (1990. 3 ~ 1992. 2), Advisor: Professor Se Young Lee, Thesis: Expression of the bovine growth hormone gene in Yeast, Saccharomyces cerevisiae
Ph.D., Dept. of Chemical Engineering, KAIST, Daejeon, Korea (2004.3 ~ 2007.8), Advisor : Professor Sang Yup Lee, Thesis: Metabolic engineering of Escherichia coli for the production of L-threonine
Professional Experience
CJ CheilJedang Corp., Institute of Science & Technology, R&D center for Bioproducts, Senior Researcher (1995.1 ~ present)
Awards
Best Paper Award, International E. coli Alliance 2006 (IECA 2006), Jeju ICC, Jeju, Korea (2006. 10. 31-11. 3) Kwang-Ho Lee, Park JH, Kim TY, Lee SY, "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis"
Best Poster Award, Asia Pacific Biochemical Engineering Conference 2007 (APBioChEC'07), Taipei International Convention Center, Taiwan (2007. 11. 4-7) Park JH, Kwang-Ho Lee, Kim TY, Lee SY, “Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation
Publications
International Journals
Jin-Ho Lee, Kwang-Ho Lee, Chang-Gyeom Kim, Se-Young Lee, Geun-Joong Kim, Young-Hoon Park, and Sung-Oh Chung, “Cloning and expression of a trehalose synthase from Pseudomonas stutzeri CJ38 in E. coli for the production of trehalose”, Appl Microbiol Biotechnol (2005) 68: 213–219
Park, J.H., Lee, K.H., Kim, T.Y., and Lee, S.Y. "Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation", Proc. Nat. Acad. Sci. (PNAS), 104 (19): 7797-7802 (2007) [pdf] [suppl]
Kim, P.J., Lee, D.Y., Kim, T.Y., Lee, K.H., Joeong, H.W., Lee, S.Y., Park, S.W., "Metabolite essentiality elucidates robustness of Escherichia coli metabolism", Proc. Nat. Acad. Sci. (PNAS), 104 (34): 13638-13642 (2007) [pdf]
Lee, K.H., Park, J.H., Kim, T.Y., Kim, H.U., and Lee, S.Y., "Systems metabolic engineering of Escherichia coli for L-threonine production", Molecular systems biology 3: 149 (2007). [pdf] [suppl]
Kim, J.M., Lee, K.H. and Lee, S.Y., "Development of a markerless gene knock-out system for Mannheimai succiniciproducens using a temperature-sensitive plasmid", FEMS Microbiol. Lett. 278: 78-85 (2008). [pdf]
International conference
Kwang-Ho Lee, Hyang Choi, Jong-Kwon Han, and Young-Hoon Park, "Metabolic engineering of riboflavin over-producing Bacillus subtilis based on comparative analysis of transcriptome", International Conference on Functional Genomics of Gram-Positive Microorganisms, Baveno, Italy, June (2003)
Kwang Ho Lee, Tae Yong Kim, Jin Hwan Park, Sang Yup Lee "Transcriptome and fluxome analysis of a metabolically engineered E.coli L-threonine production strain", Biochemical Engineering XIV, Bancouver, Canada (2005. 7).
Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee "Construction of valine-producing strain and its transcriptome analysis", Biochemical Engineering XIV, Bancouver, Canada (2005. 7).
Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim and Sang Yup "Construction of L-threonine producing strain based on in silico simulation and comparative transcriptome analysis" GIM 2006, Prague, Czech Republic (2006. 6).
Jin Hwan Park, Yu Kyung Jung, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, " Metabolic engineering of E. coli for the production of L-valine", Metabolic Engineering VI, Noordwijkerhout, The Netherlands (2006. 10).
Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Metabolic engineering of E. coli for L-valine production and its transcriptome analysis", IECA 2006, Jeju, Korea (2006. 11).
Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim, Sang Yup Lee, "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis", IECA 2006, Jeju, Korea (2006. 11).
Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Metabolic engineering of E. coli for L-valine production” The 29th Symposium on Biotechnology for Fuels and Chemicals, Denver, USA (2007. 4)
Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim, Sang Yup Lee, "Construction of L-threonine Producing Strain based on in silico Simulation and Comparative Transcriptome Analysis” The 29th Symposium on Biotechnology for Fuels and Chemicals, Denver, USA (2007. 4.)
Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, " Metabolic engineering of Escherichia coli for the production of L-valine based on combined transcriptome analysis and in silico gene knockout simulation ", Biochemical Engineering XV, Quebec City, Canada (2007. 7)
Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, " Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation ", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei International Convention Center, Taiwan, Nov 4-7 (2007)
Patents
- 6 international patents (PCT) and 18 domestic patents
Yu Sin Jang
Ph.D. '07. 8
Gyeongsang National University
Phone :+82-42-350-8814
Fax :+82-42-350-8800
Details
Research Interest
Systems Metabolic Engineering
Industrial Biotechnology
Biofuels and Biochemicals
BioButanol, Fuel Alcohols
Carbon Dioxide Fixation
Succinic Acid
Education
2003. 3 - 2007. 8 Degree: Ph.D
Division of Applied Life Science (BK21), Gyeongsang National University, Jinju, Korea
Thesis: Development of a Novel Gene Expression System for Mannheimia
succiniciproducens and Its Application for Construction of Succinic Acid Tolerant Strain.
Supervisor: Prof. Kyu Young Kang (GNU)
Co-supervisor: Prof. Sang Yup Lee (KAIST)
1998. 3 - 2000. 2 Degree: MS
Dept. of Agricultural Chemistry, Gyeongsang National University, Jinju, Korea
Thesis: Changes in Intracellular cAMP Level and 2D-PAGE Analysis of Polypeptides
during Conidial Germ Tube and Appressorium Development in Magnaporthe grisea.
Supervisor: Prof. Kyu Young Kang
1991. 3 - 1998. 2 Degree: BS
Dept. of Agricultural Chemistry, Gyeongsang National University, Jinju, Korea
Professional Experience
2010. 6. 1 – current: Research Fellow
Department of Chemical and Biomolecular Engineering,
BioProcess Engineering Research Center,
Korea Advanced Institute of Science and technology (KAIST), Daejeon, Korea
2005. 3. 1 - 2010. 5. 31: Senior Researcher & Post-Doctoral Fellow
Applied Science Research Institute,
BioProcess Engineering Research Center,
Department of Chemical and Biomolecular Engineering,
Korea Advanced Institute of Science and technology (KAIST), Daejeon, Korea.
Awards and Honors
Outstanding Poster Award, The Microbiological Society of Korea (2009. 5. 30)
Outstanding Poster Award, The Microbiological Society of Korea (2003. 10. 24)
Memberships
The Korean Society for Biotechnology and Bioengineering
The Korean Society for Microbiology and Biotechnology
Publications
International Journal Publications
Kim, S.*, Jang, Y.-S.*, Ha, S.-C.*, Ahn, J.-W., Kim, E.-J., Lim, J.H., Cho, C., Ryu, Y.S., Lee, S.K., Lee, S.Y. and Kim, K.-J. "Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum", Nature Communications, 6:8410 (2015. 9). (*Equally contribution)
Cho, C.*, Jang, Y.-S.*, Moon, H.G., Lee, J., and Lee, S.Y., "Metabolic engineering of clostridia for the production of chemicals", Biofuels Bioprod. Bioref. 9(2): 211-225 (2015. 3/4). (*Equally contribution)
Choi, Y.J., Lee, J., Jang, Y.-S., and Lee, S.Y., "Metabolic engineering of microorganisms for the production of higher alcohols", mBio, 5(5): e01524-14 (2014. 9) Featured cover paper (jpg, pdf)
Jang, Y.-S., Han, M.-J., Lee, J., Im, J.A., Lee, Y.H., Papoutsakis, E.T., Bennett, G., and Lee, S.Y. "Proteomic analyses of the phase transition from acidogenesis to solventogenesis using solventogenic and non-solventogenic Clostridium acetobutylicum strains", Appl. Microbiol. Biotechnol. 98(11): 5105-5115 (2014. 6)
Jang, Y.-S., Im, J.A., Choi, S.Y., Lee, J.I., and Lee, S.Y. "Metabolic engineering of Clostridium acetobutylicum for butyric acid production with high butyric acid selectivity", Metabolic Eng., 23: 165-174 (2014. 5)
Jang, Y.-S., Woo, H.M., Im, J.A., Kim, I.H., Lee, S.Y., "Metabolic engineering of Clostridium acetobutylicum for enhanced production of butyric acid", Appl. Microbiol. Biotechnol., 97(21): 9355-9363 (2013. 11)
Jang, Y.S., Malaviya, A., Lee, J., Im, J.A., Lee, S.Y., Lee, J., Eom, M.-H., Cho, J.-H. and Seung, D.Y., "Metabolic Engineering of Clostridium acetobutylicum for the Enhanced Production of Isopropanol-Butanol-Ethanol Fuel Mixture", Biotechnol. Prog., 29(4): 1083-1088 (2013. 7, 8)
Jang, Y.-S., Malaviya, A., and Lee, S.Y., "Acetone-Butanol-Ethanol Production with High Productivity using Clostridium acetobutylicum BKM19", Biotechnol. Bioeng., 110(6): 1646-1653 (2013. 6)
Choi, J.-D.-R., Jang, Y.-S., Cho, J.-H., Seung, D., Lee, S.Y., Papoutsakis, E.T., Bennett, G.N., Song, H., "Characterization and Evaluation of Corn Steep Liquid in Acetone- Butanol-Ethanol Production by Clostridium acetobutylicum", Biotechnol. Bioproc. Eng., 18(2): 266-271 (2013. 4)
Choi, S.J., Lee, J., Jang, Y.-S.*, Park, J.H., Lee, S.Y., and Kim, I.H.*, "Effects of nutritional enrichment on the production of acetone-butanol-ethanol (ABE) by Clostridium acetobutylicum", J. Microbiol., 50(6): 1063-1066 (2012.12).(*Corresponding authors)
Jang, Y.-S., Malaviya, A., Cho, C., Lee, J., and Lee, S.Y. “Butanol production from renewable biomass by clostridia”, Bioresource Technol., 123: 653-663 (2012. 11)
Jang, Y.-S., Lee, J.Y., Lee, J., Park, J.H., Im, J.A., Eom, M.-H., Lee, J., Lee, S.-H., Song, H., Cho, J.-H., Seung, D.Y., and Lee, S.Y., "Enhanced butanol production obtained by reinforcing the direct butanol-forming route in Clostridium acetobutylicum", mBio, 3(5): 1-9 (2012. 10)
Featured Cover Paper (1, 2, 3)
Jang, Y.-S., Kim, B., Shin, J.H., Choi, Y.J., Choi, S., Song, C.W., Lee, J., Park, H.G., Lee, S.Y. "Bio-based production of C2-C6 platform chemicals", Biotechnol. Bioeng., 109(10): 2437-2459 (2012. 10)
Journal cover paper (cover)
Jang, Y.-S., Park, J.M., Choi, S., Choi, Y.J., Seung, D.Y., Cho, J.H., and Lee, S.Y., "Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches", Biotechnol. Adv., 30(5): 989-1000 (2012. 9)
Lee, J., Jang, Y.-S., Choi, S.J., Im, J.A., Song, H., Cho, J.H., Seung, D.Y., Papoutsakis, E.T., Bennett, G.N., and Lee, S.Y., "Metabolic engineering of Clostridium acetobutylicum ATCC 824 for isopropanol-butanol-ethanol fermentation", Appl. Environ. Microbiol., 78(5): 1416-1423 (2012. 3)
Malaviya, A., Jang, Y.-S., and Lee, S.Y., "Continuous butanol production with reduced byproducts formation from glycerol by a hyper producing mutant of Clostridium pasteurianum", Appl. Microbiol. Biotechnol., 93(4): 1485-1494 (2012. 2)
Jang, Y.-S., Lee, J., Malaviya, A., Seung, D.Y., Cho, J.H., and Lee, S.Y., "Butanol production from renewable biomass: rediscovery of metabolic pathways and metabolic engineering", Biotechnol. J., 7, 186-198 (2012. 2) Journal cover paper(cover) '2012 Biotechnology Journal Cover Contest Winner
Lee, J.W., Kim, T.Y., Jang, Y.S., Choi, S., and Lee, S.Y., "Systems metabolic engineering for chemicals and materials", Trends Biotechnol. 29, 370-378 (2011. 8) Journal cover paper (cover, online)
Park, J.H., Jang, Y.-S., Lee, J.W., and Lee, S.Y., “Escherichia coli W as a new platform strain for the enhanced production of L-valine by systems metabolic engineering”, Biotechnol. Bioeng. 108, 1140-1147 (2011. 5).
Park, J.M., Jang, Y.-S., Kim, T.Y., and Lee, S.Y., "Development of a gene knockout system for Ralstonia eutropha H16 based on the broad-host-range vector expressing a mobile group II intron", FEMS Microbiol. Lett. 309, 193-200 (2010. 8)
Lee, J.Y.*, Jang, Y.-S.*, Lee, J., Papoutsakis, E.T., and Lee, S.Y., “Metabolic engineering of Clostridium acetobutylicum M5 for highly selective butanol production”, Biotechnol. J., 4, 1432-1440 (2009. 10) (*Equally contribution)
Lee, S.Y., Kim, J.M., Song, H., Lee, J.W., Kim, T.Y., and Jang, Y.-S., "From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens", Appl. Microbiol. Biotechnol. 79, 11-22 (2008. 5).
Jang, Y.-S., Jung, Y.R., Lee, S.Y., Kim, J.M., Lee, J.W., Oh, D.-B., Kang, H.A., Kwon, O., Jang, S.H., Song, H., Lee, S.J., and Kang, K.Y., “Construction and characterization of shuttle vectors for succinic acid producing rumen bacteria”, Appl. Environ. Microbiol. 73, 5411-5420 (2007. 9).
Lee, Y.K., Jang, Y.-S., Chang, H.H, Hyung, S.W., and Chung, H.Y., “A putative early response of antifungal Bacillus lentimorbus WJ5 against the plant pathogenic fungus, Colletotrichum gloeosporioides, Analyzed by a DNA Microarray”, J. Microbiol. 43, 308-312 (2005).
Kim, S.T., Yu, S., Kim, S.G., Kim, H.J., Kang, S.Y., Hwang, D.H., Jang, Y.-S., and Kang, K.Y., "Proteome analysis of rice blast fungus (Magnaporthe grisea) proteome during appressorium formation", Proteomics, 4, 3579–3587 (2004).
Park, S.J., and Jang, Y.-S., "X-ray diffraction and x-ray photoelectron spectroscopy studies of ni–p deposited onto carbon fiber surfaces: impact properties of a carbon-fiber-reinforced matrix", J. Colloid Interf. Sci. 263, 170–176 (2003).
Park, S.J., and Jang, Y.-S., "Preparation and characterization of activated carbon fibers supported with silver metal for antibacterial behavior", J. Colloid Interf. Sci. 261, 238–243 (2003).
Park, S.J., and Jang, Y.-S., Shim, J.W., and Ryu, S.K., "Studies on pore structure and surface functional groups of pitch-based activated carbon fibers", J. Colloid Interf. Sci. 260, 259–264 (2003).
Park, S.J., and Jang, Y.-S., "Pore structure and surface properties of chemically modified activated carbons for adsorption mechanism and rate of Cr(VI)", J. Colloid Interf. Sci. 249, 458-463 (2002).
Park, S.J., Jang, Y.-S., and Rhee, K.Y., "Interlaminar and ductile characteristics of carbon fibers-reinforced plastics produced by nano-scaled electroless nickel plating on carbon fiber surfaces", J. Colloid Interf. Sci., 245, 383-390 (2002).
Park, S.J., and Jang, Y.-S., "Interfacial characteristics and fracture toughness of electrolytically ni-plated carbon fiber-reinforced phenolic resin matrix composites", J. Colloid Interf. Sci. 237, 91-97 (2001).
Kim, S.T., Cho, K.S., Jang, Y.-S., and Kang, K.Y., "Two-dimensional electrophoretic analysis of rice proteins by polyethylene glycol fractionation for protein arrays", Electrophoresis 22, 2103-2109 (2001).
Domestic Journal Publications
Lee, G.N., Choi, S.Y., Na, J.*, Youn, H., and Jang, Y.-S.*, "Production of polyhydroxybutyrate from crude glycerol and spent coffee grounds extract by Bacillus cereus isolated from sewage treatment plant", KSBB J. In press. (*Corresponding authors)
Lee, S.Y., Jang, Y.-S., “Development of Industrial Strains for Biorefinery Based on Metabolic Engineering and Systems Biotechnology”, BioSafety 10, 22-31, 2009 (ISSN 1599-8630).
Lee, Y.K., Chang, H.H., Jang, Y.-S., Hyung, S.W., and Chung, H.Y. "Partial reduction of dinitroaniline herbicide pendimethalin by Bacillus sp. MS202", Kor. J. Environ. Agric. 23, 197-202, 2004.
Lee, Y.K., Dinh, L.T., Jang, Y.-S., Chung, H.Y., and Chang, H.H., "Two-dimensional electrophoresis analysis of proteins between Bacillus subtilis LTD and its antifungal activity deficient mutant", Korean J. Environ. Biol. 22, 487-493, 2004.
Lee, Y.K., Chang, H.H., Jang, Y.-S., Huh, J.H., Hyung, S.W., and Chung, H.Y., "Microarray analysis of radiation related gene expression in mutants of Bacillus lentimorbus WJ5 Induced by gamma radiation", Korean J. Environ. Biol. 22, 472-477, 2004.
Jang, Y.-S., Lee, Y.K., Kim, J.S., Cho, K.S., and Jang, B.I., "Expression of secretion-dedicated Srb homologue and antifungal activity of Bacillus lentimorbus WJ5", Kor. J. Microbiol. 39, 135-140, 2003.
Lee, Y.K., Kim, J.S., Chung, H.Y., Jang, Y.-S., Jang, B.I., "Two-dimensional electrophoresis analysis of antifungal activity related proteins in Bacillus licheniformis DM3", Kor. J. Environ. Agric. 22, 203-209, 2003.
Lee, Y.K., Kim, J.S., Jang, Y.-S., Cho, K.S., and Chang, H.H., "DNA microarray analysis of gene expression in antifungal bacterium of Bacillus lentimorbus WJ5", Kor. J. Microbiol. 39, 141-147. 2003.
Lee, Y.K., Kim, J.S., Jang, B.I., Jang, Y.-S., and Lee, H.Y., “Biological control of Pythium root rot by radiation induced mutant of Bacillus lentimorbus WJ5a17”, Korean J. Environ. Biol. 21, 276-285, 2003.
Lee, Y.K., Chang, H.H., Kim, J.S., Jang, Y.-S., and Lee, H.Y., “Gamma radiation induced mutational spectrum of laccase gene in Pleurotus ostreatus”, Korean J. Environ. Biol. 20, 316-324, 2002.
Book Chapter
Na D., Park J., Jang Y.-S., Lee J, Lee S.Y., 2012. Systems Metabolic Engineering of Escherichia coli for Chemicals, Materials, Biofuels, and Pharmaceuticals. In: Wittmann, C., Lee, S. Y., Eds., Systems Metabolic Engineering. Springer Netherlands, pp. 117-149
Proceedings & Essays
Lee, S.Y., Jang, Y.-S., "Current and Pospective of Borefinery Tchnology", Bioin Special Zine 15, 1-15, 2010 (ISBN 978-89-93675-30-6).
Park, S.J., Jang, Y.S., and Lee, J.R., In "Advances in Environmental Materials, Vol. I" (T. White and J. A. Stegemann Eds.), pp.139-144. Materials Research Society, Singapore, 2001 (ISBN 981-04-4991-7).
Intermational Conferences
Jang, Y.S. "Metabolic engineering of clostridia for butanol production", Cold Spring Harbor Asia Symposium on Synthetic Biology, November 26 – 30, 2012, Suzhou, China –Invited Talk-
Jang, Y.S., Malaviya, A., Lee, S.Y., "Continuous Solvents Production with High Productivity Using Clostridium pasteurianum", Cold Spring Harbor Asia Symposium on Synthetic Biology, November 26 – 30, 2012, Suzhou, China
Choi, S.Y., Lee, J., Jang, Y.S., Lee, S.Y., "Conversion of Acetone into Isopropanol in Clostridium acetobutylicum and Enhanced Production of Mixed Alcohol by In situ Gas-stripping", Cold Spring Harbor Asia Symposium on Synthetic Biology, November 26 – 30, 2012, Suzhou, China
Lee, J., Jang, Y.S., Lee, S.Y., "Development of an efficient knock-down method for metabolic engineering of Clostridium beijerinckii NCIMB 8052, 15th International Biotechnology Symposium and Exhibition, September 16-21, 2012, Daegu, Korea
Cho, C., Jang, Y.S., Lee, S.Y., "Effects of cyclopropane fatty acid synthase overexpression in the solventogenic phase on the solvent tolerance of Clostridium acetobutylicum ATCC 824", 15th International Biotechnology Symposium and Exhibition, September 16-21, 2012, Daegu, Korea
Lee, S.Y., Lee, J., Jang, Y.S., "Engineering of Clostridium acetobutylicum ATCC 824 towards a mixed alcohol producer", Metabolic Engineering IX, June 3-7, 2012, Biarritz, France
Lee, S.Y., Park, J.H., Jang, Y.S., Kim, J.Y., "Systems metabolic engineering of Escherichia coli W for L-valine production", Metabolic Engineering IX, June 3-7, 2012, Biarritz, France
Jang, Y-S., Lee, J.Y. , Lee, J., Song, H., Cho, J-H., Seung, D., Lee, S.Y., "Metabolic engineering of Clostridium acetobutylicum ATCC824 for enhanced butanol production", Society for industrial microbiology 61st annual meeting, July 24~28, 2011, New orleans, LA, USA
Lee, J., Jang, Y-S., Choi, S.J., Song, H , Cho, J-H., Seung, D., Lee, S.Y., "In situ recovery of isopropanol-butanol-ethanol(IBE) by gas-stripping using engineered Clostridium acetobutylicum", Society for industrial microbiology 61st annual meeting, July 24~28, 2011, New orleans, LA, USA
Park, J.H., Jang, Y.S., Lee, J.W., Lee, S.Y., "Efficient L-valine production by metabolically engineered Escherichia coli W strain", Society for industrial microbiology 61st annual meeting, July 24~28, 2011, New orleans, LA, USA
Lee, J., Malaviya, A., Jang, Y.S., Park, J.H., Lee, S.Y., "Enhanced Butanol Production from Glycerol Using a Mutant of Clostridium pasteurianum", Asian Congress on Biotechnology, May 11~15, 2011, Shanghai, China
Lee, J., Jang, Y.S., Lee, S.Y., "Isopropanol-butanol fermentation using engineered Clostridium acetobutylicum strains", 111th International Conference on the Genetics and Physiology of Acid- and Solvent-producing Clostridia, October 3-6, 2010, Hilton San Diego Resort&Spa, USA
Lee, J., Jang, Y.S., Han, M,-J., Seung, D.Y., Lee, S.Y., "Comparative proteome analyses of solvent-producing Clostridium acetobutylicum strains at acidogenic and solventogenic phases", 11th International Conference on the Genetics and Physiology of Acid- and Solvent-producing Clostridia, October 3-6, 2010, Hilton San Diego Resort&Spa, USA
Lee, S.Y., Jang, Y.S., Lee, J.Y., Lee, J., "Metabolic engineering of Clostridium acetobutylicum ATCC 824 for Enhanced Butanol Production", 11th International Conference on the Genetics and Physiology of Acid- and Solvent-producing Clostridia, October 3-6, 2010, Hilton San Diego Resort&Spa, USA
Lee, S.Y., Jang, Y.S., Lee, J.Y., Lee, J., "Metabolic Engineering of Clostridium acetobutylicum ATCC 824 for Increased Butanol Production", 14th International Biotechnology Symposium and Exhibition, September 14-18, 2010, Rimini, Italy
Lee, S.Y., Jang, Y.S., Yang, M.H., Choi, B.G., Park, T.J., Hong, W.H., "Functionalization of graphene oxide using ionic liquids for glucose biosensing", International Conference on Cellular and Molecular Bioengineering 2, August2-4, 2010, Singapore
Choi, E.J., Lee, J.W., Jang, Y.S., Lee, S.Y., "Effect of Using Phosphoenolpyruvate Carboxykinase in the Production of Succinic Acid in Escherichia coli", International Conference on Cellular and Molecular Bioengineering 2, August2-4, 2010, Singapore
Jang, Y.S., Lee, J., Lee, S.Y., "Metabolic Engineering of Clostridium acetobutylicum ATCC 824 for Enhanced Biofuel Alcohol Production", International Conference on Cellular and Molecular Bioengineering 2, August2-4, 2010, Singapore
Lee, T.W., Lee, J.Y., Jang, Y.S., Lee, S.Y., "Gene inactivation of acid formation in Clostridium acetobutylicum and identification of their metabolic characteristics", 11th international symposium of the genetics of industrial microorganisms, June 28-July 1, 2010, Melbourne, Austrailia
Jang, Y.S., Lee, J.Y., L, J., Park, J.H., Lee, S.Y., "Engineering of acetic and butyric acids pathways in Clostridium acetobutylicum ATCC 824 by using a mobile group ⅱ intron", Metabolic engineering VIII, ICC, June 13-17, 2010, Jeju Island, Korea
Lee, J.Y., Jang, Y.S., Lee, J, Lee, S.Y., "Highly selective butanol production by expression of SOL operon in Clostridium acetobutylicum M5", Metabolic engineering VIII, ICC, June 13-17, 2010, Jeju Island, Korea
Jang, Y.S., Lee, J.W., Kim, J.M., Lee, S.Y., "Identification of Sucrose Uptake System in Mannheimia succiniciproducens", 14th European Congress on Biotechnology, Barcelona, Spain, September 13-16 (2009)
Jang, Y.S., Lee, J.Y., Lee, J.M., Lee, S.Y., "Metabolic Engineering of Clostridium acetobutylicum M5 for Butanol-Ethanol Production by Complementation of adhE1 and ctfAB Genes", 14th European Congress on Biotechnology, Barcelona, Spain, September 13-16 (2009)
Lee, J.Y., Jang, Y.S., and Lee, S.Y., "Expression of aad and ctfAB operon in Clostridium acetobutylicum M5 for predominantly alcohologenic fermentation", Clostridium 10: Tenth International Workshop on Regulation of Metabolism, Genetics and Development of the Solvent- and Acid-forming Clostridia, Netherlands, September 28-October 1 (2008)
Jang, Y.S., Lee. J.Y., and Lee, S.Y., "Effect of advanced cell density on production of solvents and organic acids by batch-fermentation of Clostridium acetobutylicum", Clostridium 10: Tenth International Workshop on Regulation of Metabolism, Genetics and Development of the Solvent- and Acid-forming Clostridia, Netherlands, September 28-October 1 (2008)
Jang, Y.S., J.W. Lee, Lee, S.Y., "Development of Shuttle Vectors for Succinic Acid Producing Rumen Bacteria", 30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, LA, USA, May 4-7, 2008
K.H. Lee, J.H. Park, T.Y. Kim, Y.S. Jang, Lee, S.Y., "Systems Metabolic Engineering of Escherichia coli for L-Threonine Production", 30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, LA, USA, May 4-7, 2008
J.H. Park, K.H. Lee, T.Y. Kim, Y.S. Jang, Lee, S.Y., "Systems-Level Analysis and Engineering of Escherichia coli for the Production of L-Valine", 30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, LA, USA, May 4-7, 2008
Lim, S.W., Song, H., Jang, Y.S., and Lee, S.Y., "fdhD and fdhE Characterization of Mannheimia succiniciproducens MBEL55E", The 18th Symposium on Chemical Engineering, Daejeon/Chungnam(Korea)-Kyushu(Japan), Dec. 2-4 (2005)
Patents
Sang Yup Lee, Yu-Sin Jang, Jin Young Lee, Joungmin Lee, Park, J.H., “Enhanced Butanol Producing Recombinant Microorganisms and Method for Preparing Butanol Using the Same”, KR 10-2009-0089829 (2009. 09. 22), KR 10-2010-0092733 (2010. 09. 20), PCT/KR2010/006511 (2010. 09. 20).
Sang Yup Lee, Yu-Sin Jang, Song, H., “Recombinant Mutant Microorganisms Enhanced ability of Producing Butanol or Mixed Alcohol and ability of Removing Acetone and Method for Preparing Butanol or Mixed Alcohol Using the Same”, KR 10-2009-0089826 (2009. 09. 22), KR 10-2010-0092720 (2010. 9. 20), PCT/KR2010/006510 (2010. 09. 20).
Sang Yup Lee, Yu-Sin Jang, Joungmin Lee, Im, J.A., “Enhanced Butanol, Ethanol and Isopropanol Producing Recombinant Mutant Microorganisms and Method for Preparing It Using the Same”, KR 10-2009-0089827 (2009. 09. 22), KR 10-2010-0092721 (2010. 9. 20), PCT/KR2010/006510 (2010. 09. 20).
Sang Yup Lee, Jong Myoung Park, Yu-Sin Jang, Tae Yong Kim, “Method for Inactivating a Target Gene in the Genus Ralstonia”, KR 10-2010-0041955 (2010. 05. 04).
Sang Yup Lee, Joungmin Lee, Yu-Sin Jang, “A method for inactivating a desired gene in Bacteria belonging genus Clostridium”, KR 10-2009-0089825 (2009. 09. 22).
Sang Yup Lee, Joungmin Lee, Yu-Sin Jang, “Preparing Method for Non-degenerative Microorganism by Protecting Megaplasmid Lose and the Microorganism Thereof”, KR 10-2009-0089828 (2009. 09. 22).
Sang Yup Lee, Yu-Sin Jang, Jin Young Lee, Kim, J., Jung, K.S., “Enhanced Ethanol and Butanol Producing Microorganisms and Method for Preparing Ethanol and Butanol Using the Same”, PCT/KR08/007577 (2008. 12. 22), KR 10-2007-0134701 (2007. 12. 20), JP 2010-539309 (2010. 6. 21).
Sang Yup Lee, Papoutsakis, E.T., Yu-Sin Jang, “Method for Preparing Butanol through Butyryl-CoA as an Intermediate using Yeast”, PCT/KR08/00787 (2008. 02.11.), KR 10-2008-7004724 (2008. 02. 27), JP 2009-549003 (2009. 11. 26), AU 2008213200 (2008. 02. 11), CA 2677309 (2008. 02. 11), IN 4656/CHENP/2009 (2009.08.07).
Sang Yup Lee, Hyohak Song, Yu-Sin Jang, Ji Mahn Kim, "Novel Gene Encoding Fumarate Hydratase C and Method for Preparing Succinic Acid Using the Same”, Korean patent: no. 0727054 (2007. 6. 4), US patent: appl. no. 11/228,927 (2007. 2. 22).
Sang Yup Lee, Hyohak Song, Yu-Sin Jang, Sung Won Lim, "Novel Gene Encoding Formate dehydrogenase D & E and Method for Preparing Succinic Acid Using the Same”, Korean patent: no. 0679638 (2007. 1. 31), US patent: no. 7572615 (2009. 08. 11), US patent: no. 7241594 (2007. 07. 10).
Sang Yup Lee, Hyohak Song, Yu-Sin Jang, Jeong Wook Lee, “Novel Gene Encoding Malic Enzyme B and Method for Preparing Succinic Acid Using the Same”, Korean patent: no. 0676160 (2007. 1. 24), US patent no. 7470770 (2008. 12. 30).
Young-Keun Lee, Hwa-Hyoung Chang, Yu-Sin Jang, Kyu Seong Cho, Byung Il Jang, and Hye-Young Chung, “Recombinant Plasmid Capable of Replication in E.coli And/Or Bacillus sp.”, Korean patent: no. 0552913 (2006. 2. 9).
Young-Keun Lee, Yu-Sin Jang, Kyu Seong Cho, Byung Il Jang, and Hye-Young Chung, “Antifungal Bacillus lentimorbus WJ5, Biopesticide Containing the Same And Mutant Strain of The Microorganism”, Korean patent: no. 0489217 (2005. 5. 3).
Soo-Jin Park, Jae-Rock Lee, and, Yu-Sin Jang, “Manufacturing Process of Nickel-plated Carbon Fibers by Electroplating Method”, Korean patent: no. 0572995 (2006. 4. 14).
Soo-Jin Park, Jae-Rock Lee, and, Yu-Sin Jang, "Activated Carbon Or Activated Carbon Fiber Plated with Transition Metal And Preparation Thereof", Korean patent: appl. no. 10-2002-0033236 (2002.6.14).
Soo-Jin Park, Jae-Rock Lee, and, Yu-Sin Jang, "Manufacturing Process of Nano Scaled Nickel-plated Carbon Fibers by Non-electroplating Method", Korean patent: no. 0486962 (2005. 4. 25). -LICENSED OUT-
Soo-Jin Park, Jae-Rock Lee, and, Yu-Sin Jang, "Activated Carbon Fiber Having Silver Particles on the Surface Thereof, and Preparation Process Therefore", Korean patent: no. 0455664 (2004.10.26). -LICENSED OUT-
Jong Hwan Baek
Ph.D. '08. 2
National cancer Institute, NIH, USA,
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Research Interest
Transcriptome analysis
Trancription factor
Synthetic biology
Education
1998. 3. ~ 2002. 2. B.S. Dept. of Biological Sciences, KAIST, Daejeon, Korea
2002. 3. ~ 2004. 2. M.S. Dept. of Biological Sciences, KAIST, Daejeon, Korea (Thesis: Microbial community structure and function in common bean phytosphere)
2004. 3. ~ 2008. 2. Ph.D. Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea (Thesis: The analysis of transcription factors in Escherichia coli and its applications)
Research Activity
Publications
Quan, Z.-X., Bae, H.-S., Baek, J.-H., Chen, W.-F., Im, W.-T. and Lee, S.-T., "Rhizobium daejeonense sp. nov. isolated from a cyanide treatment bioreactor" Int. J. Syst. Evol. Microbiol. 55: 2543-2549 (2005)
Quan, Z.-X., Rhee, S.-K., Bae, J.-W., Baek, J.-H., Park, Y.-H. and Lee, S.-T., "Bacterial community structure in activated sludge reactors treating free or metal-complexed cyanides " J. Microbiol. Biotechnol. 16: 232-239 (2006)
Baek, J.H. and Lee, S.Y., "Novel gene members in the Pho regulon of Escherichia coli", FEMS Microbiol. Lett. 264: 104-109 (2006)
Baek, J.H. and Lee, S.Y., "Transcriptome analysis of phosphates starvation response in Escherichia coli", J. Microbiol. Biotechnol. 17: 244-252 (2007)
Baek, J.H., Kang, Y.J. and Lee, S.Y., "Transcript and protein level analyses of the interactions among PhoB, PhoR, PhoU and CreC in response to phosphate starvation in Escherichia coli", FEMS Microbiol. Lett. 277: 254-259 (200
International Conferences
Baek, J. H. and Lee, S. Y., "Global transcriptional analysis of phosphate starvation response in Escherichia coli" Biochemical Engineering XIV, Harrison Hot Springs, BC, Canada, July 10-14 (2005)
Kang, Y.J., Baek, J.H. and Lee, S.Y., "The analysis of protein interaction in PhoR-PhoB two-component regulatory system in Escherichia coli" The 18th Symposium on Chemical Engineering, Daejeon/Chungnam(Korea)-Kyushu(Japan), December 2-4 (2005)
Baek, J.H., Kang, Y.J. and Lee, S.Y., "Gene expression regulation and cross-regulation in phosphate starvation response of Escherichia coli" 10th international symposium on the genetics of industrial microorganisms(GIM), Prague, Czech Republic, June 24-28 (2006)
Baek, J.H., Kang, Y.J. and Lee, S.Y., "Transcript and protein level analysis of cross-regulation in phosphate starvation response in Escherichia coli" Metabolic Engineering VI: From recDNA towards Engineering Biological Systems, Noordwijkerhout, Netherlands, October 1-5 (2006)
Baek, J.H., Kang, Y.J. and Lee, S.Y., "Transcriptome and protein level analyses of PhoR-PhoB two-component regulatory system in Escherichia coli" Metabolic Engineering VI: From recDNA towards Engineering Biological Systems, Noordwijkerhout, Netherlands, October 1-5 (2006)
Baek, J.H., Kang, Y.J. and Lee, S.Y., "Elucidating the regulatory system in response to phosphate starvation of Escherichia coli" The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea, October 30-November 3 (2006)
Awards
"The Second Prize in Environmental Paper Contest" Korea Environmental Preservation Association (2003)
"The Excellent Poster Research Award" International Meeting of the Federation of Korean Microbiological Societies (2005)
"Best Research Award" The 63th Korean Society for Biochemistry and Molecular Biology Annual Meeting (2006)
Tae Yong Kim
Ph.D. '08. 8
Samsung Advanced Institute of Technology
Phone :+82-42-869-5970
Fax :+82-42-869-8800
Details
Research Interest
Metabolic engineering
Systems biology
Education
1997. 3. - 2003. 2., (B.S.) Chemical & Biological Engineering, Korea Univ., Seoul, Korea
2003 ~ 2005, (M.S.) M.Eng. Department of Chemical & Biomolecular Engineering, KAIST, Korea
2005 ~ 2008 : Dept. of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea Advisor : Professor Sang Yup Lee
Professional Experience
CJ CheilJedang Corp., Institute of Science & Technology, R&D center for Bioproducts, Senior Researcher (1995.1 ~ present)
Research Activity
International Journal
Hong, S.H., Kim, T.Y., and Lee, S.Y., "Phylogenetic analysis based on genome-scale metabolic pathway reaction content", Appl. Microbiol. Biotechnol., 65: 203-210 (2004)
Lee, S.Y., Lee, D.-Y., and Kim, T.Y., "Systems biotechnology for strain improvement", Trends Biotechnol., 23(7): 349-358 (2005.7).
Lee, S.Y., Lee, D.-Y., and Kim, T.Y., "Systems biotechnology for strain improvement", Trends Biotechnol., 23(7): 349-358 (2005.7).
Park, S.J., Lee, S.Y., Cho, J., Kim, T.Y., Lee, J.W., Park, J.H., and Han, M.-J., "Global physiological understanding and metabolic engineering of microorganisms based on omics studies", Appl. Microbiol. Biotechnol., 68:567-579 (2005. 9)
Lee, S.J., Lee, D.-Y., Kim, T.Y., Kim, B.H., Lee, J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the enhanced production of succinic acid based on genome comparison and in silico gene knock-out simulation", Appl. Environ. Microbiol., 71(12): 7880-7887 (2005.12).
Lee, S.Y., Woo, H.M., Lee, D.-Y., Choi, H.S., Kim, T.Y., and Yun, H., "Systems-level analysis of genome-scale microbial metabolisms under the integrated software environment", Biotechnol. Bioproc. Eng. 10(5): 425-431 (2005. 9~10)
Kim, J.S., Yun, H., Kim, H.U., Choi, H.S., Kim, T.Y., Woo, H.M., and Lee, S.Y. "Resources for systems biology research", J. Microbiol. Biotechnol. 16(6): 832-848 (2006. 6).
Kim, T.Y. and Lee, S.Y. "Accurate metabolic flux analysis through data reconciliation of isotope balance-based data", J. Microbiol. Biotechnol. 16(7): 1139-1143 (2006. 7).
Barrett, C.L., Kim, T.Y., Kim, H.U., Palsson, B.O., and Lee, S.Y., "Systems biology as a foundation for genome-scale synthetic biology", Curr. Opin. Biotechnol. 17: 488-492 (2006. 10.)
Choi, H.S., Kim, T.Y., Lee, D.-Y., and Lee, S.Y, "Incorporating metabolic flux ratios into constraint-based flux analysis by using artificial metabolites and converging ratio determinants", J. Biotechnol. 129(4):696-705 (2007. 5.)
Kim, T.Y., Kim, H.U., Park, J.M., Song, H., Kim, J.S. and Lee, S.Y., "Genome-scale analysis of Mannheimia succiniciproducens metabolism", Biotechnol. Bioeng. (Accelerated Publication), 97(4): 657-671 (2007. 7.)
Park, J.H., Lee, K.H., Kim, T.Y., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation", Proc. Nat. Acad. Sci. (PNAS), 104 (19): 7797-7802 (2007. 4.)
Kim, P.J., Lee, D.Y., Kim, T.Y., Lee, K.H., Joeong, H.W., Lee, S.Y., Park, S.W., "Metabolite essentiality elucidates robustness of Escherichia coli metabolism", Proc. Nat. Acad. Sci. (PNAS), 104 (34): 13638-13642 (2007. 8.)
Lee, K.H., Park, J.H., Kim, T.Y., Kim, H.U., and Lee, S.Y., " Systems metabolic engineering of Escherichia coli for L-threonine production", Molecular systems biology, 3(149): 1-8 (2007. 12.)
Kim, H.U., Kim, T.Y., and Lee, S.Y., "Metabolic flux analysis and metabolic engineering of microorganisms", Mol. Biosyst. 4: 113-120 (2008. 2.)
Kim, T.Y., Sohn, S.B., Kim, H.U., and Lee, S.Y., "Strategies for systems-level metabolic engineering", Biotechnol. J. 3:612-623 (2008. 5.)
Song, H., Kim, T.Y., Choi, B.-K., Choi, S.J., Nielsen, L., Chang, H.N., and Lee, S.Y., "Development of chemically defined medium for Mannheimia succiniciproducens based on its genome sequence", Appl. Microbiol. Biotechnol. 79(2): 263-272 (2008. 5.)
Lee, S.Y., Kim, J.M., Song, H., Lee, J.W., Kim, T.Y., and Jang, Y.-S., "From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens", Appl. Microbiol. Biotechnol. 79(1): 11-22 (2008. 5.)
Moon, S.Y., Hong, S.H., Kim, T.Y., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of malic acid", Biochem. Eng. J. 40(2): 312-320 (2008. 1.)
Park, J.H., Lee, S.Y., Kim, T.Y., and Kim, H.U., "Application of systems biology for bioprocess development", Trends Biotechnol., 26(8), 404-412 (2008. 8.)
Lee, S.Y., Kim, H.U., Park, J.H., Park, J.M., and Kim, T.Y., "Metabolic engineering of microorganisms: general strategies and drug production", Drug Discovery Today, 14(1/2): 78-88 (2009. 1)
International Conferences
Lee, S.Y., Kim, T.Y., and Hong, S.H., "Engineering the metabolic pathways of Escherichia coli for the production of various metabolites based on metabolic flux analysis", First IECA Conference on Systems Biology of E. coli., Tsuruoka, Japan, June 23-25(2003)
Lee, S.Y., Lee, D.Y., Hong, S.H., Kim, T.Y., Yun, H.S., Oh, Y.G., and Park, S.W., "MetaFluxNet, a Program Package for Metabolic Pathway Construction and Analysis, and Its Use in Large-scale Metabolic Flux Analysis of Escherichia coli", The 4th International Conference on Genome Informatics, GIW2003, Pacifico Yokohama, Yokohama, Japan December 14-17(2003)
Kim, T.Y., Hong S.H., and Lee, S.Y., "Identification of metabolic characteristics through metabolic flux analysis using MetaFluxNet", 11th Internationa Conference on Intelligent Systems for Molecular Biology, Brisbane, Queensland, Australia (2003)
Kim, T.Y., Hong, S.H., and Lee, S.Y., "Evaluating evolutionary relationship of microorganisms and their cellular metabolic pathways based on genome-scale metabolic pathway content, The Second International E. coli Allicance Conference on Systems Biology, Banff, Alberta, Canada, June 18-22 (2004)
Kim, T.Y., Hong, S.H., and Lee, S.Y., "Reconciliation of GC/MS based flux distribution data and metabolic flux analysis" The Second International E. coli Allicance Conference on Systems Biology, Banff, Alberta, Canada,(2004)
Kim, T.Y., Hong, S.H., and Lee, S.Y., "Evaluating evolutionary relationship of microorganisms and their cellular metabolic pathways based on genome-scale metabolic pathway content" Metabolic Engineering V: Genome to Product, Lake Tohoe, California, USA Sept. 19-23(2004)
Lee, S.Y., Choi, H.S., Kim, T.Y., Lee, D.Y., "Constrains-based flux analysis: Exploring internal flux patterns further constrained by split ratio determinant" The Third Asia-Pacific Bioinformatics Conference, Singapore, January 17-21 (2005)
Lee, S.Y., Kim, T.Y., Lee, D.Y., Kim, B.H., "A new strategy for in silico gene knock-out for strain improvement: Succinate production in E.coli as an example" The Third Asia-Pacific Bioinformatics Conference, Singapore, January 17-21 (2005)
Lee, S.Y., Woo, H.M., and Lee, D.Y., Choi, H.S., Kim, T.Y., Yun, H.S., "Metabolic Analysis of In Silico Genome-Scale Models Using MetaFluxNet" BioInfo 2005, Busan, Korea, Sep 22-24 (2005)
Kim, T.Y., Lee, D.Y., Lee, S.J.,Lee, S.Y., "i>In Silico Experiment for the Strain Improvement: Succinate production in Escherichia coli" BioInfo 2005, Busan, Korea, September 22-24 (2005)
Choi, H.S., Kim, T.Y., Lee, D.Y., Lee, S.Y., "Split Ratio Determinant: Newly Efficient Constraint Exploring Internal Flux Distribution" BioInfo 2005, Busan, Korea, September 22-24 (2005)
Lee, K.H., Park, J.H., Kim, T.Y., and Lee, S.Y., "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis" 10th international symposium on the genetics of industrial microorganisms(GIM), Prague, Czech Republic (2006. 6. 24-28)
Kim, T.Y., Kim, J.S., Kim, H.U., Park, J.M., Song, H., and Lee, S.Y., "Flux scanning based on enforced objective flux as new strategy for enhanced metabolite production", Metabolic Engineering VI: From recDNA towards Engineering Biological Systems, Noordwijkerhout, Netherlands (2006. 10.1-5)
Sohn, S.B., Kim, T.Y., and Lee, S.Y., "In silico genome scale modeling of Pseudomonas putida KT2440", The 7th International Conference on Systems Biology, Yokohama, Japan (2006. 10.8-13)
Kim, T.Y., Kim J.S., Kim, H.U., Park, J.M., Song, H., and Lee, S.Y., "Genome based-metabolic network of Mannheimia succiniciproducens using updated genome annotation", The 7th International Conference on Systems Biology, Yokohama, Japan (2006. 10.8-13)
Kim, H.U., Kim, T.Y., Jeong, K., Kim, S.Y., Rhee, J.H., and Lee, S.Y., "In silico analysis of vibrio vulnificus CMCP6 metabolism for the facilitated drug targeting" The 7th International Conference on Systems Biology, Yokohama, Japan (2006. 10.8-13)
Lee, K.H., Park, J.H., Kim, T.Y., and Lee, S.Y., "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis", The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3)
Kim, T.Y., Park, J.M., and Lee, S.Y., "Computational gene targeting strategy for biochemical production in Escherichia coli", The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3)
Song, H., Lee, S.J., Lee, D-,Y., Kim, T.Y., Kim, B.H., Lee, J., and Lee., S.Y., "Enhanced production of succinic acid by metabolically engineered Escherichia coli, based on Mannheimia succiniciproducens genome", The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3)
Kim, H.U., Kim, T.Y., and Lee, S.Y., "Assessment of Escherichia coli metabolism using constraints-based flux analysis and bayesian network analysis", The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3)
Lee, K.H., Park, J.H., Kim, T.Y., Song, H., and Lee, S.Y., "Construction of L-threonine Producing Strain based on in silico Simulation and Comparative Transcriptome Analysis", 29th symposium on Biotechnology for Fuels and Chemicals, Denver, Colorado, (2007. 4.29. – 5.2)
Kim, T.Y., Kim, H.U., Park, J.M., Song, H., and Lee, S.Y., "Deciphering Metabolic Flux of Mannheimia succiniciproducens MBEL55E by Genome-scale Constrains-based Flux Analysis", 29th symposium on Biotechnology for Fuels and Chemicals, Denver, Colorado, (2007. 4.29. – 5.2)
Kim, T.Y., Song, H., Kim, H.U., Park, J.M., and Lee, S.Y., "Deciphering fermentative metabolism of Mannheimia succiniciproducens MBEL55E by genome-scale constraints-base flux analysis", European BioPerspectives celebrating the 25th DECHEMA annual convention of biotechnologists, Cologne, Germany (2007. 5. 30 – 6.1.)
Kim, T.Y., Kim, H.U., and Lee, S.Y., "Identification of the in silico targets using the metabolite availability", The Eighth International Conference on Systems Biology, Long Beach, California, USA, (2007.10.1 - 6)
Park, J.M., Kim, T.Y. and Lee, S.Y., "Multi-Objective Computational simulation for the strain improvement in Escherichia coli", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei, Taiwan (2007. 11.4-7)
Park, J.H., Lee, K.H., Kim, T.Y.and Lee, S.Y., "Metabolic Engineering of Escherichia coli for the Production of L-Valine Based on Transcriptome Analysis and In silico Gene Knock-out Simulation", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei, Taiwan (2007. 11.4-7)
Lee, D.Y., Kim, T.Y., Lee, K.H., Jeong, H., Lee, S.Y., Park, S., "Metabolite essentiality elucidates robustness of Escherichia coli metabolism", The 18th Internationaol Conference on Genome Informatics(GIW2007) Singapore (2007. 12.3-12.5
Kim, T.Y., and Lee, S.Y. ,"In silico genome-scale reconstruction of Psuedomonas putida KT2440", the 18th International Conference on Genome Informatics (GIW 2007) ,Singapore (2007. 12.3-12.5)
Kim, T.Y., Jeong, K., Kim, S.Y., Rhee, J.H., and Lee, S.Y., "Reconstruction of Genome-Scale Stoichiometric Model of Vibrio vulnificus CMCP6 for Facilitated Drug Targeting", the 18th International Conference on Genome Informatics (GIW 2007) ,Singapore (2007. 12.3-12.5)
Kim, T.Y. and Lee, S.Y.,"Development of Multi-objective algorithm for in silico gene targeting and strain improvement", the 18th International Conference on Genome Informatics (GIW 2007) ,Singapore (2007. 12.3-12.5)
Lee, S.Y., Park, J.H., Lee, K.H. and Kim, T.Y., "L-valine production by systematically engineered Escherichia coli", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Lee, S.Y., Kim, T.Y., "Deciphering the evolution and metabolism of Mannheimia succiniciproducens MBEL55E by genome-scale analysis", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Moon, S.Y., Hong, S.H. and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of malic acid", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Choi, H.R. and Lee, S.Y., "Metabolic pathway analysis and its optimization for producing succinic acid in Mannheimia succiniciproducens MBEL55E", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Choi, H.R. and Lee, S.Y., "Metabolic pathway analysis and its optimization for producing succinic acid in Mannheimia succiniciproducens MBEL55E", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Choi, H.R. and Lee, S.Y., "Metabolic pathway analysis and its optimization for producing succinic acid in Mannheimia succiniciproducens MBEL55E", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Kim, H.U. and Lee, S.Y., "Identification of the In silico targets of Escherichia coli using the Metabolite acailability", Metabolic Engineering VII : Health and Sustainablility, CasaMagna Marriott Puerto Vallarta Resort, Puerto Vallarta, Mexico, September 14-19, 2008
Kim, H.U., Kim, T.Y., Kim, S.Y., Rhee, J.H. and Lee, S.Y., "Metabolite essentiality of Vivrio vulnificus CMCP6 for drug targeting", Metabolic Engineering VII : Health and Sustainablility, CasaMagna Marriott Puerto Vallarta Resort, Puerto Vallarta, Mexico, September 14-19, 2008
Park, J.H., Lee, K.H., Kim, T.Y., Lee, S.Y., "Systems metabolic engineering of Escherichia coli", International E. coli alliance (IECA), Hinxton, UK, September 24-27, 2008
Park, J.H., Lee, K.H., Kim, T.Y., and Lee, S.Y., "Metabolic Engineering of Escherichia coli for L-valine Production Based on Systems and Synthetic Biology", SB 4.0: The Fourth International Meeting on Synthetic Biology, Hong Kong University of Science and Technology, October 10-12, (2008)
Book chapter
Lee, S.Y., Lee, D.-Y., Kim, T.Y., Kim, B.H., and Lee, S.J. "Ch.7. Systems biotechnology: Combined analysis of genome, transcriptome, proteome, metabolome and fluxome for the improvement of microorganisms for industrial applications", in Systems Biology, Volume 2 (eds. Rigoutsos, I. and Stephanopoulos, G.), Oxford University Press, USA, pp. 193-231 (2006)
Patent Pended
International Patent 1, Domestic Patent 4
Hongseok Yun
Ph.D. '08. 8
Samsung SDS
Phone :+82-42-350-8867
Fax :+82-42-350-8800
Details
Research Interest
In-Silico Gemome-scale Modeling and Simulation for Strain Improvements
Systems Biology
Bioinformatics
Education
1999 (B.S.) Chemical Engineering, Hanyang Uni, Seoul, Korea
2003 (M.S.) Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea
Research Activity
Yun, H., Lee, D.-Y., Jeong, J., Lee, S., and Lee, S.Y. "MFAML: a standard data structure for representing and exchanging metabolic flux models", Bioinformatics, 21(15): 3329-3330, 2005.
2. Dong-Yup Lee, Hongseok Yun, Sunwon Park and Sang Yup Lee, "MetaFluxNet: the Management of Metabolic Reaction Information and Quantitative Metabolic Flux Analysis", Bioinformatics, Vol. 19, pp. 2144-2146, 2003
International Conferences
1. Hongseok Yun, Dong-Yup Lee, Seunghyun Lee, Joonwoo Jeong and Sang Yup Lee, "MFAML: an XML-based standard format for metabolic flux analysis ", 15th International Conference on Genome Informatics (GIW 2004), Yokohama, Japan, December 17, 2004
1. Sang Yup Lee, Dong-Yup Lee, Soon Ho Hong, Tae Yong Kim, Hongseok Yun, Young-Gyun Oh and Sunwon Park, "MetaFluxNet, a Program Package for Metabolic Pathway Construction and Analysis, and Its Use in Large-scale Metabolic Flux Analysis of Escherichia coli", 14th International Conference on Genome Informatics (GIW 2003), Yokohama, Japan, December 14 - 17, 2003
2. Dong-Yup Lee, Hongseok Yun, Sang Yup Lee and Sunwon Park, "Comparative Metabolic Flux Analysis by MetaFluxNet", 11th International Conference on Intelligent Systems for Molecular Biology (ISMB 2003), Brisbane, Australia, June 29 - July 3, 2003
3. Sang Yup Lee, Dong-Yup Lee, Hongseok Yun and Sunwon Park, "MetaFluxNet: an Integrated Program for the Management of Metabolic Reaction Information and Quntitative Metabolic Flux Analysis", First International E.coli Alliance (IECA) Conference on Systems Biology of E.coli, Tsuruoka, Japan, June 23 - 25, 2003
4. Dong-Yup Lee, Young-gyun Oh, Hongseok Yun, Sang Yup Lee and Sunwon Park, "Exploring Flux Distribution Profiles for Switching Pathways Using Multiobjective Flux Balance Analysis", 13th International Conference on Genome Informatics (GIW 2002), Tokyo, Japan, December 16 - 18, 2002
5. Hongseok Yun, Dong-Yup Lee, Sang Yup Lee and Sunwon Park, "MetaFluxNetTM: a program for metabolic flux analysis (MFA)", International Conference on Control, Automation and Systems, 2002
Korean Conferences
1. Young-gyun Oh, Dong-Yup Lee, Hongseok Yun, Sang Yup Lee and Sunwon Park, "Supporting SBML for representation and exchange of biochemical network models in MetaFluxNet", KIChE Fall meeting, Seoul, 2003.
2. Hongseok Yun, Dong-Yup Lee, Sang Yup Lee and Sunwon Park, "Development of a Software for Metabolic Flux Analysis (MFA)", KIChE Spring meeting, Soonchun, 2003
3. Dong-Yup Lee, Sung Ho Yoon, Hongseok Yun, Sunwon Park and Sang Yup Lee, "Graph-Theoretical Identification of Multiple Flux Distiributions in Metabolic Flux Analysis", Korean Society for Bioinformatics annual meeting, Pusan, 2002
Ji Mahn Kim
Honorary Ph.D.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Research Interest
Metabolic Engineering
Transcriptome Profiling
Molecular Biology
Education
2005. 2.,(B.S.) Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2007. 2 ~ present ( M.S./Ph.D. Program) : Dept. of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea
Advisor : Professor Sang Yup Lee
Awards and Honors
Best Poster Award, Korean Society for Chemical Engineers, Busan, Korea (2008. 10. 23)
Best Part/Device Award, The 4th International Conference on Synthetic Biology: SB4.0Conference Poster Competition, Hong Kong (2008. 10. 12)
Student Travel Award, The 4th International Conference on Synthetic Biology: SB4.0, Hong Kong (2008. 07)
Publications
International Journal
Jang, Y.-S., Jung, Y.R., Lee, S.Y, Kim, J.M., Lee, J.W., Oh, D.-B., Kang, H.A., Kwon, O., Jang, S.H., Song, H., Lee, S.J., and Kang, K.Y. "Construction and characterization of shuttle vectors for succinic acid producing rumen bacteria", Appl. Environ. Microbiol. 73(17): 5411-5420 (2007. 9.)
[pdf]
Kim, J.M., Lee, K.H. and Lee, S.Y., " Development of a markerless gene knock-out system for Mannheimia succiniciproducens using a temperature-sensitive plasmid", FEMS Microbiol. Lett. 278: 78-85 (2008. 1.)
[pdf]
Lee, S.Y., Kim, J.M., Song, H., Lee, J.W., Kim, T.Y., and Jang, Y.-S., "From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens", Appl. Microbiol. Biotechnol. 79(1): 11-22 (2008. 5.)
[pdf]
International Conference
Song, H., Lee, J.W., Kim, J.M., Lee, S.Y., "Succinic Acid Production and Growth Behaviors of Mannheimia succiniciproducens in Anaerobic Batch Fermentation", Asia Pacific Biochemical Engineering Conference (APBioChEC'05), Lotte Jeju Hotel, Jeju Island, Korea, May 15-19 (2005)
Song, H., Lee, J. W., Kim, J. M., Lee, K. H., Lee, S.Y., "Characterization of The Cell Growth and The Distribution of End-products in a Batch Cultivation of Mannheimia Succiniciproducnes", Biochemical Engineering XIV, Harrison Hot Springs, BC, Canada, July 10-14 (2005)
Kim, J.M., Jang, S.H., Song, H., and Lee, S.Y., "Effect of Lactate Dehydrogenase Gene Deletion in Succinic acid Production by Mannheimia succinicproducens MBEL55E", The 18th Symposium on Chemical Engineering, Daejeon/Chungnam(Korea)-Kyushu(Japan), Dec. 2-4 (2005)
Kim, J.M., Lee, S.Y., "Chromosomal Modification Systems for Synthetic Engineering of Mannheimia succiniciproducens", SB 4.0: The Fourth International Meeting on Synthetic Biology, Hong Kong University of Science and Technology, October 10-12, (2008)
Kim, J.M., Lee, S.Y., "Multiple knock-out system of Mannheimia succiniciproducens using mutant LOX sequences", 13th International Biotechnology Symposium & Exhibition (IBS-2008): Biotechnology for Sustainability of Human Society, October 12-17 (2008) Dalian World Expo Center, Dalian, China
Domestic Conference
Kim, J.M., Song, H., Jang, Y.S., Lee, S.Y., "Overexpression of fumC Gene Encoding Fumarase of Mannheimia succiniciproducens MBEL55E for Succinic Acid Production", International Meeting of the Federation of Koeran Microbiological Societies, Seoul, Korea, October 13-14 (2005)
Kim, J.M., Jang, S.H., Song, H., Lee, S.Y., "Efficient Succinic acid Production through Deletion of Lactate Dehydrogenase of Mannheimia succiniciproducens MBEL55E", International Symposium and annual meeting of KSBB, October 27-29 (2005)
Jang, Y.S., Kim, J.M., Choi, S. and Lee, S.Y., "Pole of phosphoenolpyruvate Carboxylase, Phosphoenolpyruvate Carboxy Kinase and Fumarase of Mannheimia Succiniciproducens MBEL55E of Succinic Acid Production", 2006 Annual Meeting and International Symposium(KMB), June 18-20 (2006)
Kim, J.M., Song, H., Lee, S.J. and Lee, S.Y., "Deletion of pflB Gene Encoding Pyruvate Formate Lyase of Mannheimia succiniciproducens MBEL55E for Succinic Acid Production", 2006 Annual Meeting and International Symposium(KMB), June 18-20 (2006)
Kim, J.M., Song, H., Lee, S.J., and Lee, S.Y., "Effect of Pyruvate Formate Lyase gene Deletion in Succinic acid Production by Mannheimia Succiniciproducens MBEL55E", 2006 Annual Fall Meeting of Korean Society for Biotechnology and Bioengineering Symposium, September 7-8 (2006)
Kim, J.M., Jang, S.H., Song, H., and Lee. S.Y., "Effect of lactate dehydrogenase gene and pyruvate formate lyase gene deletion in succinic acid production by mannheimia succiniciproducens MBEL55E", The 19th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, December 1-4 (2006)
Choi, S., Kim, J.M., Jang, S.H., Jang, Y., and Lee, S.Y., "Construction of Escherichia coli - Mannheimia succiniciproducens shuttle vector for genetic engineering", Annual Spring Meeting of KIChE, April 19-20 (2007)
Kim, J.M., Jang, S.H., Jang, Y.S., and Lee, S.Y., "Construction of shuttle vector for genetic engineering of Mannheimia succinciproducens", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, April. 27(2007)
Kim, J.M., Jang, S.H., and Lee, S.Y., "Construction fo Escherichia coli - Mannheimia succiniciproducens shuttle vector for genetic engineering", KSBB Fall meeting and international symposium,Hotel Inter-Burgo, Daegu,Oct.18-19(2007)
Kim, J.M., Jang, Y.S., Jang, S.H., Song, H. and Lee, S.Y., "DNA microarray analysis of succinic acid shock response in Mannheimia succiniciproducens", Annual Fall Meeting of KIChE, KAIST, Daejeon, October 26-27 (2007)
Kim, J.M., Park, T.J., Huh, Y.S., Hong, W.H. and Lee, S.Y., "Biosensor Using Active Micro-Mixer in Lab-on-a-Chip", Annual Fall Meeting of KIChE, KAIST, Daejeon, October 26-27 (2007)
Kim, J.M., Lee, K.H., Jang, S.H. and Lee, S.Y., "Markerless gene deletion of Mannheimia succiniciproducens using a New Temperature Sensitive Plasmid", Annual Fall Meeting of KIChE, KAIST, Daejeon, October 26-27 (2007)
Kim, J.M., Lee, J. and Lee, S.Y., "Cre/lox mediated multiple gene deletion in Mannheimia succiniciproducens", 2008 Spring KSBB Meeting and International Symposium, Chonbuk National University, Jeonju, April 18-19 (2008)
Kim, J.M., Lee, S.Y., "Multiple gene deletion of Mannheimia succiniciproducens using mutant lox sequences", Annual Spring Meeting of KIChE, Hyatt Regency Jeju, Jeju, April 23-25 (2008)
Kim, J.M., Han, M.S., and Lee, S.Y., "lox Sequences Mediated Multiple Knock-Out System of Mannheimia succiniciproducens", The 48th MSK Annual Meeting and 2008 International Symposium on Microbiology, Convention Center, Daejeon, May, 15-16 (2008)
Choi, S., Song, H.H., Lee, J.W., Kim, J.M. and Lee, S.Y., "Analysis of Mannheimia succiniciproducens Physiology in Different CO2 Levels", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Lee, J.W., Song, H.H., Choi, S., Yoo, J.S., Kim, J.M. and Lee, S.Y., "Improved succinic acid production based on proteomic and physiological analysis of Mannheimia succiniciproducens", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Jang, Y.S., Lee, J.Y., Kim, J.M. and Lee, S.Y., "Eggect of cell density on production of butanol by barch-fermentation of Clostridium acetobutylicum", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Jeon, Y.J., Song, H.H., Kim, J.M. and Lee, S.Y., "Modeling of batch fermentation kinetics for succinic acid production by Mannheimia succiniciproducens", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Han, M.J., Lee, J.W., Yun, H.S., Kim, J.M., Lee, S.Y. and Yoo, J.S., "Global analysis of protein localization in Escherichia coli B", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Patents - 4건
Xiao Xia Xia
Ph.D. Distinguished Associate Professor '09. 2
Department of Bioengineering, Shanghai Jiatong University
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Research Interest
Systems and synthetic biology
Protein Engineering
Proteomics
Education
1997.9-2001.7 B.S. Dept. of Fermentation Engineering, Nanchang University, Nanchang, China
2001.9-2004.3 M.S. School of Bioengineering, East China Univ. of Sci. and Technol., Shanghai, China Advisor: Prof. Ya-Ling Shen, Thesis: Purification and refolding of Apo2L/TRAIL produced as inclusion bodies from high-cell-density cultivation of recombinant E. coli
2005.3-2009.2 Ph.D. Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea, Advisor: Prof. Sang Yup Lee, Thesis: Proteomic analysis of Escherichia coli and its application for recombinant proteins production
Professional Experience
2004.3-2005.2 Researcher, Fosun Clone High-tech Biotechnology Ltd. Corp., Shanghai, China
Awards and Honors
Excellent Thesis Award of Nanchang University, 2001
Excellent Thesis Award of Shanghai, 2005
Publications
Summary (as of July, 2009)
Journal paper publications: 7 papers published
Conference presentations: 7 papers (abstracts), 1 oral presentation
Korean Patents: 3 Chinese Patent: 1
1) International Journal
1. 1 Zhi-Gang Qian, Xiao-Xia Xia, Sang Yup Lee. Metabolic engineering of Escherichia coli for the production of putrescine, a four carbon diamine. Biotechnol. Bioeng. (Accelerated Publication, In press)
2 Xiao-Xia Xia, Mee-Jung Han, Sang Yup Lee and Jong-Shin Yoo. Comparison of the extracellular proteomes of Escherichia coli B and K-12 strains during high cell density cultivation. Proteomics 2008, 8(1): 2089?2103
3 Zhi-Gang Qian*, Xiao-Xia Xia*, Jong Hyun Choi, Sang Yup Lee. Proteome-based identification of fusion partner for high-level extracellular production of recombinant proteins in Escherichia coli. Biotechnol. Bioeng. 2008, 101(3): 587-601 (Qian & Xia contributed equally to this work and this paper was selected as spotlight paper).
4 Xiao-Xia Xia, Ya-Ling Shen, and Dong-Zhi Wei. Purification and Characterization of Recombinant sTRAIL Expressed in Escherichia coli. Acta Biochimica et Biophysica Sinica 2004, 36 (2): 118?122
5 Ya-Ling Shen, Yue Zhang, Ai-You Sun, Xiao-Xia Xia, Dong-ZhiWei & Sheng-Li Yang.
High-level production of soluble tumor necrosis factor-related apoptosis-inducing ligand (Apo2L/TRAIL) in high-density cultivation of recombinant Escherichia coli using a combined feeding strategy. Biotechnology Letters 2004, 26: 981?984
6 Yue Zhang, Ya-Ling Shen, Xiao-Xia Xia, Ai-You Sun, Dong-Zhi Wei, Jin-Song Zhou, Guo-Jun Zhang, Liang-Hua Wang, Bing-Hua Jiao. High-cell density cultivation of recombinant Escherichia coli for production of TRAIL by using a 2-stage feeding strategy. Chinese Journal of Biotechnology 2004, 20(3):408-13
7 Ya-Ling Shen, Xiao-Xia Xia, Yue Zhang, Jian-Wen Liu, Dong-Zhi Wei & Sheng-Li Yang. Refolding and purification of Apo2L/TRAIL produced as inclusion bodies in high-cell-density cultures of recombinant Escherichia coli. Biotechnology Letters2003, 25: 2097?2101
2) Oral presentation
1 Xia X.-X, Shen Y L, Wei D Z. Refolding and structural characterization of TRAIL/Apo2L produced as inclusion bodies in high-cell-density cultures of recombinant Escherichia coli. International Symposium on Bioprocess and Biomolecular Engineering, Shanghai, China, Dec. 15-17, 2003.
3) International conferences presentations
1 Xiao-Xia Xia, Zhi-Gang Qian, Mee-Jung Han, Jong Hyun Choi, Sang Yup Lee and Jong-Shin Yoo. The extracellular proteomes of Escherichia coli B and K-12 strains and their application in the excretory production of recombinant proteins.? Biochemical Engineering XV, Quebec City, Canada, July 15-19, 2007
2 X.-X. Xia, M.-J. Han, J.-S. Yoo, S.-Y. Lee. Proteomics analysis of selectively released proteins from Escherichia coli BL21 and K-12 strains grown in high cell density cultivation.
HUPO 6th Annual World Congress Seoul 2007, Oct. 6-10, Coex, Seoul, Korea (Abstract published in special issue of Molecular&Cellular Proteomics 2007)
3 Zhi-Gang Qian, Xiao-Xia Xia, Jong Hyun Choi, and Sang Yup Lee. High-Level Extracellular Production of Recombinant Proteins in Escherichia coli: A Proteome-Based Approach. Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei International Convention Center, Taiwan, Nov 4-7, 2007
4 Xiao-Xia Xia, Sang Yup Lee. Comparative proteomic analysis of four typical Escherichia coli strains sheds light on rational host strain selection for synthetic biology (SB4.0), HKUST, Hongkong, China, Oct. 10-12, 2008
5 Zhi-Gang Qian, Xiao-Xia Xia, Jong Hyun Choi and Sang Yup Lee. A Systematic Proteome-Based Approach for the Secretion of Synthetic Gene Products in Escherichia coli (SB4.0), HKUST, Hongkong, China, Oct. 10-12, 2008
6 Xiao-Xia Xia, Sang Yup Lee. Comparative proteomic analysis of four biotechnology important Escherichia coli strains for rational host strain selection (IBS2008), Dalian, China, Oct. 12-17, 2008
7 Xiao-Xia Xia, Zhi-Gang Qian, Mee-Jung Han, Sang Yup Lee. The extracellular proteomes of Escherichia coli B and K-12 strains and its application in the secretory production of recombinant proteins. (IBS2008), Dalian, China, Oct. 12-17, 2008
Seung Min Yoo
Ph.D. '09. 2
Research Professor
Bioprocess Research Center, Bioinformatics Research Center
Dept. Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8813
Fax :+82-42-350-8800
Details
Education
1994.3 ~ 1998.2 (B.S. Course in Biochemistry)
Department of Applied Biology, Dogguk University , Seoul , Korea
Advisor: Prof. In-Kook Park
2004.3 ~ 2005.8 (M.S. Course in Chemical & Biomolecular Engineering)
Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Advisor: Prof. Sang Yup Lee
2005.9 ~ 2009.1 (Ph.D. Course in Chemical & Biomolecular Engineering)
Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Advisor: Prof. Sang Yup Lee
Thesis: Development of diagnostic system using molecular technology
Research Experiences
1998.5–1999.4 Researcher, Department of obstetrics and gynecology, Sungkyunkwan University, Seoul, Korea
1999.10–2002.2 Researcher, BioProcess Engineering Research Center, KAIST, Daejeon, Korea
2002.3–2005.8 Team manager, Medigenes Co., Ltd., Seoul, Korea
2009.2–2010.5 Post-doc, Bioinformatics Research center, KAIST, Korea
2010.6–2011.4 Senior Researcher, Bioinformatics Research Center, KAIST, Korea
2011.5–present Research Professor, Bioinformatics Research Center/Bioprocess Research Center, KAIST, Korea
Awards and Honors
Best Paper Award, International E. coli Alliance 2006 (IECA 2006), Jeju ICC, Jeju, Korea (2006. 10. 31-11. 3) Kwang-Ho Lee, Park JH, Kim TY, Lee SY, "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis"
Best Poster Award, Asia Pacific Biochemical Engineering Conference 2007 (APBioChEC'07), Taipei International Convention Center, Taiwan (2007. 11. 4-7) Park JH, Kwang-Ho Lee, Kim TY, Lee SY, “Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation
Publications
Summary (as of Dec. 2013)
Journal paper: 25 papers published.
Patents: 33 registered
International Journals
[25] Kim, H., Kang, T., Lee, H., Ryoo, H., Yoo, S.M., Lee, S.Y., and Kim, B., "Facile Fabrication of Multi-targeted and Stable Biochemical SERS Sensors" Chem. Asian. J. 2013, 8(12), 3010-3014. (IF: 4.572)
[24] Yoo, S.M., Na, D., Lee, S.Y. “Design and use of synthetic regulatory small RNAs to control gene expression in Escherichia coli” Nat. Protoc. 8(9), 1694–1707 (2013). ** Journal Cover paper (IF: 7.96)
[23] Yoo, S.M.†, Kang, M.†, Kang, T., Kim, D.M., Lee, S.Y., Kim, B. “Electro-triggered, Spatioselective, Quantitative Gene Delivery into a Single Cell Nucleus by Au Nanowire Nanoinjector”, Nano Lett., 13 (6), 2431–2435 (2013) †Co-first author (IF: 13.025)
[22] Na, D., Yoo, S.M., Chung, H., Park, H., Park, J.H., Lee, S.Y., "Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs", Nat. Biotechnol., 31(2): 170-174 (2013. 1) (IF: 32.438)
[21] Kang, T., Yoo, S.M., Kang, M., Lee, H., Kim, H., Lee, S.Y., Kim, B. "Single-Step Multiplex Detection of Toxic Metal Ions by Au Nanowires-on-Chip Sensor Using Reporter Elimination", Lab Chip, 12: 3077-3081 (2012. 5) (IF: 5.697)
[20] Yoo, S.M., Kang, T., Lee, S.Y., Kim, B. “Combining a Nanowire SERRS Sensor and a Target Recycling Reaction for Ultrasensitive and Multiplex Identification of Pathogenic Fungi” Small, 7(23), 3371-3376 (2011. 12). ** Journal Inside Cover paper (IF: 7.823)
[19] Kim, D.-K.†, Yoo, S.M.†, Park, T.J., Yoshikawa, H., Tamiya E., Lee, S.Y. “Plasmonic properties of the multispot copper-capped nanoparticle array chip and its application to optical biosensors for pathogen detection of multiplex DNAs.” Anal. Chem. 83(16): 6215–6222 (2011. 8). †Co-first author (IF: 5.695)
[18] Yoo, S.M., Kang, T., Kim, B., Lee, S.Y. “Detection of single nucleotide polymorphisms by a gold nanowire-on-film SERS sensor coupled with S1 nuclease treatment” Chem.-A Eur. J. 17(31): 8657-8662 (2011. 7). (IF: 5.831)
[17] Kang, T., Yoo, S.M., Yoon, I., Lee, S.Y., Choo J. Kim, B. “Au Nanowire-on-Film SERRS Sensor for Ultrasensitive Hg2+ Detection” Chem.-A Eur. J. 17(7), 2211-2214 (2011. 2). (IF: 5.831)
[16] Park, T.J., Lee, S.-K., Yoo, S.M., Yang, S-.M., Lee, S.Y. "Development of reflective biosensor using fabrication of functionalized photonic nanocrystals", J. Nanosci. Nanotechnol., 11(1):632-637 (2011. 1) (IF: 1.149)
[15] Baek, Y.K., Yoo, S.M., Kang, T., Jeon H-.J, Kim K, Lee, S.Y., Kim, B., Jung, H.T. “Large-scale, highly ordered chitosan-core Au-shell nanopatterns with plasmonic tunability: A top-down approach to fabricate in core-shell nanostructure” Adv. Funct. Mater. 20(24), 4273–4278 (2010. 12). (IF: 9.765)
[14] Baek, Y.K., Jung, D.H., Yoo, S.M., Shin S., Kim, J.H., Jeon H.-J., Choi, Y.K., Lee, S.Y., Jung, H.T. “Label-free detection of DNA hybridization on pyrene-functionalized single-walled carbon nanotubes via various DNA binding methods.”, J. Nanosci. Nanotechnol. 11(5), 4210-4216 (2010. 5). (IF: 1.149)
[13] Yoo, S.M., Lee, S.Y. “DNA microarray for the identification of pathogens causing bloodstream infections”, Expert Rev. Mol. Diagn., 10(3), 263-268 (2010. 4). (IF: 4.089)
[12] Kang, T.†, Yoo, S.M.†, Yoon, I., Lee, S.Y., Kim, B. “Patterned multiplex pathogen DNA detection by Au particle-on-wire SERS sensor” Nano Lett., 10 (4), 1189–1193 (2010. 3). †Co-first author (IF: 13.025)
[11] Yoo, S.M., Choi, J.Y., Yun, J.K., Choi, J.K., Lee, K.W., Kim, J.M., Lee, S.Y. “DNA Microarray-based identification of bacterial and fungal pathogens in bloodstream infections”. Mol. Cell. Probes, 24(1): 44-52 (2010. 2). (IF: 1.873)
[10] Baek, Y.K., Yoo, S.M., Kim, J.H., Jung, D.H., Kim, Y.S., Choi, Y.K., Lee, S.Y., Jung, H.T. “The effect of network density on the DNA-sensing performance of single-walled carbon nanotubes”. J. Phys. Chem. C, 113(52), 21566–21571 (2009.10.30). (IF: 4.814)
[9] Yoo, S.M., Choi, J.H., Lee, S.Y., Yoo, N.C., “Applications of DNA microarray in Disease Diagnostics” J. Microbiol. Biotechn. 19(7): 635–646 (2009.7). (IF: 1.399)
[8] Yoo, S.M., Lee, S.Y., Chang, K.H., Yoo, S.Y., Yoo, N.C., Keum, K.C., Yoo, W.M., Kim, J.M., Choi, J.Y. “High-throughput identification of clinically important bacterial pathogen using DNA microarray”, Mol. Cell. Probes, 23(3-4): 171-177 (2009.6-8). (IF: 1.873)
[7] Kim, J.H., Kang, T., Yoo, S.M., Lee, S.Y., Kim, B., Choi, Y.K. “A well-ordered flower-like gold nanostructure for integrated sensors via surface-enhanced Raman scattering”, Nanotechnology, 20(23): 1-6 (2009.6). (IF: 3.842)
[6] Park, T.J., Yoo, S.M., Keum, K.C., Lee, S.Y. “Microarray of DNA-protein complexes on poly-3-hydroxybutyrate surface for pathogen detection” Anal. Bioanal. Chem., 393: 1639-1647 (2009.3). (IF: 3.659)
[5] Kim, K-.H., Kim, J-.H., Huang, X-.J., Yoo, S.M., Lee, S.Y., Choi, Y-.K. “Doping Free Nanoscale Complementary Carbon Nanotube Field Effect Transistors with DNA-templated Molecular Lithography”, Small, 4(11): 1959-1963 (2008. 11). (IF: 7.823)
[4] Yoo, S.M., Lee, S.Y., “Diagnosis of Pathogens Using DNA Microarray” Recent patents on Biotechnology 2(2): 124-129 (2008).
[3] Keum, K.C.†, Yoo, S.M.†, Lee, S.Y., Chang, K.H., Yoo, N.C., Yoo, W.M., Kim, J.M., Choi, J.Y., Kim, J.S., Lee, G. "DNA microarray-based detection of nosocomial pathogenic Pseudomonas aeruginosa and Acinetobacter baumannii", Mol. Cell. Probes, 20: 42-50 (2006). †Co-first author (IF: 1.873)
[2] Yoo, S.M., Keum, K.C., Yoo, S.Y., Choi, J.Y., Chang, K.H., Yoo, N.C., Yoo, W.M., Kim, J.M., Lee Duke, Lee, S.Y. "Development of DNA Microarray for Pathogen Detection", Biotech. Bioproc. Eng., 9:93-99 (2004. 3~4). (IF: 1.277)
[1] Yoo, S.Y., Chang, K. H., Yoo, S.M., Park, S.Y., Yoo, N.C., Keum, K.C., Yoo W.M., Kim, J. M., Lee S.Y. "Design of ITS and 23S rDNA-targeted probes and its usefulness for the identification of bacterial pathogens", Genome Informatics 13:589-590 (2002).
International Proceeding/Conference
Chang, K.H., Lee, S.Y., Yoo, S.M., Yoo, S.Y., Park, D.E., Yong K., W. Lee, J.Y., Choi, K.S. Lee, A. Huh, Yeo,, J.S., Song, Y.S., Kim, J.M. “Rapid Identification of Bacterial Pathogens by Amplifying 23S Ribosomal DNA and ITS for Application on Oligonucleotide Microarray” The 42th ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy),San Diego, California, USA September 27-30 (2002)
Yoo, S.Y., Chang, K.H., Yoo, S.M., Park, S.Y., Yoo, N.C., Keum, K.C., Yoo, W.M., Kim, J.M., Lee, S.Y. “Design of ITS and 23S rDNA-targeted probes and its usefulness for the identification of bacterial pathogens” The 13th International Conference on Genome Informatics, Tokyo, Japan, December 16-18(2002)
Lee, S.Y., Lee, S.J., Yoo, S.M., Choi, J.H. "Protein arrays for protein-protein interactions analysis", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov-4 December (2003)
Park, J.P., Lee, S.J., Park, T.J., Yoo, S.M., Lee, D., Lee, S.Y. “Systematic detection of pathogenic bacteria using carbohydrate-encapsulated quantum dot”, The Eighth World Congress on Biosensors, Granada, Spain, May 24-26 (2004)
Yoo, S.M. Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M., Lee, S.Y. “High-throughput detection of clinically predominant pathogen and evaluation of antibiotics effect by using DNA microarray”, Biochemical Engineering XV, Quebec, Canada, (2007.7.15 - 19)
Park, T.J., Yoo, S.M., Lee, S.Y. “Polyhydroxybutyrate Microarray using Immobilization of Fusion Proteins for Immunodiagnostics and Pathogen Detections”, Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei, Taiwan (2007. 11.4-7)
Park, T.J., Lee, S-.K., Yoo, S.M., Yi, G-.R., Yang, S-.M., Lee, S.Y. "Fabrication for the photonic-fluidic biosensor using functionalized photonic nanocrystals", The 22th International Liquid Crystal Conference, Jeju, Jun 29 - Jul 4 (2008)
Choi, J.Y., Yoo, S.M., Lee, K.W., Kim, J.M., Lee, S.Y. High-throughput identification of microbial pathogens in bloodstream infections using microarray hybridization. The 46th Infectious Disease Society of America, USA (2008)
Yoo, S.M. Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M., Lee, S.Y. Development of diagnostic array for infectious disease caused by bacterial pathogen. 2008 International E. coli alliance (IECA), Hinxton, UK (2008.9.24-27)
Yoo, S.M. Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M., Lee, S.Y. “Pathogenic bacteria identification by diagnostic DNA microarray” The 13th International Biotechnology Symposium and Exhibition. Dalian, China (2008. 10.12-17).
Lee, S.Y., Park, T.J., Yoo, S.M. "Polyhydroxybutyrate microarray for immunodiagnostics and pathogen detections by immobilizing fusion proteins", 14th European Congress on Biotechnology, Barcelona, Spain, Sep 13-16 (2009)
Yoo, S.M., Kim, H.Y., Kim, T.Y., Lee, S.Y., “Bayesian analysis of perturbed Escherichia coli metabolism”, GIW2009, The 20th International Conference on Genome Informatics, PACIFICO YOKOHAMA, Yokohama, Japan (2009. 12.14-16).
Yoo, S.M., Kim, T.Y., Choi, H.R., Lee, S.Y., “Metabolic network reconstruction and pathway analysis of Mannheimia succinicproducens”, GIW2009, The 20th International Conference on Genome Informatics, PACIFICO YOKOHAMA, Yokohama, Japan (2009. 12.14-16).
Na, D.K., Yoo, S.M., Lee, S.Y., "Computational design of regulatory small RNAs as a new component of synthetic genetic circuits", Metabolic engineering VIII, ICC, June 13-17, 2010, Jeju Island, Korea
Yoo, S.M., Baek, Y.K., Choi, E.J., Kim, J.H., Jung, D.H., Cho, Y.K., Jung, H.T., Lee, S.Y., "Label free DNA detection using the network density-modulated single-walled carbon nanotube sensor", International Conference on Cellular and Molecular Bioengineering 2, August2-4, 2010, Singapore
Yoo, S.M., Kang, T.J., Yoon, I.S., Kim, B.S., Lee, S.Y., "Multiple detection of pathogenic bacteria using patterned Au particle-on-wire SERS sensor", International Conference on Cellular and Molecular Bioengineering 2, August2-4, 2010, Singapore
Yoo, S.M., Kang, T.J., Yoon, I.S., Kim, B.S., Lee, S.Y., “Patterned Au particle-on-wire sensor for multiplex identification of pathogenic bacteria” Biochemical Engineering XVI, Seattle, USA, (2011.7.25 -29)
Yoo, S.M., Kang, T.J., Kim, B.S., Lee, S.Y., “Detection of Single Nucleotide Polymorphism by Au Nanowire-on-film SERS system Coupled with S1 Nuclease Reaction” Biochemical Engineering XVI, Seattle, USA, (2011.7.25 -29)
Patent
Registered
Lee, S.Y, Kim, D.K, Yoo, S.M., and Park, T.J
“Copper-Capped Nanoparticle Array Biochip Based on LSPR Optical Properties and Use Thereof”
Korea 2011, 10-10932030000
Kim, B., Kang, T., Yoon, I., Lee, S. Y., and Yoo, S.M.
“Detection Method of Bio-Chemical Material using Surface-Enhanced Raman Scattering”
USA 2011, 12/900,248, Japan 2010, 2010-229292, EU 2010, 10187095.4
Lee, S.Y., Yoo, S.M., Yoo, S.Y., Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M, Lee, J., Kim, J.M.
“DNA chip for detection of infectious bacteria”
Korea 2009, 10-09359190000
Lee, S.Y., Yoo, S.M., Yoo, S.Y., Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M, Lee, J., Kim, J.M.
"Nucleic Acid Probes for Detection of Aeromonas hydrophila"
Korea 2008, 10-0828551
Lee, S.Y., Yoo, S.M.,Yoo, S.Y., Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M, Lee, J., Kim, J.M.
“Nucleic Acid Probes for Detection of Candida albicans"
Korea 2007, 10-0781559
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Acinetobacter baumanii "
Korea 2006, 0617647
Lee, S.Y., Chang, K.H., Yoo, S. M.,Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Kingella kingaep "
Korea 2006, 0617640
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Clostridium ramosum "
Korea 2006, 0617646
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Ochrobactrum anthropi "
Korea 2006, 0617639
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Eikenella corrodens "
Korea 2006, 0617645
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Cardiobacterium hominis ”
Korea 2006, 0617641
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Porphyromonas gingivalis "
Korea 2006, 0617643
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Proteus vulgaris "
Korea 2006, 0617642
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Peptostreptococcus magnus "
Korea 2006, 0577460
Lee, S.Y., Chang, K.H., Yoo, S. M.,Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Klebsiella oxytoca "
Korea 2006, 0577449
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Comamonas acidovorans "
Korea 2006, 0577456
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Streptococcus mutans "
Korea 2006, 0577440
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Bacteroides fragilis "
Korea 2006, 0577455
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Corynebacterium diphtheriae "
Korea 2006, 0577451
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Clostridium diffcile "
Korea 2006, 0577408
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Branhamella catarrhalis "
Korea 2006, 0577397
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Enterobacter aerogenes "
Korea 2006, 0577444
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Haemophilus aprophilas "
Korea 2006, 0577407
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Bacteroides ovatus "
Korea 2006, 0577438
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
“DNA chips for Detection of Peptostreptococcus anarobius "
Korea 2006, 0577459
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Bacteroides thetaiotaomicron "
Korea 2006, 0577412
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Bacteroides vulgatus "
Korea 2006, 0577404
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Anaerobiospirillum succiniciproducens "
Korea 2006, 0577454
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Chryseobacterium meningosepticum "
Korea 2006, 0577453
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Sutterella wadsworthensis "
Korea 2006, 0577386
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Peptostreptococcus prevotii "
Korea 2006, 0577458
Zhi-Gang Qian
Ph.D. Associate Professor '09. 8
Department of Bioscience and Biotechnology, Shanghai Jiatong University
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Research Interest
Synthetic biology
Metabolic engineering
Systems biology
Education
09/1997 - 07/2001 B.S. Department of Biochemical Engineering, East China University of Science and Technology, Shanghai, China
09/2001 - 03/2004 M.S. Department of Biochemical Engineering, East China University of Science and Technology, Shanghai, China
Advisor: Prof. Jian-Jiang Zhong Thesis: Novel chemically-synthesized chemicals induced taxoid biosynthesis in Taxus chinensis suspension cultures
09/2005 - 08/2009 Ph.D. Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Advisor: Prof. Sang Yup Lee Thesis: Metabolic engineering of Escherichia coli for the production of diamines
Professional Experience
CJ CheilJedang Corp., Institute of Science & Technology, R&D center for Bioproducts, Senior Researcher (1995.1 ~ present)
Awards and Honors
08/2009 - current Post-doc researcher, BioProcess Engineering Research Center, Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
05/2004 - 07/2005 Researcher, Research Center for the Development of Advanced Horticultural Technology, Chungbuk National University, Cheongju, Korea
Publications
Summary (as of 23 August 2010)
Journal paper publications: 12 papers plus 1 under review
Oral presentations: 3
International poster presentations: 15
Patents: 11 (PCT, 2; Korean, 7; Chinese, 2)
INTERNATIONAL JOURNAL
13. Xia XX, Qian ZG, Lee SY. 2010. Comparative proteomic and genetic analyses reveal unidentified mutations in Escherichia coli XL1-Blue and DH5α. FEMS Microbiol Lett (under peer review)
12. Qian ZG, Xia XX, Lee SY. 2010. Metabolic engineering of Escherichia coli for the production of cadaverine: A five carbon diamine. Biotechnol Bioeng (accepted on August 18, 2010)
11. Xia XX, Qian ZG, Ki, CS, Park, YH, Kaplan, DL, Lee SY. 2010. Native-sized recombinant spider silk protein produced in metabolically engineered Escherichia coli results in a strong fiber. Proc Natl Acad Sci USA 107(32):14059-14063. (Xia and Qian contributed equally).
10. Qian ZG, Xia XX, Lee SY. 2009. Metabolic engineering of Escherichia coli for the production of putrescine: A four carbon diamine. Biotechnol Bioeng 104(4):651-662. Editors' Choice, Journal cover paper
Wiley-Blackwell Press Release 'Pioneering research succeeds in producing industrially vital chemical through engineered bacteria' (27 August 2009); in numerous science news web sites
Nature Research Highlight 'Bacterial factories' (Nature 461, 14-15; 3 September 2009)
BTJ-FORUM 'Metabolic engineering of E. coli' (Biotechnology Journal, 4, 1376; October 2009)
9. Qian ZG, Xia XX, Choi JH, Lee SY. 2008. Proteome-based identification of fusion partner for high-level extracellular production of recombinant proteins in Escherichia coli. Biotechnol Bioeng 101(3):587-601.
Spotlight 'A proteome-based approach to identifying fusion partner for recombinant protein excretion' (Biotechnology and Bioengineering DOI: 10.1002/bit.22096; 15 October 2008)
8. Xu Y, Zhao Z, Qian X, Qian Z, Tian W, Zhong J. 2006. Novel, unnatural benzo-1,2,3-thiadiazole-7-carboxylate elicitors of taxoid biosynthesis. J Agric Food Chem 54(23):8793-8798.
7. Qian ZG, Zhao ZJ, Xu Y, Qian X, Zhong JJ. 2006. Novel synthetic 2,6-dichloroisonicotinate derivatives as effective elicitors for inducing the biosynthesis of plant secondary metabolites. Appl Microbiol Biotechnol 71(2):164-167.
6. Qian ZG, Zhao ZJ, Xu Y, Qian X, Zhong JJ. 2006. Novel chemically synthesized salicylate derivative as an effective elicitor for inducing the biosynthesis of plant secondary metabolites. Biotechnol Prog 22(1):331-333.
5. Qian ZG, Zhao ZJ, Xu Y, Qian X, Zhong JJ. 2005. A novel synthetic fluoro-containing jasmonate derivative acts as a chemical inducing signal for plant secondary metabolism. Appl Microbiol Biotechnol 68(1):98-103.
4. Qian ZG, Zhao ZJ, Xu Y, Qian X, Zhong JJ. 2005. Highly efficient strategy for enhancing taxoid production by repeated elicitation with a newly synthesized jasmonate in fed-batch cultivation of Taxus chinensis cells. Biotechnol Bioeng 90(4):516-521.
3. Zhao Z, Xu Y, Qian Z, Tian W, Qian X, Zhong JJ. 2004. Novel fluoro- and hydroxyl-containing jasmonate derivatives as highly efficient elicitors in suspension cultures of Taxus chinensis. Bioorg Med Chem Lett 14(18):4755-4758.
2. Qian ZG, Zhao ZJ, Xu Y, Qian X, Zhong JJ. 2004. Novel chemically synthesized hydroxyl-containing jasmonates as powerful inducing signals for plant secondary metabolism. Biotechnol Bioeng 86(7):809-816.
1. Qian ZG, Zhao ZJ, Tian WH, Xu Y, Zhong JJ, Qian X. 2004. Novel synthetic jasmonates as highly efficient elicitors for taxoid production by suspension cultures of Taxus chinensis. Biotechnol Bioeng 86(5):595-599.
ORAL PRESENTATIONS
3. Qian ZG, Xia XX, Lee SY. A systematic proteome-based approach for high-level extracellular production of recombinant proteins in E. coli. The Korean Society for Microbiology and Biotechnology (KMB) international symposium & annual meeting. June 25-26, 2009, Daejeon, Korea.
2. Qian ZG, Xia XX, Choi JH, Lee SY. High-level extracellular production of recombinant proteins in Escherichia coli: a proteome-based approach. Korean Society for Biotechnology and. Bioengineering (KSBB) international symposium & annual meeting, October 18-19, 2007, Daegu, Korea.
1. Qian ZG, Yu KW, Hahn EJ, Paek KY. Towards efficient production of useful plant secondary metabolites by the use of newly chemically synthesized elicitors. Conference for the Korean Society for Horticultural Science, May 26-27, 2005, Jeju, Korea.
INTERNATIONAL POSTER PRESENTATIONS
15. Lee SY, Qian ZG, Xia XX. Metabolic Engineering of Escherichia coli for the Production of 1,4-Diaminobutane. 11th international symposium on the genetics of industrial microorganisms (GIM), June 28-July 1, 2010, Melbourne, Australia.
14. Lee SY, Qian ZG, Xia XX. A systematic proteome-based approach for high-level extracellular production of recombinant proteins in Escherichia coli. 11th international symposium on the genetics of industrial microorganisms (GIM), June 28-July 1, 2010, Melbourne, Australia.
13. Qian ZG, Xia XX, Lee SY. Systems metabolic engineering of Escherichia coli for the production of putrescine, a four carbon linear chain diamine. Metabolic Engineering VIII: Metabolic engineering for green growth. June 13-17, 2010, Jeju Island, Korea.
12. Qian ZG, Xia XX, Lee SY. Metabolic engineering of Escherichia coli for the production of large spider dragline silk proteins. Metabolic Engineering VIII: Metabolic engineering for green growth. June 13-17, 2010, Jeju Island, Korea.
11. Xia XX, Qian ZG, Lee SY. Comparative proteomic analysis of four biotechnologically important Escherichia coli strains for rational host selection. Asia Pacific Biochemical Engineering Conference (APBioChEC'09), November 24-27, 2009, Kobe, Japan.
10. Qian ZG, Xia XX, Lee SY. A systematic approach for high-level extracellular production of recombinant proteins in Escherichia coli. Asia Pacific Biochemical Engineering Conference (APBioChEC'09), November 24-27, 2009, Kobe, Japan.
9. Qian ZG, Xia XX, Lee SY. Systematic proteome-based approach for high-level extracellular production of recombinant proteins in Escherichia coli. The 16th Biochemical Engineering, July 5-9, 2009, Burlington, Vermont, USA.
8. Qian ZG, Xia XX, Choi JH, Lee SY. Systematic proteome-based approach for high-level extracellular production of recombinant proteins in Escherichia coli. 13th International Biotechnology Symposium & Exhibition (IBS2008), October 12-17, 2008, Dalian, China.
7. Xia XX, Qian ZG, Han MJ, Lee SY. The extracellular proteomes of Escherichia coli B and K-12 strains and its application in the secretory production of recombinant proteins. 13th International Biotechnology Symposium & Exhibition (IBS2008), October 12-17, 2008, Dalian, China.
6. Qian ZG, Xia XX, Choi JH, Lee SY. A systematic proteome-based approach for the secretion of synthetic gene products in Escherichia coli. Synthetic Biology 4.0 (SB4.0), October 10-12, 2008, Hong Kong, China.
5. Qian ZG, Xia XX, Choi JH, Lee SY. High-level extracellular production of recombinant proteins in Escherichia coli: a proteome-based approach. Asia Pacific Biochemical Engineering Conference (APBioChEC'07), November 4-7, 2007, Taipei, Taiwan.
4. Xia XX, Qian ZG, Han MJ, Choi JH, Lee SY, Yoo JS. The extracellular proteomes of Escherichia coli B and K-12 strains and their application in the excretory production of recombinant proteins. Biochemical Engineering XV, July 15-19, 2007, Quebec City, Canada.
3. Choi JH, Qian ZG, Lee SY. Development of extracellular production systems of recombinant proteins in recombinant Escherichia coli. The 4th recombinant protein production meeting: a comparative view on host physiology, September 21-23, 2006, Barcelona, Spain.
2. Choi JH, Qian ZG, Jang SH, Lee SY. Extracellular production of recombinant proteins. 10th international symposium on the genetics of industrial microorganisms (GIM), June 24-28, 2006, Prague, Czech Republic.
1. Qian ZG, Zhao ZJ, Tian WH, Xu Y, Zhong JJ, Qian X. Novel chemically-synthesized elicitors for overproduction of secondary metabolites by plant cells. The 9th Symposium of Young Asian Biochemical Engineers' Community (YABEC 2003), November 13-15, 2003, Jeju Island, Korea.
Jeong Wook Lee
Honorary Ph.D. '09. 8
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Research Interest
metabolic engineering
strain development for amino acids, vitamins, nucleotides, and trehalose
systems biotechnology
Education
B.S., Dept. of Agricultural chemistry, Korea University, Seoul, Korea (1986. 3 ~ 1990. 2)
M.S., Dept. of Agricultural chemistry, Korea University, Seoul, Korea (1990. 3 ~ 1992. 2), Advisor: Professor Se Young Lee, Thesis: Expression of the bovine growth hormone gene in Yeast, Saccharomyces cerevisiae
Ph.D., Dept. of Chemical Engineering, KAIST, Daejeon, Korea (2004.3 ~ 2007.8), Advisor : Professor Sang Yup Lee, Thesis: Metabolic engineering of Escherichia coli for the production of L-threonine
Professional Experience
CJ CheilJedang Corp., Institute of Science & Technology, R&D center for Bioproducts, Senior Researcher (1995.1 ~ present)
Awards and Honors
Best Paper Award, International E. coli Alliance 2006 (IECA 2006), Jeju ICC, Jeju, Korea (2006. 10. 31-11. 3) Kwang-Ho Lee, Park JH, Kim TY, Lee SY, "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis"
Best Poster Award, Asia Pacific Biochemical Engineering Conference 2007 (APBioChEC'07), Taipei International Convention Center, Taiwan (2007. 11. 4-7) Park JH, Kwang-Ho Lee, Kim TY, Lee SY, “Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation
Publications
International Journals
Jin-Ho Lee, Kwang-Ho Lee, Chang-Gyeom Kim, Se-Young Lee, Geun-Joong Kim, Young-Hoon Park, and Sung-Oh Chung, “Cloning and expression of a trehalose synthase from Pseudomonas stutzeri CJ38 in E. coli for the production of trehalose”, Appl Microbiol Biotechnol (2005) 68: 213–219
Park, J.H., Lee, K.H., Kim, T.Y., and Lee, S.Y. "Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation", Proc. Nat. Acad. Sci. (PNAS), 104 (19): 7797-7802 (2007) [pdf] [suppl]
Kim, P.J., Lee, D.Y., Kim, T.Y., Lee, K.H., Joeong, H.W., Lee, S.Y., Park, S.W., "Metabolite essentiality elucidates robustness of Escherichia coli metabolism", Proc. Nat. Acad. Sci. (PNAS), 104 (34): 13638-13642 (2007) [pdf]
Lee, K.H., Park, J.H., Kim, T.Y., Kim, H.U., and Lee, S.Y., "Systems metabolic engineering of Escherichia coli for L-threonine production", Molecular systems biology 3: 149 (2007). [pdf] [suppl]
Kim, J.M., Lee, K.H. and Lee, S.Y., "Development of a markerless gene knock-out system for Mannheimai succiniciproducens using a temperature-sensitive plasmid", FEMS Microbiol. Lett. 278: 78-85 (2008). [pdf]
International conference
Kwang-Ho Lee, Hyang Choi, Jong-Kwon Han, and Young-Hoon Park, "Metabolic engineering of riboflavin over-producing Bacillus subtilis based on comparative analysis of transcriptome", International Conference on Functional Genomics of Gram-Positive Microorganisms, Baveno, Italy, June (2003)
Kwang Ho Lee, Tae Yong Kim, Jin Hwan Park, Sang Yup Lee "Transcriptome and fluxome analysis of a metabolically engineered E.coli L-threonine production strain", Biochemical Engineering XIV, Bancouver, Canada (2005. 7).
Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee "Construction of valine-producing strain and its transcriptome analysis", Biochemical Engineering XIV, Bancouver, Canada (2005. 7).
Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim and Sang Yup "Construction of L-threonine producing strain based on in silico simulation and comparative transcriptome analysis" GIM 2006, Prague, Czech Republic (2006. 6).
Jin Hwan Park, Yu Kyung Jung, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, " Metabolic engineering of E. coli for the production of L-valine", Metabolic Engineering VI, Noordwijkerhout, The Netherlands (2006. 10).
Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Metabolic engineering of E. coli for L-valine production and its transcriptome analysis", IECA 2006, Jeju, Korea (2006. 11).
Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim, Sang Yup Lee, "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis", IECA 2006, Jeju, Korea (2006. 11).
Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Metabolic engineering of E. coli for L-valine production” The 29th Symposium on Biotechnology for Fuels and Chemicals, Denver, USA (2007. 4)
Kwang Ho Lee, Jin Hwan Park, Tae Yong Kim, Sang Yup Lee, "Construction of L-threonine Producing Strain based on in silico Simulation and Comparative Transcriptome Analysis” The 29th Symposium on Biotechnology for Fuels and Chemicals, Denver, USA (2007. 4.)
Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, " Metabolic engineering of Escherichia coli for the production of L-valine based on combined transcriptome analysis and in silico gene knockout simulation ", Biochemical Engineering XV, Quebec City, Canada (2007. 7)
Jin Hwan Park, Kwang Ho Lee, Tae Yong Kim, Sang Yup Lee, " Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation ", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei International Convention Center, Taiwan, Nov 4-7 (2007)
Patents
- 6 international patents (PCT) and 18 domestic patents
Yu Kyung Jung
Ph.D. '10. 1.
CJ Business Strategy Institute
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
B.S., 2000. 3 - 2004. 2. Chemical Engineering, Pusan National Univ., Busan, Republic of Korea
M.S., 2004. 3 - 2006. 2. Chemical & Biomolecular Engineering, KAIST, Daejeon, Republic of Korea
Ph.D., 2006. 3 - 2010. 1. Chemical & Biomolecular Engineering, KAIST, Daejeon, Republic of Korea
Research Interest
Biopolymer Production
Systems Metabolic Engineering
Synthetic Biology
White Biotechnology
Research Experiences
Metabolic engineering for the production of polylactic acid (PLA) and its copolymers
Metabolic engineering for the production of bioplastics (polyhydroxyalkanoates)
Metabolic engineering for the production of unnatural polymers
White biotechnology towards bioplastics industry
Development of a versatile platform for the one-step production of lactate-based polymers from renewable resources
Construction of new pathways for the biosynthesis of poly(lactate) and poly(3-hydroxybutyrate-co-lactate)
Metabolic engineering of Escherichia coli for the production of PLA and its copolymers
Enhanced production of PLA and its copolymers having high lactate fraction by further engineering based on in silico genome-scale simulation
Metabolic engineering of E. coli for more efficient production of PLA and its copolymers
Enzyme (PHA synthases from Pseudomonas sp. strains) engineering for the production of PLA and its copolymers
Fermentative production of PLA and its copolymers from renewable resources
Microbial production of various PLA copolymers by further metabolic engineering
Awards and Honors
Best Researcher Award, Korean Society for Biochemistry and Molecular Biology,Seoul, Republic of Korea (2005. 5. 20)
Student Fellowship Award, Metabolic Engineering VII, Puerto Vallata, Mexico (2008. 9. 16)
Best Paper Presentation Award, The Korean Society for Biotechnology and Bioengineering, Daejeon, Republic of Korea (2009. 11. 3)
Recognition by major news media including CNN (www.cnn.com) (2009. 11-12) (All other relevant articles are available at http://mbel.kaist.ac.kr.)
Representative international news
"Koreans make plastics without fossil fuel" – CNN Home, CNN Tech
"S. Koreans make bioengineered plastics" – CNN Asia
"A genetically engineered bacterium makes a greener plastic" – Economist
"Korean researchers find one-step route to PLA" – European Plastics News
Representative domestic news
"대사공학적으로 개량된 박테리아로 범용플라스틱 생산기술 개발"
'석유, 석탄 없이 바이오 플라스틱' 국내 성공 – 조선일보
세균에서 플라스틱 뽑아내는 기술 첫 개발 – 동아일보
박테리아 이용 플라스틱 생산기술 개발 – 연합뉴스
Publications
International Journal
Jung YK, Kim TY, Park SJ, Lee SY. 2010. Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers. Biotechnol Bioeng 105:161-171. (selected as a Spotlight paper)
Book Chapter
Lee SY, Jung YK, Song H, Kim JM, Park JH. 2009. Fermentative production of organic acids for polymer synthesis. Microbial Production of Biopolymers and Polymer Precursors:Applications and Perspectives. p181-195, Caister Academic Press, United Kingdom.
Jung YK, Lee SY, Tam TT. 2010. Towards systems metabolic engineering of PHA producers. In Plastic from bacteria: Natural functions and applications. Microbiology Monographs, Vol. 14, p63-84, Springer, Berlin Heidelberg, Germany.
Chen GQ, Wu Q, Jung YK, Lee SY. in press. PHA/PHB. In Industrial Biotechnology. Comprehensive Biotechnology (2nd edn), Vol. 3, Elsevier, Amsterdam, Netherlands.
Patent
Cho JH, Park SJ, Lee SY, Jung YK. 2006. Cells or plants that can produce polylactate or its copolymers and to a method for preparing polylactate or its copolymers using the same. WO/2006/126796.
Park SJ, Yang TH, Kim TW, Lee SY, Jung YK. 2009. Mutant microorganism with improved productivity of polylactate and its copolymer and method for preparing them using the same. 10-2009-0056652 .
Lee SY, Jung YK, Yang TH. 2009. Method for preparing poly(lactate-co-glycolate) or poly(lactate-co-glycolate-co-hydroxyalkanoate) copolymers using cells or plants having producing ability of poly(lactate-co-glycolate) or poly(lactate-co-glycolate-co-hydroxyalkanoate) copolymers. 10-2009-0030133.
Lee SY, Park JH, Jung YK. 2009. Method for preparing hydroxyalkanoate alkylester using the microorganisms producing polyhydroxyakanoate. 10-2009-0060496.
Jin Young Lee
Ph.D. Post-doc. '10. 8.
BioProcess Engineering Research Center, Department of Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Research Interest
Protein engineering
Metabolic engineering
Polyhydroxyalkanoates
Biofuels
Education
B.S., Dept. of Chemical and Biological Engineering, Inha University, Incheon, Korea (1997. 3 ~ 2003. 2)
M.S., Dept. of Biological Engineering, Inha University, Incheon, Korea (2003. 3 ~ 2005. 2)
Advisor : Professor Byung Ki Hur, Research professor Geun Joong Kim
Thesis : Functional expression and mutant construction of transketolase from Corynebacterium ammoniagenes
Ph.D., Dept. of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea (2005. 9 ~ present)
Advisor : Professor Sang Yup Lee
Research Experiences
Summary (as of April, 2009)
Journal paper publications: 5 paper published
Awards: 2
Patents: 2
Conference presentations/Abstracts: 8 papers
International Journals
Kim, J. H., Choi, G.. S., Kim, S. B., Kim, W. H., Lee, J. Y., Ryu, Y. W., and Kim, G. J., "Enhanced thermostability and tolerance of high substrate concentration of an esterase by directed evolution" J. Mol. Catal. B: Enzymatic. 27: 169-175. (2004)
Seung-Hye Park, Dae-Eun Cheong, Jin-Young Lee, Sang-Soo Han, Jin-Ho Lee, Geun-Joong Kim., "Analyses of the structural organization of unidentified open reading frames from metagenome" Biochem Biophysl Res Comm. 356: 961–967.(2007)
Jin-Young Lee, Dae-Eun Cheong, Geun-Joong Kim., "A novel system for the measurement of transketolase activity using xylulokinase from Saccharomyces cerevisiae" Biotechnol Lett. (2007)
Han, Sang-Soo, Jin-Young Lee, Won-Ho Kim, Hyun-Jae Shin, and Geun-Joong Kim., "Screening of Promoters from Metagenomic DNA and Their Use for the Construction of Expression Vectors", J Microbiol Biotechnol. 18: 1634–1640. (2008)
Ji-Yun Kim, Jin-Young Lee, Youn-Sook Shin, and Geun-Joong Kim., "Mining and identification of a glucosidase family enzyme with high activity toward the plant extract indicant", J. Mol. Catal. B: Enzymatic. 57: 284–291. (2009)
Awards
Best Poster award, "Promoter screening from environmental metagenome library by a directional reporting vector system" Annual Meeting and International Symposium ( The Korean Society for Microbiology and Biotechnology, 2005.7.1)
Poster award, "Construction of advanced promoter/operon-trap vector systems for screening of environmental metagenome library" Annual Meeting and International Symposium ( The Korean Society for Microbiology and Biotechnology, 2005.7.1)
Patents
2 Application of Domestic Patent
International Proceedings/Conferences
Kim W.H., Lee J. Y., Lee S. J., Hur, B. K., and Kim, G. J., "Construction and utilization of promoter/operon-trap vector systems for screening of environmental metagenome library" Enzyme Eng., Gyeongju, Korea, October 9-14 (2005)
Jin Young Lee, Yu-Sin Jang, and Sang Yup Lee, "Expression of aad and ctfAB operon in Clostridium acetobutylicum M5 for Predominantly Alcohologenic Fermentation", Clostridium 10, Wageningen, Netherlands, 28 September - 1 October 2008
Yu-Sin Jang, Jin Young Lee, and Sang Yup Lee, "Effect of advanced cell density on production of solvents and organic acids by batch-fermentation of Clostridium acetobutylicum", Clostridium 10, Wageningen, Netherlands, 28 September - 1 October 2008
Domestic Proceedings/Conferences
Jung, I. S., Kim W. H., Lee, J. Y., Choi, K. H, Hur, B. K., and Kim G. J., "Tractical Applications of A Systematic Approach for Yielding A Potential Pool of Enzymes" Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October 22-24(2003)
Kim, W. H., Lee, J. Y., Lee, S. J., Hur, B. K., and Kim, G. J., "Construction of promoter/operon-trap vector systems for screening of environmental metagenome library" Annual meeting of Korean Society for Biotechnology and Bioengineering, Chuncheon, Korea, April 15-16(2005)
Lee, J. Y., Park, S. H., Hur, B. K., and Kim, G. J., "Novel assay system for transketolase activity using xylulokinase from Saccharomyces cerevisiae"Annual meeting of Korean Society for Biotechnology and Bioengineering, Chuncheon, Korea, April 15-16(2005)
Kim, W. H., Lee, J. Y., Kim, H. O., Hur, B. K., and Kim, G. J., "Promoter screening from environmental metagenome library by a directional reporting vector system" Annual Meeting and International Symposium of The Korean Society for Microbiology and Biotechnology , Seoul, Korea, June 30- July 1(2005)
Kim, H. O., Kim, W. H., Lee, J. Y., Hur, B. K., and Kim, G. J., "Construction of advanced promoter/operon-trap vector systems for screening of environmental metagenome library" Annual Meeting and International Symposium of The Korean Society for Microbiology and Biotechnology , Seoul, Korea, June 30- July 1(2005)
Min Jeong Sohn
Ph.D. '10. 8.
Korean Research Institute of Bioscience and Biotechnology
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2002 (B.S.) Dept. of Microbiology, Chungnam National Univ. Daejeon, Korea
Research Interest
Global transcriptional response of yeast to environmental stress
Research Experiences
International publication
1. Ubiyvovk V.M., Nazarko T.Y., Stasyk O.G., Sohn M.J., Kang H.A., Sibirny A.A., "GSH2, a gene encoding a-glutamylcysteine synthetase in the methylotrophic yeast Hansenula polymorpha", FEMS Yeast Research, 2: 327-332 (2002).
International conference
1. Min Jeong Sohn, Eun-Young Cho, Moo Woong Kim, Sang Ki Rhee, Hyun Ah Kang, "Cloning and characterization of the Hansenula polymorpha YPS1 gene encoding a functional yeast aspartyl endopeptidase", 9th International Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
2. Min Jeong Sohn, Se-Jeong Kim, Sang Ki Rhee, Vira M. Ubiyvovk1, Andrei A. Sibirny1, Hyun Ah Kang, "Transcriptional Regulation of the Hansenula polymorpha GSH2 gene by Cadmium and Oxidative stress", 2003 Annual meeting, Bioexhibition & International symposium Microbial Functional Genomics Its Application, Muju, Koea, June 24-26 (2003)
3. Min Jeong Sohn, Se-Jeong Kim, Chul Ho Kim, Sang Ki Rhee, Vira M. Ubiyvovk, Andrei A. Sibirny. Hyun Ah Kang, "Comparative analysis of cadmium tolerance and glutathione biosynthesis in different strains of the methylotrophic yeast Hansenular polymorpha", XXI International Conference on Yeast Genetics and Molecular Biology, Gothenburg, Sweden, July 6-12 (2003)
Hyun Uk Kim
Assistant Professor '11. 2.
Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology (KAIST)
Phone :+82-42-350-3915
Fax :+82-42-350-8800
Jong Myoung Park
Ph.D. '11. 8.
GS Caltex
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
3/2002 – 2/2006 B.S., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3/2002 – 2/2006 B.S., Dept. of Biological Sciences, KAIST, Daejeon, Korea.
3/2006 – 8/2011, M.S./Ph.D. Program, Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic engineering
Metabolic Flux Analysis
Bioinformatics/ Genome Analysis
Systems Biology/ Biotechnology
Research Experiences
11/2004 ~ 2/2005 : LG Life Science CO., LTD. practical training, separation and refinement of drug component.
2/2006 – Present Graduate research assistant at Metabolic and Biomolecular Engineering Laboratory (Prof. Sang Yup Lee), KAIST, Daejeon, Korea
Honors and Awards
2/2006 Honor Student, KAIST
8/2010 한국을 빛내는 사람들에 게재 (한빛사 논문: Park, J.M., Kim, T.Y., and Lee, S.Y. "Prediction of metabolic fluxes by incorporating genomic context and flux-converging pattern analyses", Proc. Nat. Acad. Sci. (PNAS), 107(33): 14931-14936 (2010.8))
8/2010 가상세포 방법론 PNAS 논문 다수 언론에 발표 (디지털타임즈, 충청투데이, 파이낸셜뉴스, 한국경제, 대전일보, 이투데이, 매일경제, 데일리메디, 아이뉴스24, 아주경제, 아시아경제, 헬스코리아뉴스, YTN, 뉴시스, 헤럴드생생뉴스, HelloDD.com, 동아사이언스)
1/2011 Outstanding Poster Award, “Metabolic flux analysis based on genomic context and flux-converging pattern analyses”, The Nineth Asia Pacific Bioinformatics Conference 2011 (APBC 2011)
Journal Publications
11. Park, J.M., Kim, T.Y., and Lee, S.Y. “Genome-scale reconstruction and in silico analysis of the Ralstonia eutropha H16 for polyhydroxyalkanoate synthesis, lithoautotrophic growth, and 2-methyl citric acid production”, BMC Syst. Biol., In press.
10. Jang, Y-S., Park, J.M., Choi, S., Choi, Y.J., Seung, D.Y., Cho, J.H., and Lee, S.Y. “Systems metabolic engineering of microorganisms for the production of biofuels”, Biotechnol. Adv., Submitted.
9. Lee, K.Y., Park, J.M., Kim, T.Y., Yun, H., and Lee, S.Y. "The genome-scale metabolic network analysis of Zymomonas mobilis ZM4 explains physiological features and suggests ethanol and succinic acid production strategies", Microbial Cell Factories, 9(94):1-12 (2010. 11.)
8. Park, J.M., Kim, T.Y., and Lee, S.Y. “Prediction of metabolic fluxes by incorporating genomic context and flux-converging pattern analyses”, Proc. Nat. Acad. Sci. USA (PNAS), 107(33): 14931-14936 (2010. 8.)
7. Park, J.M., Jang, Y-.S., Kim, T.Y., and Lee, S.Y. “Development of a gene knockout system for Ralstonia eutropha H16 based on the broad-host-range vector expressing a mobile group II intron”, FEMS Microbiol. Lett., 309(2): 193-200 (2010. 8.)
6. Sohn, S.B., Kim, T.Y., Park, J.M., and Lee, S.Y. “In silico genome-scale metabolic analysis of Pseudomonas putida KT2440 for polyhydroxyalkanoate synthesis, degradation of aromatics, and anaerobic survival”, Biotechnol. J., 5(7): 739-750 (2010. 7.)
5. Park, J.M., Kim, T.Y., and Lee, S.Y., “Constraints-based genome-scale metabolic simulation for systems metabolic engineering”, Biotechnol. Adv., 27(6): 978-988 (2009. 11.)
4. Lee, S.Y., Kim, H.U., Park, J.H., Park, J.M., and Kim, T.Y. "Metabolic engineering of microorganisms: general strategies and drug production", Drug Discovery Today, 14(1/2): 78-88 (2009. 1.)
3. Song, H., Jang, S.H., Park, J.M., and Lee, S.Y., "Modeling of batch fermentation kinetics for succinic acid production by Mannheimia succiniciproducens" Biochem. Eng. J., 40(1): 107-115 (2008. 5.)
2. Yun, H., Lee, J. W., Jeong, J., Chung, J., Park, J.M., Myoung, H. N., and Lee, S. Y., "EcoProDB: the Escherichia coli protein database", Bioinformatics, 23(18): 2501-2503 (2007. 9.)
1. Kim, T.Y., Kim, H.U., Park, J.M., Kim, J.S., Song, H. & Lee, S.Y. Genome-scale analysis of Mannheimia succiniciproducens metabolism. Biotechnol. Bioeng., 97, 657-671 (2007. 7) (Accelerated publication)
Patents
Lee, S.Y., Park, J.M., Jang, Y-.S., and Kim, T.Y., “Method for inactivating a target gene in the genus Ralstonia”, Korean patent applied (10-2010-0041955) (2010. 5. 4.)
7. Conferences
International conference
Park, J.M., Kim, T.Y. and Lee, S.Y., "Incorporating genomic context and flux-converging pattern analyses into genome-scale simulation for the prediction of metabolic fluxes", 11th International Conference on Systems Biology, Edinburgh, U.K. (2010. 10.10-10.16)
Park, J.M., Kim, T.Y. and Lee, S.Y., "Improved prediction of metabolic fluxes through genomic context analysis across organisms and stoichiometric analysis of carbon fluxes", 2009 Asia Pacific Biochemical Engineering Conference (APBioChEC 2009), Kobe, Japan (2009. 11. 24-11.28)
Park, J.M., Yun, H., Lee, J.W., Jeong, J., Chung, J. and Lee, S.Y., "EcoProDB: The protein database for Escherichia coli", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore (2008. 3. 29-4.2)
Park, J.M., Lee, K.Y., Kim, T.Y., Lee, S.Y., "In silico identification of gene amplification target for increasing biochemical production", The Ninth Asia Pacific Bioinformatics Conference 2011, January 11-14 , 2011, Songdo Convensia, Incheon, Korea
등 총 20회
Dometstic conference
Park, J.M., Kim, T.Y., Lee, S.Y., “Computational simulations to overproduce biochemical in Escherichia coli", The Korean Society for Microbiology and Biotechnology, COEX Grand Ballroom, Seoul, June. 28-29(2007)
Park, J.M., Kim, T.Y., Lee, J. and Lee, S.Y., “Improvement of Escherichia coli to produce biochemical based on computational simulation", 2008 Spring KSBB Meeting and International Symposium, Chonbuk National University, Jeonju, April 18-19 (2008)
Park, J.M., Song, H.H., Jang, S.H., Lee, J.H., Lee, S.Y., “Kinetic model of batch fermentation for succinic acid production by Mannheimia succiniciproducens”, Annual Spring Meeting of KIChE, Kwangju, April 22-24 (2009)
Park, J.M., Kim, T.Y., Lee, S.Y., "Prediction of metabolic fluxes based on genomic context and flux-converging pattern analysises for genome-scale simulation" Annual Meeting of KIChE 2011, Daejeon Convention Center, Daejeon, Korea , October 20-22 (2010)
Park, J.M., Kim, T.Y., Lee, S.Y., “Improving the genome-scale prediction of metabolic fluxes based on genomic context and flux-converging pattern analyses”, 2011 Spring KSBB Meeting and International Symposium, Jeju island, April 14-16 (2011)
등 총 53회
8. Books
Lee, S.Y., Park, J.M., Kim, T.Y., “Application of metabolic flux analysis in metabolic engineering”, Methods in Enzymology (v. 498), Elsevier Academic Press, Burlington, USA, 67 - 93 (2011)
1 Book chapter published, 2 Book chapter submitted
Seung Bum Sohn
Ph.D., Post-doc. '12. 8.
BioInformatics Research Center, KAIST
Korea Advanced Institute of Science and Technology (KAIST)
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2004(B.S.) : Dept of Chemical Engineering, University of California Los Angeles
2007(M.S.) : Dept. of Biomolecular and Chemical Engineering, KAIST
Research Interest
Systems biology
Research Experiences
1. Intern with Baxter Biosciences through Kelly Services 2005
2. Undergraduate Research Assistant, UCLA: Dept of Chemical Engineering 2003-2004
Yong Jun Choi
Ph.D. '12. 8.
Professor, University of Seoul
Korea Advanced Institute of Science and Technology (KAIST)
Phone :+82-42-350-8816~7
Fax :+82-42-350-8800
Details
Education
Postdoctoral Research Associate: 2012. 8~ BioProcess Engineering Research Center, Dept. of Chemical & Biomolecular Engineering, KAIST
Ph. D. : Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea (2008~2012)
M.S. : Dept. of Life Science, GIST, Gwangju, Korea (2006~2008)
B.S. : Dept. of Biological Science, Chungnam national Univ. Daejeon, Korea (1999~2006)
Research Interest
Systems metabolic engineering
Industrial Biotechnology
Biofuels and Biochemical production
Bio-gasoline, Bio-diesel and Carbon Dioxide fixation
Bioprocess and Synthetic Biotechnology
Anti-tumor and inflammation metabolism
Research Experiences
Metabolic engineering of Escherichia coli for the production of biofuels
Microbial production of gasoline, biodiesel and alcohols
Bio-polymer production [poly(3-hydroxybutyrate-co-3-hydroxyvalerate)]
Engineering of fatty acid biosynthesis and metabolism for chemicals
Honors and Awards
2005 – 2006 Honor student based Scholarship
2012 Best Paper Presentation Award, 2012, The Korean Society for Microbiology Biotechnology
2013 People glorifying Korea (Han-vit-sa), Biology Research Information Center (BRIC)
Journal Publications
[Nature] Choi, Y.J. and Lee, S.Y., ��Microbial production of short-chain alkanes��, 502(7472): 571-574 (2013. 10) Featured by Han-vit-sa, BRIC, Oct. 2013, Journal Cover paper, Featured by Faculty of 1000 papers
[Appl. Microbiol. Biotechnol.] Yang, J.E., Choi, Y.J., Lee, S.J., Kang, K.-H., Lee, H., Oh, Y.H., Lee, S.H., Park, S.J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from glucose", In press, *equal contribution
[Biotechnol. Bioeng.] Jang, Y.-S., Kim, B., Shin, J.H., Choi, Y.J., Choi, S., Song, C.W., Lee, J., Park, H.G., Lee, S.Y. "Bio-based production of C2-C6 platform chemicals",109(10): 2437-2459 (2012. 10)
[Metabol. Eng.] Choi, Y.J., Park, J.H., Kim, T.Y., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of 1-propanol",14(5): 477-486 (2012. 9)
[Biotechnol. Adv.] Jang, Y.-S., Park, J.M., Choi, S., Choi, Y.J., Seung, D.Y., Cho, J.H., and Lee, S.Y., "Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches", 30(5): 989-1000 (2012. 9)
[Immunology] Kim, S.Y., Choi, Y.J., Jung, S.M., Lee, B.H., Jung, Y.S. and Lee, J.Y., ��Hypoxic stress up-regulates the expression of Toll-like receptor 4 in macrophages via hypoxia-inducible factor��, 129, 516-524 (2009. 10)
[International Immunopharmacology] Youn, H.S., Lim, H.J., Choi, Y.J., Lee, J.Y., Lee, M.Y., and Ryu, J.H., ��Selenium suppresses the activation of transcription factor NF-kappaB and IRF3 induced by TLR3 or TLR4 agonists��, 8(3): 495-501 (2008. 3)
[Biochemical Pharmacology] Youn, H.S., Lee, J.K., Choi, Y.J., Saitoh, S.I., Kensuke Miyake, Hwang D.H., and Lee, J.Y., ��Cinnamaldehyde suppresses toll-like receptor 4 activation mediated through the inhibition of receptor oligomerization��, 15;75(2): 494-502 (2008. 1)
[Biochemical Pharmacology] Youn, H.S., Lee, J.Y., Saitoh, S.I., Kensuke Miyake, Kang, K.W., Choi, Y.J. and Hwang, D.H., ��Suppression of MyD88- and TRIF-dependent signaling pathways of toll-like receptor by (-)-epigallocatechin-3-gallate, a polyphenol component of green tea�� 28;72(7): 850-859 (2006. 9)
6. Patents
1. Sang Yup Lee, Yong Jun Choi, ��Microorganism variants having hydrocarbon producing ability and method for producing hydrocarbon using the same��
KOR, 10-2010-0054994
PCT/KR 10-2011-0056523
USA, 13/702,920
EP, 11792710.3
Japan, 2013-514122
Brazil, 1120120313835
China, 201180035839.3
2. Sang Yup Lee, Yong Jun Choi, Jin Hwan Park, �� Microorganism variants having 1-propanol producing ability and method for producing 1-propanol using the same��
KOR, 10-2011-0064088
USA, 13/537,988
3. Sang Yup Lee, Yong Jun Choi, �� Recombinant microorganism producing taurine and method for preparing taurine using the same��
KOR, 10-1214632
4. Sang Yup Lee, Yong Jun Choi, �� Method for preparing fatty acid alkylester using a microorganism capable of producing oil��
KOR, 10-2009-0065490
PCT/KR2010/004701
Indonesia, W-00201200208
USA, 13/384,576
EP, 10800069.6
Japan, 2012-520549
Brazil, 1120120011316
Thailand, 1201000178
5. Sang Yup Lee, Yong Jun Choi, Jin Hwan Park, �� Recombinant microorganisms producing butanol and method for preparing butanol using the same��
KOR, 10-2010-0055069
6. Sang Yup Lee, Yong Jun Choi, Jin Hwan Park, �� Enhanced butanol producing recombinant microorganisms and method for preparing butanol using the same��
KOR, 10-2010-0087550
PCT/KR2011/006607
Sol Choi
Ph.D., Post-doc. '13. 8.
CJ
Korea Advanced Institute of Science and Technology (KAIST)
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
3/2002 – 2/2006 B.S., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3/2006 – 8/2008 M.S., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
9/2008 – 8/2013 Ph.D., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
8/2013 – present Post-Doctor., BioProcess Engineering Research Center, KAIST
Research Interest
Systems metabolic engineering
Systems Biology/ Biotechnology
Bio-based fundamental chemical production
Research Experiences
11/2004 ~ 2/2005 : LG Life Science CO., LTD. practical training, separation and refinement of drug component.
2/2006 – Present Graduate research assistant at Metabolic and Biomolecular Engineering Laboratory (Prof. Sang Yup Lee), KAIST, Daejeon, Korea
Journal Publications
Lee, J.W., Choi, S., Park, J.H., Vickers, C., Nielsen, L..K., and Lee, S.Y. "Development of sucrose-utilizing Escherichia coli K-12 strain by cloning B-fructofuranosidases and its application for L-threonine production", Appl. Microbiol. Biotechnol. 88(4): 905-913
Lee, J.W., Choi, S., Kim, J.M., and Lee, S.Y., "Mannheimia succiniciproducens Phosphotransferase System for Sucrose Utilization", Appl. Environ. Microbiol. 76(5): 1699-1703
Song, H., Lee, J.W., Choi, S., You, J.K., Hong, W.H., and Lee, S.Y., "Effects of dissolved CO2 levels on the growth of Mannheimia succiniciproducens and succinic acid production", Biotechnol. Bioeng, 98(6): 1296-1304 (2007. 12.)
Lee, J.W., Kim, T.Y., Jang, Y.S., Choi, S., and Lee, S.Y. "Systems metabolic engineering for chemicals and materials", Trends Biotechnol. 29(8): 370-378 (2011. 8)
Lee, J.W., Kim, H.U., Choi, S., Yi, J., and Lee, S.Y. "Microbial production of building block chemicals and polymers", Curr. Opin. Biotechnol., 22(6): 758-767
Lee, J.W., Na, D., Park, J.M., Lee, J., Choi, S., and Lee, S.Y. "Systems metabolic engineering of microorganisms for natural and non-natural chemicals", Nature Chem. Biol. 8(6): 536-546
Jang, Y.-S., Park, J.M., Choi, S., Choi, Y.J., Seung, D.Y., Cho, J.H., and Lee, S.Y., "Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches", Biotechnol. Adv., 30(5): 989-1000
Jang, Y.-S., Kim, B., Shin, J.H., Choi, Y.J., Choi, S., Song, C.W., Lee, J., Park, H.G., Lee, S.Y. "Bio-based production of C2-C6 platform chemicals", Biotechnol. Bioeng., 109(10): 2437-2459
Song, C.W., Kim, D.I., Choi, S., Jang, J.W., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of fumaric acid", Biotechnol. Bioeng., 110(7): 2025-2034 (2013. 7)
Choi, S., Kim, H.U., Kim, T.Y., Kim, W.J., Lee, M.H., and Lee, S.Y., "Production of 4-hydroxybutyric acid by metabolically engineered Mannheimia succiniciproducens and its conversion to gamma-butyrolactone by acid treatment", Metabol. Eng., 20: 73-83 (2013. 11)
Patent
Lee, S.Y., Choi, S., Kim, J.M., Lee, J.W., Song, H. "Novel Rumen Bacteria Variant Producing High Yield Homo-succinic Acid and Process for Preparing Succinic Acid Employing the Same", Korean patent appl. (10-2007-0070219) (2007. 07. 06)
Lee, S.Y., Choi, S., Kim, J.M., Lee, J.W., Song, H. " HOMO-SUCCINIC ACID PRODUCING MICROORGANISM VARIANT AND PROCESS FOR PREPARING SUCCINIC ACID USING THE SAME", PCT (PCT/KR2008/000241) (2008. 01. 15)
Lee, S.Y., Choi, S., Kim, J.M., Lee, J.W., Song, H. " HOMO-SUCCINIC ACID PRODUCING MICROORGANISM VARIANT AND PROCESS FOR PREPARING SUCCINIC ACID USING THE SAME", China (200880106559.5) (2010. 03.11) Registered (ZL200880106559.5) (2014.01.22)
Lee, S.Y., Choi, S., Kim, J.M., Lee, J.W., Song, H. " HOMO-SUCCINIC ACID PRODUCING MICROORGANISM VARIANT AND PROCESS FOR PREPARING SUCCINIC ACID USING THE SAME", USA (12/668,868) (2010. 01.12)
Lee, S.Y., Kim, P., Choi, S. "Microorganism Enhanced Resistance of Succinic Acid and Method for Preparing Succinic Acid Using the Same", Korean patent appl. (10-2009-0062064) (2009. 07.08) Registered (10-1028039-0000) (2011.04.01)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "Novel Engineered Microorganism Producing Succinic Acid with High Yield by Utilizing Both Sucrose and Glycerol at the Same Time and Method for Preparing Succinic Acid Using the Same", Korean patent appl. (10-2010-0084327) (2010. 08. 30) Registered (10-1221557-0000) (2013.01.07)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", PCT (PCT/KR2011/6382) (2011. 08. 30)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Australia (2011296791) (2013. 03. 21)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Brazil (1120130046520) (2013. 02. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Canada (2,809,942) (2013. 04. 03)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", China (2,809,942) (2013. 04. 03)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", EPO (11822105.0) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Indonesia (W00201300864) (2013. 02. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Indonesia (W00201300864) (2013. 02. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", India (1534/CHENP/2013) (2013. 02. 26)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Japan (2013527009) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Japan (2013527009) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Mexico (MX/a/2013/002394) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Malaysia (PI2013000662) (2013. 02. 26)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", New Zealand (607585) (2013. 02. 26)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", OAPI (2013/01510) (2013. 02. 27) Resistered (2013/01510) (2013. 11. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Philippines (12013500378) (2013. 02. 26)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Russia (2013109055) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", USA (2013109055) (2013. 02. 28) Registered (8,691,516) (2014.04.08)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Vietnam (1201300959) (2013. 03. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Vietnam (1201300959) (2013. 03. 27)
Lee, S.Y., Choi, S., Lee, J.W., Park, S.J. "Mutants Having a High Producing Ability of 4-hydroxybutyrate and Preparing Method for 4-hydroxybutyrate Using Thereof", Korean patent appl. (10-2011-0130183) (2011. 12. 07)
Lee, S.Y., Choi, H.S., Choi, S. "Recombinant Microorganisms Having Producibility of Coenzyme Q10 and Method for Preparing Coenzyme Q10 Using the Same", Korean patent appl. (10-2008-0000643) (2008. 04. 03) Registered (10-0936216-0000) (2010.01.04)
book chapter
Lee, J.W., Han, M.-S., Choi, S., Yi, J., Lee, T.W., and Lee, S.Y., "Organic Acids: Succinic and Malic Acids", Vol. III: Industrial biotechnology edited by Antonio Moreira, Comprehensive biotechnology 2nd edition, Elsevier
Yi, J., Choi, S., Han, M.-S., Lee, J.W., and Lee, S.Y., "Chapter 17. Succinic Acid", Bioprocessing Technologies in Integrated Biorefinery for Production of Biofuels, Biochemicals, and Biopolymers from Biomass edited by Hesham Al El Enshasy, John Wiley & Sons, Inc.
Conference presentation
Choi, S., "Systems Metabolic Engineering for the production of 4-Hydroxybutyric acid by Mannheimia succiniciproducens and its Conversion to gamma-Butyrolactone by Acid Treatment", Microbiology and Biotechnology:from Traditional to Cutting Edge11, Korea (Busan), June 27, 2014
Seok Hyun Park
Ph.D. '14. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
Dept. of Biotechnology, Hankuk University of Foreign Studies(HUFS), Korea : 1991~1997(B.S.)
Dept. of Biotechnology, Hankuk University of Foreign Studies(HUFS), Korea : 1997~1999(M.S.)
Research Interest
Bioengineering
Synthetic biology
Metabolic engineering
Joungmin Lee
Ph.D., Post-doc. '15. 2.
CJ
Korea Advanced Institute of Science and Technology (KAIST)
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
1. 2007. 8. (B.S.) Dept. of Biological Sciences, KAIST, Daejeon, Korea
2. 2007. 9-2015. 2. (Ph.D.) Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3 . 2015. 2.-present (Post-doc) BioProcess Engineering Research Center, KAIST, Daejeon, Korea
Research Interest
1. Metabolic engineering of clostridia for 1-butanol production
2. Characterization of hypothetical proteins in solventogenic clostridia
3. In silico genome-scale metabolic network
Research Experiences
1. 2010. 2. - 2010. 5. Teaching assistant, KAIST, Chemical and Biomolecular Engineering Laboratory (CBE301)
2. 2010. 9. - 2010. 12. Teaching assistant, KAIST, Molecular Engineering Laboratory (CBE201)
3. 2010. 10. Visiting researcher, Papoutsakis Lab, University of Delaware
Honors and awards
1. 2009. 4. 23. Best Paper Presentation Award, 2009 Korean Institute of Chemical Engineers (KIChE) Spring Meeting
2. 2010. 10. 6. Second Best Poster Winner, Clostridium 11
Journal Publications
1. Lee, J.†, Yun, H.†, Feist, A.M., Palsson, B.Ø., and Lee, S.Y. "Genome-scale reconstruction and in silico analysis of the Clostridium acetobutylicum ATCC 824 metabolic network", Appl. Microbiol. Biotechnol. 80 (5): 849-862 (2008. 10) Times cited: 72
2. Lee, J.Y., Jang, Y.-S., Lee, J., Papoutsakis, E.T., and Lee, S.Y., "Metabolic engineering of Clostridium acetobutylicum M5 for highly selective butanol production", Biotechnol. J. 4 (10): 1432-1440 (2009.10)
3. Jang, Y.-S., Lee, J., Malaviya, A., Seung, D.Y., Cho, J.H., and Lee, S.Y., "Butanol production from renewable biomass: rediscovery of metabolic pathways and metabolic engineering", Biotechnol. J., 7 (2): 186-198 (2012. 2)
4. Lee, J., Jang, Y.-S., Choi, S.J., Im, J.A., Song, H., Cho, J.H., Seung, D.Y., Papoutsakis, E.T., Bennett, G.N., and Lee, S.Y., "Metabolic engineering of Clostridium acetobutylicum ATCC 824 for isopropanol-butanol-ethanol fermentation", Appl. Environ. Microbiol. 78 (5): 1416-1423 (2012. 3) Times cited: 26
5. Lee, J.W., Na, D., Park, J.M., Lee, J., Choi, S., and Lee, S.Y., "Systems metabolic engineering of microorganisms for natural and non-natural chemicals", Nat. Chem. Biol. 8 (6): 536-546 (2012. 5)
6. Jang, Y.-S., Kim, B., Shin, J.H., Choi, Y.J., Choi, S., Song, C.W., Lee, J., Park, H.G., Lee, S.Y. "Bio-based production of C2-C6 platform chemicals", Biotechnol. Bioeng. (2012. 10)
7. Jang, Y.-S., Lee, J.Y., Lee, J., Park, J.H., Im, J.A., Eom, M.-H., Lee, J., Lee, S.-H., Song, H., Cho, J.-H., Seung, D.Y., and Lee, S.Y., "Enhanced butanol production obtained by reinforcing the direct butanol-forming route in Clostridium acetobutylicum", mBio. 3(5): 1-9 (2012. 10)
8. Jang, Y.-S., Malaviya, A., Cho, C., Lee, J., and Lee, S.Y., "Butanol production from renewable biomass by clostridia", Bioresour. Technol., 123: 653-663 (2012. 11)
9. Choi, S.J., Lee, J., Jang, Y.-S., Park, J.H., Lee, S.Y., and Kim, I.H., "Effects of nutritional enrichment on the production of acetone-butanol-ethanol (ABE) by Clostridium acetobutylicum", J. Microbiol., 50(6): 1063-1066 (2012.12)
10. Jang, Y.-S., Malaviya, A., Lee, J., Im, J.A., Lee, S.Y., Lee, J., Eom, M.-H., Cho, J.-H. and Seung, D.Y., "Metabolic engineering of Clostridium acetobutylicum for the enhanced production of isopropanol-butanol-ethanol fuel mixture", Biotechnol. Prog., 29(4): 1083-1088 (2013. 7)
11. Jang, Y.-S., Han, M.-J., Lee, J., Im, J.A., Lee, Y.H., Papoutsakis, E.T., Bennett, G., and Lee, S.Y. "Proteomic analyses of the phase transition from acidogenesis to solventogenesis using solventogenic and non-solventogenic Clostridium acetobutylicum strains", Appl. Microbiol. Biotechnol. 98(11): 5105-5115 (2014. 6)
12. Song, C.W., Lee, J., and Lee, S.Y. "Genome engineering and gene expression control for bacterial strain development", Biotechnol. J. In press.
13. Choi, Y.J.†, Lee, J.†, Jang, Y.-S., and Lee, S.Y. "Metabolic engineering of microorganisms for the production of higher alcohols", mBio. In press.
14. Kim, S.Y., Lee, J., and Lee, S.Y. "Metabolic engineering of Corynebacterium glutamicum for the production of L-ornithine", Biotechnol. Bioeng. In press.
Chan Woo Song
Ph.D. '16. 2.
GS Caltex
Korea Advanced Institute of Science and Technology (KAIST)
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
3/2005 – 2/2011 B.S., Biotechnology, Yonsei University, Seoul, Korea graduated with the highest honor
2/2011 - 2/2013 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3/2013 - 2/2016 Ph.D., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Systems Biology / Biotechnology
Metabolic Engineering
Bioprocess engineering
Value added chemicals production using bacteria
Development of tools for gene manipulation and pathway optimization
Research Experiences
2013. 9. - 2013. 12. Teaching assistant, KAIST, Molecular Engineering Laboratory (CBE201)
2014. 3. - 2014. 6. Teaching assistant, KAIST, Chemical and Biomolecular Engineering Laboratory (CBE301)
Journal Publications
Publications
1. Jang, Y.-S., Kim, B., Shin, J.H., Choi, Y.J., Choi, S., Song, C.W., Lee, J., Park, H.G., Lee, S.Y. "Bio-based production of C2-C6 platform chemicals", 2012, Biotechnol. Bioeng., 109(10): 2437-2459
2. Song, C.W., Kim, D.I., Choi, S., Jang, J.W., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of fumaric acid", Biotechnol. Bioeng., 110(7): 2025-2034 (2013. 7) Journal cover paper
3. Song, C.W. and Lee, S.Y., "Rapid one-step inactivation of single or multiple genes in Escherichia coli", Biotechnol. J., 8(7): 776-784 (2013. 7) Journal cover paper
4. Song, C.W., Lee, J., and Lee, S.Y., "Genome engineering and gene expression control for bacterial strain development", Biotechnol. J. 10:48-60 (2015. 1) Journal cover paper
5. Choi, S.*, Song, C.W.*, Shin, J.H., and Lee, S.Y., "Biorefineries for the production of top building block chemicals and their derivatives", Metab. Eng., 28: 223-239 (2015.3) (*Equally contribution)
6. Song, C.W., Lee, J., Ko, Y.-S., and Lee, S.Y. "Metabolic engineering of Escherichia coli for the production of 3-aminopropionic acid", Metab. Eng., 30:121-129 (2015.7)
7. Song, C.W. and Lee, S.Y. "Combining rational metabolic engineering and flux optimization strategies for efficient production of fumaric acid", Appl. Microbiol. Biotechnol., 99(20): 8455-8464 (2015. 10)
8. Song, C.W., Kim, J.W., Cho, I.J., and Lee, S.Y. "Metabolic engineering of Escherichia coli for the production of 3-hydroxypropionic acid and malonic acid through beta-alanine route", ACS Syn. Biol. In press.
Patents - 3건 출원
Oral presentations
1. Chan Woo Song, Dong In Kim, Sol Choi, Jae Won Jang, and Sang Yup Lee, "Metabolic Engineering of Escherichia coli for the production of fumaric acid", 2013 KMB’s 40th anniversary 2013 international symposium & annual meeting (Recent breakthroughs in microbial biotechnology: from bench to industry), July 3~5, 2013, Alpensia, Pyeongchang, Korea
2. Chan Woo Song and Sang Yup Lee, "Rapid one-step inactivation of single or multiple genes in Escherichia coli", 2013 KSBB Fall Meeting and International Symposium (Innovative biotechnology for human life and industry), Oct 16~18, 2013, Bexco, Busan, Korea
3. Chan Woo Song and Sang Yup Lee, “Development of rapid one-step inactivation tool and engineering of E. coli to produce fumaric acid”, 2014 International Meeting of the Microbiological Society of Korea, April 30 - May 2, Daegu, Korea
4. Chan Woo Song and Sang Yup Lee, “Production of 3-aminopropionic acid through novel platform route using fumaric acid producing E. coli”, 2015 KIChE spring meeting, April 22-24, 2015, Jeju island, Korea
5. Chan Woo Song and Sang Yup Lee, “Metabolic Engineering of Escherichia coli for the Production of Industrial Platform Chemicals”, 2015 FKMS International meeting, November 5-6, 2015, KINTEX, Korea
Honors and Awards
Best Student Presentation Award, 2013 Korean Society for Microbiology and Biotechnology Conference (2013. 7. 5)
Best Oral Presentation Award, 2015 International Meeting of the Federation of Korean Microbiological Societies (2015. 11. 6)
Changhee Cho
Ph.D., Hanwha Chemical '16. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
Sep. 2011 - present Ph. D., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Mar. 2009 - Feb. 2011, M.S. in Functional Genomics, University of Science and Technology, Daejeon-KRIBB-FHCRC Research Cooperation Center, KRIBB, Daejeon, South korea
(Advisor: Dr. Jeong-Heon Ko, Thesis: Development of a Novel Validation Method with High Sensitivity and Multiplexity based on DNA-tagged antibodies for Cancer Biomarker Discovery)
Mar. 2001 - Feb. 2008, B.S. in Biochemistry, Department of Biochemistry, Chungnam National University, Daejeon, South Korea
Research Interest
Metabolic Engineering
Research Experiences
Mar. 2011 - Jun. 2011, Researcher, Daejeon-KRIBB-FHCRC Research Cooperation Center, KRIBB, Daejeon, South Korea
Journal Publications
Jang, Y.-S., Malaviya, A., Cho, C., Lee, J., and Lee, S.Y., "Butanol production from renewable biomass by clostridia", Bioresource Technol., 123: 653-663 (2012. 11)
Cho, C., Jang, Y.-S., Moon, H.G., Lee, J., and Lee, S.Y., "Metabolic engineering of clostridia for the production of chemicals", Biofuels Bioprod. Bioref. 9:211-225 (2015.3)
Lee, J.H., Cho, C., Kim, S.H., Kang, J.G., Yoo, J.S., Chang, C.L., Ko, J.H., and Kim, Y.S.,“Semi-quantitative Measurement of a Specific Glycoform Using a DNA-tagged Antibody and Lectin Affinity Chromatography for Glyco-biomarker Development”, Mol Cell Proteomics., 14:782-795 (2015. 03)
Kim, S., Jang, Y.-S., Ha, S.-C., Ahn, J.-W., Kim, E.-J., Lim, J.H., Cho, C., Ryu, Y.S., Lee, S.K., Lee, S.Y. and Kim, K.-J. "Redox-switch regulatory mechanism of thiolase from Clostridium acetobutylicum", Nature Communications, 6:8410, DOI: 10.1038/ncomms9410 (2015. 9)
Cho, C., Choi, S.Y., Luo, Z.W., and Lee, S.Y., "Recent advances in microbial production of fuels and chemicals using tools and strategies of systems metabolic engineering", Biotechnol. Adv., 33(7): 1455–1466 (2015. 11)
International conferences
Cho, C., Jang, Y.S., Lee, S.Y., "Effects of cyclopropane fatty acid synthase overexpression in the solventogenic phase on the solvent tolerance of Clostridium acetobutylicum ATCC 824", 15th International Biotechnology Symposium and Exhibition, September 16-21, 2012, Daegu, Korea
Cho, C., Cho, S., Jang, Y.S., Lee, S.Y. "Altered membrane fluidities and their effects on solvent production in recombinant Clostridium acetobutylicum strains", ECI's Biochemical and molecular Engineering XVIII, June 16-20, 2013, Beijing, China
Cho, C., Jang, Y.S., Lee, S.Y. "Continuous butanol fermentation using a butanol-overproducing mutant of Clostridium pasteurianum", ECI's Biochemical and Molecular Engineering XVIII, June 16-20, 2013, Beijing, China
Cho, C., Jang, Y.S., Lee, S.Y., "Development and genome analysis of a hyper-ABE producing Clostridium acetobutylicum", Clostridium XIII, Shanghai, China, 19-21, September, 2014
Cho, C., Jang, Y.S., Lee, S.Y., "Effects of thiolase knockout on acids and solvents fermentation in Clostridium acetobutylicum", Clostridium XIII, Shanghai, China, 19-21, September, 2014
Oral presentation
Cho, C.H., Jang, Y.S., Yoo, S.M., Lee, S.Y., "Construction of gene knockdown system using a modified small regulatory RNA system in Clostridium acetobutylicum", 2015 KIChE Spring Meeting, ICC Jeju, Korea, April 22-24
Domestic patents
이상엽, 조창희, 유승민, “합성 조절 sRNA를 이용한 클로스트리듐 속 미생물 유전자의 발현 조절 방법” (출원번호 10-2014-0070869)
So Young Choi
Research Professor '17. 2.
BioProcess Engineering Research Center, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2012.02 B.S Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea
2012.2 ~ 2017.02 Ph.D. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Synthetic biology
Metabolic engineering
Jung Eun Yang
Ph.D., Post-doc. '17. 2.
BioProcess Engineering Research Center, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2007.03 – 2011.02 B.S., Polymer Engineering, Suwon University, Korea
2011.09 – 2013.08 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2013.09 – 2017.02 Ph.D., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Journal Publications
Park, S.J., Kang, K.-H., Lee, H., Park, A.-R., Yang, J.E., Oh, Y.H., Song, B.K., Jegal, J., Lee, S.H., Lee, S.Y., "Propionyl-CoA dependent biosynthesis of 2-hydroxybutyrate containing polyhydroxyalkanoates in metabolically engineered Escherichia coli", J. Biotechnol., 165(2): 93-98 (2013. 5)
Park, S.J., Jang, Y.-A., Lee, H., Park, A.-R., Yang, J.E., Shin, J., Oh, Y.H., Song, B.K., Jegal, J., Lee, S.H., and Lee, S.Y., "Metabolic engineering of Ralstonia eutropha for the biosynthesis of 2-hydroxyacid-containing polyhydroxyalkanoates", Metabolic Eng., 20: 20-28 (2013. 11)
Yang, J.E., Choi, S.Y., Shin, J.H., Park, S.J. and Lee, S.Y., "Microbial production of lactate-containing polyesters", Microbial Biotechnol., 6(6): 621-636 (2013. 11)
Yang, J.E., Choi, Y.J., Lee, S.J., Kang, K.-H., Lee, H., Oh, Y.H., Lee, S.H., Park, S.J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from glucose", Appl. Microbiol. Biotechnol., 98(1): 95-104 (2014.1)
Park, S.J., David, Y., Baylon, M.G., Hong, S.H., Oh, Y.H., Yang, J.E., Choi, S.Y., Lee, S.H., Lee, S.Y., "Development of Metabolic Engineering Strategies for Microbial Platform to Produce Bioplastics", Appl. Chem. Eng., 25(2): 134-141 (2014. 4)
Park, S.J., Jang, Y.-A., Noh, W., Oh, Y.H., Lee, H., David, Y., Baylon, M.G., Shin, J., Yang, J.E., Choi, S.Y., Lee, S.H., Lee, S.Y., "Metabolic engineering of Ralstonia eutropha for the production of polyhydroxyalkanoates from sucrose", Biotechnol. Bioeng., 112:638–643 (2015. 3)
Park, S.J., Shin, J., Yang, J.E., and Lee, S.Y. ��Synthetic Biology of Hydrophobic Polymer Production��, Part of the series Springer Protocols Handbooks, 1-11 (2015. 3)
Chung, H., Yang, J.E., Ha, J.Y., Chae, T.U., Shin, J.H., Gustavsson, M., and Lee, S.Y. "Bio-based production of monomers and polymers by metabolically engineered microorganisms", Curr. Opin. Biotechnol., 36: 73-84 (2015. 12)
Chae, C.G., Kim, Y.J., Lee, S.J., Oh, Y.H., Yang, J.E., Joo, J.C., Kang, K.H., Jang, Y.-A., Lee, H., Park, A.-R., Song, B.K., Lee, S.Y., Park, S.J., "Biosynthesis of poly(2-hydroxybutyrate-co-lactate) in metabolically engineered Escherichia coli", Biotechnol. Bioproc. Eng., 21: 169-174 (2016. 1)
Choi, S.Y., Park, S.J., Kim, W.J., Yang, J.E., Lee, H., Shin, J., and Lee, S.Y. "One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli", Nature Biotechnol. (2016. 4)
Yang, J.E., Kim, J.W., Oh, Y.H., Choi, S.Y., Lee, H., Park, A.-R., Shin, J., Park, S.J., and Lee,S.Y. "Biosynthesis of poly(2-hydroxyisovalerate-co-lactate) by metabolically engineered Escherichia coli", Biotechnol. J. (2016. 9)
Patents
Lee, S.Y. and Yang, J.E" Preparing Method of 4-hydroxyphenyllactic Acid Using Variant Microorganism�� Korea patent app. 10-2015-0067345 (2015.05)
Honors/ Awards
Lee, S.Y. and Yang, J.E" Preparing Method of 4-hydroxyphenyllactic Acid Using Variant Microorganism�� Korea patent app. 10-2015-0067345 (2015.05)Best Poster Award, The Rubber Society of Korea (RSK) conference (2010.03)
Honor Student , Suwon University (2011.02)
Outstanding Poster Award, The Feberation of Korean Microbiological Societies (2012.10)
Best Poster Award, The Korean Society for Microbiology and Biotechnology (2012.06)
Silver Prize, Cold Spring Harbor Asia Fellowship Award (2014.12)
Best Poster Award, International Meeting of the Microbiological Society of Korea (2015.04)
Excellent Speaker Award, International Meeting of the Microbiological Society of Korea (2015.04)
International conferences
Yang, J.E., Kim, M.K., Park, S.J., Lee, S.H., Song, B.K., Lee, S.Y., "Production of polyhydroxyalkanoates (PHAs) containing 2-hydroxybutyrate (2HB) by metabolic engineered E.coli", Cold Spring Harbor Asia Symposium on Synthetic Biology, November 26 – 30, 2012, Suzhou, China
Yang, J.E., Jung, Y.K., Kim, T.Y., Park, S.J., Lee, S.Y., "Microbial production of lactate-containing polyhydroxyalkanoates (PHAs) using metabolically engineered Escherichia coli", BioBricks Foundation SB6.0: The Sixth International Meeting on Synthetic Biology, July 9-11, 2013, London, UK
Yang, J.E., Choi, Y.J., Lee, S.H., Song, B.K., Park, S.J., Lee, S.Y., "Biosynthesis of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Metabolically Engineered Escherichia coli", The 4th International Conference on Biobased Polymers (ICBP2013), September 25-28, 2013, HIT (Hanyang Institute of Technology), Hanyang University, Seoul, Korea
Yang, J.E., Choi Y.J., Lee, S.H., Song, B.K., Park, S.J., Lee, S.Y., "Microbial production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)", Synthetic Biology, Suzhou, China, 1-5, December, 2014
Yang, J. E., Choi, Y. J., Lee, S. H., Song, B. K., Park, S. J., Lee, S. Y., ��Bisynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Escherichia coli by a rational metabolic engineering��, Metabolic Engineering Summit, Beijing, China, 30, November-2, December, 2015
Hye Mi Kim
Ph.D. '17. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8817
Fax :+82-42-350-8800
Details
Education
3/2000 - 2/2004 B.S., Biochemistry, Chungbuk National University, cheongju, Korea
3/2004 - 2/2006 M.S., Biochemistry and molecular biology, Chungbuk National University, cheong-ju, Korea
2/2011- 8/2017 Ph. D., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic Engineering
Synthetic Biology/ Biotechnology
Biofuel
Sang Jin Park
Ph.D. '17. 8.
Dept. of Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Minho Roh
Ph.D. '17. 8.
Dept. of Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Research Interest
Metabolic Engineering
Jae Yong Ryu
Ph.D., Post-doc. '18. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8865
Fax :+82-42-350-8800
Details
Education
3/2007 ~ 2/2011 B.S., Dept. of Bioinformatics, Soongsil University, Seoul, Korea
3/2011 ~ 2/2013 M.S., Dept. of Life Sciences, GIST, Gwangju, Korea
3/2013 ~ 2/2018 Ph.D., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Systems and computational biology
Drug targeting and discovery
Yoojin Choi
Research assistant professor '18. 8.
BioProcess Engineering Research Center, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
3/2007 - 2/2011 B.S., Division of Environmental and Chemical Engineering, Chonbuk National University, Korea
3/2011 - 2/2013 M.S., School of Environmental Science and Engineering, Gwangju Institute of Science and Technology (GIST), Korea
3/2013 - 8/2018 Ph.D., Dept. of Chemical & Biomolecular Engineering, KAIST, Korea
Research Interest
Nanomaterial biosynthesis
Nano-bio hybrid
Quantum biology
Honors and Awards
8/2020 ~ Current, Co-PI, 2020-1 Novel Material, Samsung Research Funding & Incubation Center for Future Technology
10/2019, Best Poster (The Second Prize), 2019 Metabolic Engineering Summit (MES 2019)
7/2019, Young Scientists Competition Oral Awards 3rd Place, The 14th Asian Congress on Biotechnology 2019 (ACB 2019)
10/2018, Rising Researcher, 2018 Inter-Academy Seoul Science Forum, The Korean Academy of Science and Technology (KAST)
6/2018, Best Student Oral Presentation Award, The Korean Society for Microbiology and Biotechnology
7/2017, Best Poster Presentation Award, The 13th Asian Congress on Biotechnology 2017 (ACB 2017)
6/2017, Best Student Oral Presentation Award, The Korean Society for Microbiology and Biotechnology
4/2016, Best Student Poster Presentation Award, The Korean Society for Biotechnology and Bioengineering
Zi Wei Luo
Research assistant professor '18. 8.
BioProcess Engineering Research Center, KAIST
Phone :+82-42-350-8817
Fax :+82-42-350-8800
Details
Education
8/2008~7/2012, B.S., Biotechnology, Harbin Institute of Technology, Harbin, China
8/2010~7/2011, Exchange study program, Bioengineering, Hanyang University, Seoul, Republic of Korea
8/2012~8/2018, MS-PhD integrated, Chemical & Biomolecular Engineering, KAIST, Daejeon, Republic of Korea
Research Interest
Metabolic engineering
Professional experience
9/2018~12/2020, Postdoctoral researcher, BioProcess Engineering Research Center, KAIST, Daejeon, Republic of Korea
1/2021~present, Research assistant professor, BioProcess Engineering Research Centerng, KAIST, Daejeon, Republic of Korea
Tong Un Chae
Ph.D. '19. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2/2008 ~ 2/2012 B.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2012/2 ~ 2/2019 Ph.D. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic engineering
Hannah Chung
Ph.D. '19. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
09.2006 - 02.2011 B.S Chemical & Biomolecular Engineering, KAIST
Research Interest
Synthetic Biology
Metabolic Engineering
Jung Ho Ahn
Ph.D. '19. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8814
Fax :+82-42-350-8800
Details
Education
(2010) B.S., University of Michigan, Ann Arbor, MI, USA
(2013) M.S., Seoul National University, Seoul, Korea
(9/2013~2/2019) Ph.D., KAIST, Daejeon, Korea
Research Interest
Metabolic engineering
Junho Bang
Ph.D. '19. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8814
Fax :+82-42-350-8800
Details
Education
(2013) B.S., Korea University, Seoul, Korea
(9/2013~8/2019) Ph.D., KAIST, Daejeon, Korea
Research Interest
Metabolic engineering
Kyeong Rok Choi
Research Assistant Professor, Ph.D. '19. 8.
BioProcess Engineering Research Center, Metabolic and Biomolecular Engineering Laboratory, Dept. Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology (KAIST)
E-mail : chkr1018 at kaist.ac.kr
Phone : +82-42-350-5970
Address : Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 291, Daehakro, Yuseong-Gu, DAEJEON, 34141, Republic of KOREA
Details
Education
2014.09 – 2019.08 Integrated M.S.-Ph.D.
Dept. Chemical and Biomolecular Engineering, KAIST,
Daejeon, Korea
Advisor: Prof. Sang Yup Lee, Ph.D.
2012.02 – 2014.08 B.S., Double Major, summa cum laude
Dept. Chemical and Biomolecular Engineering,
Dept. Biological Sciences, KAIST, Daejeon, Korea
Advisor: Prof. Sang Yup Lee, Ph.D.
2009.03 – 2012.02 Korea Science Academy of KAIST, Busan, Korea
1st Place in Dept. Biology
Research Experience
2022.09 – 2023.07 Co-principal investigator, Technology project (삼성미래기술육성사업 소재 프로그램; Project No. SRFC-MA2001-07), Samsung Science & Technology Foundation, Korea
2021.01 – 2023.02 Principal investigator, Cooperative Research Program for Agriculture Science and Technology Development (Project No. RS-2021-RD009210), Rural Development Administration, Korea
2020.11 – 2023.02 Research assistant professor, BioProcess Engineering Research Center, KAIST, Daejeon, Korea, PI: Prof. Sang Yup Lee, Ph.D.
2019.09 – 2020.10 Post-doctoral researcher, BioProcess Engineering Research Center, KAIST, Daejeon, Korea, PI: Prof. Sang Yup Lee, Ph.D.
2013.06 – 2013.08 Intern, Hasan lab, Wellman Center for Photomedicine, Massachusetts General Hospital & Harvard Medical School, Boston, MA, U.S.A., PI: Prof. Tayyaba Hasan, Ph.D.
2012.06 – 2012.08 Intern, Collins lab, Boston University, Boston, MA, U.S.A., PI: Prof. James J. Collins, Ph.D.
2011.08 – 2014.08 Researcher, Metabolic and Biomolecular Engineering National Laboratory, KAIST, Daejeon, Korea, PI: Prof. Sang Yup Lee, Ph.D.
Publications
*These authors equally contributed to each work
†Corresponding authors
Choi, K.R., Jung, S.Y., and Lee, S.Y.† “From sustainable feedstocks to microbial foods” Nat. Microbiol. In press.
Choi, K.R., Luo, Z.W., Kim, G.B., Xu, H., and Lee, S.Y.† “A microbial process for the production of benzyl acetate” Nat. Chem. Eng. 2024. 1(3). https://doi.org/10.1038/s44286-023-00022-0.
Chung, H., Kim, J., Lee, Y.J., Choi, K.R., Jeong, K.J., Kim, G.-J., and Lee, S.Y.† "Enhanced production of difficult-to-express proteins through knocking down rnpA gene expression" Biotechnol. J. 2023. 18(10):2200641. https://doi.org/10.1002/biot.202200641.
Choi, K.R. and Lee, S.Y.† “Systems metabolic engineering of microorganisms for food and cosmetics production” Nat. Rev. Bioeng. 2023. 1:832-857. https://doi.org/10.1038/s44222-023-00076-y.
Cho, J.S., Yang, D., Prabowo, C.P.S., Ghiffary, M.R., Han, T.H., Choi, K.R., Moon, C.W., Zhou, H., Ryu, J.Y., Kim, H.U., and Lee, S.Y.† "Targeted and high-throughput gene knockdown in diverse bacteria using synthetic sRNAs", Nat. Commun. 2023. 14:2359. https://doi.org/10.1038/s41467-023-38119-y.
Luo, Z.W.*, Choi, K.R.*, and Lee, S.Y.† “Improved terephthalic acid production from p-xylene using metabolically engineered Pseudomonas putida” Metab. Eng. 2023. 76:75-86.
Ahn, Y.-J., Lee, J.A., Choi, K.R., Bang, J., and Lee, S.Y.† “Can microbes be harnessed to reduce atmospheric loads of greenhouse gases?” Environ. Microbiol. 2023. 25(1):17-25.
Choi, K.R.†, Yu, H.E., and Lee, S.Y.† “Production of zinc protoporphyrin IX by metabolically engineered Escherichia coli” Biotechnol. Bioeng. 2022. 119(11): 3319-3325.
Choi, K.R.†, Yu, H.E., Lee, H., and Lee, S.Y.† “Improved production of heme using metabolically engineered Escherichia coli” Biotechnol. Bioeng. 2022. 119(11): 3178-3193.
Choi, K.R.*, Ahn, Y.-J.*, and Lee, S.Y† “Bacterial conversion of CO2 to organic compounds” J. CO2 Util. 2022. 58:101929.
Choi, K.R.*,†, Yu, H.E.*, and Lee, S.Y.† “Microbial food: microorganisms repurposed for our food” Microb. Biotechnol. 2022. 15(1):18-25.
Kim, J.-S., Choi, K.R., Eun, H., Heo, J., Kwon, S.-W., Ko, Y.-J., and Kim, S.-J.† “Complete genome sequence of Sphingomonas sanguinis NP2-R2, a carotenoid producing bacterium, isolated from morning glory” Korean J. Microbiol. 2021. 57(3):238-241.
Choi, K.R.*, Jiao, S.*, and Lee, S.Y.† “Metabolic engineering strategies toward production of biofuels” Curr. Opin. Chem. Biol. 2020. 59:1-14.
Cho, I.J., Choi, K.R., and Lee, S.Y.† “Microbial production of fatty acids and derivative chemicals” Curr. Opin. Biotechnol. 2020. 65:129-141.
Chang, H.N.*,†, Choi, K.R.*, Lee, S.Y, Seon, M.-H., and Chang, Y.-S. “Chang approximation for the osmotic pressure of dilute to concentrated solutions” Korean J. Chem. Eng. 2020.37(4):583-587.
Choi, K.R. and Lee, S.Y.† “Protocols for RecET-based markerless recombineering for gene knockout and integration to express heterologous biosynthetic gene clusters in Pseudomonas putida” Microb. Biotechnol. 2020.13(1):199-209.
Choi, K.R., Jang, W.D., Yang, D., Cho, J.S., Park, D., and Lee, S.Y.† “Systems metabolic engineering strategies: Integrating systems and synthetic biology with metabolic engineering”, Trends Biotechnol. 2019. 37(8):817-837.
Choi, K.R., Ryu, J.Y., and Lee, S.Y.† “Revisiting statistical design and analysis in scientific research”, Small 2018. 14(40):1802604.
Zhao, X.R., Choi, K.R., and Lee, S.Y.† “Metabolic engineering of Escherichia coli for secretory production of free haem” Nat. Catal. 2018. 1(8):720-728.
Choi, K.R.*, Kim, W.J.*, and Lee, S.Y.† “Metabolomics for industrial fermentation” Bioprocess Biosyst. Eng. 2018. 41(7):1073-1077.
Choi, K.R., Cho, J.S., Cho, I.J., Park, D., and Lee, S.Y.† “Markerless gene knockout and integration to express heterologous biosynthetic gene clusters in Pseudomonas putida” Metab. Eng. 2018. 47:463-474.
Yang, D.S., Cho, J.S., Choi, K.R., Kim, H.U., and Lee, S.Y.† “Systems metabolic engineering as an enabling technology in accomplishing sustainable development goals” Microb. Biotechnol. 2017. 10(5):1254-1258.
Cho, J.S.*, Choi, K.R.*, Prabowo, C.P.S., Shin, J.H., Yang, D., Jang, J., and Lee, S.Y.† “CRISPR/Cas9-coupled recombineering for metabolic engineering of Corynebacterium glutamicum”, Metab. Eng. 2017. 42:157-167.
Choi, K.R. and Lee, S.Y.† “CRISPR technologies for bacterial systems: Current achievements and future directions”, Biotechnol. Adv. 2016. 34(7):1180-1209.
Lee, J.W., Gyorgy, A., Cameron, D.E., Pyenson, N., Choi, K.R., Way, J.C., Silver, P.A., Vecchio, D.D., and Collins, J.J.† “Creating single-copy genetic circuits”, Mol. Cell 2016. 63(2):329-336.
Choi, K.R.*, Shin, J.H.*, Cho, J.S., Yang, D., and Lee, S.Y.† “Systems metabolic engineering of Escherichia coli” EcoSal Plus 2016. 7(1): 10.1128/ecosalplus.ESP-0010-2015.
Oral Presentations
Choi, K.R. “Microbial production of heme and zinc protoporphyrin IX for the sustainable consumption of meat”, 2023 KSBB Fall Meeting and International Symposium, Busan, Korea
Choi, K.R. “Microbial production of heme and zinc protoporphyrin IX toward the production of alternative meats”, 2022 KoSFoST International Symposium and Annual Meeting, Busan, Korea
Choi, K.R. and Lee, S.Y. “RecET recombineering system for markerless integration of heterologous biosynthetic gene clusters to Pseudomonas putida chromosome”, 8th Congress of European Microbiologists (FEMS2019), Glasgow, Scotland
Choi, K.R. and Lee, S.Y. “Donor plasmid system for rapid and markerless integration of heterologous genes into bacterial chromosomes”, 2019 International Meeting of the Microbiological Society of Korea, Jeju, Korea
Choi, K.R. Cho, J.S., Cho, I.J., Park, D., and Lee, S.Y. “RecET recombineering system for markerless integration of heterologous biosynthetic gene clusters into chromosomal DNA of Pseudomonas putida”, 2018 International Meeting of the Microbiological Society of Korea, PyeongChang, Korea
Choi, K.R. and Lee, S.Y. “Engineering Escherichia coli producing fragrant benzyl acetate from benzoic acid”, The 28th International Symposium on Chemical Engineering, Jeju, Korea
Patents
[Granted]
Lee, S.Y., Cho, J.S., and Choi, K.R. “Method of Preparing Corynebacterium Variant Based on CRISPR/Cas System, Recombinase, and ssODN”, Korea patent 10-2118705.
Lee, S.Y., Zhao, X.R., and Choi, K.R. “Method for Producing Extracellular Heme Using Metabolically Engineered Microorganism”, Korea patent 10-2168039.
Lee, S.Y., Zhao, X.R., and Choi, K.R. “Extracellular heme production method using metabolically engineered microorganism”, US patent 11,371,068.
[Pending]
Lee, S.Y., Choi, K.R., Ahn, D.-H., and Jung, S.Y. “Production of microbial-based alternative egg liquid and milk and uses thereof”, Korea patent appl. 10-2024-0020345
Lee, D.C., Kim, J., Choi, K.R., Kim, G.-M., Lee, I., and Lee, B. “Production method of ammonia using quantum dot-bacteria hybrid system”, Korea patent appl. 10-2023-0095600.
Lee, S.Y., Choi, K.R., and Yu, H.E. “Food having improved flavor, nutrition, and color and preparation method thereof”, Europe patent appl. 22807762.4.
Lee, S.Y., Choi, K.R., and Yu, H.E. “Food having improved flavor, nutrition, and color and preparation method thereof”, India patent appl. 202347057780.
Lee, S.Y., Choi, K.R., and Yu, H.E. “Food having improved flavor, nutrition, and color and preparation method thereof”, US patent appl. 18/548,248.
Lee, S.Y., Choi, K.R., and Yu, H.E. “Food Having Improved Flavor, Nutrition and Color and Method for Preparing Thereof”, PCT patent PCT/KR2022/006611.
Lee, S.Y., Choi, K.R., and Yu, H.E. “Food Having Improved Flavor, Nutrition and Color and Method for Preparing Thereof”, Korea patent appl. 10-2022-0056963.
Kim, S.-J., Kwon, S.-W., Kim, J.-S., Ko, Y.-J., Lee, S.Y., Choi, K.R., and Yu, H. “Transformable Non-auxotrophic Bacillus subtilis strain E5, and Uses Thereof”, Korea patent appl. 10-2021-0176906.
Lee, S.Y., Zhao, X.R., and Choi, K.R. “Method for Producing Extracellular Heme Using Metabolically Engineered Microorganism”, India patent appl. 201947034799.
Lee, S.Y., Zhao, X.R., and Choi, K.R. “Method for Producing Extracellular Heme Using Metabolically Engineered Microorganism”, China patent appl. 201880016137.2.
Lee, S.Y., Zhao, X.R., and Choi, K.R. “Method for Producing Extracellular Heme Using Metabolically Engineered Microorganism”, Europe patent appl. 18889100.6.
Lee, S.Y., Zhao, X.R., and Choi, K.R. “Method for Producing Extracellular Heme Using Metabolically Engineered Microorganism”, PCT patent PCT/KR2018/015748.
Lee, S.Y., Cho, J.S., and Choi, K.R. “Method of Preparing Corynebacterium Variant Based on CRISPR/Cas System, Recombinase, and ssODN”, PCT patent PCT/KR2018/003784.
Honors and Awards
2022.07. Poster Presentation Encouragement Award, (포스터발표장려상), 2022 KMB 49th Annual Meeting and International Symposium, Gyeongju, Korea
2021.08. Best Poster Presentation Award (우수포스터발표상), 2021 International Meeting of the Microbiological Society of Korea (MSK2021), Changwon, Korea
2019.07. FEMS Congress Attendance Grant, 8th Congress of European Microbiologists (FEMS2019), Glasgow, Scotland
2019.04. Presentation Awards (최우수구두발표상), 2019 International Meeting of the Microbiological Society of Korea, Jeju, Korea
2018.04. Presentation Awards, 2018 International Meeting of the Microbiological Society of Korea, PyeongChang, Korea
2017.11. Outstanding Poster Award, 2017 International Meeting of the Federation of Korean Microbiological Societies, Goyang, Korea
2017.06. Biosecurity Fellowship, Synthetic Biology 7.0, Singapore, Singapore
2016.04. Best Poster Award (우수포스터논문상), 2016 International Meeting of the Microbiological Society of Korea, Gwangju, Korea
2015.12. Best Oral Presentation Award, The 28th International Symposium on Chemical Engineering, Jeju, Korea
2015.06. Best Poster Presentation Award (우수포스터발표상), 2015 KMB 42nd Annual Meeting and International Symposium, Gyeongju, Korea
2014.08. Dean’s list, College of Engineering, KAIST
2014.08. Excellence Award, 2014 Winter/Spring Undergraduate Research Participation Program (URP), KAIST
2013.08. Excellence Award
2013 Winter/Spring Undergraduate Research Participation Program (URP), KAIST
2012.02.-2014.08. Korea Presidential Science Scholarship
2012.02.-2014.08. KAIST Presidential Fellowship
2012.02. KAIST Presidential Award
2011.08.-present Samsung Electronics SuperRookie Membership
2011.07. 3rd Place, International Brain Bee 2011, Firenze, Italy
Book Translations
“뇌에 관한 사실들: 뇌와 신경계 입문서” Society for Neuroscience 2013. “Brain Facts: A Primer on the Brain and Nervous System” Society for Neuroscience 2012.
“뇌에 관한 사실들: 뇌와 신경계 입문서” Society for Neuroscience 2012. “Brain Facts: A Primer on the Brain and Nervous System” Society for Neuroscience 2008.
Won Jun Kim
Ph.D. '20. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
3/2005 ~ 8/2011 B.S Chemical & Biomolecular Engineering, Sogang University, Seoul, Korea
9/2011 ~ 8/2013 M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Bioengineering
Synthetic biology
Metabolic engineering
Professional experience
1/2010 - 5/2010 Exchange Student, Dept. of Chemistry, Northern Arizona University, Flagstaff, AZ, U.S.A
Yoo Sung Ko
Ph.D. '20. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2007.3 ~ 2010.8 Korea Science Academy of KAIST
2011.2 ~ 2014.2 Department of Chemical Engineering, KAIST (B. S.)
2014.3 ~ 2020.8 Department of Chemical Engineering, KAIST (Ph.D.)
Research Interest
Metabolic Engineering
Seon Young Park
Ph.D. '20. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8816
Fax :+82-42-350-8800
Details
Education
2010/2 ~ 2014/8 B.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2014/8 ~ 2016/8 M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2016/8 ~ 2020/8 Ph.D., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic Engineering
Dong Soo Yang
Ph.D. '20. 8.
Korea University
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
Mar 2015 – Aug 2020 - Ph.D. Chemical and biomolecular engineering (Advisor: Sang Yup Lee), KAIST, Daejeon, Korea
Feb 2011 – Feb 2015 - B.S. Chemical and biomolecular engineering, KAIST, Daejeon, Korea
Jan 2013 – May 2013 - An exchange student for 2013 spring in chemical and biomolecular engineering, Rensselaer Polytechnic Institute, New York, USA
Research Interest
Metabolic engineering
Systems Biology/ Biotechnology
Research Experience
Dec 2013 – Feb 2015 - KAIST Metabolic & Biomolecular Engineering National Research Laboratory
Sep 2013 – Dec 2013 - KAIST Biomedical Micro-Nano Delivery Laboratory
Jul 2013 – Aug 2013 - Ilcheon Genome Medicine Institute, Department of Biomedical Sciences
Honors/ Awards
Jul 2014 – Dec 2014 - KAIST Undergraduate Research Participation Program, Grand Prix
Jul 2014 – Sep 2014 - GS Caltex Best Research Presentation Contest, Bronze Prize
Mar 2014 – Feb 2015 - KAIST Alumni Scholarship, KAIST Alumni Scholarship Foundation
Sep 2013 – Feb 2015 - Kim Young-Han Global Leader Scholarship, Kim Young-Han Foundation
Jan 2013 – May 2013 - Mirae Esset Exchange Student Scholarship, Mirae Esset Foundation
Feb 2012 – May 2012 - Chemical and Biomolecular Engineering Leaders Scholarship, Hyoseong Foundation
Feb 2011 – Dec 2012 - National Science and Engineering Scholarship, Korea Student Aid Foundation(KOSAF)
Je Woong Kim
Ph.D. '21. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2014.3 ~ Department of Chemical Engineering, KAIST (M. S.)
2014/2 ~ 2021/2 M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic Engineering
Woo Dae Jang
Ph.D., Post-doc. '21. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
(2014.02) B.S., Department of Microbiology and Molecular Biology, Chungnam National University, Daejeon, Korea
(2016.02) M.S., Graduate School of New Drug Discovery and Development, Chungnam National University, Daejeon, Korea
(2021.02) Ph.D., Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Systems and computational biology
Protein engineering for metabolic engineering
Jae Sung Cho
Ph.D., Post-doc. '21. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
Aug. 2011 – Dec. 2014 | B.S. with Highest Honor in Biomedical Engineering, Georgia Institute of Technology, Atlanta, Georgia, USA
Mar. 2015 – Feb. 2021 | Ph.D., in Chemical and Biomolecular Engineering, KAIST
Research Interest
Metabolic engineering
Systems Biology/ Biotechnology
In Jin Cho
Ph.D. '22. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2012. 2 ~ 2016. 2 B.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2016. 3 ~ 2022. 2. Ph.D. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic engineering
Systems Biology/ Biotechnology
Professional experience
2022. 2 ~ present, Postdoctoral researcher, & BioProcess Engineering Research Center, KAIST, Daejeon, Korea
Ye Ji Kim
Ph.D. '22. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8865
Fax :+82-42-350-8800
Details
Education
2/2007 ~ 2/2011 B.S. Chemistry, Military Art & Science, Korea Military Academy, Seoul, Korea
8/2013 ~ 8/2015 M.S. Biochemistry, University of Maryland, College Park, MD, U.S.
2/2018 ~ Present Ph.D. Student, Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Systems and computational biology
Research Experience
08/2016 ~ 02/2018, Researcher, Korea Armed Forces CBR Defense Research Institute, Seoul, Korea
Jong An Lee
Ph.D. '22. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8817
Fax :+82-42-350-8800
Details
Education
Mar 2017 - Aug 2022 - Ph.D. Chemical and biomolecular engineering (Advisor: Sang Yup Lee), KAIST, Daejeon, Korea
Mar 2013 - Feb 2017 - B.S. Chemical and biomolecular engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic engineering
Systems biology / Biotechnology
Research Experience
Sep 2016 - Jan 2017 - KAIST Metabolic & Biomolecular Engineering National Research Laboratory
Jul 2015 - Aug 2015 - KAIST Biomedical Micro-Nano Delivery Laboratory
Honors/ Awards
Feb 2017 - Magna Cum Laude graduation prize, KAIST
Sep 2015 - Feb 2017 - Honor's student, KAIST
Sep 2015 - Dec 2015 - Dean's list of Engineering Department, KAIST
Mar 2015 - Feb 2017 - Miwon Commercial Co. Scholarchip, Miwon Commercial Co.
Mar 2013 – Feb 2017 - National Science and Engineering Scholarship, Korea Student Aid Foundation(KOSAF)
Ji Yong Kim
Ph.D. '23. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
(2011-2014) B.S., Chemical and Biological Engineering course, Seoul National University, Seoul, South Korea
(2015-2016) M.S., Chemical and Biological Engineering course, Seoul National University, Seoul, South Korea
(2017-2023) Ph.D., Chemical and Biomolecular Engineering Department, KAIST, Daejeon, South Korea
Research Interest
Metabolic engineering
Protein engineering for metabolic engineering
Young Joon Lee
Ph.D. '23. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8817
Fax :+82-42-350-8800
Details
Education
2012.2 - 2017.2 B.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2015.8-2016.2 An exchange student for 2015 fall in material sciences department, ETH Zurich, Switzerland
2017.3 - 2023.2 Ph.D. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic Engineering
Honors / Awards
Jul 2014 – Sep 2014 - GS Caltex Best Research Presentation Contest, Bronze Prize
Aug 2015 – Dec-2015 – ASEMDUO-Korea Fellowship scholarship, ASEMDUO Foundation
Cindy Pricilia Surya Prabowo
Ph.D. '23. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2012. 9 ~ 2016. 8 B.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2016. 9 ~ 2018. 8 M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2018. 9 ~ 2023. 2 Ph.D. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic engineering
Synthetic Biology
Tae Hee Han
Ph.D. '23. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2010.02 ~ 2013.02 Korea Science Academy of KAIST, Busan, Korea
2013.03 ~ 2017.02 B.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2017.02 ~ 2019.02 M.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic engineering
Gi Bae Kim
Ph.D. '24. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Details
Education
2014.03 ~ 2018.08 B.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2018.09 ~ 2024.02 Ph.D. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Research Interest
Metabolic Engineering
Synthetic biology
Systems and computational biology
M.S
Kang Sup Yim
M.S. '94.2
Chemical & Biomolecular Engineering, KAIST
Young Lee
Ph.D. (M.S. '97. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-863-8609
Fax: +82-303-2020-8609
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
PolyHydroxyAlkanoate(PHA) monomer production/modification/application
Recombinant protein production
2. Education
1992 (B.S.) Dept. of Chemical Engineering, KAIST, Taejon, Korea
1997 (M.S.) Dept. of Chemical Engineering, KAIST, Taejon, Korea
2002 (Ph.D.) Dept. of Chemical & Biomolecular Engineering, KAIST, Taejon, Korea
3. Experience and Academic Activity
Researcher, BioProcess Engineering Research Center (1994-2002)
Member, Korean Institute of Chemical Engineers (1995-present)
Member, Korean Society for Biotechnology and Bioengineering (1995-present)
CEO, ChiroBio Inc., Taejon, Korea (2000-present)
4. Honor/Awards
The First Elmer Garden Award - coauthor, Biotechnology and Bioengineering (John Wiley & Sons, USA) – American Chemical Society (San Francisco National Meeting) (2000.3.27)
Award for Excellent Poster, Korean Society for Biotechnology and Bioengineering (2000.11.10)
SejongDaeWang Award – The Best Patent Award, KIPO (2001.3)
5. Publications
International Journal
1. Lee, Y. and Lee, S.Y. "Enhanced production of poly(3-hydroxybutyrate) by filamentation-suppressed recombinant Escherichia coli in a defined medium", J. Environ. Polymer Degrad. 4: 131-134 (1996)
2. Lee, Y., Lee, S.Y. and Yang, J. "Production of rhamnolipid biosurfactant by fed-batch culture of Pseudomonas aeruginosa using glucose as a sole carbon source", Biosci. Biotechnol. Biochem. 63(5): 946-947(1999)
3. Lee, S.Y., Lee, Y., and Wang, F. "Chiral compounds from bacterial polyesters: Sugars to plastics to fine chemicals" Biotechnol. Bioeng.. 65:363-368(1999)
4. Lee, Y., Park, S.H., Lim, I.T., Han, K. and Lee, S.Y. "Preparation of alkyl (R)-(-)-3-hydroxybutyrate by acidic alchoholysis of poly-(R)- (-)-3-hydroxybutyrate" Enzyme Microb. Technol. 27:33-36 (2000).
5. Lee, S.H., Oh, D.H., Ahn, W.S., Lee, Y., Choi, J., and Lee, S.Y., "Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas hydrophila" Biotechnol. Bioeng. 67:240-244(2000)
6. Lee, Y., Park, S.H., Lim, I.T., Han, K. and Lee, S.Y., "Preparation of alkyl (R)-(-)-3-hydroxybutyrate by acidic alchoholysis of poly-(R)- (-)-3-hydroxybutyrate" Enzyme Microb. Technol. 27:33-36 (2000).
7. Lee, S.Y. and Lee, Y., "Metabolic engineering of Escheichia coli for production of enantiomenically pure (R)-(-)-hydroxycarboxylic acids", Appl. Environ. Microbiol., 69(6) : 3421-3426 (2003).
8. Park, S.J., Lee, Y., and Lee, S.Y. "Biosynthesis of (R)-3-hydroxyalkanic acid by metabolically engineered E.coli" Appl. Biochem. Biotechnol., In press.
International Proceedings
1. Lee, Y., Lim, I.-T., Han, K., and Lee S.Y. "Preparation of Enatiomerically pure hydroxycarboxylic acid"CD ROM (No. P-IB15) Proceedings of APBioCheC "9, Phuket, Thailand (1999)
Korean Journal
1. Lee, S.Y., Lee, Y., and Choi, J. "Production and application of polyhydroxyalkanoates", Kor. J. Biotechnol. Bioeng., 10(4): 406-420 (1995).
2. Lee, Y., Lee, S.Y., Yang, J.W., and Park, C.H. "Biosurfactants", Biochemical Eng. 10: 53-63 (1996).
3. Lee, Y., Lee, S.H., Lee, S.Y."Fed-batch culture of Aeromonass hydrophila for the production of poly(3-hydroxybutyrate-co-hydroxyhexanoate) using two carbon sources" Biotechnol.Bioproc. Eng. 4:195-198(1999)
Korean Proceedings
1. Lee, S.Y. and Lee, Y. "PHB synthesis by filamentation suppressed recombinant E. coli", Proceedings of BPERC International Symposium '95, p. 181-182 (1995).
2. Lee, S.Y., Lee, Y., and Chang, H.N. "High cell density culture of recombinant E. coli for the production of PHB", Proceedings of BPERC International Symposium '95, p. 183-184 (1995).
3. Lee, Y. and Lee, S.Y. "Enhancement of production of poly(3-hydroxybutyrate) by using filamentation-suppressed recombinant E. coli in a defined medium", Theories and Applications of Chemical Engineering 2(1): 493-496 (1996).
4. Lee, Y. and Lee, S.Y. "Production of Optically Pure Monomer of PHB and It's Methyl-, Ethyl-esters by using Acidic degradation of PHB", proceedings of BPERC International Symposium '97, 149-150 (1997).
5. Lee, Y. and Lee, S.Y. "Production of optically pure[D]-hydroxybutyric acid and it's methyl-, ethyl-esters by chemical depolymerization of PHB", Theories and Applications of Chemical Engineering, 2361-2364 (1997)
6. Lee, Y., Lee, S.Y., Han, K.B., and Lim, I.T. "Production of optically pure methyl (D)-3-hydroxybutyrate by acidic depolymerization of microbial polymer, polyhydroxybutyrate(PHB)", Theories and Applications of Chemical Engineering, 1217-1220 (1998)
7. Lee, Y., Lim, I.T., Han,K.B., Lee, S.Y. " Preparation of optically acive alkyl (R)-(-)-3-hydroxybutyrate by chemical depolymerization of Polyhydroxyalkanoate"Proceedings of Korea Institute of Biotechnology and Bioengineering Symposium, 106-109 (1999)
8. Lee, Y., and Lee, S.Y. "Preparation of enantiomerically pure (R)-3-hydroxybutyrate"Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 579-582 (2000, Apr.)
9. Lee, Y., Kang, K.H. and Lee, S.Y. "Production of enantiomerically pure (R)-3-hydroxybutyric acid using metabolically engineered Escherichia coli" Theories and Applications of Chemical Engineering 7(2): 4039-4042 (2001)
International Conferences
1. Lee, S.Y. , Lee, Y., Chang, Y.K., and Chang, H.N. "Enhanced synthesis of poly(3-hydroxybutyrate) by filamentation-suppressed recombinant E. coli", Pacifichem-95, Honolulu, Hawaii, U.S.A., December (1995).
2. Lee, S.Y., Lee, Y., Park, S., Lee, S.H., "Production of (R)-hydroxycarboxylic acids by bacteria" ISBP/BEDPS 2000, Honolulu, Hawaii, December (2000)
3. Park, S.H., Lee, S.H., Lee, Y., Lee, S.Y., "Preparation of optically active b-amino acids from microbial polymer" 221st National meeting of American Chemical Society" San Diego,CA, USA, April (2001)
Korean Conferences
1. Lee, S.Y., Lee, Y., and Chang, H.N., "Comparison of PHB synthesis depending on the E. coli strain characteristics", '94 BPERC International Symposium, KAIST, September (1994).
2. Lee, S.Y., Lee, Y., and Chang, H.N. "Production of PHB by fed-batch culture of recombinant E. coli in a defined medium containing small amounts of amino acids", Annual Meeting of KIChE, ChunBuk Univ., October (1994).
3. Lee, S.Y., Lee, Y., and Chang, H.N. "High cell density culture and production of PHB by recombinant E. coli using sucrose as a carbon source", Annual Meeting of KIBB, Inha Univ., October (1994).
4. Lee, S.Y., Lee, Y., and Chang, H.N. "Effect of growth temperature and nutrients on the synthesis of poly(3-hydroxybutyric acid) by filamentation-suppressed recombinant E. coli", Annual Meeting of KIBB, KAIST, April (1995).
5. Chung, Y.L., Lee, Y., Yang, J.W., Lee, S.Y., and Park, C.H. "Screening of microorganisms producing emulsifiers", Annual Meeting of Korean Society for Applied Microbiology, Seoul National Univ., April (1995).
6. Lee, Y., Lee, S.Y., and Chang, H.N. "Production of PHB by high cell density cultivation of filamentation-suppressed recombinant E. coli", Annual Meeting of Korean Society for Applied Microbiology, MyungJi University, YongIn, October (1995).
7. Lee, Y. and Lee, S.Y. "Production of PHB by filamentation-suppressed recombinant E. coli", ChungNam-Kyushu International Symposium 1995, ChungNam Univ., Taejon, December (1995).
8. Lee, Y. and Lee, S.Y. "Enhanced production of PHB by filamentation -suppressed recombinant E. coli in a defined medium", Annual Symposium of KIChE, KOEX, Seoul, May (1996).
9. Lee, Y. and Lee, S.Y. "Cloning of Pseudomonas aeruginosa YPJ80 rhamnolipid byosynthesis genes", ibid (1996).
10. Lee, Y. and Lee, S. Y. " Efficient production of biosurfactant by fed-batch culture of Pseudomonas aerusinosas YPJ-80", Annual Symposium of KIBB, MyungJi Univ. Yongin, April (1997)
11. Lee, Y. and Lee, S.Y. "Production of optically pure (D)-hydroxybutyric acid and it's methyl-, ethyl-esters by chemical depolymerization of PHB", Annual Symposium of KIChE, ChungNam Univ., October (1997)
12. Lee, Y., Lee, S.Y. , Han, K.B., and Lim, I.T. "Production of optically pure methyl (D)-3-hydroxybutyrate by acidic depolymerization of microbial polymer, polyhydroxybutyrate(PHB)", Annual Symposium of KIChE, KOEX, Seoul, April (1998)
13. Lee, Y. and Lee, S.Y. "Efficient production of biosurfactant by fed-batch culture of Pseudomonas aeruginosa YPJ-80", A Day's Workshop for New Surfactants, KAIST, Taejon, Korea, July (1998)
14. Lee, Y., Lim, I.-T., Han, K., and Lee, S.Y. "Preparation of optically active alkyl (R)-(-)-3-hydroxybutyrate by chemical depolymerization of Polyhydroxyalkanoate"Annual Symposium of Korea Institute of Biotechnology and Bioengineering (KIBB). Chunnam Univ., Kwangju (1999)
15. Lee, Y., and Lee, S.Y. "Production of Optically active (R)-(-)-Hydroxycarboxylic acid"Annual Meeting of The Korean Society for Applied Microbiology, Youngnam Univ, Taegu (1999).
16. Lee, Y., and Lee, S.Y. "Preparation of enantiomerically pure (R)-3-hydroxybutyrate"Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, KAIST, April (2000)
17. Lee, S.Y., Park, S.H., Lee, Y., and Lee, S.H. "Metabolic engineering for the production of fine chemicals" Annual Meeting of the Korean Chemical Society , Hanyang Univ., April (2001)
18. Lee, S.Y., Park, S.J. and Lee, Y. "Metabolic Engineering of Escherichia coli for the Production of Novel PHA and Chiral Compounds" Annual Meeting of Korean Society for Applied Microbiology, Chonan Sangnok Resort, June(2001)
19. Lee, Y., Kang, K.H. and Lee, S.Y. "Production of enantiomerically pure (R)-3-hydroxybutyric acid using metabolically engineered Escherichia coli" KIChE meeting, Taejon , Korea (2001)
Books
1. Lee, S.Y., Park, S.H., Lee, Y. and Lee, S.H. "Production of chiral and other valuable compounds from microbial polyesters", Biopolymers Vol 3b, Ch 14, 375-387, VCH (2001)
2. Lee, S.Y., Park, S.H., Hong, S.H., Lee, Y. and Lee, S.H. "Fermentative Production of Building Blocks for Chemical Synthesis of Polyesters", Biopolymers Vol 4, Ch 10, 265-325, VCH (2001)
3. Lee, S.Y., Park, S.J., Park, J.P., Lee, Y. and Lee, S.H. "Economic aspects of biopolymer production", Biopolymers Vol 10, Ch 2, VCH in press (2002)
4. Lee, S.Y., Park, S.J., Lee, Y. and Lee, S.H. "Biotechnological processes for the production of monomers for subsequent chemical polymer synthesis", Biopolymers Vol 10, Ch 3, VCH in press (2002)
Sung Ho Yoon
Ph.D. (M.S. '98. 2.)
Chemical & Biomolecular Engineering, KAIST
Details
Professional Experience
2009.3 - present Postdoctorial Fellow, Institute for Systems Biology at Seattle
2009.1 - 2009.3 Senior Research Scientist, Industrial Biotechnology and Bioenergy Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 111 Gwahangno, Yuseong-gu, Daejeon 305-806, Republic of Korea
2008 - present Editorial Advisory Board Member, Recent Patents on Biotechnology, Bentham Science Publishers, USA
2006.9 - 2009.2 Lecturer, Functional Genomics Major, University of Science and Technology (UST), Daejeon, Korea
2004.7 - 2008.12 Senior Research Scientist, Systems Microbiology Research Center, KRIBB2003.7 - 2004.6 Senior Research Scientist, Genome Research Center, KRIBB
2003 - 2006 Committee Member, Korean Society for Bioinformatics (KSBI)
2002.11 - 2003.6 Post. Doc National Center for Genome Informatics, KRIBB
1998. 3 - 2002. 2 Teaching Assistant, Department of Chemical Engineering, Korea Advanced Institute of Science and Technology (KAIST)
ad hoc Reviewer
Biotechnology and Bioengineering / Biotechnology Journal / Process Biochemistry
BMC Genomics / BMC Bioinformatics / Computer Methods and Programs in Biomedicine / Gene
Educational Background
1998.3 - 2002.8 Department of Chemical & Biomolecular Engineering, KAIST (Ph.D.)
(Dissertation: Development of Escherichia coli DNA microarray and global gene expression profiling in Escherichia coli. Supervor: Sang Yup Lee)
1996.3 - 1998.2 Department of Chemical Engineering, KAIST (M. S.)
(Dissertation: Development of fermentation strategies for the production of poly (γ-lutamic acid) and insulin-like growth factor I. Supervisor: Sang Yup Lee)
1992.3 - 1996.2 Department of Chemical Engineering, KAIST (B. S.)
Research Interests
Metabolic Engineering / Synthetic Biology
Pathogenomics / Host-Pathogen Interactio
Bioinformatics / Omics Analysis
Systems Microbiology
ad hoc Awards
Award for Excellent Staff, KRIBB (2007.2.1)
Award for Most Excellent Poster, Korean Society for Biotechnology and Bioengineering (2002.4.13)
Media Recognition
2007. 2. 6. Daejonilbo (newspaper), "Scientist opening 21 century - Dr. Sung Ho Yoon"
2006.11.28. MBC TV newstoday, "Development of pathogenicity island database"
2006.11.28. YTN TV "Development of pathogenicity island database"
Publications
20) Yoon SH, Kim SK, and Kim JF "Secretory production of recombinant proteins in Escherichia coli" Recent Patents on Biotechnology (2010) (in press)
19) Barrick JE, Yu D-S, Yoon SH, Jeong H, Oh TK, Schneider D, Lenski RE, and Kim JF "Genome dynamics in a long-term experiment with Escherichia coli" Nature 461:1243-1247 (2009)
18) Jeong H, Barbe V, Lee CH, Vallenet D, Yu D-S, Choi S-H, Couloux A, Lee S-W, Yoon SH, Cattolico L, Hur C-G, Park H-S, Ségurens B, Kim SC, Oh TK, Lenski RE, Studier FW, Daegelen P, and Kim JF "Genome sequences of Escherichia coli B strains REL606 and BL21(DE3)" J. Mol. Biol. (Published online 26 September 2009)
17) Yoon SH, Jeong H, Kwon S-K, and Kim JF "Chapter 1. Genomics, biological features, and biotechnological applications of Escherichia coli B: "Is B for better?!"", pp. 1-17, In: Systems Biology and Biotechnology of E. coli, Lee SY (ed.) Springer, Berlin, Germany (2009. 4)
16) Kim JF, Jeong H, Yu DS, Choi S-H, Hur C-G, Park M-S, Yoon SH, Kim D-W, Ji GE, Park H-S, and Oh TK "Genome sequence of the probiotic bacterium Bifidobacterium animalis subsp. lactis AD011" J. Bacteriol. 191:678-679 (2009)
15) Jeong H, Yoon SH, Yu D-S, Oh TK, and Kim JF "Recent progress in microbial genome projects of Korea" Biotechnol. J. 3:601-611 (2008)
14) Nam D, Yoon SH, and Kim JF "Ensemble learning of genetic networks from time-series expression data" Bioinformatics 23:3225-3231 (2007)
13) Yoon SH, Park YK, Lee S, Choi D, Oh TK, Hur C-G, and Kim JF "Towards pathogenomics: a web-based resource for pathogenicity islands" Nucleic Acids Res. 35:D395-D400 (2007)
12) Hur C-G, Kim S, Kim CH, Yoon SH, In YH, Kim C, and Cho HG "FASIM: Fragments assembly simulation using biased-sampling model and assembly simulation for microbial genome shotgun sequencing" J. Microbiol.Biotechnol. 16:683-688 (2006)
11) Jiang H, Shang L, Yoon SH, Lee SY, and Yu Z "Optimal production of poly-¥lutamic acid by metabolically engineered Escherichia coli" Biotechnol. Lett. 28:1241-1246 (2006)
10) Jeong H, Yoon SH, Lee HK, Oh TK, and Kim JF "Lessons from the sea: genome sequence of an algicidal marine bacterium Hahella chejuensis (적조 살상 해양 미생물 Hahella chejuensis의 유전체 구조)" Kor. J. Microbiol. Biotechnol. 34:1-6 (2006)
9) Jeong H, Yim JH, Lee C, Choi SH, Park YK, Yoon SH, Hur CG, Kang HY, Kim D, Lee HH, Park KH, Park SH, Park HS, Lee HK, Oh TK, and Kim JF "Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent", Nucleic Acids Res. 33:7066-7073 (2005)
8) Yoon SH, Hur C-G, Kang HY, Kim YH, Oh TK, and Kim JF "A computational approach for identifying pathogenicity islands in prokaryotic genomes" BMC Bioinformatics 6:184 (2005)
7) Yoon SH, Han MJ, Lee SY, Jeong KJ, and Yoo JS "Combined transcriptome and proteome analysis of Escherichia coli during the high cell density culture", Biotechnol. Bioeng. 81:753-767 (2003)
6) Kim JS, Yoon SH, and Lee SY "Development of database systems by integrating heterogeneous metabolic databases", Genome Informatics 13:486-487 (2002)
5) Heo WJ, Yoon SH, and Lee SY "Global gene expression profiling of E. coli and its mutant unable to produce acetate", Genome Informatics 13: 270-271 (2002)
4) Yoon SH and Lee SY "Comparison of transcript levels by DNA microarray and metabolic flux based on flux analysis for the production of poly-γ-glutamic acid in recombinant Escherichia coli", Genome Informatics 13:587-588 (2002)
3) Chung BH, Choi YJ, Yoon SH, Lee SY, and Lee YI "Process development for production of recombinant human insulin-like growth factor-I in Escherichia coli", J. Ind. Microbiol. Biotechnol. 24:94-99 (2000)
2) Yoon SH, Do JH, Lee SY, and Chang HN "Production of poly-γ-glutamic acid by fed-batch culture of Bacillus licheniformis" Biotechnol. Lett. 22:585-588 (2000)
1) Yoon SH, Choi J, and Lee SY "Development of DNA chip microarrayer" J. Microbiol.Biotechnol., 10:21-26 (2000) (The result was presented at Nature Genetics, Microarray Meeting (1999)
Patents
3) Jeong H, Han JH, Yoon SH, Ryu C-M, Kim JF, Oh TK, Jung MH, Yoon SP "Method for Selecting Alcohol Resistant Variants of Microorganism Using Mutagenesis by Proton Beam Irradiation" Korean Patent: appl. 10-2009-0080393 (2009.08.28)
정해영 한지희 윤성호 류충민 김지현 오태광 정명환 윤상필 “양성자 빔 조사에 의한 돌연변이 유도방법을 이용한 알코올 내성 미생물 변이체의 선별 방법” 특허출원번호10-2009-0080393 (2009.08.28)
2) Hong JW, Kim JF, Oh TK, and Yoon SH "A fluidic array system for biological, chemical, and biochemical assessments" PCT/US08/59777 (PCT/US08/59777) (filed on April 9, 2008)
1) Lee SY and Yoon SH "Methods for producing high concentration of poly (gamma-glutamic acid) by fed-batch culture of Bacillus licheniformis" Korean Patent: appl. 97-67605 (12. 10. 1997), registered 250627 (1. 5. 2000)
이상엽, 윤성호 "바실러스 리케니포니스에 의한 폴리글루탐산(g-PGA)의 고효율 생산방법" 특허출원번호 10-1997-0067605 (1997. 12. 10.), 등록번호 1002506270000 (2000. 01. 05)
Program Registration
2) 김지현, 윤성호, 허철구, 오태광. "미생물 유전체 내에서 외래에서 유입된 병원성 유전자군인 pathogenicity island를 예측하는 방법" (등록일자: 2007년 7월 29일; 등록번호: 2007-01-129-3962)
1) 김지현, 윤성호, 허철구, 박영규, 오태광. "미생물 유전체 내에서 외래에서 유입된 병원성 유전자군인 pathogenicity island를 분석, 예측하는 시스템" (등록일자: 2007년 7월 29일; 등록번호: 2007-01-129-3964)
Essays
6) Yoon SH "Systems and Synthetic Biology" In State of the Art Report on Microbial Genomics 미생물유전체 연구동향 분석연구), Ministry of Science and Technology, Korea (2007)
5)Yoon SH “최신 기술동향: Biolog사의 Phenotype Microarray (PM) Technology” 미생물과 산업, 32(2): 28-29, 한국미생물학회 (2006)6)
4) 이승구, 김지현, 정흥채, 송재준, 류충민, 윤성호 “Development of Platform Technologies for Synthetic Biology” (바이오기반 경제구축을 위한 합성생물학 핵심기술 개발), KRIBB, Korea (2006)
3) 김지현, 정해영, 윤성호, 박승환 “시스템 미생물학 : 유전체 해독에서 네트워크 재설계까지”, e-생물산업, 16(3) (2003)
2) Kim JS, Yoon SH, and Lee SY "미생물 게놈 연구", BioZine (http://biozine.kribb.re.kr) (2001.6)
1) Lee SY, Yoon SH, Im GB, and Cho YK "Genomics와 DNA chip" News & Information for Chemical Engineers, 18(3): 307-311 (2000)
Invited talks
14) "Computational identification of pathogenicity islands in prokaryotic genomes" KOGO 2009 Winter Symposium, YongPyung Resort, Gangwon-do, Korea (2009.01.15)
13) "Multi-omics-based Systems Approach Captures the Whole-cellular Features of closely related Escherichia coli B and K-12" International Symposium on Microbiology, Daejeon convention center, Daejeon, Korea (2008. 5.16)
12) "Integrated Omics Analysis of Escherichia coli B and K-12" International Meeting of the Federation of Korean Microbiological Societies, Seoul KyoYuk MunHwa HoeKwan, Seoul, Korea ( 2007.10.12)
11) "In silico identification of pathogenicity islands in pathogenic genomes", BIO KOREA 2007, COEX, Seoul , Korea (2007. 9.13)
10) "General Concepts of Systems Biology", National Institute for Mathematical Sciences (NIMS), Daejeon, Korea (2007. 7.13)
9) "PAIDB: a web-based resource for pathogenicity islands", 신변종 전염병 출현 조기탐지 기반사업 Workshop, Korea Centers for Disease Control and Prevention, Seoul, Korea (2007. 6.22)
8) "Systems Microbiology" Korea Institute of Oriental Medicine, Daejeon , Korea (2007. 5.1)
7) "Computational approach for identifying genomic and pathogenicity islands in prokaryotic genomes", National Institute for Mathematical Sciences (NIMS), Daejeon, Korea (2007. 2.28)
6) "Microarray Experiment and Image Analysis", The Korean Society for Microbiology and Biotechnology. BEXCO Convention Hall, Pusan, Korea (2006. 6. 18)
5) "Systems Microbiology" Korea Maritime University, Division of Civil and Environmental Engineering (Major of Environmental Engineering), Pusan, Korea (2006. 5. 4)
4) "Genome chip analysis workshop" KRIBB Conference - Synthetic and Systems Biology of Escherichia coli, KRIBB, Daejeon, Korea (2006. 4.27)
3) "A Computational Approach for Identifying PathogenicityIslands in Prokaryotic Genomes", The Korean Society for Microbiology and Biotechnology. Korea University, Seoul , Korea (2005. 7. 1)
2) "Genomic Islands & Pathogenicity Islands", International Meeting of the Federation of Korean Microbiological Societies, Seoul , Korea (2005.10.21)
1) "Applications of DNA microarray: transcriptome profiling", The 1st International Symposium on Environmental Biosensors and DNA Microarrays for Environmental Biomonitoring, Kwangju Institute of Science and Technology, Korea (2002.5.20)
Soon Ho Hong
Post Doc. (M.S. '99. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-869-5970
Fax: +82-42-869-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic engineering
Recombinant protein production
2. Education
B.S., Dept. of Chemical Engineering, KAIST, Daejeon, Korea (1993. 3. 1.~ 1997. 2. 29.)
M.S., Dept. of Chemical Engineering, KAIST, Daejeon, Korea (1997. 3. 1.~ 1999. 2. 28.)
Ph.D., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea (1999. 3. 1. ~ 2003. 8. 31.)
3. Award
IBM Basic Research Award, Korean Society for Bioinformatics (2002. 11. 16.)
4. Research Activity
International Journal
1. Lee, S.Y. , Chang, H.N., Um, Y.S., and Hong, S.H., "Bacteriorhodopsin production by cell recycle culture of Halobacterium halobium", Biotechnol. Lett., 20(8): 763-765 (1998).
2. Hong, S.H. and Lee, S.Y., "Metabolic Flux distribution in metabolically engineered Escherichia coli strain producing succinic acid", J. Microbiol. Biotechnol., 10(4) : 496-501 (2000).
3. Hong, S.H. and Lee, S.Y., "Metabolic flux analysis for succinic acid production by recombinant Escherichia coli with amplified malic enzyme activity", Biotechnol. Bioeng., 20;74(2):89-95(2001).
4. Hong,S.H. and Lee,S.Y., "Importance of redox balance on the production of succinic acid by metabolically engineered Escherichia coli", Appl. Microbiol. Biotechnol., 58 : 286-290(2002).
5. Lee, P.C., Lee, S.Y., Hong, S.H., and Chang, H.N. "Isolation and characterization of a new succinic acid producing bacterium, Mannheimia succiniciproducens MBEL 55E, from bovine rumen", Appl. Microbiol. Biotechnol., 58 : 663-668 (2002).
6. Lee, S.Y., Hong S.H., and Moon S.Y. "In Silico Metabolic Pathway Analysis and Design: Succinic acid Production by Metabolically Engineered Escherichia coli as an example", Genome Informatics 2002, 13: 214-223 (2002)
7. Lee, P.C., Lee, S.Y, Hong, S.H., and Chang, H.N. "Biological conversion of wood hydrolysate to succinic acid by Anaerobiospirillum succiniciproducens", Biotechnol.Lett., 25: 111-114 (2003)
8. Hong, S.H., Park, S.J., Moon, S.Y., Park, J.P. and Lee, S.Y., "In silico prediction and validation of the importance of Entner-Doudoroff pathway in poly(3-hydroxybutyrate) production by metabolically engineered Echerichia coli", Biotech. Bioeng., 83: 854-863 (2003).
9. Hong, S.H., Moon, S.Y. and Lee, S.Y. "Prediction of the maximum yields of metabolites and optimal pathways for their production by metabolic flux analysis", J. Microbiol. Biotechnol., 13: 571-577 (2003).
10. Lee, P.C., Lee, S.Y., Hong, S.H., and Chang, H.N. "Batch and Continuous cultures of Mannheimia succiniciproducens MBEL55E for the production of succinic acid from whey and corn steep liquor", Bioproc. Biosystems Eng., in press.
11. Hong, S.H. and Lee, S.Y., "Evaluating evolutionary relationships of microorganisms and cellular metabolic pathways based on genome-scale metabolic pathway content", submitted.
12. Hong, S.H., Park, S.J. and Lee, S.Y., "Metabolic flux profiling and clustering: New strategies for identification of microbial metabolic characteristics", submitted.
13. Moon, S.Y., Hong, S.H., and Lee.S.Y., "Production of malic acid by the amplification of Mannheimia succiniproducens phosphoenolpyruvate carboxykinase in Escherichia coli", submitted.International Proceedings
1. Lee, S.Y. and Hong, S.H., "Engeering of E. coli central metabolic pathways for the production of succinic acid", Proceedings of Pacifichem 2000, Hawaii, pp. 30-38 (2000).Korean Journal
1. Um, Y.S., Park, J.T., Hong, S.H., Lee, S.Y. and Chang, H.N. "Production of bacteriorhodopsin by Halobacterium halobium in the internal membrane bioreactor", Kor. J. Biotechnol. Bioeng. 13(3): 268-271 (1998)
2. Lee, P.C., Lee, S.Y., Hong, S.H., and Chang, H.N. "Cloning and characterization of Mannheimia succiniciproducens MBEL55E phophoenol pyruvate carboxykinase (pckA) gene", Biotechnol. Bioprocess Eng. 7:95-99 (2002)Korean Proceedings
1. Hong, S.H., Park, J.T., Lee, S.Y. , and Chang, H.N. "The effects of complex nitrogen sources and initial pH on growth of Halobacterium halobium S9-P", Proceedings of The 10th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 233-234 (1997)
2. Hong, S.H., Lee, S.Y. and Chang, H.N., "Production of succinic acid by recombinant Escherichia coli", Proceedings of BPERC International Symposium '98, 183-184 (1998)
3. Hong, S.H., Park, J.T., Lee, S.Y., and Chang, H.N., "Production of bacteriorhodopsin by Halobacterium halobium S9-P using various nitrogen sources", Proceedings of BPERC International Symposium '98, 185-186 (1998)
4. Hong, S.H. and Lee, S.Y., "Production of succinic acid by recombinant Escherichia coli", Proceedings of The 11th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 155-156 (1998)
5. Hong, S.H., Lee, S.Y., "Production of Succinic Acid by Recombinant Escherichia coli and metabolic flux analysis", Theories and Applications of Chemical Engineering 5(1): 1053-1056 (1999).
6. Hong, S.H., Lee, S.Y., "Production of Succinic acid by recombinant Escherichia coli and Metabolic analysis", Proceedings of The 12th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 127-128 (1999)
7. Hong, S.H., Lee, S.Y., "Succinic acid production by metabolically reoriented Escherichia coli and metabolic flux analysis", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 329-330 (1999)
8. Hong, S.H., and Lee, S.Y., "Effect of fumarase on the production of succinic acid", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 531-534 (2000, Apr.)
9. Hong, S.H., and Lee, S.Y., "Metabolic flux analysis for succinic acid and production by recombinant Escherichia coli with amplified malic enzyme activity", Theories and Applications of Chemical Engineering 6(1): 1253-1256 (2000).
10. Hong, S.H., Lee, S.Y., "Prediction of intracellular metabolites accumulation in succinic acid producing recombinant Escherichia coli by metabolic flux analysis", Theories and Applications of Chemical Engineering 7(1): 1413-1416 (2001).
11. Hong, S.H. and Lee, S.Y., "Identification of metabolic characteristics by metabolic flux analysis", Proceeding of Annual fall meeting of KIChE, 8 (2): 3941-3944 (2002)
International Conferences
1. Lee, S.Y., Hong, S.H., "Metabolic engineering of Escherichia coli for the production of succinic acid and metabolic flux analysis", Annual Meeting of Society for Industrial Microbiology, San Diego, CA, July (2000)
2. Hong, S.H. and Lee, S.Y., "Metabolic engineering of E. coli for the production of succinic acid", Metabolic Engineering III, Colorado Springs, Colorado, USA, October (2000)
3. Lee, S.Y., Hong, S.H., "Metabolic engineering of Escherichia coli for the production of succinic acid", ISBP/BEDPS 2000, Honolulu, Hawaii, December (2000)
4. Hong, S.H. and Lee, S.Y., "Identification of metabolic characteristics by metabolic flux analysis", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
5. Moon, S.Y., Hong, S.H., and Lee, S.Y., "Prediction of the maximum yields of various metabolites and optimal pathways by metabolic flux analysis", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
6. Moon, S.Y., Hong, S.H., and Lee, S.Y., "Metabolic flux analysis for the succinic acid production in Escherichia coli", ChungNam-Kyushu International Symposium, Kumamoto, Japan,December,6 (2002)
7. Lee, S.Y., Hong, S.H., and Moon, S.Y., "In Silico Metabolic Pathway Analysis and Design: Succinic acid Production by Metabolically Engineered Escherichia coli as an example", The 13th International conference on genome informatics GIW2002 meeting, Yebisu garden place, Tokyo, Japan, December 16-18(2002)
8. Lee, S.Y., Hong, S.H., and Moon, S.Y., "Metabolic Engineering of Escherichia coli for the Production of Succinic Acid", Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, Colorado, May 4-7 (2003)
9. Lee, S.Y., Hong, S.H., and Moon, S.Y., "Production of Short-Length and Medium-chain-Length Polyhyroxyalkanote Copolymer by Metabolically Engineered E. coli" , Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, Colorado, May 4-7 (2003)
10. Lee, S.Y., Hong, S.H. , Lee, P.C., and Chang, H.N., "Production of Succinic acid by Anaerobiospirillum succiniproducens from Wood Hydrolysate" , Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, Colorado, May 4-7 (2003)
11. Lee, S.Y., Hong, S.H., Lee, P.C., and Chang, H.N., "Batch and Continuous of Mannheimia succiniciproducens MBEL55E for the production of Succinic Acid from Whey and Corn Steep Liquor" , Symposium on Biotechnology for Fuels and Chemicals, Breckenridge, Colorado, May 4-7 (2003)Korean Conferences
1. Kim, B.K., Hong, S.H., Lee, S.Y. , Lee, Y.H., and Chung, B.H., "Production of IGF-I by recombinant Escherichia coli", Annual Symposium of KIBB, Chosun Univ., Kwangju, April (1996).
2. Um, Y.S., Park, J.T., Hong, S.H., Lee, S.Y. , and Chang, H.N., "Production of bacteriorhodopsin by Halobacterium halobium R1 using internal and external membrane bioreactor systems", Annual Symposium of KIBB, Taegu Univ., Kyungsan, October (1997)
3. Hong, S.H., Park, J.T., Lee, S.Y. , and Chang, H.N., "The effects of complex nitrogen sources and initial pH on growth of Halobacterium halobium S9-P", The 10th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, KAIST, Teajon, November (1997)
4. Hong, S.H., Lee, S.Y., and Chang, H.N., "Production of succinic acid by recombinant Escherichia coli", Annual Symposium of BPERC '98, KAIST, Taejon, Korea, September (1998)
5. Hong, S.H., Park, J.T., Lee, S.Y., and Chang, H.N., "Production of bacteriorhodopsin by Halobacterium halobium S9-P using various nitrogen sources", Annual Symposium of BPERC '98, KAIST, Taejon, Korea, September (1998)
6. Hong, S.H. and Lee, S.Y., "Production of succinic acid by metabolically engineered Escherichia coli", Annual Symposium of KSAM, KOFST Bldg., Seoul, October (1998)
7. Hong, S.H., Lee, S.Y., "Production of Succinic Acid by Recombinant Escherichia coli and metabolic flux analysis", Annual Symposium of KIChE, SeongKyunKwan Univ. Suwon (1999)
8. Hong, S.H., Lee, S.Y., "Production of Succinic acid by recombinant Escherichia coli and Metabolic analysis", The 12th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, Kongju Univ., Kongju (1999)
9. Hong, S.H., Lee, S.Y., "Succinic acid production by metabolically reoriented Escherichia coli and metabolic flux analysis", Annual Symposium of Korean Society for Biotechnology and Bioengineering, Kangwon University, Chuncheon (1999)
10. Hong, S.H., and Lee, S.Y., "Effect of fumarase on the production of succinic acid", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, KAIST, April (2000)
11. Hong, S.H., and Lee, S.Y., "Metabolic flux analysis for succinic acid and production by recombinant Escherichia coli with amplified malic enzyme activity", KIChE Meeting, Hanyang Univ., Ansan , April (2000)
12. Hong, S.H., Lee, S.Y., "Effect of redox potential on the production of succinic acid by metabolically engineered Escherichia coli", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Chunan, November(2000)
13. Hong, S.H., Lee, S.Y., "Prediction of intracellular metabolites accumulation in succinic acid producing recombinant Escherichia coli by metabolic flux analysis", KIChE meeting, Yonsei Univ., April (2001)
14. Hong, S.H. and Lee, S.Y., "Importance of redox balance on the production of succinic acid by metabolically engineered Escherichia coliâ€, The 14th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, Chungnam Univ., Taejon , Korea (2001)
15. Hong, S.H. and Lee S.Y., "In Silico Metabolic Pathway Analysis and Design", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Chungju, October 12(2002)
16. Moon, S.Y, Hong. S.H., and Lee, S.Y., "Prediction of the optimal metabolic pathways for the production of metabolites in Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Chungju, October 12(2002)
17. Hong, S.H. and Lee S.Y., "Identification of metabolic characteristics of Mannheimia succiniciproducens MBEL55E", Annual Meeting of Korean Society for Biotechnology and Bioengineering symposium, Chungju, October 12(2002)
18. Hong, S.H. and Lee, S.Y., "Identification of metabolic characteristics by metabolic flux analysis", Annual Fall Meeting of KIChE, Seoul, October 24-26 (2002)
19. Hong, S.H., Park, S.J., Moon, S.Y., Park, J.P. and Lee, S.Y., "In Silico Prediction of the Importance of Enter-Doudoroff Pathway in Poly (3-Hydroxybutyrate) Production", Korean Society for Bicrobiology and Biotechnology Meeting, Konkuk univ., October, 26 (2002)
20. Hong, S. H., Lee, P.C., Chang, H.N. and Lee, S.Y., "Continuous Cultures of Mannheimia succiniciproducens MBEL55E for the Production of Succinic Acid from various carbon substrates", Korean society for Bicrobiology and Biotechnology Meeting, Konkuk Univ., October, 26 (2002)
21. Hong, S.H., Lee, S.Y. and Moon, S.Y., "In silico metabolic network construction and metabolic flux analysis for the production of succinic acid in Escherichia coli", Korean Society For Bioinformatics Annual Meeting, Haeundae, Korea, November,15-16 (2002)
22. Han, M.J., Lee, S.Y., Hong, S. H., and Park, S.J., "Role of Eda in polyhydroxyalkanoate biosynthesis deciphered from proteome analysis and metabolic flux analysis", Korean Society For Bioinformatics Annual Meeting, Haeundae, Korea, November, 15-16 (2002)
23. Lee, S.Y., Jeong, K.J., Yoon, S.H., Han, M.J., Choi, J.H., Park, S.J., and Hong, S.H., "Integrated analysis of the transcriptome and proteome of recombinant E. coli fermentation", 2002 Nanobio International Symposium, Haeundae, Korea, November 22-23 (2002)
24. Hong, S.H., Moon, S.Y.and Lee, S.Y., "“Prediction of the maximum yields of metabolites by metabolic flux analysis", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Busan, Korea, April 11-12(2003)
Books/Book Editing
1. Lee, S.Y. and Hong, S.H., "Engineering of E. coli central metabolic pathways for the production of succinic acid", In:Advances in Biochemical Production Technology(Park, T.H. and Martin, eds.), American Chemical Society, Washington DC, USA, pp.30-38 (2002)
2. Lee S.Y., Hong S.H., Park S.J., van Wegen, R. and Middelberg A.P.J., "Metabolic flux analysis on the prodcution of poly(3-hydroxybutyrate)", Biopolymers Vol 3a, Ch 8, pp.249-262 ,VCH-Wiley, Weinheim, Germany (2001)
3. Lee, S.Y., Park, S.H., Hong, S.H., Lee, Y. and Lee, S.H., "Fermentative Production of Building Blocks for Chemical Synthesis of Polyesters", Biopolymers Vol 3b, Ch 10, pp.265-326, VCH-Wiley, Weinheim, Germany (2001)
Si Jae Park
Ph.D. (M.S. '99. 2.)
Senior Scientist / Engineer
LG Chem, Ltd. / Research Park
Phone: +82-42-866-5990
Fax: +82-42-863-7446
Address: LG Chem. Ltd.,104-1 Moonji-dong, Yuseong-gu, DAEJEON, 305-380, Republic of KOREA
Details
1. Research Interest
Metabolic engineering
Polyhydroxyalkanoate (PHA)
High cell density cultivation
Protein engineering
2. Education
1993. 3.-1997. 2. Department of Chemical Engineering, Seoul National University, Seoul, Korea, B. S
1997. 3 – 1999. 2. Department of Chemical Engineering, KAIST, Taejon, Korea M. S (M. S. thesis : Cloning of desulfurization genes from Gordona sp. CYKS1 and its expression in Escherichia coli (Advisor: Prof. Sang Yup Lee))
1999. 3 – 2003. 8. Department of Chemical Engineering, KAIST, Taejon, Korea, Ph. D. (Dissertation title: Metabolic engineering for the production of poly(3-hydroxyalkanoate) in recombinane Escherichia coli. (Advisor: Prof. Sang Yup Lee))
3. Publications
International Journal
1. Park SJ,Lee SY (1998) "Efficient recovery of secretory recombinant protein from protease negative mutant Escherichia coli strains", Biotechnol Techniques 12: 815-818
2. Park SJ,Georgiou G, Lee SY (1999) "Secretory production of recombinant protein by high cell density culture of protease negative mutant Escherichia coli strain", Biotechnol Prog 15: 164-167
3. Ahn WS, Park SJ, Lee SY (2000) "Production of poly(3-hydroxybutyrate) by fed-batch culture of recombinant Escherichia coli with a highly concentrated whey solution", Appl Environ Microbiol 66:3624-3627
4. Park SJ, Ahn WS, Green PR, Lee SY (2001) "High level production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains" Biomacromolecules 2:248-254
5. Park SJ, Ahn WS, Green PR, Lee SY (2001) "Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains¢¢ç", Biotechnol Bioeng 74:82-87
6. Ahn WS, Park SJ, Lee SY (2001) "Production of poly(3-hydroxybutyrate) from whey by cell recycle fed-batch culture of recombinant Escherichia coli" Biotechnol Lett 23:235-240
7. Chen GQ, Zhang G, Park SJ, Lee, SY (2001) "Industrial scale production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate)" Appl Microbiol Biotechnol 57: 50-55
8. Park SJ, Park JP, Lee SY (2002) "Production of poly(3-hydroxybutyrate) from whey by fed-batch culture of recombinant Escherichia coli in a pilot-scale fermentor", Biotechnol. Lett., 24:185-189
9. Park SJ, Park JP, Lee SY (2002)" Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates rich in specific monomers", FEMS Microbiol. Lett., 214:217-222.
10. Hong SH, Park SJ, Moon SY, Park JP, Lee SY "In silico prediction and validation of the importance of enter-doudoroff pathway in poly(3-hydroxybutyrate) production by metabolically engineered Escherichia coli" Biotechnol Bioeng, 83: 854-863
11. Park SJ, Park JP, Lee SY, Doi Y "Enrichment of specific monomer in medium-chain-length poly(3-hydroxyalkanoates) by amplification of fadD and fadE genes in recombinant Escherichia coli" Enzyme Microb Technol., 33 : 62-70.
12. Park SJ, Lee I-S, Chang YK, Lee SY "Desulfurization of dibenzothiophene by metabolically engineered Escherichia coli", J. Microbiol. Biotechnol., 13(4):578-583.
13. Park S J and Lee S Y "Identification and characterization of a new enoyl Coenzyme A hydratase involved in the biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant Escherichia coli", J. Bacteriol., 185(18) : 5391-5397.
14. Park, S.J., Lee, Y., and Lee, S.Y., "Biosynthesis of (R)-3-hydroxyalkanic acid by metabolically engineered E.coli", Appl. Biochem. Biotechnol., In press
Domestic Journal
1. Choi J, Lee SY, Shin K, Lee WG, Park SJ, Chang HN, Chang YK (2002) "Pilot scale production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) by fed-batch culture of recombinant Escherichia coli", Biotechnol Bioprocess Eng 7: 371-374
Book chapters
1. Lee SY, Park SJ, "Fermentative production of SCL-PHAs", in Biopolymers, Vol. 3a(Steinbuchel A Ed), Wiley-VCH, 263-290.
2. Lee SY, Park SJ, "Biosynthesis and fermentative production of SCL-MCL-PHAs", in Biopolymers, Vol. 3a (Steinbuchel A Ed), Wiley-VCH, 317-336.
3. Lee SY, Hong SH, Park SJ, van Wegen R, Middelberg APJ, "Metabolic flux analysis on the production of poly(3-hydroxybutyrate)" in Biopolymers, Vol. 3a (Steinbuchel A Ed), Wiley-VCH, 249-261.
4. Lee SY, Park SJ, Park JP, Lee Y, Lee SH (2002), "Economic aspects of biopolymer production" in Biopolymers, Vol. 10 (Steinbuchel A Ed), Wiley-VCH, in press.
5. Lee SY, Park SJ, Lee Y, Lee SH (2002), "Biotechnological Processes for the Production of Monomers for Subsequent Chemical Polymer Synthesis", in Biopolymers, Vol. 10 (Steinbuchel A Ed), Wiley-VCH, in press.
Patents: 6 patents were pended.
Domestic Proceedings
1. Park SJ, Lee SY "Production of heterogeneous protein by fed-batch culture of protease negative mutant Escherichia coli", Proceedings of The 10th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 367-368 (1997)
2. Park SJ, Lee SY, Chang YK "Cloning of desulfurization genes from Gordona sp.", Proceedings of BPERC International Symposium '98, 177-178 (1998)
3. Park SJ, Lee SY "Production of secretory recombinant protein by fed-batch culture of protease negative mutant Escherichia coli strain", Proceedings of BPERC International Symposium '98, 179-180 (1998)
4. Park SJ, Lee SY "Development of efficient recovery methods for secretory recombinant protein from protease-negative mutant Escherichia coli strains", Proceedings of BPERC International Symposium '98, 181-182 (1998)
5. Park SJ, Lee SY "Production of heterologous protein by fed-batch culture of protease negative mutant Escherichia coli" Proceedings of The 11th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 149-150 (1998)
6. Park SJ, Lee SY, Chang YK "Cloning of desulfurization genes from newly isolated Gordona sp. CYKS1", Proceedings of Korea Institute of Biotechnology and Bioengineering Symposium, 293-294(1998)
7. Park SJ, Lee SY "Clonig of desulfurization genes from Gordona sp. CYKS1 and development of recombinant Escherichia coli for desulfurization", Theories and Applications of Chemical Engineering 5(1): 1145-1148 (1999).
8. Park SJ, Lee SY "Development of Recombinant Escherichia coli for Biodesulfurization", Proceedings of The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 123-124 (1999)
9. Park SJ, Ahn WS, Lee SY "Production of poly (3-hydroxybutyrate) by high cell density cultivation of recombinant Escherichia coli from whey", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 223-226 (2000. Apr.)
10. Choi J, Park SJ, Lee SY "Production of Poly (3-hydroxybutyrate) with high molecular mass by recombinant Escherichia coli", Theories and Applications of Chemical Engineering 6(1): 1233-1236 (2000).
11. Lee SH, Park SJ, Lee SY, Park SH "Production of Medium-chain-length Polyhydroxyalkanoate from Newly Screened Pseudomonas sp. MBEL21", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 153-156 (2001, Apr.)
12. Park SJ, Ahn WS, Lee SY "Production of poly (3- hydroxybutyrate- co- 3- hydroxyvalerate- co- 3- hydroxyhexanoate by recombinant Escherichia coli strains)", Theories and Applications of Chemical Engineering 7(1): 1425-1428 (2001).
13. Park SJ, Park JP, Lee SY "Biosynthesis of medium-chain-length poly(3-hydroxyalkanoates) by metabolically engineered Escherichia coli strains", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 735-738, November (2001)
14. Park JP, Park SJ, Lee SY "Production and characterization of ultra-high-molecular weight poly (3-hydroxybutyrate) by recombinant Escherichia coli", Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 731-734, November (2001)
15. Park SJ, Park JP, Lee SY "Production of poly (3-hydroxybutyrate) by recombinant Escherichia coli strain in pilot-scale fermentor from whey", Theories and Applications of Chemical Engineering 7(2): 3943-3946 (2001)
International Conferences
1. Lee SY, Ahn WS, Park SJ "Production of poly (3-hydroxybutyrate) from whey by fed-batch culture of recombinant Escherichia coli", Annual Meeting of Society for Industrial Microbiology, San Diego, CA, July (2000)
2. Park SJ, Ahn WS, Green PR, Lee SY "Production of poly (3-hydroxybutyrate-co-3- hydroxyhexanoate) by metabolically engineered Escherichia coli strains", The 8th Annual International Symposium on Biological Polyesters, MIT, Masachusetts, USA, September (2000)
3. Park SJ, Ahn WS, Lee SY "Production of poly (3-hydroxybutyrate) by fed-batch culture of recombnant Escherichia coli using highly concentrated whey solution", The 8th Annual International Symposium on Biological Polyesters, MIT, Masachusetts, USA, September (2000)
4. Lee SY, Ahn WS, Park SJ "High level production of poly (3-hydroxybutyrate) from whey by metabolically engineered E. coli", Metabolic Engineering III, Colorado Springs, Colorado, USA, October (2000)
5. Lee SH, Park SJ, Park JP, Lee SY "Biosynthesis of medium-chain-length polyhydroxyalkanoates in recombinant Escherichia Coli by engineering ¥â-oxidation pathway", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
6. Park JP, Park SJ, Lee SY "Production of medium-chain–length polyhydroxyalkanoates in metabolically engineered Escherichia Coli strains", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
7. Park SJ, Park JP, Lee SY "Biosynthesis of poly (3-hydroxybutyrate-co-3-hydroxyalkanoate) in metabolically engineered Escherichia Coli strains", GIM2002 9th international Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
8. Park JP, Park SJ, Lee SY "Biosynthesis and chataterization of polyhydroxalkanotes in newly screened Pseudomonas sp. MBEL21", International Symposium on Biological Polyesters,Munster, Germany, September 24(2002)
9. Park SJ, Park JP, Lee SY "Biosynthesis of medium-chain-length polyhydroxyalkanotates in recombinant Escherichia coli", International Symposium on Biological Polyesters, Munster, Germany, September 24(2002)
10. Park JP, Park SJ, Lee SY "Biosythesis and chacterization of polyhydroxyalkanotes from newly screened strain from sludge" , International Symposium on Biological Polyesters, Munster, Germany, September 22-26(2002)
11. Park JP, Park SJ, Lee SY "Production of (R)-(-)-3-hydroxybutyric acid by metabolically engineered Escherichia coli" , International Symposium on Biological Polyesters, Munster, Germany, September 22-26(2002)
12. Park JP, Park SJ, Lee SY "Amplification of glycolytic pathway increases the yield of poly(3-hydroxbutyrate) in Esxherichia coli", International Symposium Biological Polyesters, Munster, Germany, September 22-26(2002)
13. Choi JH, Park JP, Park SJ, Lee SY "Metabolic engineering of Escherichia coli for the production of polyhydroxyalkanoates consisting of short-chain–length and medium-chain-length monomers", Metabolic Engneering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11 (2002)
14. Lee SH, Park JP, Park SJ, Lee SY "Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates" Metabolic Engneering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11(2002)
Domestic Conferences
1. Park SJ, Lee SY "Production of heterogeneous protein by fed-batch culture of protease negative mutant Escherichia coli", The 10th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, KAIST, Taejon, November (1997)
2. Park SJ, Lee SY, Chang YK "Cloning of desulfurization genes from Gordona sp.", Annual Symposium of BPERC '98, KAIST, Daejeon, Korea, September (1998)
3. Park SJ, Lee SY "Production of secretory recombinant protein by fed-batch culture of protease negative mutant Escherichia coli strain", Annual Symposium of BPERC '98, KAIST, Daejeon, Korea, September (1998)
4. Park SJ, Lee SY "Development of efficient recovery methods for secretory recombinant protein from protease-negative mutant Escherichia coli strains", Annual Symposium of BPERC '98, KAIST, Daejeon, Korea, September (1998)
5. Park SJ, Lee SY, Chang YK "Cloning of desulfurization genes from newly isolated Gordona sp. CYKS1" Annual Symposium of KIBB, Hanyang Univ., Ansan, October (1998)
6. Park SJ, Jeong KJ, Lee HS, Lee SY, Chang YK "Development of recombinant bacteria for the degradation of dibenzothiophene" Annual Symposium of KIChE, Chosun Univ., Kwangju, October (1998)
7. Park SJ, Lee SY "Clonig of desulfurization genes from Gordona sp. CYKS1 and development of recombinant Escherichia coli for desulfurization", Annual Symposium of KIChE, SeongKyunKwan Univ. Suwon (1999)
8. Park SJ, Lee SY "Development of Recombinant Escherichia coli for Biodesulfurization", The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Kongju Univ., Kongju (1999)
9. Park SJ, Ahn WS, Lee SY "Production of poly (3-hydroxybutyrate) by high cell density cultivation of recombinant Escherichia coli from whey", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, KAIST, April (2000)
10. Park SJ, Ahn WS, Green PR, Lee SY "Production of poly (3-hydroxybutyrate-co-3- hydroxyhexanoate) by high cell density cultivation of recomninant Escherichia coli", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Chunan, November(2000)
11. Lee SH, Park SJ, Lee SY, Park SH " Production of Medium-chain-length Polyhydroxyalkanoate from Newly Screened Pseudomonas sp. MBEL21", Annual meeting of Korean society for Biotechnology and Bioengineering, Konkuk Univ., Seoul, April (2001)
12. Park SJ, Ahn WS, Lee SY "Production of poly (3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate by recombinant Escherichia coli strains), KIChE meeting, Yonsei Univ., April (2001)
13. Lee SY, Park SJ, Lee Y "Metabolic Engineering of Escherichia coli for the Production of Novel PHA and Chiral Compounds", Annual Meeting of Korean Society for Applied Microbiology, Chonan Sangnok Resort, June (2001)
14. Park SJ, Lee SY "Biosynthesis of medium-chain-length poly (3-hydroxyalkanoates) by metabolically engineered Escherichia coli strains", The 14th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Chungnam Univ., Daejeon, Korea (2001)
15. Park JP, Park SJ, Lee SY "Production and characterization of ultra-high-molecular weight poly (3-hydroxybutyrate) by recombinant Escherichia coli", The 14th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Chungnam Univ., Daejeon, Korea (2001)
16. Park SJ, Park JP, Lee SY "Biosynthesis of medium-chain-length poly (3-hydroxyalkanoates) by metabolically engineered Escherichia coli strains", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Seoul, November (2001)
17. Park JP, Park SJ, Lee SY "Production and characterization of ultra-high-molecular weight poly(3-hydroxybutyrate) by recombinant Escherichia coli", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Seoul, November(2001)
18. Park SJ, Park JP, Lee SY "Production of poly (3-hydroxybutyrate) by recombinant Escherichia coli strain in pilot-scale fermentor from whey", KIChE meeting, Daejeon, Korea (2001)
19. Park JP, Park SJ, Lee SY "Molecular cloning of (R)-specific enoyl-CoA hydratase genes from Pseudomonas sp. MBEL21 and their use for polyhydroxyalkanoate synthesis", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium,chungju ,October 12(2002)
20. Park SJ, Park JP, Lee SY "Evaluation of the roles of 3-ketoacyl-ACP reductases in the polyhydroxyalkanoates in recombinant Escherichia coli", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Chungju, October 12(2002)
21. Hong SH, Park SJ, Moon SY, Park JP, Lee SY "In SilicoPrediction of the Importance of Enter-Doudoroff Pathway in Poly (3-Hydroxybutyrate) Production", Korean society for Bicrobiology and Biotechnology meeting, Konkuk univ. October, 26 (2002)
22. Park SJ, Choi J, Lee SY "Production of Poly (3-Hydroxybutyrate-co-3-Hydroxyvalerate) by Fed-Batch Culture of Recombinant Escherichia coli in a Pilot Scale Fermentor", Korean society for Bicrobiology and Biotechnology meeting, Konkuk univ. October, 26 (2002)
23. Park JP, Park SJ, Lee SY " Production of medium-chain-length polyhydroxyalkanoates by a newly isolated strain of Pseudomonas sp. MBEL21", Korean society for Bicrobiology and Biotechnology meeting, Konkuk univ. October, 26 (2002)
24. Park JP, Park SJ, Lee SY "Medium-chain-length polyhydroxyalkanoate biosynthesis and accumulation in metabolic engineered recombinant E. coli" Korean society for Bicrobiology and Biotechnology meeting, Konkuk univ. October, 26(2002)
25. Han MJ, Lee SY, Hong SH, Park SJ "Role of Eda in polyhydroxyalkanoate biosynthesis deciphered from proteome analysis and metabolic flux analysis", Korean Society For Bioinformatics Annual Meeting, Haeundae, Korea, November, 15-16 (2002)
26. Lee SY, Jeong KJ, Yoon SH, Han MJ, Choi JH, Park SJ, Hong SH "Integrated analysis of the transcriptome and proteome of recombinant E. coli fermentation", 2002 Nanobio international symposium, Haeundae, Korea, November, 22-23 (2002)
Seung Hwan Lee
Ph.D. (M.S. '00. 2)
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Biocatalysts
Kinetic resolution
Enantiomerically pure compound
2. Education
1998 (B.S.) Dept. of Biological Science, KAIST, Taejon, Korea
2000 (M.S.) Dept. of Biological Science, KAIST, Taejon, Korea
2004. 8(Ph. D) Department of Chemical Engineering, KAIST, Taejon, Korea
3. Sissertation title
M.S. Thesis : Development of fed-batch culture for the production of Medium-chain-length Polyhydroxyalkanoate by Pseudomonas (Advisor: Professor Sang Yup Lee)
Ph.D. Thesis : Synthesis of enantiomerically pure compounds by biocatalysis (Advisor: Professor Sang Yup Lee)
4. Publications
International Journals
1. Lee, S.H., Oh, D.H., Ahn, W.S., Lee, Y., Choi, J., and Lee, S.Y. , “Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas hydrophilaâ€, Biotechnol. Bioeng. 67:240-244(2000)
2. Lee, S.Y. , Choi, J., and Lee, S.H. “Production of polyhydroxyalkanoates by fermentation of bacteriaâ€Macromol. Symp. 159:259-266(2000)
3. Lee, S.Y. , Wong, H.H., Choi, J., Lee, S.H., Lee, S.C., and Han, C.S., “Production of medium-chain-length polyhydroxyalkanoates by high cell density cultivation of Peudomonas putida under phosphorus limitationâ€, Biotechnol. Bioeng., 68:466-470(2000)
4. Park, S.H., Lee, S.H., and Lee, S.Y., "Preparation of optically active beta-amino acids from microbial polyester polyhydroxyalkanoates", J. Chem. Reseach (S), 498-499(2001)
5. Lee, S.Y., Hong, S.H., Lee, S.H., Park, S.J. "Fermentative Production of Chemicals That Can Be Used for Polymer Synthesis", Macromolecular Bioscience, 4 : 157-164 (2004).
6. Lee, S. H., Choi, J., Park, S. J., Lee, S.Y., Park, B. C. " Display of bacterial lipase on the Escherichia coli cell surface by using FadL as an anchoring motif and its use in enantioselective biocatalysis", Appl. Environ. Microbiol. 70(9) : 5074-5080 (2004).
7. Lee, S. H., Choi, J.H., Park, S.H., Choi, J.-I., and Lee, S.Y., "Enantioselective resolution of racemic compounds by cell surface displayed lipase", Enzyme Microbial Technol., 35 : 429-436 (2004).
8. Lee, S.H., Choi, J.-I., Han, M.-J., Choi, J.H., and Lee, S.Y. "Display of lipase on the cell surface of Escherichia coli using OprF as an anchor and its applications to enantioselective resolution in organic solvent", Biotechnol. Bioeng. in press(2004).
Korean Journals
1. Lee, Y., Lee, S.H., Lee, S.Y. “Fed-batch culture of Aeromonass hydrophila for the production of poly(3-hydroxybutyrate-co-hydroxyhexanoate) using two carbon sourcesâ€, Biotechnol.Bioproc. Eng. 4:195-198(1999)
2. Choi, J.-I., Lee, S.H., and Lee, S.Y., "Isolation and characteristics of polyhydroxyalkanoates producing Pseudomonas sp. MBEL21", Kor. J. Microbiol. Biotechnol. 32(2) : 123-127 (2004).
Korean Proceedings
1. Lee, S.H., Choi, J, and Lee, S.Y. “Economical recovery of poly(3-hydroxybutyrate)from recombinant Escherichia coli by simple digestion†Proceedings of The 12th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 331-332 (1999)
2. Lee, S.H., and Lee, S.Y. “Production of Poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas Hydrophila†Proceedings of The 12th Taejon/Chungnam-Kyushu Symposium on Chemical Engineering, 325-326 (1999)
3. Lee, S.H., and Lee, S.Y. “Production of medium-chain-length polyhydroxyalkanoates by the fed-batch culture of Pseudomonas putida†Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 329-330 (1999) Kangwon University.
4. Lee, S.H., Park, S.J., Lee, S.Y., and Park, S.H. “ Production of Medium-chain-length Polyhydroxyalkanoate from Newly Screened Pseudomonas sp. MBEL21â€, Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 153-156 (2001, Apr.)
5. Choi, J.H., Lee, S.H., Park, S.H. and Lee, S.Y. “Chiral Resolution by Lipase on the Eshcherichia coli Cell Surfaceâ€, Theories and Applications of Chemical Engineering 7(2): 4027-4030 (2001).
International Conferences
1. Lee, S.Y., Lee, Y., Park, S., Lee, S.H., “Production of (R)-hydroxycarboxylic acids by bacteriaâ€, ISBP/BEDPS 2000, Honolulu, Hawaii, December (2000)
2. Park, S.H., Lee, S.H., Lee, Y., Lee, S.Y., “Preparation of optically active β-amino acids from microbial polymerâ€, 221st National meeting of American Chemical Societyâ€, San Diego,CA, USA, April (2001)
3. Lee, S. H., Choi, J.H., and Lee, S.Y., "Resolution of racemic compounds by genetically immobilized lipase", Metabolic Engineering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11(2002)
4. Lee, S. H., Park, J.P., Park, S.J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of medium-chain-length polyhydroxyalkanoates", Metabolic Engineering IV applied Systems Biology, Castelvecchio Pascoli, Italy, October 6-11(2002)
5. Choi, J.H., Lee, S.H., and Lee, S.Y., "Display of polyhistidine and lipase on the surface of Escherichia coli by using the salmonella ompC as an anchoring motif and its application to chemoenzymatic synthesis", Biochemical Engineering (XIII) 2003, Boulder, Colorado, USA July 17-23 (2003)
6. Lee, S.H., Choi, J.H., and Lee, S.Y., "Dynamic kinetic resolution using cell surface displayed biocatalysts", Biochemical Engineering (XIII) 2003, Boulder, Colorado, USA July 17-23 (2003)
7. Choi, J.H., Lee, S.H., and Lee, S.Y., "Production of chiral compounds by cell surface displayed lipase", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov - 4 December (2003)
Korean Conferences
1. Lee, S.H., and Lee, S.Y. “Production of medium-chain-length polyhydroxyalkanoates by the fed-batch culture of Pseudomonas putida†Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 329-330 (1999) Kangwon University.
2. Lee, S.H. and Lee, S.Y., "Production of Poly (3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas Hydrophila", The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Kongju Univ., Kongju (1999)
3. Lee, S.H., Choi, J., and Lee, S.Y., "Economical recovery of poly (3-hydroxybutyrate) from recombinant Escherichia coli by simple digestion", The 12th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, Kongju Univ., Kongju (1999)
4. Lee, S.H., Park, S.J., Lee, S.Y., Park, S.H. “ Production of Medium-chain-length Polyhydroxyalkanoate from Newly Screened Pseudomonas sp. MBEL21â€, Proceedings of Korean society for Biotechnology and Bioengineering Symposium, 153-156 (2001, Apr.)
5. Choi, J.H., Lee, S.H., Park, S.H. and Lee, S.Y. “Chiral Resolution by Lipase on the Eshcherichia coli Cell Surfaceâ€, Theories and Applications of Chemical Engineering 7(2): 4027-4030 (2001).
6. Lee, S.H., Choi, J.H., and Lee, S.Y., "Production of chiral compounds by cell surface displayed lipase", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Busan, Korea, April 11-12(2003)
7. Lee, S.H., Choi, J.H., and Lee, S.Y., "Kinetic resolution of beta-lactams by cell surface displayed Lipase", Annual Spring Meeting of KIChE, Soonchun, April 25-26(2003)
8. Lee, S.H., and Lee, S.Y., "Dynamic kinetic resolution of styrene oxide by metabolically engineered Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October 22-24(2003)
9. Lee, S.H., and Lee, S.Y., "Kinetic resolution of epoxides by metabolically engineered Escherichia coli", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October 22-24(2003)
10. Lee, S.H. and Lee, S.Y., "Cell surface display of lipase using Escherichia coli FadL as an anchoring motif", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daegu, Korea, April 16-17(2004)
Book chapter
1. Lee, S. Y., Choi, J., Lee, S. H., “Production of polyhydroxyalkanoates by fermentation of bacteriaâ€, pp. 259-266 In: Polymer Science and Industrial Research in the Fast-changing Age (Kajiyama, T. ed) Wiley-VCH, Germany (2000)
2. Lee S.Y., Park S.H., Lee Y., Lee S.H., "Production of chiral and other valuable compounds from microbial polyesters", Biopolymers Vol 4, Ch.14.pp.375-388, VCH-Wiley, Weinheim, Germany (2001)
3. Lee, S.Y., Park, S.H., Hong, S.H., Lee, Y., Lee, S.H., "Fermentative Production of Building Blocks for Chemical Synthesis of Polyesters", Biopolymers Vol 3b, Ch 10, pp.265-326, VCH-Wiley, Weinheim, Germany (2001)
4. Lee, S.Y., Park, S.J., Park, J.P., Lee, Y., Lee, S.H., "Economic aspects of biopolymer production", Biopolymers Vol.10,Ch.10, pp.307-337, VCH-Wiley, Weinheim Germany (2003)
5. Lee, S.Y., Park, S.J., Lee, Y., Lee, S.H., "Biotechnological process for production of monomers for subsequent chemical polymer synthesis", Biopolymers Vol.10,Ch.9, pp.281-305, VCH-Wiley, Weinheim, Germany (2003)
Woo Suk Ahn
Ph.D. University of Delaware (M.S. '00. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone: +1-302-379-7217
Fax: +1-302-831-1048
Address: Dept. of Chemical Engineering, University of Delaware 150 Academy St., Colburn Lab.Newark, DE 19716, USA
Details
1. Education
PhD candidate: University of Delaware, USA, July 2008 to present
Department of Chemical Engineering
- Toward global analysis of mammalian cell physiology using multiple isotopic tracers
M.S.: Korea Advanced Institute of Science and Technology, Republic of Korea, Feb 1998 to Jan 2000
Department of Chemical Engineering
- Production of polyhydroxyalkanoate (PHA) with Aeromonas.
- Cloning genes related to metabolic pathway of PHA from Aeromonas.
- Development of metabolically engineered recombinant E. coli producing PHA
B.S.: Sung Kyun Kwan University, Republic of Korea, Jan 1994 to Feb 1998
Department of Polymer Science and Engineering
- Summa cum laude (the highest achievement in university), GPA 4.45/4.50
2. Employment Experience
Research scientist, Jan 2000 to Jun 2008
LG Life Sciences, Ltd. / R&D, Biotech Group
- Development of recombinant strains, cultivation, purification process, and scale-up for the production of generic drug or proteins
- Characterization of strains and fermentation process for biopharmaceutical approval
- Analysis of proteins
3. Military Service
Armored personal carrier driver, Mar 1990 to Sep 1992
Armored brigade II, The Korean Army
4. Honors and Fellowship
Achievement award, LG Life Sciences, Ltd. 2006
-EMEA approval of Valtropin (recombinant human Growth Hormone)
Pride Award-A grade, LG Life Sciences, Ltd. 2005
Scholarship, Korea Advanced Institute of Science and Technology 1998-1999
Summa cum laude with top honors, Sung Kyun Kwan University 1998
Whole alumni association prize, Sung Kyun Kwan University 1998
Fellowship for academic excellence, Sung Kyun Kwan University 1994-1997
5. Publications
Seung Hwan Lee, Dong Hyun Oh, Woo Suk Ahn, Young Lee, Jong-il Choi, and Sang Yup Lee. 2000. Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by high cell density cultivation of Aeromonas hydrophila. Biotechnol. Bioeng. 67(2): 240-244
Woo Suk Ahn, Si Jae Park, and Sang Yup Lee. 2000. Production of poly(3-hydroxybutyrate) by fed-batch culture of recombinant Escherichia coli with a highly concentrated whey solution. Appl. Environ. Microbiol. 66(8): 3624-3627
Woo Suk Ahn, Si Jae Park, and Sang Yup Lee. 2001. Production of poly(3-hydroxybutyrate) from whey by cell recycle fed-batch culture of recombinant Escherichia coli. Biotech. Lett. 23:235-240
Si Jae Park, Woo Suk Ahn, Phillip R. Green, and Sang Yup Lee. 2001. Production of poly(3-hydroxybutyrate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains. Biomacromolecules 2(1): 248-254
Si Jae Park, Woo Suk Ahn, Phillip R. Green, and Sang Yup Lee. 2001. Biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate-co-3-hydroxyhexanoate) by metabolically engineered Escherichia coli strains. Biotechnol. Bioeng. 74(1): 81-86
Woo Suk Ahn, Jae-Jin Jeon, Yeong_Ran Jeong, Seung Joo Lee, and Sung Kwan Yoon. 2008. Effect of culture temperature on erythropoietin production and glycosylation in a perfusion culture of recombinant CHO cells. Biotechnol. Bioeng. 101(6): 1234-1244
6. Research Experience
Graduate student, University of Delaware
Metabolic flux analysis of gluconeogenesis fluxes in FAO rat hepatoma cell lines July 2008 to present
-Investigate Type II diabetes using metabolic flux analysis and multiple isotopic tracers
Research scientist and manager, LG Life Sciences, Ltd. / R&DPerfusion culture of CHO Cell for Erythropoietin (EPO) production and Glycan characterization of EPO, Mar 2007 to Jun 2008
- Investigate optimal temperature for high-level expression and quality of glycoprotein.
- Characterize glycan structure and glycosylation types in order to confirm the effects of culture temperatures.
Purification of COMP-Angiopoietin1 Jan 2007 to Apr 2007
- Purify COMP-Ang1 using chromatography techniques.
Animal cell culture for antibody production by fed-batch fermentation Jan 2007 to Jun 2008
- Design serum-free medium and cultivation strategy of fed-batch with Bioreactor.
Project for FDA and EMEA approval of ValtropinO (hGH) 2003 to 2006
- Developed and characterized recombinant Saccharomyces cerevisiae and fermentation process for the production of human growth hormone (hGH).
- Characterized cell banks and end-of-process cells for the production of leucine aminopeptidase with recombinant Bacillus subtilis.
* Our product, Valtropina (hGH) was approved from FDA (23 April 2007) and EMEA (12 April 2006)
Project for FDA approval of SR-hGH (sustained release-hGH) 2006
- Scale-up study of 10,000 L fermentation process for the production of SR-hGH
MALDI-TOF mass analysis for characterization and identification of proteins 2005
- Operated Voyager DE-STRa and protein database with MS-Fit.
Developed stable fermentation process of recombinant B. subtilis for the production of leucine aminopeptidase that can remove methionine of met-hGH. 2002
- Solved genetic instability of recombinant B. subtilis, optimized media and fermentation process for high level of protein expression.
Developed fermentation strategies for hG-CSF production by recombinant Saccharomyces cerevisiae. 2001
Investigated new folding process of bG-CSF from recombinant E. coli. 2001
- Denaturation of inclusion body by isopropyl alcohol, refolding, and column separation
Lovastatin production from mutant Aspergillus terreus 2000
Graduate student, Korea Advanced Institute of Science and Technology
Project on the commercialization of PHA supported by Procter & Gamble 1998 to 2000
- Investigated fermentation strategies for PHA production with Aeromonas hydrophila.
- Cloned PHA synthesis genes from Aeromonas.
- Developed metabolically engineered recombinant E. coli for PHA production.
Project supported by Ministry Of Science and Technology 1998 to 2000
- Produced polyhydroxybutyrate (PHB) from whey (by-product in dairy industry) using recombinant E. coli.
7. Research Interests
Biotechnology
Metabolic Engineering, Protein Engineering, Cell Engineering, Drug Delivery
8. SKills
[Cloning]
Recombinant techniques for recombinant E. coli, S. cerevisiae, B. subtilis, and CHO cells
-Vector design and transformation skills using PCR, restriction enzymes, DNA separation, and purification tools
[Cultivation]
Culture Skills (medium and fermentation optimization) of bacterial, fungal and mammalian cells: E. coli, S. cerevisiae, B. subtilis, A. terreus, and CHO Cell
For bacterial and mammalian cell:
Small Scale Production: 5, and 10 L bioreactors
Large Scale Production: 30, 50, 200, 500, and 1500 L bioreactors
[Purification]
ACTA Explorer 10s, Purifier for protein purification
[Analysis]
Mass Spectroscopy Analysis: MALDI-TOF and GC-MS
-Protein Characterization: Total Mass, Peptide Mapping, Identification of unknown proteins
-Metabolic Flux Analysis: Separation and Identification of metabolites from cells, Analysis of mass isotopomer distribution
Glycan Characterization
-Charge profiles, antenary profiles, glycan structure
Fundamental Protein Analysis Tools such as SDS-PAGE, IEF, Elisa, and 2D Gel
HPLC, GC
Sung Ho Cho
M.S. '00. 8.
Chemical Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Recombinant protein production
Bioconversion
2. Education
1998 (B.S.) Dept. of Chemical Engineering, SCH Univ., Korea
2000 (M.S.) Dept. of Chemical Engineering, KAIST, Korea
3. Research Activity
Sang Sun Yoon
Ph.D. (M.S. '00. 8.)
University of Cincinnati, USA
Chemical & Biomolecular Engineering, KAIST
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Proteomics
2. Education
1998 (B.S.) Dept. of Industrial Chemistry, Hanyang, Seoul, Korea
2000 (M.S.) Dept. of Chemical Engineering, KAIST, Korea
3. Research Activity
Jong Gil Choi
M.S. '01. 2
Chemical Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
DNA chip (Genetic Desease)
2. Education
1999 (B.S.) Dept. of Biological Science, KAIST, Taejon, Korea
3. Research Activity
Jin Sik Kim
Ph.D. (M.S. '02. 2.)
PLUS International Patent Law Office
Office Phone: +82-42-869-8867
Fax: +82-42-869-8800 or 3910
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interests
Genome Analysis
Bioinformatics
2. Education
B.Sc. ChE (Minor: CS), KAIST, Korea, 1995.3.- 2000.2.
M.Eng. CBE, KAIST, Korea, 2000.3.- 2002.2.
Ph.D. CBE, KAIST, Korea, 2002.3.- 2006.8.
3. Experiences and Academic/Research Activities
Research Assistant, KAIST (Mar. 2000 - Aug. 2006)
Teaching Assistant, KAIST (Sep. 2002 - Jun. 2003; Sep. 2004 - Dec. 2004)
Postdoc., Applied Science Research Institute, KAIST, Daejeon, Korea (Sep. 2006 – present)
4. Publications
5 international journals, 2 domestic journals published
1 international proceedings, 2 book chapters
Soo Yun Moon
M.S. '03. 2.
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
2. Education
2001, (B.S.) Chemical Engineering, Sogang Univ., Seoul, Korea
3. Research Activity
International Journals
1. Lee, S.Y., Hong S.H., and Moon S Y., "In Silico Metabolic Pathway Analysis and Design: Succinic acid Production by Metabolically Engineered Escherichia coli as an example", Genome Informatics, 13: 214-223 (2002).
2. Hong, S.H., Park, S.J., Moon, S.Y., Park, J.P., and Lee, S.Y., "In silico prediction and validation of the importance of Entner-Doudoroff pathway in poly(3-hydroxybutyrate) production by metabolically engineered Echerichia coli", Biotech. Bioeng., 83(7) : 854-863 (2003).
3. Hong, S.H., Moon, S.Y., and Lee, S.Y., "Prediction of the maximum yields of metabolites and optimal pathways for their production by metabolic flux analysis", J. Microbiol. Biotechnol., 13(4) : 571-577 (2003).
Won Jae Heo
M.S. '03. 2.
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Bioinformatics (Sequence analysis)
Transcriptome analysis with DNA chip
High cell density cultivation
2. Education
2001, (B.S.) Dept. of Chemical Engineering, KAIST, Taejon, Korea
2001.3.-present (M.S.) Dept. of Chemical Engineering, KAIST, Taejon, Korea
3. Research Activity
International Journals
1. Heo, W.J., Yoon, S.H. and Lee, S.Y., "Global gene expression profiling of E. coli and its mutant unable to produce acetate", Genome Informatics,13: 270-271 (2002).
Domestic Conferences / Proceedings
1. Heo, W.J., Yoon, S.H., and Lee, S.Y. "Transcriptome analysis for the production of recombinant protein in Escherichia coli using DNA microarray", Annual meeting of Korean society for Biotechnology and Bioengineering Symposium, Seoul, November(2001)
International Conferences / Proceedings
1. Heo, W.J., Yoon, S.H., and Lee, S.Y. "Comprehensive analysis of E. coli metabolism under interference of acetate-producing pathway using DNA microarray", The 9th international symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July(2002).
2. Heo, W.J., Yoon, S.H., and Lee, S.Y. "Global gene expression profiling of E. coli with interruption of acetate production", The 10th international conference on Intelligent Systems for Molecular Biology, Edmonton, Canada, August 3-7(2002).
3. Heo, W.J. ,Yoon, S.H., and Lee, S.Y., "Global gene expression profiling of E. coli and its mutant unable to produce acetate", The 13th international conference on genome informatics GIW2002 meeting, yebisu garden place, Tokyo, Japan, December 16-18(2002).
Ae Jin Song
Hyundae Engineering Co., Ltd. (M.S. '04. 2.)
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Polyhydroxyalkanoates(PHA)
2. Education
2002 (B.S.) Dept. of Chemical Engineering, Sogang Univ., Seoul, Korea
2004 (M.S.) Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Research Experience
Hyun Ok Bang
Celtrion Co., Ltd. (M.S. '04. 2.)
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
2. Education
2002 (B.S.) Chemical, Polymer and Biological Engineering, Inha Univ., Incheon, Korea
2004 (M.S.) Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Research Activity
Korean Conferences
1. Bang, H. O., Lee, S. J., and Lee, S.Y., "High-Level production of lycopene by high cell density culture of Escherichia coli", Annual spring meeting of KIChE, Soonchun, April 25-26(2003)
2. Bang, H.O., Lee, S.J., and Lee, S.Y., "High cell density culture of metabolically engineered Escherichia coli for the production of lycopene", Annual meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seoul, Korea, October 22-24(2003)
3. Bang, H.O., Han, M.J., Park, S.J., and Lee, S.Y., "Roles of the Escherichia coli small Roles of the Escherichia coli small heat shock proteins IbpA and IbpB in recombinant proteins productionin recombinant proteins production", Annual fall meeting of KIChE, Seoul, October 24-25(2003)
4. Bang, H.O., Kim, T.Y., Hong, S.H., and Lee, S.Y., "Comparative Metabolic flux analysis in E. coli using MetaFluxNet", Annual fall meeting of KIChE, Seoul, October 24-25(2003)
International Conferences
1. Bang, H.O., Lee, S.J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of isoprenoids", First IECA conference on Systems Biology of E.coli., Tsuruoka, Japan, June 23-25(2003)
Byung Hun Kim
Ph.D. Student (M.S. '04. 8.)
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic engineering and gene targeting
Microbial genetics and genomics
Transcriptomics
2. Education
2002. 8., (B.S.) Dept. of Chemical & Biological Engineering, Korea Univ., Seoul, Korea
2004. 8., (M.S.) Dept. of Chemical and Biomoelcular Engineering, KAIST, Daejeon, Korea
M.S. Thesis : Transcriptome analysis of sulfur containing amino acid biosynthesis regulator genes and production of L-methionine in Escherichia coli.
3. Research Experience
Lee, S.J., Kim, B.H., and Lee, S. Y. (2004) "Comparative metabolic engineering of microbial succinate production" in preparation.
Lee, S.J., Kim, B.H., and Lee, S. Y. (2004) "Genome-based metabolic engineering of succinate-producing Mannheimia succiniciproducens" submitted.
Jung, D.H., Kim, B.H., Ko, Y.K., Jung, M.S, Jung, S.O., Lee, S.Y., Jung, H.T. (2004) "Covalent Attachment and Hybridization of DNA Oligonucleotides on Patterned Single-Walled Carbon Nanotube Films" Langmuir, 20: 8886-8891.
4. Patents
Lee, S.Y., Lee, S.J., Kim, B.H. “Bacteria variant and method for preparing succinate and amino acidsâ€, 10-2004-0060149 (2004-07-30).
Jung, H.T., Lee, S.Y., Jung, D.H., Kim, B.H., Ko, Y.K. “Development of high density nanotube pattern for biosensor applicationsâ€, 10-2003-0051140 (2003-07-24).
Jung, H.T., Lee, S.Y., Jung, D.H., Kim, B.H., Ko, Y.K., “Development of high density nanotube film and its application to biochip manufactureâ€, 10-2003-0051826 (2003-07-26).
5. Presentation
Kim, B.H., Park, S.J., and Lee, S.Y. "Transcriptome profiling of Escherichia coli fadR mutant", Genome Informatics, 2003, Yokohama, Japan.
Kim, B.H., Lee, S.J. and Lee, S.Y. "Transcriptome profiling of Escherichia coli metJ mutant: in relation to sulfur metabolism", Korean Society for Biotechnology and Bioengineering, 2004, Kyung-Book, Korea.
Tae Yong Kim
Ph.D. (M.S. '05. 8.)
Samsung Advanced Institute of Technology
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: (373-1, Guseong-Dong) 291 Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic engineering
Systems biology
2. Education
1997. 3. - 2003. 2., (B.S.) Chemical & Biological Engineering, Korea Univ., Seoul, Korea
2003 ~ 2005, (M.S.) M.Eng. Department of Chemical & Biomolecular Engineering, KAIST, Korea
2005 ~ 2008 : Dept. of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea Advisor : Professor Sang Yup Lee
3. Research Experience
International Journal
Hong, S.H., Kim, T.Y., and Lee, S.Y., "Phylogenetic analysis based on genome-scale metabolic pathway reaction content", Appl. Microbiol. Biotechnol., 65: 203-210 (2004)
Lee, S.Y., Lee, D.-Y., and Kim, T.Y., "Systems biotechnology for strain improvement", Trends Biotechnol., 23(7): 349-358 (2005.7).
Lee, S.Y., Lee, D.-Y., and Kim, T.Y., "Systems biotechnology for strain improvement", Trends Biotechnol., 23(7): 349-358 (2005.7).
Park, S.J., Lee, S.Y., Cho, J., Kim, T.Y., Lee, J.W., Park, J.H., and Han, M.-J., "Global physiological understanding and metabolic engineering of microorganisms based on omics studies", Appl. Microbiol. Biotechnol., 68:567-579 (2005. 9)
Lee, S.J., Lee, D.-Y., Kim, T.Y., Kim, B.H., Lee, J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the enhanced production of succinic acid based on genome comparison and in silico gene knock-out simulation", Appl. Environ. Microbiol., 71(12): 7880-7887 (2005.12).
Lee, S.Y., Woo, H.M., Lee, D.-Y., Choi, H.S., Kim, T.Y., and Yun, H., "Systems-level analysis of genome-scale microbial metabolisms under the integrated software environment", Biotechnol. Bioproc. Eng. 10(5): 425-431 (2005. 9~10)
Kim, J.S., Yun, H., Kim, H.U., Choi, H.S., Kim, T.Y., Woo, H.M., and Lee, S.Y. "Resources for systems biology research", J. Microbiol. Biotechnol. 16(6): 832-848 (2006. 6).
Kim, T.Y. and Lee, S.Y. "Accurate metabolic flux analysis through data reconciliation of isotope balance-based data", J. Microbiol. Biotechnol. 16(7): 1139-1143 (2006. 7).
Barrett, C.L., Kim, T.Y., Kim, H.U., Palsson, B.O., and Lee, S.Y., "Systems biology as a foundation for genome-scale synthetic biology", Curr. Opin. Biotechnol. 17: 488-492 (2006. 10.)
Choi, H.S., Kim, T.Y., Lee, D.-Y., and Lee, S.Y, "Incorporating metabolic flux ratios into constraint-based flux analysis by using artificial metabolites and converging ratio determinants", J. Biotechnol. 129(4):696-705 (2007. 5.)
Kim, T.Y., Kim, H.U., Park, J.M., Song, H., Kim, J.S. and Lee, S.Y., "Genome-scale analysis of Mannheimia succiniciproducens metabolism", Biotechnol. Bioeng. (Accelerated Publication), 97(4): 657-671 (2007. 7.)
Park, J.H., Lee, K.H., Kim, T.Y., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of L-valine based on transcriptome analysis and in silico gene knockout simulation", Proc. Nat. Acad. Sci. (PNAS), 104 (19): 7797-7802 (2007. 4.)
Kim, P.J., Lee, D.Y., Kim, T.Y., Lee, K.H., Joeong, H.W., Lee, S.Y., Park, S.W., "Metabolite essentiality elucidates robustness of Escherichia coli metabolism", Proc. Nat. Acad. Sci. (PNAS), 104 (34): 13638-13642 (2007. 8.)
Lee, K.H., Park, J.H., Kim, T.Y., Kim, H.U., and Lee, S.Y., " Systems metabolic engineering of Escherichia coli for L-threonine production", Molecular systems biology, 3(149): 1-8 (2007. 12.)
Kim, H.U., Kim, T.Y., and Lee, S.Y., "Metabolic flux analysis and metabolic engineering of microorganisms", Mol. Biosyst. 4: 113-120 (2008. 2.)
Kim, T.Y., Sohn, S.B., Kim, H.U., and Lee, S.Y., "Strategies for systems-level metabolic engineering", Biotechnol. J. 3:612-623 (2008. 5.)
Song, H., Kim, T.Y., Choi, B.-K., Choi, S.J., Nielsen, L., Chang, H.N., and Lee, S.Y., "Development of chemically defined medium for Mannheimia succiniciproducens based on its genome sequence", Appl. Microbiol. Biotechnol. 79(2): 263-272 (2008. 5.)
Lee, S.Y., Kim, J.M., Song, H., Lee, J.W., Kim, T.Y., and Jang, Y.-S., "From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens", Appl. Microbiol. Biotechnol. 79(1): 11-22 (2008. 5.)
Moon, S.Y., Hong, S.H., Kim, T.Y., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of malic acid", Biochem. Eng. J. 40(2): 312-320 (2008. 1.)
Park, J.H., Lee, S.Y., Kim, T.Y., and Kim, H.U., "Application of systems biology for bioprocess development", Trends Biotechnol., 26(8), 404-412 (2008. 8.)
Lee, S.Y., Kim, H.U., Park, J.H., Park, J.M., and Kim, T.Y., "Metabolic engineering of microorganisms: general strategies and drug production", Drug Discovery Today, 14(1/2): 78-88 (2009. 1)
International Conferences
Lee, S.Y., Kim, T.Y., and Hong, S.H., "Engineering the metabolic pathways of Escherichia coli for the production of various metabolites based on metabolic flux analysis", First IECA Conference on Systems Biology of E. coli., Tsuruoka, Japan, June 23-25(2003)
Lee, S.Y., Lee, D.Y., Hong, S.H., Kim, T.Y., Yun, H.S., Oh, Y.G., and Park, S.W., "MetaFluxNet, a Program Package for Metabolic Pathway Construction and Analysis, and Its Use in Large-scale Metabolic Flux Analysis of Escherichia coli", The 4th International Conference on Genome Informatics, GIW2003, Pacifico Yokohama, Yokohama, Japan December 14-17(2003)
Kim, T.Y., Hong S.H., and Lee, S.Y., "Identification of metabolic characteristics through metabolic flux analysis using MetaFluxNet", 11th Internationa Conference on Intelligent Systems for Molecular Biology, Brisbane, Queensland, Australia (2003)
Kim, T.Y., Hong, S.H., and Lee, S.Y., "Evaluating evolutionary relationship of microorganisms and their cellular metabolic pathways based on genome-scale metabolic pathway content, The Second International E. coli Allicance Conference on Systems Biology, Banff, Alberta, Canada, June 18-22 (2004)
Kim, T.Y., Hong, S.H., and Lee, S.Y., "Reconciliation of GC/MS based flux distribution data and metabolic flux analysis" The Second International E. coli Allicance Conference on Systems Biology, Banff, Alberta, Canada,(2004)
Kim, T.Y., Hong, S.H., and Lee, S.Y., "Evaluating evolutionary relationship of microorganisms and their cellular metabolic pathways based on genome-scale metabolic pathway content" Metabolic Engineering V: Genome to Product, Lake Tohoe, California, USA Sept. 19-23(2004)
Lee, S.Y., Choi, H.S., Kim, T.Y., Lee, D.Y., "Constrains-based flux analysis: Exploring internal flux patterns further constrained by split ratio determinant" The Third Asia-Pacific Bioinformatics Conference, Singapore, January 17-21 (2005)
Lee, S.Y., Kim, T.Y., Lee, D.Y., Kim, B.H., "A new strategy for in silico gene knock-out for strain improvement: Succinate production in E.coli as an example" The Third Asia-Pacific Bioinformatics Conference, Singapore, January 17-21 (2005)
Lee, S.Y., Woo, H.M., and Lee, D.Y., Choi, H.S., Kim, T.Y., Yun, H.S., "Metabolic Analysis of In Silico Genome-Scale Models Using MetaFluxNet" BioInfo 2005, Busan, Korea, Sep 22-24 (2005)
Kim, T.Y., Lee, D.Y., Lee, S.J.,Lee, S.Y., "i>In Silico Experiment for the Strain Improvement: Succinate production in Escherichia coli" BioInfo 2005, Busan, Korea, September 22-24 (2005)
Choi, H.S., Kim, T.Y., Lee, D.Y., Lee, S.Y., "Split Ratio Determinant: Newly Efficient Constraint Exploring Internal Flux Distribution" BioInfo 2005, Busan, Korea, September 22-24 (2005)
Lee, K.H., Park, J.H., Kim, T.Y., and Lee, S.Y., "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis" 10th international symposium on the genetics of industrial microorganisms(GIM), Prague, Czech Republic (2006. 6. 24-28)
Kim, T.Y., Kim, J.S., Kim, H.U., Park, J.M., Song, H., and Lee, S.Y., "Flux scanning based on enforced objective flux as new strategy for enhanced metabolite production", Metabolic Engineering VI: From recDNA towards Engineering Biological Systems, Noordwijkerhout, Netherlands (2006. 10.1-5)
Sohn, S.B., Kim, T.Y., and Lee, S.Y., "In silico genome scale modeling of Pseudomonas putida KT2440", The 7th International Conference on Systems Biology, Yokohama, Japan (2006. 10.8-13)
Kim, T.Y., Kim J.S., Kim, H.U., Park, J.M., Song, H., and Lee, S.Y., "Genome based-metabolic network of Mannheimia succiniciproducens using updated genome annotation", The 7th International Conference on Systems Biology, Yokohama, Japan (2006. 10.8-13)
Kim, H.U., Kim, T.Y., Jeong, K., Kim, S.Y., Rhee, J.H., and Lee, S.Y., "In silico analysis of vibrio vulnificus CMCP6 metabolism for the facilitated drug targeting" The 7th International Conference on Systems Biology, Yokohama, Japan (2006. 10.8-13)
Lee, K.H., Park, J.H., Kim, T.Y., and Lee, S.Y., "Enhanced production of L-threonine based on in silico simulation and comparative transcriptome analysis", The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3)
Kim, T.Y., Park, J.M., and Lee, S.Y., "Computational gene targeting strategy for biochemical production in Escherichia coli", The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3)
Song, H., Lee, S.J., Lee, D-,Y., Kim, T.Y., Kim, B.H., Lee, J., and Lee., S.Y., "Enhanced production of succinic acid by metabolically engineered Escherichia coli, based on Mannheimia succiniciproducens genome", The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3)
Kim, H.U., Kim, T.Y., and Lee, S.Y., "Assessment of Escherichia coli metabolism using constraints-based flux analysis and bayesian network analysis", The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3)
Lee, K.H., Park, J.H., Kim, T.Y., Song, H., and Lee, S.Y., "Construction of L-threonine Producing Strain based on in silico Simulation and Comparative Transcriptome Analysis", 29th symposium on Biotechnology for Fuels and Chemicals, Denver, Colorado, (2007. 4.29. – 5.2)
Kim, T.Y., Kim, H.U., Park, J.M., Song, H., and Lee, S.Y., "Deciphering Metabolic Flux of Mannheimia succiniciproducens MBEL55E by Genome-scale Constrains-based Flux Analysis", 29th symposium on Biotechnology for Fuels and Chemicals, Denver, Colorado, (2007. 4.29. – 5.2)
Kim, T.Y., Song, H., Kim, H.U., Park, J.M., and Lee, S.Y., "Deciphering fermentative metabolism of Mannheimia succiniciproducens MBEL55E by genome-scale constraints-base flux analysis", European BioPerspectives celebrating the 25th DECHEMA annual convention of biotechnologists, Cologne, Germany (2007. 5. 30 – 6.1.)
Kim, T.Y., Kim, H.U., and Lee, S.Y., "Identification of the in silico targets using the metabolite availability", The Eighth International Conference on Systems Biology, Long Beach, California, USA, (2007.10.1 - 6)
Park, J.M., Kim, T.Y. and Lee, S.Y., "Multi-Objective Computational simulation for the strain improvement in Escherichia coli", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei, Taiwan (2007. 11.4-7)
Park, J.H., Lee, K.H., Kim, T.Y.and Lee, S.Y., "Metabolic Engineering of Escherichia coli for the Production of L-Valine Based on Transcriptome Analysis and In silico Gene Knock-out Simulation", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei, Taiwan (2007. 11.4-7)
Lee, D.Y., Kim, T.Y., Lee, K.H., Jeong, H., Lee, S.Y., Park, S., "Metabolite essentiality elucidates robustness of Escherichia coli metabolism", The 18th Internationaol Conference on Genome Informatics(GIW2007) Singapore (2007. 12.3-12.5
Kim, T.Y., and Lee, S.Y. ,"In silico genome-scale reconstruction of Psuedomonas putida KT2440", the 18th International Conference on Genome Informatics (GIW 2007) ,Singapore (2007. 12.3-12.5)
Kim, T.Y., Jeong, K., Kim, S.Y., Rhee, J.H., and Lee, S.Y., "Reconstruction of Genome-Scale Stoichiometric Model of Vibrio vulnificus CMCP6 for Facilitated Drug Targeting", the 18th International Conference on Genome Informatics (GIW 2007) ,Singapore (2007. 12.3-12.5)
Kim, T.Y. and Lee, S.Y.,"Development of Multi-objective algorithm for in silico gene targeting and strain improvement", the 18th International Conference on Genome Informatics (GIW 2007) ,Singapore (2007. 12.3-12.5)
Lee, S.Y., Park, J.H., Lee, K.H. and Kim, T.Y., "L-valine production by systematically engineered Escherichia coli", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Lee, S.Y., Kim, T.Y., "Deciphering the evolution and metabolism of Mannheimia succiniciproducens MBEL55E by genome-scale analysis", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Moon, S.Y., Hong, S.H. and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of malic acid", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Choi, H.R. and Lee, S.Y., "Metabolic pathway analysis and its optimization for producing succinic acid in Mannheimia succiniciproducens MBEL55E", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Choi, H.R. and Lee, S.Y., "Metabolic pathway analysis and its optimization for producing succinic acid in Mannheimia succiniciproducens MBEL55E", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Choi, H.R. and Lee, S.Y., "Metabolic pathway analysis and its optimization for producing succinic acid in Mannheimia succiniciproducens MBEL55E", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Kim, T.Y., Kim, H.U. and Lee, S.Y., "Identification of the In silico targets of Escherichia coli using the Metabolite acailability", Metabolic Engineering VII : Health and Sustainablility, CasaMagna Marriott Puerto Vallarta Resort, Puerto Vallarta, Mexico, September 14-19, 2008
Kim, H.U., Kim, T.Y., Kim, S.Y., Rhee, J.H. and Lee, S.Y., "Metabolite essentiality of Vivrio vulnificus CMCP6 for drug targeting", Metabolic Engineering VII : Health and Sustainablility, CasaMagna Marriott Puerto Vallarta Resort, Puerto Vallarta, Mexico, September 14-19, 2008
Park, J.H., Lee, K.H., Kim, T.Y., Lee, S.Y., "Systems metabolic engineering of Escherichia coli", International E. coli alliance (IECA), Hinxton, UK, September 24-27, 2008
Park, J.H., Lee, K.H., Kim, T.Y., and Lee, S.Y., "Metabolic Engineering of Escherichia coli for L-valine Production Based on Systems and Synthetic Biology", SB 4.0: The Fourth International Meeting on Synthetic Biology, Hong Kong University of Science and Technology, October 10-12, (2008)
Book chapter
Lee, S.Y., Lee, D.-Y., Kim, T.Y., Kim, B.H., and Lee, S.J. "Ch.7. Systems biotechnology: Combined analysis of genome, transcriptome, proteome, metabolome and fluxome for the improvement of microorganisms for industrial applications", in Systems Biology, Volume 2 (eds. Rigoutsos, I. and Stephanopoulos, G.), Oxford University Press, USA, pp. 193-231 (2006)
Patent Pended
International Patent 1, Domestic Patent 4
Seung Min Yoo
Ph.D. (M.S. '05. 8.)
Research Professor
Bioprocess Research Center, Bioinformatics Research Center
Dept. Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-8813
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 291, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
Education
1994.3 ~ 1998.2 (B.S. Course in Biochemistry)
Department of Applied Biology, Dogguk University , Seoul , Korea
Advisor: Prof. In-Kook Park
2004.3 ~ 2005.8 (M.S. Course in Chemical & Biomolecular Engineering)
Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Advisor: Prof. Sang Yup Lee
2005.9 ~ 2009.1 (Ph.D. Course in Chemical & Biomolecular Engineering)
Department of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Advisor: Prof. Sang Yup Lee
Thesis: Development of diagnostic system using molecular technology
Research Experiences
1998.5–1999.4 Researcher, Department of obstetrics and gynecology, Sungkyunkwan University, Seoul, Korea
1999.10–2002.2 Researcher, BioProcess Engineering Research Center, KAIST, Daejeon, Korea
2002.3–2005.8 Team manager, Medigenes Co., Ltd., Seoul, Korea
2009.2–2010.5 Post-doc, Bioinformatics Research center, KAIST, Korea
2010.6–2011.4 Senior Researcher, Bioinformatics Research Center, KAIST, Korea
2011.5–present Research Professor, Bioinformatics Research Center/Bioprocess Research Center, KAIST, Korea
Publications
Summary (as of Dec. 2013)
Journal paper: 25 papers published.
Patents: 33 registered
International Journals
[25] Kim, H., Kang, T., Lee, H., Ryoo, H., Yoo, S.M., Lee, S.Y., and Kim, B., "Facile Fabrication of Multi-targeted and Stable Biochemical SERS Sensors" Chem. Asian. J. 2013, 8(12), 3010-3014. (IF: 4.572)
[24] Yoo, S.M., Na, D., Lee, S.Y. “Design and use of synthetic regulatory small RNAs to control gene expression in Escherichia coli” Nat. Protoc. 8(9), 1694–1707 (2013). ** Journal Cover paper (IF: 7.96)
[23] Yoo, S.M.†, Kang, M.†, Kang, T., Kim, D.M., Lee, S.Y., Kim, B. “Electro-triggered, Spatioselective, Quantitative Gene Delivery into a Single Cell Nucleus by Au Nanowire Nanoinjector”, Nano Lett., 13 (6), 2431–2435 (2013) †Co-first author (IF: 13.025)
[22] Na, D., Yoo, S.M., Chung, H., Park, H., Park, J.H., Lee, S.Y., "Metabolic engineering of Escherichia coli using synthetic small regulatory RNAs", Nat. Biotechnol., 31(2): 170-174 (2013. 1) (IF: 32.438)
[21] Kang, T., Yoo, S.M., Kang, M., Lee, H., Kim, H., Lee, S.Y., Kim, B. "Single-Step Multiplex Detection of Toxic Metal Ions by Au Nanowires-on-Chip Sensor Using Reporter Elimination", Lab Chip, 12: 3077-3081 (2012. 5) (IF: 5.697)
[20] Yoo, S.M., Kang, T., Lee, S.Y., Kim, B. “Combining a Nanowire SERRS Sensor and a Target Recycling Reaction for Ultrasensitive and Multiplex Identification of Pathogenic Fungi” Small, 7(23), 3371-3376 (2011. 12). ** Journal Inside Cover paper (IF: 7.823)
[19] Kim, D.-K.†, Yoo, S.M.†, Park, T.J., Yoshikawa, H., Tamiya E., Lee, S.Y. “Plasmonic properties of the multispot copper-capped nanoparticle array chip and its application to optical biosensors for pathogen detection of multiplex DNAs.” Anal. Chem. 83(16): 6215–6222 (2011. 8). †Co-first author (IF: 5.695)
[18] Yoo, S.M., Kang, T., Kim, B., Lee, S.Y. “Detection of single nucleotide polymorphisms by a gold nanowire-on-film SERS sensor coupled with S1 nuclease treatment” Chem.-A Eur. J. 17(31): 8657-8662 (2011. 7). (IF: 5.831)
[17] Kang, T., Yoo, S.M., Yoon, I., Lee, S.Y., Choo J. Kim, B. “Au Nanowire-on-Film SERRS Sensor for Ultrasensitive Hg2+ Detection” Chem.-A Eur. J. 17(7), 2211-2214 (2011. 2). (IF: 5.831)
[16] Park, T.J., Lee, S.-K., Yoo, S.M., Yang, S-.M., Lee, S.Y. "Development of reflective biosensor using fabrication of functionalized photonic nanocrystals", J. Nanosci. Nanotechnol., 11(1):632-637 (2011. 1) (IF: 1.149)
[15] Baek, Y.K., Yoo, S.M., Kang, T., Jeon H-.J, Kim K, Lee, S.Y., Kim, B., Jung, H.T. “Large-scale, highly ordered chitosan-core Au-shell nanopatterns with plasmonic tunability: A top-down approach to fabricate in core-shell nanostructure” Adv. Funct. Mater. 20(24), 4273–4278 (2010. 12). (IF: 9.765)
[14] Baek, Y.K., Jung, D.H., Yoo, S.M., Shin S., Kim, J.H., Jeon H.-J., Choi, Y.K., Lee, S.Y., Jung, H.T. “Label-free detection of DNA hybridization on pyrene-functionalized single-walled carbon nanotubes via various DNA binding methods.”, J. Nanosci. Nanotechnol. 11(5), 4210-4216 (2010. 5). (IF: 1.149)
[13] Yoo, S.M., Lee, S.Y. “DNA microarray for the identification of pathogens causing bloodstream infections”, Expert Rev. Mol. Diagn., 10(3), 263-268 (2010. 4). (IF: 4.089)
[12] Kang, T.†, Yoo, S.M.†, Yoon, I., Lee, S.Y., Kim, B. “Patterned multiplex pathogen DNA detection by Au particle-on-wire SERS sensor” Nano Lett., 10 (4), 1189–1193 (2010. 3). †Co-first author (IF: 13.025)
[11] Yoo, S.M., Choi, J.Y., Yun, J.K., Choi, J.K., Lee, K.W., Kim, J.M., Lee, S.Y. “DNA Microarray-based identification of bacterial and fungal pathogens in bloodstream infections”. Mol. Cell. Probes, 24(1): 44-52 (2010. 2). (IF: 1.873)
[10] Baek, Y.K., Yoo, S.M., Kim, J.H., Jung, D.H., Kim, Y.S., Choi, Y.K., Lee, S.Y., Jung, H.T. “The effect of network density on the DNA-sensing performance of single-walled carbon nanotubes”. J. Phys. Chem. C, 113(52), 21566–21571 (2009.10.30). (IF: 4.814)
[9] Yoo, S.M., Choi, J.H., Lee, S.Y., Yoo, N.C., “Applications of DNA microarray in Disease Diagnostics” J. Microbiol. Biotechn. 19(7): 635–646 (2009.7). (IF: 1.399)
[8] Yoo, S.M., Lee, S.Y., Chang, K.H., Yoo, S.Y., Yoo, N.C., Keum, K.C., Yoo, W.M., Kim, J.M., Choi, J.Y. “High-throughput identification of clinically important bacterial pathogen using DNA microarray”, Mol. Cell. Probes, 23(3-4): 171-177 (2009.6-8). (IF: 1.873)
[7] Kim, J.H., Kang, T., Yoo, S.M., Lee, S.Y., Kim, B., Choi, Y.K. “A well-ordered flower-like gold nanostructure for integrated sensors via surface-enhanced Raman scattering”, Nanotechnology, 20(23): 1-6 (2009.6). (IF: 3.842)
[6] Park, T.J., Yoo, S.M., Keum, K.C., Lee, S.Y. “Microarray of DNA-protein complexes on poly-3-hydroxybutyrate surface for pathogen detection” Anal. Bioanal. Chem., 393: 1639-1647 (2009.3). (IF: 3.659)
[5] Kim, K-.H., Kim, J-.H., Huang, X-.J., Yoo, S.M., Lee, S.Y., Choi, Y-.K. “Doping Free Nanoscale Complementary Carbon Nanotube Field Effect Transistors with DNA-templated Molecular Lithography”, Small, 4(11): 1959-1963 (2008. 11). (IF: 7.823)
[4] Yoo, S.M., Lee, S.Y., “Diagnosis of Pathogens Using DNA Microarray” Recent patents on Biotechnology 2(2): 124-129 (2008).
[3] Keum, K.C.†, Yoo, S.M.†, Lee, S.Y., Chang, K.H., Yoo, N.C., Yoo, W.M., Kim, J.M., Choi, J.Y., Kim, J.S., Lee, G. "DNA microarray-based detection of nosocomial pathogenic Pseudomonas aeruginosa and Acinetobacter baumannii", Mol. Cell. Probes, 20: 42-50 (2006). †Co-first author (IF: 1.873)
[2] Yoo, S.M., Keum, K.C., Yoo, S.Y., Choi, J.Y., Chang, K.H., Yoo, N.C., Yoo, W.M., Kim, J.M., Lee Duke, Lee, S.Y. "Development of DNA Microarray for Pathogen Detection", Biotech. Bioproc. Eng., 9:93-99 (2004. 3~4). (IF: 1.277)
[1] Yoo, S.Y., Chang, K. H., Yoo, S.M., Park, S.Y., Yoo, N.C., Keum, K.C., Yoo W.M., Kim, J. M., Lee S.Y. "Design of ITS and 23S rDNA-targeted probes and its usefulness for the identification of bacterial pathogens", Genome Informatics 13:589-590 (2002).
International Proceeding/Conference
Chang, K.H., Lee, S.Y., Yoo, S.M., Yoo, S.Y., Park, D.E., Yong K., W. Lee, J.Y., Choi, K.S. Lee, A. Huh, Yeo,, J.S., Song, Y.S., Kim, J.M. “Rapid Identification of Bacterial Pathogens by Amplifying 23S Ribosomal DNA and ITS for Application on Oligonucleotide Microarray” The 42th ICAAC (Interscience Conference on Antimicrobial Agents and Chemotherapy),San Diego, California, USA September 27-30 (2002)
Yoo, S.Y., Chang, K.H., Yoo, S.M., Park, S.Y., Yoo, N.C., Keum, K.C., Yoo, W.M., Kim, J.M., Lee, S.Y. “Design of ITS and 23S rDNA-targeted probes and its usefulness for the identification of bacterial pathogens” The 13th International Conference on Genome Informatics, Tokyo, Japan, December 16-18(2002)
Lee, S.Y., Lee, S.J., Yoo, S.M., Choi, J.H. "Protein arrays for protein-protein interactions analysis", APBioChEC '03, Carlton Crest Hotel, Brisbane, Australia, 30 Nov-4 December (2003)
Park, J.P., Lee, S.J., Park, T.J., Yoo, S.M., Lee, D., Lee, S.Y. “Systematic detection of pathogenic bacteria using carbohydrate-encapsulated quantum dot”, The Eighth World Congress on Biosensors, Granada, Spain, May 24-26 (2004)
Yoo, S.M. Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M., Lee, S.Y. “High-throughput detection of clinically predominant pathogen and evaluation of antibiotics effect by using DNA microarray”, Biochemical Engineering XV, Quebec, Canada, (2007.7.15 - 19)
Park, T.J., Yoo, S.M., Lee, S.Y. “Polyhydroxybutyrate Microarray using Immobilization of Fusion Proteins for Immunodiagnostics and Pathogen Detections”, Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei, Taiwan (2007. 11.4-7)
Park, T.J., Lee, S-.K., Yoo, S.M., Yi, G-.R., Yang, S-.M., Lee, S.Y. "Fabrication for the photonic-fluidic biosensor using functionalized photonic nanocrystals", The 22th International Liquid Crystal Conference, Jeju, Jun 29 - Jul 4 (2008)
Choi, J.Y., Yoo, S.M., Lee, K.W., Kim, J.M., Lee, S.Y. High-throughput identification of microbial pathogens in bloodstream infections using microarray hybridization. The 46th Infectious Disease Society of America, USA (2008)
Yoo, S.M. Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M., Lee, S.Y. Development of diagnostic array for infectious disease caused by bacterial pathogen. 2008 International E. coli alliance (IECA), Hinxton, UK (2008.9.24-27)
Yoo, S.M. Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M., Lee, S.Y. “Pathogenic bacteria identification by diagnostic DNA microarray” The 13th International Biotechnology Symposium and Exhibition. Dalian, China (2008. 10.12-17).
Lee, S.Y., Park, T.J., Yoo, S.M. "Polyhydroxybutyrate microarray for immunodiagnostics and pathogen detections by immobilizing fusion proteins", 14th European Congress on Biotechnology, Barcelona, Spain, Sep 13-16 (2009)
Yoo, S.M., Kim, H.Y., Kim, T.Y., Lee, S.Y., “Bayesian analysis of perturbed Escherichia coli metabolism”, GIW2009, The 20th International Conference on Genome Informatics, PACIFICO YOKOHAMA, Yokohama, Japan (2009. 12.14-16).
Yoo, S.M., Kim, T.Y., Choi, H.R., Lee, S.Y., “Metabolic network reconstruction and pathway analysis of Mannheimia succinicproducens”, GIW2009, The 20th International Conference on Genome Informatics, PACIFICO YOKOHAMA, Yokohama, Japan (2009. 12.14-16).
Na, D.K., Yoo, S.M., Lee, S.Y., "Computational design of regulatory small RNAs as a new component of synthetic genetic circuits", Metabolic engineering VIII, ICC, June 13-17, 2010, Jeju Island, Korea
Yoo, S.M., Baek, Y.K., Choi, E.J., Kim, J.H., Jung, D.H., Cho, Y.K., Jung, H.T., Lee, S.Y., "Label free DNA detection using the network density-modulated single-walled carbon nanotube sensor", International Conference on Cellular and Molecular Bioengineering 2, August2-4, 2010, Singapore
Yoo, S.M., Kang, T.J., Yoon, I.S., Kim, B.S., Lee, S.Y., "Multiple detection of pathogenic bacteria using patterned Au particle-on-wire SERS sensor", International Conference on Cellular and Molecular Bioengineering 2, August2-4, 2010, Singapore
Yoo, S.M., Kang, T.J., Yoon, I.S., Kim, B.S., Lee, S.Y., “Patterned Au particle-on-wire sensor for multiplex identification of pathogenic bacteria” Biochemical Engineering XVI, Seattle, USA, (2011.7.25 -29)
Yoo, S.M., Kang, T.J., Kim, B.S., Lee, S.Y., “Detection of Single Nucleotide Polymorphism by Au Nanowire-on-film SERS system Coupled with S1 Nuclease Reaction” Biochemical Engineering XVI, Seattle, USA, (2011.7.25 -29)
Patent
Registered
Lee, S.Y, Kim, D.K, Yoo, S.M., and Park, T.J
“Copper-Capped Nanoparticle Array Biochip Based on LSPR Optical Properties and Use Thereof”
Korea 2011, 10-10932030000
Kim, B., Kang, T., Yoon, I., Lee, S. Y., and Yoo, S.M.
“Detection Method of Bio-Chemical Material using Surface-Enhanced Raman Scattering”
USA 2011, 12/900,248, Japan 2010, 2010-229292, EU 2010, 10187095.4
Lee, S.Y., Yoo, S.M., Yoo, S.Y., Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M, Lee, J., Kim, J.M.
“DNA chip for detection of infectious bacteria”
Korea 2009, 10-09359190000
Lee, S.Y., Yoo, S.M., Yoo, S.Y., Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M, Lee, J., Kim, J.M.
"Nucleic Acid Probes for Detection of Aeromonas hydrophila"
Korea 2008, 10-0828551
Lee, S.Y., Yoo, S.M.,Yoo, S.Y., Chang, K.H., Keum, K.C., Yoo, N.C., Yoo, W.M, Lee, J., Kim, J.M.
“Nucleic Acid Probes for Detection of Candida albicans"
Korea 2007, 10-0781559
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Acinetobacter baumanii "
Korea 2006, 0617647
Lee, S.Y., Chang, K.H., Yoo, S. M.,Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Kingella kingaep "
Korea 2006, 0617640
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Clostridium ramosum "
Korea 2006, 0617646
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Ochrobactrum anthropi "
Korea 2006, 0617639
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Eikenella corrodens "
Korea 2006, 0617645
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Cardiobacterium hominis ”
Korea 2006, 0617641
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Porphyromonas gingivalis "
Korea 2006, 0617643
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Proteus vulgaris "
Korea 2006, 0617642
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Peptostreptococcus magnus "
Korea 2006, 0577460
Lee, S.Y., Chang, K.H., Yoo, S. M.,Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Klebsiella oxytoca "
Korea 2006, 0577449
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Comamonas acidovorans "
Korea 2006, 0577456
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Streptococcus mutans "
Korea 2006, 0577440
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Bacteroides fragilis "
Korea 2006, 0577455
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Corynebacterium diphtheriae "
Korea 2006, 0577451
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Clostridium diffcile "
Korea 2006, 0577408
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Branhamella catarrhalis "
Korea 2006, 0577397
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Enterobacter aerogenes "
Korea 2006, 0577444
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Haemophilus aprophilas "
Korea 2006, 0577407
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Bacteroides ovatus "
Korea 2006, 0577438
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
“DNA chips for Detection of Peptostreptococcus anarobius "
Korea 2006, 0577459
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Bacteroides thetaiotaomicron "
Korea 2006, 0577412
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Bacteroides vulgatus "
Korea 2006, 0577404
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Anaerobiospirillum succiniciproducens "
Korea 2006, 0577454
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Chryseobacterium meningosepticum "
Korea 2006, 0577453
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Sutterella wadsworthensis "
Korea 2006, 0577386
Lee, S.Y., Chang, K.H., Yoo, S. M., Yoo, S.Y., Keum, K.C., Yoo, N.C., Yoo, W.M, Park, S.Y., Lee, J., Kim, J.M.
"DNA chips for Detection of Peptostreptococcus prevotii "
Korea 2006, 0577458
Han Min Woo
M.S. '06. 2.
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-8867
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
2. Education
2004, 2., (B.S.) Dept. of Chemical & Biological Engineering, Korea Univ., Seoul, Korea 　
3. Honor / Awadrds
Woo, H.M. “3M Honorable award, the certificate of achievement - Innovation at 3M,†3M Korea, Seoul, November (2003)
Woo, H.M. “CJ Bio Award,†CJ Group- KichE, Seoul, December (2004)
4. Research Activity
1. Publications
2. International Conference
Choi, J.H., Woo, H.M., and Lee, S.Y., “Extracellular production of recombinant proteins in Escherichia coliâ€, Metabolic Engineering V: Genome to Product, Lake Tahoe, California, USA Sept. 19-23 (2004).
3. Korean Conference
Woo, H.M., Kim, T.Y., Song, H.H., Lee, D.Y., and Lee, S.Y., “Regulatory Metabolic Flux Analysis at Different pH Levels of Eschreichia coli W3110â€, Annual Fall Meeting of KIChE, Hoseo Univ, Asan. October 29-30 (2004).
Woo, H.M., Kim, T.Y., Song, H.H., Lee, D.Y., and Lee, S.Y., “Metabolic Flux Analysis of Eschreichia coli W3110 at Various pH Levelsâ€, The 3rd Annual Conference of The Korean Society for Bioinformatics, Yonsei Univ, Seoul. November 4 -5 (2004).
Woo, H.M., Choi, H.S., and Lee, S.Y., “Enhanced Lycopene Production using Gene Amplification with Metabolic Flux Analysisâ€, Annual Spring Meeting of KSBB, GangWon Univ, Chucheun. April 15 -16 (2005).
Choi, H.S., Kim, T.Y. Woo, H.M., Lee, D.Y., and Lee, S.Y., “Gene targets prediction for products biosynthesis by sytems biotechnology,†Annual Spring Meeting of KSBB, GangWon Univ, Chucheun. April 15 -16 (2005).
Woo, H.M., Choi, H.S., and Lee, S.Y., “Bilevel Optimization of gene amplification for enhanced lycopene productionâ€, Annual Spring Meeting of KIChE, YeoSoo Univ, YeoSoo. April 22 -23 (2005).
Choi, H.S., Kim, T.Y. Woo, H.M., Lee, D.Y., and Lee, S.Y., “Gene targets prediction for products biosynthesis by sytems biotechnology,†Annual Spring Meeting of KIChE, YeoSoo Univ, YeoSoo. April 22 -23 (2005).
4. Presentations
Practical Class as Teaching Assistant “Metabolic flux analysis using MetaFluxNetⓡ,†2005 China-Japan-Korea Joint-Bioinformatics Training Course, Daejeon, Korea (March, 7-10, 2005)
Jeong Wook Lee
Ph.D. Senior Researcher (M.S./Ph.D. Program '06. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 291 Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
I. Education
1999.3-2004.2 Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, Republic of Korea (B. S.)
2004.3-2009.8 Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, Republic of Korea (M. S. and Ph.D.)
II. Research Interests
Metabolic Engineering
Systems metabolic engineering
Development of integrated bioprocess for succinic acid
Bio-based fundamental chemical production
Proteomic analysis on industrial microorganisms
III. Experiences and Academic/Research Activities
Teaching Assistant, KAIST (Mar. 2007 – Feb. 2008)
Research Assistant, KAIST (Mar. 2006 – Aug. 2009)
Senior postdoctoral Researcher, KAIST (Aug. 2009 – Apr. 2010)
Senior Researcher, KAIST (May. 2010 – present)
IV. Honors and Awards
Young Scientist Award, KHUPO 5th International Proteomics Conference, Seoul, Republic of Korea (2005. 4. 29)
Jeong-San Scholarship Award, Jeong-San Scholarship Foundation, Republic of Korea (2005. 10. 27)
Young Scientist Award, KHUPO 7th International Proteomics Conference, Seoul, Republic of Korea (2007. 3. 30)
Award for Excellence as a Teaching Assistant (CBE301: Chemical and Biomolecular Engineering Laboratory), Department of Chemical and Biomolecular Engineering, KAIST, Daejeon, Republic of Korea (2007. 6)
Silver Best Paper Award, Frontiers in the Convergence of Bioscience and Information Technologies 2007 (FBIT 2007), Jeju Island, Republic of Korea (2007. 10. 13)
Best Poster Presentation Award, The 48th MSK Annual Meeting and 2008 International Symposium on Microbiology, Daejeon, Republic of Korea (2008. 5. 16)
Student Fellowship Award, Metabolic Engineering VII, Puerto Vallata, Mexico (2008. 9. 16)
Best Oral Presentation Award, 2009 International Symposium and Annual Meeting organized by the Korean Society for Microbiology and Biotechnology, Daejeon, Republic of Korea (2009. 6. 26)
Best Poster Presentation Award, 2009 International Symposium organized by the Federation of Korean Microbiological Societies, Seoul, Republic of Korea (2009. 10. 23)
Best Poster Presentation Award, 2010 International Symposium organized by the Federation of Korean Microbiological Societies, Seoul, Republic of Korea (2010. 10. 15)
V. Journal Publications
Park, S.J., Lee, S.Y., Cho, J., Kim, T.Y., Lee, J.W., Park, J.H., and Han, M.-J., "Global physiological understanding and metabolic engineering of microorganisms based on omics studies", Appl. Microbiol. Biotechnol., 68:567-579. (2005)
Han, M.-J., Lee, J.W., and Lee, S.Y., "Enhanced Proteome Profiling by Inhibiting Proteolysis with Small Heat Shock Proteins", J. Proteome Res., 4(6): 2429-2434. (2006)
Lee, J.W., Lee, S.Y., Song, H., and Yoo, J.S. "The proteome of Mannheimia succiniciproducens, a capnophilic rumen bacterium", Proteomics, 6: 3550-3566. (2006)
Han, M.-J., Park, S.J., Lee, J.W., Min, B.H., Lee, S.Y., Kim, S.-J., and Yoo, J.-S. "Analysis of poly(3-hydroxybutyrate) granule-associated proteome in recombinant Escherichia coli", J. Microbiol. Biotechnol., 16(6): 901-910 (2006).
Song, H., Lee, J.W., Choi, S., You, J.K., Hong, W.H., and Lee, S.Y., "Effects of dissolved CO2 levels on the growth of Mannheimia succiniciproducens and succinic acid production", Biotechnol. Bioeng., 98(6): 1296-1304 (2007).
Jang, Y.-S., Jung, Y.R., Lee, S.Y., Kim, J.M., Lee, J.W., Oh, D.-B., Kang, H.A., Kwon, O., Jang, S.H., Song, H., Lee, S.J., and Kang, K.Y. "Construction and characterization of shuttle vectors for succinic acid producing rumen bacteria", Appl. Environ. Microbiol., 73(17): 5411-5420 (2007).
Yun, H., Lee, J. W., Jeong, J., Chung, J., Park, J. M., Myoung, H. N., and Lee, S. Y., "EcoProDB: the Escherichia coli protein database", Bioinformatics, 23(18): 2501-2503 (2007).
Han, M. -J., Lee, J. W., Lee, S. Y., and Yoo, J. S. "Proteome-Level Responses of Escherichia coli to Long-Chain Fatty Acids and Use of Fatty Acid Inducible Promoter in Protein Production", J. Biomed. Biotechnol., Article ID 735101, (2007).
Lee, S.Y., Kim, J.M., Song, H., Lee, J.W., Kim, T.Y., and Jang, Y.-S., "From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens", Appl. Microbiol. Biotechnol., 79(1): 11-22 (2008).
Lee, J.W. and Lee, S.Y., "Proteome-based physiological analysis of the metabolically engineered succinic acid producer Mannheimia succiniciproducens LPK7", Bioprocess Biosyst. Eng. 33(1): 97-107 (2010).
Lee, J.W., Choi, S., Kim, J.M., and Lee, S.Y., "Mannheimia succiniciproducens phosphotransferase system for sucrose utilization ", Appl. Environ. Microbiol. 76(5): 1699-1703 (2010)
Lee, J.W., Choi, S., Park, J.H., Vickers, C., Nielsen, L.K., and Lee, S.Y., “Development of sucrose-utilizing Escherichia coli K-12 strain by cloning β-fructofuranosidases and its application for L-threonine production”, Appl. Microbiol. Biotechnol. 88(4): 905-913 (2010).
Han, M.-J., Yun, H., Lee, J. W., Lee, Y. H., Lee, S. Y., Yoo, J.-S., Kim, J. F. Hur, C.-G., "Genome-wide identification of the subcellular localization of the Escherichia coli B proteome using experimental and computational methods", Proteomics, 11(7): 1213-1227 (2011).
Han, M.-J.*, Lee, J. W.*, Lee, S. Y., "Understanding and engineering microbial cells based on proteomics and its combined analyses", Proteomics, 11(4): 721-743 (2011). (*Equal contribution)
Park, J.H., Jang, Y.S., Lee, J.W., and Lee, S.Y. "Escherichia coli W as a new platform strain for the enhanced production of L-valine by systems metabolic engineering", Biotechnol. Bioeng., 108(5):1140-1147 (2011).
Lee, J.W., Kim, H.U., Choi, S., Yi, J., and Lee, S.Y. “Microbial production of building block chemicals and polymers”, Curr. Opin. Biotechnol., In press (2011).
Lee, J.W., Kim, T.Y., Jang, Y.S., Choi, S., and Lee, S.Y. “Systems metabolic engineering for chemicals and materials”, Trends Biotechnol., In press (2011).
VI. Book Chapter
Lee, J.W., Han, M.J., and Lee, S.Y., "Chapter 4. Improved 2-Dimensional Electrophoresis by Inhibiting Proteolysis with Small Heat Shock Proteins”, Methods in Proteomics, The Korean Human Proteome Organization, 71-79 (2007)
Lee, J.W., Han, M.-S., Choi, S., Yi, J., Lee, T.W., and Lee, S.Y., “Organic Acids: Succinic and Malic Acids”, Vol. III: Industrial biotechnology edited by Antonio Moreira, Comprehensive biotechnology 2nd edition, Elsevier (in press)
Yi, J., Choi, S., Han, M.-S., Lee, J.W., and Lee, S.Y., “Chapter 17. Succinic Acid”, Bioprocessing Technologies in Integrated Biorefinery for Production of Biofuels, Biochemicals, and Biopolymers from Biomass edited by Hesham Al El Enshasy, John Wiley & Sons, Inc. (in press)
VII. Oral presentation
Lee, J.W. and Lee, S.Y., “Proteomic and physiological characteristics of succinic acid-overproducing Mannheimia succiniciproducens and its application”, Metabolic Engineering VII, 20080917, Puerto Vallarta, Mexico (Invited)
Lee, J.W. and Lee, S.Y., “Identification and engineering of sucrose uptake system in Mannheimia succiniciproducens”, 2009 International Symposium and Annual Meeting organized by the Korean Society for Microbiology and Biotechnology, 20090626, Daejeon, Republic of Korea
Lee, J. W. and Lee, S. Y., “Development of recombinant Mannheimia succiniciproducens using systems metabolic engineering strategies”, 16th Workshop on integrated bioprocess development for succinic acid production, 20100727, Daejeon, Republic of Korea
VIII. Patent
국내특허 10건 출원, 1건 등록
국외특허 5건 출원, 1건 등록
IX. Domestic Proceedings
Lee, J.W., Han, M.J. and Lee, S.Y., “Proteomic analysis of oleic acid stimulon in Escherichia coli and its application”, Proceedings of The 17th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, 21 (2004)
X. International Conference
Han, M.J., Park, S.J., Lee, J.W., Yoo, J.S., and Lee, S.Y., "Analyses of poly(3-hydroxybutyrate) granule-associted proteins in recombinant Escherichia coli", KHUPO 4th Annual International Proteomics Conference, March, 25-26 (2004)
Han, M.J., Park, S.J., Park, T.J., Lee, J.W., and Lee, S.Y., "Essential roles and applications of small heat shock proteins in the production of recombinant proteins in Escherichia coli", KHUPO 4th Annual International Proteomics Conference , March, 25-26 (2004)
Lee, S.Y., Han, M.J., Park, S.J, and Lee, J.W., "Roles and applications of small heat shock proteins for the production of recombinant proteins in Escherichia coli”, 3rd Recombinant Protein Production Meeting, Tavira, Portugal, Nov 11-14 (2004).
Lee, J.W., Han, M.J., Yoo, J.S. and Lee, S.Y., "Proteomic analysis of Escherichia coli cultured in oleic acid and its application", KHUPO 5th International Proteomics Conference AOHUPO Workshop/Symposium, April 27-29 (2005)
Han, M.J., Park, S.J., Lee, J.W., Yoo, J.S. and Lee, S.Y., "Analysis of poly(3-Hydroxybutyrate) granule-associated proteome in recombinant Escherichia coli", KHUPO 5th International Proteomics Conference AOHUPO Workshop/Symposium, April 27-29 (2005)
Song, H., Lee, J.W., Kim, J.M., Lee, S.Y., “Succinic Acid Production and Growth Behaviors of Mannheimia succiniciproducens in Anaerobic Batch Fermentation”, Asia Pacific Biochemical Engineering Conference (APBioChEC'05), Lotte Jeju Hotel, Jeju Island, Korea, May 15-19 (2005)
Lee, J.W., Han, M.J. and Lee, S.Y., "Enhanced proteome profiling by inhibiting proteolysis with small heat shock proteins", KHUPO 6th International Proteomics Conference, March 30-31 (2006)
Lee, J.W., Lee, S.Y., Song, H.H., "The proteome of Mannheimia succiniciproducens, a capnophilic rumen bacterium", KHUPO 6th International Proteomics Conference, March 30-31 (2006)
Lee, J.W., Lee, S.Y., Song, H., and Yoo, J.S., “The proteome of Mannheimia succiniciproducens, a capnophilic rumen bacterium”, 10th international symposium on the genetics of industrial microorganisms(GIM), Prague, Czech Republic (2006. 6. 24-28)
Lee, J.W., Han, M-.J., and Lee, S.Y., “Improved proteome profiling method by inhibiting proteolysis with small heat shock proteins”, The 3rd International E.coli Alliance Conference on Systems Biology 2006, Jeju, Korea (2006. 10.30-11.3)
Lee, J.W., Han, M.J., Yoo, J.S. and Lee, S.Y., "Mining Low Abundance Proteins by Inhibiting Proteolysis with Small Heat Shock Proteins", KHUPO 7th International Proteomics Conference, March 29-30 (2007)
Lee, J.W., Song, H.H., Yoo, J.S. and Lee, S.Y., "Proteome analysis of succinic acid overproducing bacterium, Mannheimia succiniciproducens", KHUPO 7th International Proteomics Conference, March 29-30 (2007)
Jang, S.H., Song, H., Lee, J.W., and Lee, S.Y., "Systems-level analysis of M. succiniciproducens MBEL55E by Combined Omics Analyses", 29th symposium on Biotechnology for Fuels and Chemicals, Denver, Colorado, (2007. 4.29.– 5.2)
Lee, J.W., Song, H., Choi, S., Yoo, J.S., and Lee, S.Y., "The proteome of succinic acid overproducing bacterium, Mannheimia succiniciproducens", European BioPerspectives celebrating the 25th DECHEMA annual convention of biotechnologists, Cologne, Germany (2007. 5. 30– 6.1.)
Han, M-.J., Lee, J.W., Lee, S.Y. ,Yoo, J.S. “Proteomic Analysis of a Response to Long-Chain Fatty Acid in Escherichia coli and Its Application”, Frontiers in the convergence of Bioscience and Information Technologies, Korea, (2007. 10.11-13)
Lee, J.W., Song, H., Choi, S., Yoo, J.S., and Lee, S.Y.,"Proteome analysis of Mannheimia succiniciproducens and its strain improvement", Asia Pacific Biochemical Engineering Conference (APBioChEC'07), Taipei International Convention Center, Taiwan, Nov 4-7, 2007
Yun, H., Lee, J.W., Jeong, J.W., Park, J.M., and Lee. S.Y., “EcoProDB: the protein knowledge base for Escherichia coli”, the 18th International Conference on Genome Informatics (GIW 2007), Singapore (2007. 12.3-12.5)
Park, J.M., Yun, H., Lee, J.W., Jeong, J., Chung, J. and Lee, S.Y., "EcoProDB: The protein database for Escherichia coli", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore, March 29-April 2, 2008
Y.S. Jang, J.W. Lee, Lee, S.Y., "Development of Shuttle Vectors for Succinic Acid Producing Rumen Bacteria", 30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, LA, USA, May 4-7, 2008
H. Song, J.W. Lee, S. Choi, Lee, S.Y., "Effects of Dissolved CO2 Levels on the Growth of Mannheimia succiniciproducens and Succinic Acid Production",30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, LA, USA, May 4-7, 2008
J.W. Lee, H. Song, S. Choi, Lee, S.Y., "Proteome Characteristics of Succinic Acid Overproducing Bacterium, Mannheimia succiniciproducens", 30th Symposium on Biotechnology for Fuels and Chemicals, New Orleans, LA, USA, May 4-7, 2008
Lee, J.W., Song, H.H., Choi, S., Yoo, J.S. and Lee, S.Y., "Proteomic and physiological Characteristics of succinic acid-overproducing Mannheimia succiniciproducens and its strain improvement", Metabolic Engineering VII : Health and Sustainablility, CasaMagna Marriott Puerto Vallarta Resort, Puerto Vallarta, Mexico, September 14-19, 2008
Han, M.S., Song, H.H., Lee, J.W., Choi, S., Lee, S.Y., “Dissolved CO2 level growth, succinic acid production, and enzyme activities of Mannheimia succiniciproducens MBEL55E”, The 21st International Symposium on Chemical Engineering, Dec 6-7(2008), Saga, Japan
Lee, J.W., Song, H.H., Lee, S.Y., Yoo, J.S., "The proteome of Mannheimia and its use in metabolic engineering", The 16th Biochemical Engineering, Burlington, Vermont, USA, July 5-9 (2009)
Lee, J.W., Choi, S., Song, H.H., Lee, S.Y., "Identification and engineering of sucrose transport and utilization system in Mannheimia succiniciproducens", The 16th Biochemical Engineering, Burlington, Vermont, USA, July 5-9 (2009)
Jang, Y. S., Lee, J. W., Kim, J. M., Lee, S. Y., "Identification of Sucrose Uptake System in Mannheimia succiniciproducens", 14th European Congress on Biotechnology, Barcelona, Spain, September 13-16 (2009)
Lee, Y.H., Lee, J.W., Kim, M.H., Lee, S.Y., “Proteome analysis of the succinic acid producer Mannheimia succinicproducens and byproduct elimination strategy”, GIW2009, The 20th International Conference on Genome Informatics, PACIFICO YOKOHAMA, December 14-16, 2009, Yokohama, Japan.
Lee, J.W., Choi, S., Lee, T.W., Lee, S.Y., "Mannheimia succiniciproducens phosphotransferase system for sucrose utilization and its use in the enhanced succinate production", Metabolic engineering VIII, ICC, June 13-17, 2010, Jeju Island, Korea
Lee, J.W., Yi, J., Baek, J.H., Lee, S.Y., "Characterization of acid-tolerant Mannheimia succiniciproducens by transcriptome Analysis", Metabolic engineering VIII, ICC, June 13-17, 2010, Jeju Island, Korea
Choi, S., Lee, J.W., Lee, S.Y., "Genome-based metabolic engineering of malate and fumarate production in Mannheimia succiniciproducens", 11th international symposium of the genetics of industrial microorganisms, June 28-July 1, 2010, Melbourne, Austrailia
Lee, T.W., Lee, J.W., Choi, S., Lee, S.Y., "The phosphotransferase system for sucrose utilization in Mannheimia succiniciproducens", 11th international symposium of the genetics of industrial microorganisms, June 28-July 1, 2010, Melbourne, Austrailia
XI. Domestic Conference
Lee, J.W., Choi, S., Kim, J.M., Han, M.S., Lee, S.Y., "Characterization of sucrose uptake system in Mannheimia succiniciproducens", 2009 Annual Fall Meeting of KIChE, KINTEX, Ilsna, Korea, October 21-23 (2009)
외 59건
Yeon Jae Kang
M.S. '06. 2.
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-8867
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST (373-1, Guseong-Dong) 335 Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
2. Education
2004, 2., (B.S.) Dept. of Chemical Engineering, Sogang Univ., Seoul, Korea
3. Research Experience
Yu Kyung Jung
Ph.D. (M.S. '06. 2.)
CJ Business Strategy Institute
Phone: +82-42-350-5970
Fax +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 291, Daehak-ro, Yuseong-Gu, DAEJEON, 34141, Republic of KOREA
Details
1. Education
B.S., 2000. 3 - 2004. 2. Chemical Engineering, Pusan National Univ., Busan, Republic of Korea
M.S., 2004. 3 - 2006. 2. Chemical & Biomolecular Engineering, KAIST, Daejeon, Republic of Korea
Ph.D., 2006. 3 - 2010. 1. Chemical & Biomolecular Engineering, KAIST, Daejeon, Republic of Korea
2. Research Interest
Biopolymer Production
Systems Metabolic Engineering
Synthetic Biology
White Biotechnology
3. Research Experiences
Metabolic engineering for the production of polylactic acid (PLA) and its copolymers
Metabolic engineering for the production of bioplastics (polyhydroxyalkanoates)Metabolic engineering for the production of unnatural polymers
White biotechnology towards bioplastics industry
Development of a versatile platform for the one-step production of lactate-based polymers from renewable resources
Construction of new pathways for the biosynthesis of poly(lactate) and poly(3-hydroxybutyrate-co-lactate)
Metabolic engineering of Escherichia coli for the production of PLA and its copolymers
Enhanced production of PLA and its copolymers having high lactate fraction by further engineering based on in silico genome-scale simulation
Metabolic engineering of E. coli for more efficient production of PLA and its copolymers
Enzyme (PHA synthases from Pseudomonas sp. strains) engineering for the production of PLA and its copolymers
Fermentative production of PLA and its copolymers from renewable resources
Microbial production of various PLA copolymers by further metabolic engineering
4. Awards and Honors
Best Researcher Award, Korean Society for Biochemistry and Molecular Biology,Seoul, Republic of Korea (2005. 5. 20)
Student Fellowship Award, Metabolic Engineering VII, Puerto Vallata, Mexico (2008. 9. 16)
Best Paper Presentation Award, The Korean Society for Biotechnology and Bioengineering, Daejeon, Republic of Korea (2009. 11. 3)
Recognition by major news media including CNN (www.cnn.com) (2009. 11-12) (All other relevant articles are available at http://mbel.kaist.ac.kr.)
Representative international news
"Koreans make plastics without fossil fuel" – CNN Home, CNN Tech
"S. Koreans make bioengineered plastics" – CNN Asia
"A genetically engineered bacterium makes a greener plastic" – Economist
"Korean researchers find one-step route to PLA" – European Plastics News
Representative domestic news
"대사공학적으로 개량된 박테리아로 범용플라스틱 생산기술 개발"
'석유, 석탄 없이 바이오 플라스틱' 국내 성공 – 조선일보
세균에서 플라스틱 뽑아내는 기술 첫 개발 – 동아일보
박테리아 이용 플라스틱 생산기술 개발 – 연합뉴스
5. Publications
International Journal
Jung YK, Kim TY, Park SJ, Lee SY. 2010. Metabolic engineering of Escherichia coli for the production of polylactic acid and its copolymers. Biotechnol Bioeng 105:161-171. (selected as a Spotlight paper)
Book Chapter
Lee SY, Jung YK, Song H, Kim JM, Park JH. 2009. Fermentative production of organic acids for polymer synthesis. Microbial Production of Biopolymers and Polymer Precursors:Applications and Perspectives. p181-195, Caister Academic Press, United Kingdom.
Jung YK, Lee SY, Tam TT. 2010. Towards systems metabolic engineering of PHA producers. In Plastic from bacteria: Natural functions and applications. Microbiology Monographs, Vol. 14, p63-84, Springer, Berlin Heidelberg, Germany.
Chen GQ, Wu Q, Jung YK, Lee SY. in press. PHA/PHB. In Industrial Biotechnology. Comprehensive Biotechnology (2nd edn), Vol. 3, Elsevier, Amsterdam, Netherlands.
Patent
Cho JH, Park SJ, Lee SY, Jung YK. 2006. Cells or plants that can produce polylactate or its copolymers and to a method for preparing polylactate or its copolymers using the same. WO/2006/126796.
Park SJ, Yang TH, Kim TW, Lee SY, Jung YK. 2009. Mutant microorganism with improved productivity of polylactate and its copolymer and method for preparing them using the same. 10-2009-0056652 .
Lee SY, Jung YK, Yang TH. 2009. Method for preparing poly(lactate-co-glycolate) or poly(lactate-co-glycolate-co-hydroxyalkanoate) copolymers using cells or plants having producing ability of poly(lactate-co-glycolate) or poly(lactate-co-glycolate-co-hydroxyalkanoate) copolymers. 10-2009-0030133.
Lee SY, Park JH, Jung YK. 2009. Method for preparing hydroxyalkanoate alkylester using the microorganisms producing polyhydroxyakanoate. 10-2009-0060496.
Min Jeong Sohn
Ph.D. (M.S. '06. 2.)
Korean Research Institute of Bioscience and Biotechnology (http://www.kribb.re.kr/metabolic)
TEL: 82-42-860-4454
FAX: 82-42-860-4594
Address: Metabolic Engineering Lab. Korea Research Institute of Bioscience and Biotechnology (KRIBB), 52 Eoeun-dong, Yuseong-gu, Daejeon 305-333, Korea
e-mail: picorna at kribb.re.kr
Details
1. Research Interest
Global transcriptional response of yeast to environmental stress
2. Education
2002 (B.S.) Dept. of Microbiology, Chungnam National Univ. Daejeon, Korea
3. Research activity
International publication
1. Ubiyvovk V.M., Nazarko T.Y., Stasyk O.G., Sohn M.J., Kang H.A., Sibirny A.A., "GSH2, a gene encoding a-glutamylcysteine synthetase in the methylotrophic yeast Hansenula polymorpha", FEMS Yeast Research, 2: 327-332 (2002).
International conference
1. Min Jeong Sohn, Eun-Young Cho, Moo Woong Kim, Sang Ki Rhee, Hyun Ah Kang, "Cloning and characterization of the Hansenula polymorpha YPS1 gene encoding a functional yeast aspartyl endopeptidase", 9th International Symposium on the Genetics of Industrial Microorganisms, Gyeongju, Korea, July 1-5 (2002)
2. Min Jeong Sohn, Se-Jeong Kim, Sang Ki Rhee, Vira M. Ubiyvovk1, Andrei A. Sibirny1, Hyun Ah Kang, "Transcriptional Regulation of the Hansenula polymorpha GSH2 gene by Cadmium and Oxidative stress", 2003 Annual meeting, Bioexhibition & International symposium Microbial Functional Genomics Its Application, Muju, Koea, June 24-26 (2003)
3. Min Jeong Sohn, Se-Jeong Kim, Chul Ho Kim, Sang Ki Rhee, Vira M. Ubiyvovk, Andrei A. Sibirny. Hyun Ah Kang, "Comparative analysis of cadmium tolerance and glutathione biosynthesis in different strains of the methylotrophic yeast Hansenular polymorpha", XXI International Conference on Yeast Genetics and Molecular Biology, Gothenburg, Sweden, July 6-12 (2003)
Patent
1. 2002년 「한세눌라 폴리모르파 앱신 유전자 결손 변이주 및 이를 이용한 재조합 단백질 생산방법」
2. 2002년 「감마 글루타밀시스테인 합성효소 및 이를 코딩하는 유전자」
Manish Jaideo Patil
M.S. '06. 8.
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 291, Daehak-ro, Yuseong-Gu, DAEJEON, 34141, Republic of KOREA
Details
1. Research Interest
2. Education
2002 (B.S.) Dept. of Chemical Engineering, UDCT Mumbai, India
4. Research Experience
2002.7. ~ 2004.5. : Researcher, Department Chemical Engineering, Indian Institute of Technology Bombay, India
3. Research Activity
Sung Won Lim
M.S. '07. 2.
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 291, Daehak-ro, Yuseong-Gu, DAEJEON, 34141, Republic of KOREA
Details
1. Research Interest
2. Education
2005. 2., (B.S.) Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2007. 2., (M.S.) Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Research Activity
International Proceedings
1. Lim, S.W., Song, H., Jang, Y.S., and Lee, S.Y., “fdhD and fdhE Characterization of Mannheimia succiniciproducens MBEL55Eâ€, Proceedings of The 18th Symposium on Chemical Engineering, Daejeon/Chungnam(Korea)-Kyushu(Japan), Dec. 2-4 (2005)
Patents
International Conferences
1. Jang, S.H., Lim, S.W., Song, H. and Lee, S.Y., “Systems-level analysis of M. succiniciproducens MBEL55E for the production of succinic acid by combined transcriptome and fluxome analysisâ€, 10th international symposium on the genetics of industrial microorganisms(GIM), Prague, Czech Republic (2006. 6. 24-28)
2. Lim, S.W., Song, H., Jang, Y.S., and Lee, S.Y., “fdhD and fdhE Characterization of Mannheimia succiniciproducens MBEL55Eâ€, The 18th Symposium on Chemical Engineering, Daejeon/Chungnam(Korea)-Kyushu(Japan), Dec. 2-4 (2005)
Korean Conferences
1. Lim, S.W., Song, H., Jang, Y.S., Lee, S.Y., “Overexpression of Formate Dehydrogenase for Succinic Acid Production by Mannheimia succiniciproducens MBEL55Eâ€, International Meeting of the Federation of Koeran Microbiological Societies, Seoul, Korea, October 13-14 (2005)
2. Lim, S.W., Song, H., Jang, Y.S., Lee, S.Y., “Characterization of Formate Dehydrogenase D and E of Mannheimia succiniciproducens MBEL55Eâ€, International Symposium and annual meeting of KSBB , October 27-29 (2005)
3. Lim, S.W., Lee, S.J., Song, H., Lee, S.Y., “Mannheimia succiniciproducens PTLK: a metabolically engineered novel bacteria for succinic acid productionâ€, Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, May 10-12 (2006)
4. Jang, S.H., Lim, S.W., Lee, S.Y., “Systems-level analysis of M.succiniciproducens MBEL55E by combined transcriptome and metabolic flux analysisâ€, Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, May 10-12 (2006)
5. Lim, S.W., Lee, S.J., Song, H., and Lee, S.Y., “Effect of ldhA and pta-ackA Gene Deletions of Succinic Acid Production in Mannheimia Succiniciproducens MBEL55Eâ€, 2006 Annual Meeting and International Symposium(KMB), June 18-20 (2006)
6. Jang, S.H., Lim, S.W., Lee, J.W. and Lee S.Y., “Systems-level Analysis of M. Succiniciproducens MBEL55E by Conbined Omics Analysisâ€, 2006 Annual Meeting and International Symposium(KMB), June 18-20 (2006)
Ji Mahn Kim
Honorary Ph.D. (M.S./Ph.D. Program'07. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Dept. of Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 335, Daehak-ro, Yuseong-Gu, DAEJEON, 34141, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Transcriptome Profiling
Molecular Biology
2. Education
2005. 2.,(B.S.) Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2007. 2 ~ present ( M.S./Ph.D. Program) : Dept. of Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea
Advisor : Professor Sang Yup Lee
3. Awards and Honors
Best Poster Award, Korean Society for Chemical Engineers, Busan, Korea (2008. 10. 23)
Best Part/Device Award, The 4th International Conference on Synthetic Biology: SB4.0Conference Poster Competition, Hong Kong (2008. 10. 12)
Student Travel Award, The 4th International Conference on Synthetic Biology: SB4.0, Hong Kong (2008. 07)
4. Publications
International Journal
Jang, Y.-S., Jung, Y.R., Lee, S.Y, Kim, J.M., Lee, J.W., Oh, D.-B., Kang, H.A., Kwon, O., Jang, S.H., Song, H., Lee, S.J., and Kang, K.Y. "Construction and characterization of shuttle vectors for succinic acid producing rumen bacteria", Appl. Environ. Microbiol. 73(17): 5411-5420 (2007. 9.)
Kim, J.M., Lee, K.H. and Lee, S.Y., " Development of a markerless gene knock-out system for Mannheimia succiniciproducens using a temperature-sensitive plasmid", FEMS Microbiol. Lett. 278: 78-85 (2008. 1.)
Lee, S.Y., Kim, J.M., Song, H., Lee, J.W., Kim, T.Y., and Jang, Y.-S., "From genome sequence to integrated bioprocess for succinic acid production by Mannheimia succiniciproducens", Appl. Microbiol. Biotechnol. 79(1): 11-22 (2008. 5.)
International Conference
Song, H., Lee, J.W., Kim, J.M., Lee, S.Y., "Succinic Acid Production and Growth Behaviors of Mannheimia succiniciproducens in Anaerobic Batch Fermentation", Asia Pacific Biochemical Engineering Conference (APBioChEC'05), Lotte Jeju Hotel, Jeju Island, Korea, May 15-19 (2005)
Song, H., Lee, J. W., Kim, J. M., Lee, K. H., Lee, S.Y., "Characterization of The Cell Growth and The Distribution of End-products in a Batch Cultivation of Mannheimia Succiniciproducnes", Biochemical Engineering XIV, Harrison Hot Springs, BC, Canada, July 10-14 (2005)
Kim, J.M., Jang, S.H., Song, H., and Lee, S.Y., "Effect of Lactate Dehydrogenase Gene Deletion in Succinic acid Production by Mannheimia succinicproducens MBEL55E", The 18th Symposium on Chemical Engineering, Daejeon/Chungnam(Korea)-Kyushu(Japan), Dec. 2-4 (2005)
Kim, J.M., Lee, S.Y., "Chromosomal Modification Systems for Synthetic Engineering of Mannheimia succiniciproducens", SB 4.0: The Fourth International Meeting on Synthetic Biology, Hong Kong University of Science and Technology, October 10-12, (2008)
Kim, J.M., Lee, S.Y., "Multiple knock-out system of Mannheimia succiniciproducens using mutant LOX sequences", 13th International Biotechnology Symposium & Exhibition (IBS-2008): Biotechnology for Sustainability of Human Society, October 12-17 (2008) Dalian World Expo Center, Dalian, China
Domestic Conference
Kim, J.M., Song, H., Jang, Y.S., Lee, S.Y., "Overexpression of fumC Gene Encoding Fumarase of Mannheimia succiniciproducens MBEL55E for Succinic Acid Production", International Meeting of the Federation of Koeran Microbiological Societies, Seoul, Korea, October 13-14 (2005)
Kim, J.M., Jang, S.H., Song, H., Lee, S.Y., "Efficient Succinic acid Production through Deletion of Lactate Dehydrogenase of Mannheimia succiniciproducens MBEL55E", International Symposium and annual meeting of KSBB, October 27-29 (2005)
Jang, Y.S., Kim, J.M., Choi, S. and Lee, S.Y., "Pole of phosphoenolpyruvate Carboxylase, Phosphoenolpyruvate Carboxy Kinase and Fumarase of Mannheimia Succiniciproducens MBEL55E of Succinic Acid Production", 2006 Annual Meeting and International Symposium(KMB), June 18-20 (2006)
Kim, J.M., Song, H., Lee, S.J. and Lee, S.Y., "Deletion of pflB Gene Encoding Pyruvate Formate Lyase of Mannheimia succiniciproducens MBEL55E for Succinic Acid Production", 2006 Annual Meeting and International Symposium(KMB), June 18-20 (2006)
Kim, J.M., Song, H., Lee, S.J., and Lee, S.Y., "Effect of Pyruvate Formate Lyase gene Deletion in Succinic acid Production by Mannheimia Succiniciproducens MBEL55E", 2006 Annual Fall Meeting of Korean Society for Biotechnology and Bioengineering Symposium, September 7-8 (2006)
Kim, J.M., Jang, S.H., Song, H., and Lee. S.Y., "Effect of lactate dehydrogenase gene and pyruvate formate lyase gene deletion in succinic acid production by mannheimia succiniciproducens MBEL55E", The 19th Daejeon/Chungnam-Kyushu Symposium on Chemical Engineering, December 1-4 (2006)
Choi, S., Kim, J.M., Jang, S.H., Jang, Y., and Lee, S.Y., "Construction of Escherichia coli - Mannheimia succiniciproducens shuttle vector for genetic engineering", Annual Spring Meeting of KIChE, April 19-20 (2007)
Kim, J.M., Jang, S.H., Jang, Y.S., and Lee, S.Y., "Construction of shuttle vector for genetic engineering of Mannheimia succinciproducens", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, April. 27(2007)
Kim, J.M., Jang, S.H., and Lee, S.Y., "Construction fo Escherichia coli - Mannheimia succiniciproducens shuttle vector for genetic engineering", KSBB Fall meeting and international symposium,Hotel Inter-Burgo, Daegu,Oct.18-19(2007)
Kim, J.M., Jang, Y.S., Jang, S.H., Song, H. and Lee, S.Y., "DNA microarray analysis of succinic acid shock response in Mannheimia succiniciproducens", Annual Fall Meeting of KIChE, KAIST, Daejeon, October 26-27 (2007)
Kim, J.M., Park, T.J., Huh, Y.S., Hong, W.H. and Lee, S.Y., "Biosensor Using Active Micro-Mixer in Lab-on-a-Chip", Annual Fall Meeting of KIChE, KAIST, Daejeon, October 26-27 (2007)
Kim, J.M., Lee, K.H., Jang, S.H. and Lee, S.Y., "Markerless gene deletion of Mannheimia succiniciproducens using a New Temperature Sensitive Plasmid", Annual Fall Meeting of KIChE, KAIST, Daejeon, October 26-27 (2007)
Kim, J.M., Lee, J. and Lee, S.Y., "Cre/lox mediated multiple gene deletion in Mannheimia succiniciproducens", 2008 Spring KSBB Meeting and International Symposium, Chonbuk National University, Jeonju, April 18-19 (2008)
Kim, J.M., Lee, S.Y., "Multiple gene deletion of Mannheimia succiniciproducens using mutant lox sequences", Annual Spring Meeting of KIChE, Hyatt Regency Jeju, Jeju, April 23-25 (2008)
Kim, J.M., Han, M.S., and Lee, S.Y., "lox Sequences Mediated Multiple Knock-Out System of Mannheimia succiniciproducens", The 48th MSK Annual Meeting and 2008 International Symposium on Microbiology, Convention Center, Daejeon, May, 15-16 (2008)
Choi, S., Song, H.H., Lee, J.W., Kim, J.M. and Lee, S.Y., "Analysis of Mannheimia succiniciproducens Physiology in Different CO2 Levels", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Lee, J.W., Song, H.H., Choi, S., Yoo, J.S., Kim, J.M. and Lee, S.Y., "Improved succinic acid production based on proteomic and physiological analysis of Mannheimia succiniciproducens", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Jang, Y.S., Lee, J.Y., Kim, J.M. and Lee, S.Y., "Eggect of cell density on production of butanol by barch-fermentation of Clostridium acetobutylicum", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Jeon, Y.J., Song, H.H., Kim, J.M. and Lee, S.Y., "Modeling of batch fermentation kinetics for succinic acid production by Mannheimia succiniciproducens", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Han, M.J., Lee, J.W., Yun, H.S., Kim, J.M., Lee, S.Y. and Yoo, J.S., "Global analysis of protein localization in Escherichia coli B", Annual Fall Meeting of KIChE, BEXCO, Busan, October 22-24 (2008)
Patents - 4건
Hyun Uk Kim
Assistant Professor (M.S. '07. 8.)
Department of Chemical and Biomolecular Engineering
Korea Advanced Institute of Science and Technology (KAIST)
phone: +82-42-350-3915
fax: +82-42-350-8800
Seung Bum Sohn
Ph.D., Post-doc. (M.S. '07. 8.)
BioInformatics Research Center, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Systems biology
2. Education
2004(B.S.) : Dept of Chemical Engineering, University of California Los Angeles
2007(M.S.) : Dept. of Biomolecular and Chemical Engineering, KAIST
3. Experience
1. Intern with Baxter Biosciences through Kelly Services 2005
2. Undergraduate Research Assistant, UCLA: Dept of Chemical Engineering 2003-2004
Jong Myoung Park
Ph.D. (M.S./Ph.D. Program '08. 2.)
GS Caltex
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic engineering
Metabolic Flux Analysis
Bioinformatics/ Genome Analysis
Systems Biology/ Biotechnology
2. Education
3/2002 – 2/2006 B.S., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3/2002 – 2/2006 B.S., Dept. of Biological Sciences, KAIST, Daejeon, Korea.
3/2006 – 8/2011, M.S./Ph.D. Program, Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Experience
11/2004 ~ 2/2005 : LG Life Science CO., LTD. practical training, separation and refinement of drug component.
2/2006 – Present Graduate research assistant at Metabolic and Biomolecular Engineering Laboratory (Prof. Sang Yup Lee), KAIST, Daejeon, Korea
4. Honors and Awards
2/2006 Honor Student, KAIST
8/2010 한국을 빛내는 사람들에 게재 (한빛사 논문: Park, J.M., Kim, T.Y., and Lee, S.Y. "Prediction of metabolic fluxes by incorporating genomic context and flux-converging pattern analyses", Proc. Nat. Acad. Sci. (PNAS), 107(33): 14931-14936 (2010.8))
8/2010 가상세포 방법론 PNAS 논문 다수 언론에 발표 (디지털타임즈, 충청투데이, 파이낸셜뉴스, 한국경제, 대전일보, 이투데이, 매일경제, 데일리메디, 아이뉴스24, 아주경제, 아시아경제, 헬스코리아뉴스, YTN, 뉴시스, 헤럴드생생뉴스, HelloDD.com, 동아사이언스)
1/2011 Outstanding Poster Award, “Metabolic flux analysis based on genomic context and flux-converging pattern analyses”, The Nineth Asia Pacific Bioinformatics Conference 2011 (APBC 2011)
5. Journal Publications
11. Park, J.M., Kim, T.Y., and Lee, S.Y. “Genome-scale reconstruction and in silico analysis of the Ralstonia eutropha H16 for polyhydroxyalkanoate synthesis, lithoautotrophic growth, and 2-methyl citric acid production”, BMC Syst. Biol., In press.
10. Jang, Y-S., Park, J.M., Choi, S., Choi, Y.J., Seung, D.Y., Cho, J.H., and Lee, S.Y. “Systems metabolic engineering of microorganisms for the production of biofuels”, Biotechnol. Adv., Submitted.
9. Lee, K.Y., Park, J.M., Kim, T.Y., Yun, H., and Lee, S.Y. "The genome-scale metabolic network analysis of Zymomonas mobilis ZM4 explains physiological features and suggests ethanol and succinic acid production strategies", Microbial Cell Factories, 9(94):1-12 (2010. 11.)
8. Park, J.M., Kim, T.Y., and Lee, S.Y. “Prediction of metabolic fluxes by incorporating genomic context and flux-converging pattern analyses”, Proc. Nat. Acad. Sci. USA (PNAS), 107(33): 14931-14936 (2010. 8.)
7. Park, J.M., Jang, Y-.S., Kim, T.Y., and Lee, S.Y. “Development of a gene knockout system for Ralstonia eutropha H16 based on the broad-host-range vector expressing a mobile group II intron”, FEMS Microbiol. Lett., 309(2): 193-200 (2010. 8.)
6. Sohn, S.B., Kim, T.Y., Park, J.M., and Lee, S.Y. “In silico genome-scale metabolic analysis of Pseudomonas putida KT2440 for polyhydroxyalkanoate synthesis, degradation of aromatics, and anaerobic survival”, Biotechnol. J., 5(7): 739-750 (2010. 7.)
5. Park, J.M., Kim, T.Y., and Lee, S.Y., “Constraints-based genome-scale metabolic simulation for systems metabolic engineering”, Biotechnol. Adv., 27(6): 978-988 (2009. 11.)
4. Lee, S.Y., Kim, H.U., Park, J.H., Park, J.M., and Kim, T.Y. "Metabolic engineering of microorganisms: general strategies and drug production", Drug Discovery Today, 14(1/2): 78-88 (2009. 1.)
3. Song, H., Jang, S.H., Park, J.M., and Lee, S.Y., "Modeling of batch fermentation kinetics for succinic acid production by Mannheimia succiniciproducens" Biochem. Eng. J., 40(1): 107-115 (2008. 5.)
2. Yun, H., Lee, J. W., Jeong, J., Chung, J., Park, J.M., Myoung, H. N., and Lee, S. Y., "EcoProDB: the Escherichia coli protein database", Bioinformatics, 23(18): 2501-2503 (2007. 9.)
1. Kim, T.Y., Kim, H.U., Park, J.M., Kim, J.S., Song, H. & Lee, S.Y. Genome-scale analysis of Mannheimia succiniciproducens metabolism. Biotechnol. Bioeng., 97, 657-671 (2007. 7) (Accelerated publication)
6. Patents
Lee, S.Y., Park, J.M., Jang, Y-.S., and Kim, T.Y., “Method for inactivating a target gene in the genus Ralstonia”, Korean patent applied (10-2010-0041955) (2010. 5. 4.)
7. Conferences
International conference
Park, J.M., Kim, T.Y. and Lee, S.Y., "Incorporating genomic context and flux-converging pattern analyses into genome-scale simulation for the prediction of metabolic fluxes", 11th International Conference on Systems Biology, Edinburgh, U.K. (2010. 10.10-10.16)
Park, J.M., Kim, T.Y. and Lee, S.Y., "Improved prediction of metabolic fluxes through genomic context analysis across organisms and stoichiometric analysis of carbon fluxes", 2009 Asia Pacific Biochemical Engineering Conference (APBioChEC 2009), Kobe, Japan (2009. 11. 24-11.28)
Park, J.M., Yun, H., Lee, J.W., Jeong, J., Chung, J. and Lee, S.Y., "EcoProDB: The protein database for Escherichia coli", 12th Annual International Conference on Research in Computational Molecular Biology, National University of Singapore, Singapore (2008. 3. 29-4.2)
Park, J.M., Lee, K.Y., Kim, T.Y., Lee, S.Y., "In silico identification of gene amplification target for increasing biochemical production", The Ninth Asia Pacific Bioinformatics Conference 2011, January 11-14 , 2011, Songdo Convensia, Incheon, Korea
등 총 20회
Dometstic conference
Park, J.M., Kim, T.Y., Lee, S.Y., “Computational simulations to overproduce biochemical in Escherichia coli", The Korean Society for Microbiology and Biotechnology, COEX Grand Ballroom, Seoul, June. 28-29(2007)
Park, J.M., Kim, T.Y., Lee, J. and Lee, S.Y., “Improvement of Escherichia coli to produce biochemical based on computational simulation", 2008 Spring KSBB Meeting and International Symposium, Chonbuk National University, Jeonju, April 18-19 (2008)
Park, J.M., Song, H.H., Jang, S.H., Lee, J.H., Lee, S.Y., “Kinetic model of batch fermentation for succinic acid production by Mannheimia succiniciproducens”, Annual Spring Meeting of KIChE, Kwangju, April 22-24 (2009)
Park, J.M., Kim, T.Y., Lee, S.Y., "Prediction of metabolic fluxes based on genomic context and flux-converging pattern analysises for genome-scale simulation" Annual Meeting of KIChE 2011, Daejeon Convention Center, Daejeon, Korea , October 20-22 (2010)
Park, J.M., Kim, T.Y., Lee, S.Y., “Improving the genome-scale prediction of metabolic fluxes based on genomic context and flux-converging pattern analyses”, 2011 Spring KSBB Meeting and International Symposium, Jeju island, April 14-16 (2011)
등 총 53회
8. Books
Lee, S.Y., Park, J.M., Kim, T.Y., “Application of metabolic flux analysis in metabolic engineering”, Methods in Enzymology (v. 498), Elsevier Academic Press, Burlington, USA, 67 - 93 (2011)
1 Book chapter published, 2 Book chapter submitted
Sol Choi
CJ (M.S. '08. 8.)
BioProcess Engineering Research Center, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Systems metabolic engineering
Systems Biology/ Biotechnology
Bio-based fundamental chemical production
2. Education
3/2002 – 2/2006 B.S., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3/2006 – 8/2008 M.S., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
9/2008 – 8/2013 Ph.D., Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
8/2013 – present Post-Doctor., BioProcess Engineering Research Center, KAIST
3. Journal Publications
Lee, J.W., Choi, S., Park, J.H., Vickers, C., Nielsen, L..K., and Lee, S.Y. "Development of sucrose-utilizing Escherichia coli K-12 strain by cloning B-fructofuranosidases and its application for L-threonine production", Appl. Microbiol. Biotechnol. 88(4): 905-913
Lee, J.W., Choi, S., Kim, J.M., and Lee, S.Y., "Mannheimia succiniciproducens Phosphotransferase System for Sucrose Utilization", Appl. Environ. Microbiol. 76(5): 1699-1703
Song, H., Lee, J.W., Choi, S., You, J.K., Hong, W.H., and Lee, S.Y., "Effects of dissolved CO2 levels on the growth of Mannheimia succiniciproducens and succinic acid production", Biotechnol. Bioeng, 98(6): 1296-1304 (2007. 12.)
Lee, J.W., Kim, T.Y., Jang, Y.S., Choi, S., and Lee, S.Y. "Systems metabolic engineering for chemicals and materials", Trends Biotechnol. 29(8): 370-378 (2011. 8)
Lee, J.W., Kim, H.U., Choi, S., Yi, J., and Lee, S.Y. "Microbial production of building block chemicals and polymers", Curr. Opin. Biotechnol., 22(6): 758-767
Lee, J.W., Na, D., Park, J.M., Lee, J., Choi, S., and Lee, S.Y. "Systems metabolic engineering of microorganisms for natural and non-natural chemicals", Nature Chem. Biol. 8(6): 536-546
Jang, Y.-S., Park, J.M., Choi, S., Choi, Y.J., Seung, D.Y., Cho, J.H., and Lee, S.Y., "Engineering of microorganisms for the production of biofuels and perspectives based on systems metabolic engineering approaches", Biotechnol. Adv., 30(5): 989-1000
Jang, Y.-S., Kim, B., Shin, J.H., Choi, Y.J., Choi, S., Song, C.W., Lee, J., Park, H.G., Lee, S.Y. "Bio-based production of C2-C6 platform chemicals", Biotechnol. Bioeng., 109(10): 2437-2459
Song, C.W., Kim, D.I., Choi, S., Jang, J.W., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of fumaric acid", Biotechnol. Bioeng., 110(7): 2025-2034 (2013. 7)
Choi, S., Kim, H.U., Kim, T.Y., Kim, W.J., Lee, M.H., and Lee, S.Y., "Production of 4-hydroxybutyric acid by metabolically engineered Mannheimia succiniciproducens and its conversion to gamma-butyrolactone by acid treatment", Metabol. Eng., 20: 73-83 (2013. 11)
4. Patent
Lee, S.Y., Choi, S., Kim, J.M., Lee, J.W., Song, H. "Novel Rumen Bacteria Variant Producing High Yield Homo-succinic Acid and Process for Preparing Succinic Acid Employing the Same", Korean patent appl. (10-2007-0070219) (2007. 07. 06)
Lee, S.Y., Choi, S., Kim, J.M., Lee, J.W., Song, H. " HOMO-SUCCINIC ACID PRODUCING MICROORGANISM VARIANT AND PROCESS FOR PREPARING SUCCINIC ACID USING THE SAME", PCT (PCT/KR2008/000241) (2008. 01. 15)
Lee, S.Y., Choi, S., Kim, J.M., Lee, J.W., Song, H. " HOMO-SUCCINIC ACID PRODUCING MICROORGANISM VARIANT AND PROCESS FOR PREPARING SUCCINIC ACID USING THE SAME", China (200880106559.5) (2010. 03.11) Registered (ZL200880106559.5) (2014.01.22)
Lee, S.Y., Choi, S., Kim, J.M., Lee, J.W., Song, H. " HOMO-SUCCINIC ACID PRODUCING MICROORGANISM VARIANT AND PROCESS FOR PREPARING SUCCINIC ACID USING THE SAME", USA (12/668,868) (2010. 01.12)
Lee, S.Y., Kim, P., Choi, S. "Microorganism Enhanced Resistance of Succinic Acid and Method for Preparing Succinic Acid Using the Same", Korean patent appl. (10-2009-0062064) (2009. 07.08) Registered (10-1028039-0000) (2011.04.01)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "Novel Engineered Microorganism Producing Succinic Acid with High Yield by Utilizing Both Sucrose and Glycerol at the Same Time and Method for Preparing Succinic Acid Using the Same", Korean patent appl. (10-2010-0084327) (2010. 08. 30) Registered (10-1221557-0000) (2013.01.07)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", PCT (PCT/KR2011/6382) (2011. 08. 30)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Australia (2011296791) (2013. 03. 21)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Brazil (1120130046520) (2013. 02. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Canada (2,809,942) (2013. 04. 03)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", China (2,809,942) (2013. 04. 03)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", EPO (11822105.0) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Indonesia (W00201300864) (2013. 02. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Indonesia (W00201300864) (2013. 02. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", India (1534/CHENP/2013) (2013. 02. 26)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Japan (2013527009) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Japan (2013527009) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Mexico (MX/a/2013/002394) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Malaysia (PI2013000662) (2013. 02. 26)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", New Zealand (607585) (2013. 02. 26)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", OAPI (2013/01510) (2013. 02. 27) Resistered (2013/01510) (2013. 11. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Philippines (12013500378) (2013. 02. 26)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Russia (2013109055) (2013. 02. 28)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", USA (2013109055) (2013. 02. 28) Registered (8,691,516) (2014.04.08)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Vietnam (1201300959) (2013. 03. 27)
Lee, S.Y., Lee, J.W., Yi, J.H., Choi, S., "NOVEL MUTANT MICROORGANISM PRODUCING SUCCINIC ACID SIMULTANEOUSLY USING SUCROSE AND GLYCEROL,AND METHOD FOR PREPARING SUCCINIC ACID USING SAME", Vietnam (1201300959) (2013. 03. 27)
Lee, S.Y., Choi, S., Lee, J.W., Park, S.J. "Mutants Having a High Producing Ability of 4-hydroxybutyrate and Preparing Method for 4-hydroxybutyrate Using Thereof", Korean patent appl. (10-2011-0130183) (2011. 12. 07)
Lee, S.Y., Choi, H.S., Choi, S. "Recombinant Microorganisms Having Producibility of Coenzyme Q10 and Method for Preparing Coenzyme Q10 Using the Same", Korean patent appl. (10-2008-0000643) (2008. 04. 03) Registered (10-0936216-0000) (2010.01.04)
5. book chapter
Lee, J.W., Han, M.-S., Choi, S., Yi, J., Lee, T.W., and Lee, S.Y., "Organic Acids: Succinic and Malic Acids", Vol. III: Industrial biotechnology edited by Antonio Moreira, Comprehensive biotechnology 2nd edition, Elsevier
Yi, J., Choi, S., Han, M.-S., Lee, J.W., and Lee, S.Y., "Chapter 17. Succinic Acid", Bioprocessing Technologies in Integrated Biorefinery for Production of Biofuels, Biochemicals, and Biopolymers from Biomass edited by Hesham Al El Enshasy, John Wiley & Sons, Inc.
6. Conference presentation
Choi, S., "Systems Metabolic Engineering for the production of 4-Hydroxybutyric acid by Mannheimia succiniciproducens and its Conversion to gamma-Butyrolactone by Acid Treatment", Microbiology and Biotechnology:from Traditional to Cutting Edge11, Korea (Busan), June 27, 2014
Shun Zheng
Researcher (M.S. '08. 8.)
BioProcess Engineering Research Center, KAIST
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Biosensor/Biochip
Recombinant DNA Technology
2. Education
2002.09-2006.07 (B.S.), School of Life Science and Technology, Beijing Institute of Technology, Beijing, China
2006.09-2008.09, (M.S.), Dep. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Research Activity (as of August 2009)
International Journal Publications
1. Tae Jung Park, Yun Suk Huh, Eun Zoo Lee, Seok Jae Lee, Shun Zheng, Kwang Seok Yang, Sang Yup Lee, Won Hi Hong, Do Hyun Kim and Sungho Ko. "An active mixing microfluidic system for the colorimetric analysis of intracellular enzymes", BioChip J., 2(1):33-38 (2008) [Abstract]
2. Tae Jung Park+, Shun Zheng+, Yeon Jae Kang, and Sang Yup Lee. "Development of whole cell biosensor by cell surface display of gold binding polypeptide on the gold surface", FEMS Microbiol. Lett., 293(1):141-147 (2009) +Equally contributed. [Abstract]
International Conferences
1. Ho Seok Park, Tae Jung Park, Shun Zheng, Byung Gil Choi, Won Hi Hong, and Sang Yup Lee. "Synthesis of organophosphorus hydrolase immobilized gamma-alumina nanoparticles for enzymatic reaction", 22nd International Liquid Crystal Conference, Jeju, Jun 29 - Jul 4 (2008)
2. Ho Seok Park, Tae Jung Park, Shun Zheng, Byung Gil Choi, Won Hi Hong, and Sang Yup Lee. "Immobilization of organophosphorus hydrolase on carbon nanotube/ionic liquid bucky gel electrode for biosensor", 22nd International Liquid Crystal Conference, Jeju, Jun 29 - Jul 4 (2008)
3. Shun Zheng, Tae Jung Park, Seok Jae Lee, Won Min Park, Won Hi Hong, and Sang Yup Lee. "Ultrasensitive detection of c-reactive protein using colloidal gold nanoparticles", 22nd International Liquid Crystal Conference, Jeju, Jun 29 - Jul 4 (2008)
4. Do-Kyun Kim, Shun Zheng, Tae-Jung Park, and Sang-Yup Lee. "Analysis of optical properties on surface of nano-plasmonics materials for application to biochip", Biotronics 2008, Jeju, Oct 8 (2008)
5. Do-Kyun Kim, Shun Zheng, Hee-Yon Kim, Tae-Jung Park, Eiichi Tamiya, and Sang-Yup Lee. "Fabrication of gold-capped nanoparticle array chip and application to label-free optical biosensors", NanoBio-Seoul 2008, Seoul, Oct 30-31 (2008)
Domestic Conferences
1. Shun Zheng, Tae Jung Park, and Sang Yup Lee. "Immobilization of recombinant proteins onto the gold surface for cell biosensor", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, Apr 26-28 (2007)
2. Shun Zheng, Tae Jung Park, Xiao Xia Xia, Hyun Uk Kim, and Sang Yup Lee. "Novel stationary phase expression system in Escherichia coli for the production of recombinant protein", Annual Meeting of Korean Society for Biotechnology and Bioengineering, Jeonju, Apr 18-19 (2008)
3. Sang Yup Lee, Shun Zheng, Tae Jung Park. "C-Reactive Protein detection based on surface plasmon resonance and electrochemical analysis", Annual Spring Meeting of KIChE, Jeju, Apr 23-25 (2008)
4. Do-Kyun Kim, Shun Zheng, Tae-Jung Park, and Sang-Yup Lee. "Label free optical biosensor based on nano-plasmonics materials for detection of DNA-protein interaction", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jeju, Oct 6-7 (2008)
5. Shun Zheng, Tae Jung Park, and Sang Yup Lee. "HBsAg detection based on SPR and electrochemical assay", Annual Fall Meeting of KIChE, Busan, Oct 22-24 (2008)
6. Tae Jung Park, Shun Zheng, and Sang Yup Lee. "HBsAg detection based on SPR and electrochemical assay", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Pohang, Apr 9-11 (2009)
7. Shun Zheng, Tae Jung Park, and Sang Yup Lee. "Detection of HBV surface antigen based on genetic-engineered fusion protein", 2009 Korean BioChip Conference, Daejeon, Jun 4-5 (2009)
Joungmin Lee
Ph.D., Post-doc. as Integrated Master’s Ph.D. Program (M.S. '09. 8.)
CJ
Phone: +82-42-350-5970
Fax: +82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research interest
1. Metabolic engineering of clostridia for 1-butanol production
2. Characterization of hypothetical proteins in solventogenic clostridia
3. In silico genome-scale metabolic network
2. Education
1. 2007. 8. (B.S.) Dept. of Biological Sciences, KAIST, Daejeon, Korea
2. 2007. 9-2015. 2. (Ph.D.) Dept. of Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3 . 2015. 2.-present (Post-doc) BioProcess Engineering Research Center, KAIST, Daejeon, Korea
3. Experience
1. 2010. 2. - 2010. 5. Teaching assistant, KAIST, Chemical and Biomolecular Engineering Laboratory (CBE301)
2. 2010. 9. - 2010. 12. Teaching assistant, KAIST, Molecular Engineering Laboratory (CBE201)
3. 2010. 10. Visiting researcher, Papoutsakis Lab, University of Delaware
4. Honors and awards
1. 2009. 4. 23. Best Paper Presentation Award, 2009 Korean Institute of Chemical Engineers (KIChE) Spring Meeting
2. 2010. 10. 6. Second Best Poster Winner, Clostridium 11
5. Journal publications (2014. 8)
1. Lee, J.†, Yun, H.†, Feist, A.M., Palsson, B.Ø., and Lee, S.Y. "Genome-scale reconstruction and in silico analysis of the Clostridium acetobutylicum ATCC 824 metabolic network", Appl. Microbiol. Biotechnol. 80 (5): 849-862 (2008. 10) Times cited: 72
2. Lee, J.Y., Jang, Y.-S., Lee, J., Papoutsakis, E.T., and Lee, S.Y., "Metabolic engineering of Clostridium acetobutylicum M5 for highly selective butanol production", Biotechnol. J. 4 (10): 1432-1440 (2009.10)
3. Jang, Y.-S., Lee, J., Malaviya, A., Seung, D.Y., Cho, J.H., and Lee, S.Y., "Butanol production from renewable biomass: rediscovery of metabolic pathways and metabolic engineering", Biotechnol. J., 7 (2): 186-198 (2012. 2)
4. Lee, J., Jang, Y.-S., Choi, S.J., Im, J.A., Song, H., Cho, J.H., Seung, D.Y., Papoutsakis, E.T., Bennett, G.N., and Lee, S.Y., "Metabolic engineering of Clostridium acetobutylicum ATCC 824 for isopropanol-butanol-ethanol fermentation", Appl. Environ. Microbiol. 78 (5): 1416-1423 (2012. 3) Times cited: 26
5. Lee, J.W., Na, D., Park, J.M., Lee, J., Choi, S., and Lee, S.Y., "Systems metabolic engineering of microorganisms for natural and non-natural chemicals", Nat. Chem. Biol. 8 (6): 536-546 (2012. 5)
6. Jang, Y.-S., Kim, B., Shin, J.H., Choi, Y.J., Choi, S., Song, C.W., Lee, J., Park, H.G., Lee, S.Y. "Bio-based production of C2-C6 platform chemicals", Biotechnol. Bioeng. (2012. 10)
7. Jang, Y.-S., Lee, J.Y., Lee, J., Park, J.H., Im, J.A., Eom, M.-H., Lee, J., Lee, S.-H., Song, H., Cho, J.-H., Seung, D.Y., and Lee, S.Y., "Enhanced butanol production obtained by reinforcing the direct butanol-forming route in Clostridium acetobutylicum", mBio. 3(5): 1-9 (2012. 10)
8. Jang, Y.-S., Malaviya, A., Cho, C., Lee, J., and Lee, S.Y., "Butanol production from renewable biomass by clostridia", Bioresour. Technol., 123: 653-663 (2012. 11)
9. Choi, S.J., Lee, J., Jang, Y.-S., Park, J.H., Lee, S.Y., and Kim, I.H., "Effects of nutritional enrichment on the production of acetone-butanol-ethanol (ABE) by Clostridium acetobutylicum", J. Microbiol., 50(6): 1063-1066 (2012.12)
10. Jang, Y.-S., Malaviya, A., Lee, J., Im, J.A., Lee, S.Y., Lee, J., Eom, M.-H., Cho, J.-H. and Seung, D.Y., "Metabolic engineering of Clostridium acetobutylicum for the enhanced production of isopropanol-butanol-ethanol fuel mixture", Biotechnol. Prog., 29(4): 1083-1088 (2013. 7)
11. Jang, Y.-S., Han, M.-J., Lee, J., Im, J.A., Lee, Y.H., Papoutsakis, E.T., Bennett, G., and Lee, S.Y. "Proteomic analyses of the phase transition from acidogenesis to solventogenesis using solventogenic and non-solventogenic Clostridium acetobutylicum strains", Appl. Microbiol. Biotechnol. 98(11): 5105-5115 (2014. 6)
12. Song, C.W., Lee, J., and Lee, S.Y. "Genome engineering and gene expression control for bacterial strain development", Biotechnol. J. In press.
13. Choi, Y.J.†, Lee, J.†, Jang, Y.-S., and Lee, S.Y. "Metabolic engineering of microorganisms for the production of higher alcohols", mBio. In press.
14. Kim, S.Y., Lee, J., and Lee, S.Y. "Metabolic engineering of Corynebacterium glutamicum for the production of L-ornithine", Biotechnol. Bioeng. In press.
Yong Jae Jeon
M.S. '09. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Bioinformatics/Genome Analysis
Metabolic Engineering
Transcriptome Profiling
Molecular Biology
2. Education
2007. 2.,(B.S.) Dept. of Chemical Engineering, Yonsei university, Seoul,Korea
2009. 8.,(M.S.) Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Tran Thanh Tam
M.S. '09. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
bioproducts, intrusdial biotechnology, metabolic engineering
2. Education
2002-2007 Ho Chi Minh city University of Technology (Good graduation) Biotechnology, Faculty of Chemical Engineering
2009. 8. M.S., Chemical and Biomolecular Engineering,Korea Advanced Institute of Science and Technology,Daejeon,Korea
3. Experience
2007.05 Ho Chi Minh city Biotechnology Center Engineer
Min Sun Han
M.S. '10. 1.
Seoul Natuonal University, Technology Management, Economics and Policy Program
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Systems Biology / Biotechnology
2. Education
3/2003 – 2/2008 B.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2/2008 – 1/2010 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Experience
9/2006 – 12/2006 Exchange Student at Nanyang Technological University, Singapore.
9/2007 – 1/2008 Research Assistant at Separation Processes Laboratory (Prof. Marco Mazzotti), ETH Zurich, Switzerland
Jae Eun Oh
M.S. '10. 8.
Honam Petrochemical Corp.
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Amino Acid Production System
Systems Biology/Biotechnology
2. Education
3/2002 - 2/2006 B.S., Biotechnology, Yonsei University, Seoul, Korea
8/2008 - 8/2010 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Experience
7/2003 - 5/2004 Undergraduate Research Assistant at Bioprocess engineering laboratory(Prof. Shin, Chul Soo), Yonsei University, Seoul, Korea
9/2007 - 7/2008 Korea Technology Transfer Center (KTTC), Seoul, Korea
4. Publication
International conferences
Jae Eun Oh, Jin Hwan Park, Kwang Ho Lee, Sang Yup Lee, "Metabolic engineering of Escherichia coli for the production of L-isoleucine" Asia Pacific Biochemical Engineering Conference 2009(APBioChEC'09), Kobe, Japan, November 24-28.
Patents - 1 patent applied
Ryeojin Lee
M.S. '10. 8.
LG Household & Health Care Ltd.
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Systems Biology / Biotechnology
Bioenergy
2. Education
3/2004 – 8/2008 B.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
9/2008 – 8/2010 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Experience
9/2007 – 8/2008 Exchange Student at Tokyo Institute of Technology, Tokyo, Japan
Tae Woo Lee
M.S. '11. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Synthetic Biology
Biotechnologyy
Bioenergy
2. Education
3/2005 - 2/2009 B.S., Chemical Engineering, SungKyunKwan University, Seoul, Korea
2/2009 – 2/2011 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Experience
Intern with KIST through co-op program of SungKyunKwan University 2007
Eun Jung Choi
M.S. '11. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Synthetic Biology
Bioenergy
Systems Biology
2. Education
3/2005 - 2/2009 B.S., Chemical Engineering, Yonsei University, Seoul, Korea
2/2009 - 2/2011 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Experience
9/2007 - 8/2008 Exchange Student at University of Illinois, Urbana-Champaign, U.S.A
4. Honors and Awards
8/2005 - 8/2007 Yonsei Merit Based Scholarship
8/2005 - 2/2007 Honor Student, Yonsei University
8/2007 High Honor Student, Yonsei University
2/2009 Graduation as an Honor Student, Yonsei University
MinHo Yang
M.S. '11. 8.
Chemical & Biomolecular Engineering, KAIST
Phone +82-42-350-8814
Fax +82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Nano-bio Technology
Carbon based nanomaterials (SWNTs, Graphene)
Electrochemical biosensors
2. Education
2009. 09. - 2011.08 (M.S.) Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2000. 03 - 2008. 02 (B.S.) Dept. of Chemical Engineering, Chungnam Nat'l Univ., Daejeon, Korea
3. Experience
2009. 01. - 2009. 08. BioProcess Engineering Research Center, KAIST, Daejeon, Korea, Researcher
4. Research Activity
International Journal Publications
1. Min Ho Yang,+ Bong Gill Choi,+ HoSeok Park, Won Hi Hong, Sang Yup Lee, and Tae Jung Park. "Development of the glucose biosensor using advanced electrode modified by nanohybrid composing chemically modified graphene and ionic liquid", Electroanalysis, 22(11): 1223-1228 (2010) +Equally contributed
2. Bong Gill Choi, HoSeok Park, Tae Jung Park, Min Ho Yang, Joon Sung Kim, Sung-Yeon Jang, Nam Su Heo, Sang Yup Lee, Jing Kong, and Won Hi Hong. "Solution chemistry of self-assembled graphene nanohybrids for high performance flexible biosensors", ACS Nano, 4(5):2910-2918 (2010)
3. Bong Gill Choi, HoSeok Park, Min Ho Yang, Young Mee Jung, Sang Yup Lee, Won Hi Hong, and Tae Jung Park. "Microwave-assisted synthesis of highly water-soluble graphene towards electrical DNA sensor", Nanoscale, 12(2):2692-2697 (2010)
4. Tae Jung Park, Seok Jae Lee, Jong Pil Park, Min Ho Yang, Jong Hyun Choi, and Sang Yup Lee, "Characterization of a bacterial self-assembly surface layer protein and its application as an electrical nanobiosensor", J. Nanosci. Nanotechnol., 11(1):402-407 (2011)
5. MinHo Yang,+ Bong Gill Choi,+ HoSeok Park, Tae Jung Park, Won Hi Hong, and Sang Yup Lee. "Directed self-assembly of gold nanoparticles on graphene-ionic liquid hybrid for enhancing electrocatalytic activity", Electroanalysis, 23(4):850-857 (2011) +Equally contributed
6. MinHo Yang, Bong Gill Choi, Tae Jung Park, Nam Su Heo, Won Hi Hong, Sang Yup Lee. "Site-specific immobilization of gold binding polypeptide on gold nanoparticle-coated graphene sheet for biosensor application", Nanoscale, in press (2011)
7. Bong Gill Choi, MinHo Yang, Tae Jung Park, Yun Suk Huh, Sang Yup Lee, Won Hi Hong, HoSeok Park, "Programmable peptide-directed two dimentional arrays of various nanoparticles on grapheme sheets", Nanoscale, in press (2011)
Domestic Journal Publications
1. Tae Jung Park, Min Ho Yang, Sang Yup Lee, and Soo Hyun Kim. "Biosensor system for the detection of agrichemicals and its applications", Korean Soc. Biotechnol. Bioeng. J., 24(3): (2009)
Awards
1. Min Ho Yang, Bong Gill Choi, Tae Jung Park, Won Hee Hong, Sang Yup Lee. "Electrochemical Charaterization of the Exfoliated Graphene/Nafion Hybrid as a Biosensing Platform", IEEE NANO 2010 10th IEEE International Conference on Nanotechnology Joint Symposium with NANO KOREA, IlSan, August 17-20 (2010), Best Poster Awards
International Proceedings
1. Tae Jung Park, MinHo Yang, Bong Gill Choi, Nam Su Heo, Seok Jae Lee, Won Hi Hong, and Sang Yup Lee. "Label-free electrochemical biosensor based on graphene/ionic liquid nanocomposite for the detection of organophosphate pesticides", Materials Research Society, 2010 Fall Meeting, (2010)
International Conferences
1. Sang Yup Lee, Yu Sin Jang, Min Ho Yang, Bong Gill Choi, Tae Jung Park, Won Hee Hong. "Functionalization of graphene oxide using ionic liquids for glucose biosensing", International Conference on Cellular and Molecular Bioengineering 2, Singapore, August 2-4 (2010)
2. Min Ho Yang, Bong Gill Choi, Tae Jung Park, Won Hee Hong, Sang Yup Lee. "Electrochemical Charaterization of the Exfoliated Graphene/Nafion Hybrid as a Biosensing Platform", IEEE NANO 2010 10th IEEE International Conference on Nanotechnology Joint Symposium with NANO KOREA, IlSan, August 17-20 (2010)
3. Tae Jung Park, MinHo Yang, Bong Gill Choi, Nam Su Heo, Seok Jae Lee, Won Hi Hong, and Sang Yup Lee. "Label-free electrochemical biosensor based on graphene/ionic liquid nanocomposite for the detection of organophosphate pesticides", Materials Research Society, 2010 Fall Meeting, Boston, Massachusetts, Nov 29-Dec 3 (2010)
Domestic Conferences
1. Min Ho Yang, Bong Gill Choi, Tae Jung Park, Won Hee Hong, and Sang Yup Lee. "Advanced electrochemical biosensor integrating single-walled carbon nanotubes and peptides", Annual Spring Meeting of KIChE, Gwangju, Apr 22-24 (2009)
2. Tae Jung Park, Byung-Seon Kong, Min Ho Yang, Nam Su Heo, Hee-Tae Jung, and Sang Yup Lee. "Label-free electrochemical biosensor on the highly conductive carbon nanotube film and gold nanocomplexes", 2009 Korean BioChip Conference, Daejeon, Jun 4-5 (2009)
3. Min Ho Yang, Bong Gill Choi, Tae Jung Park, Sang Yup Lee, and Won Hee Hong. "Development of an Exfoliated Graphene/Nafion Electrode and Electrochemical Characteristics of Glucose Biosensor", 2009 Annual Fall Meeting of The Polymer Society of Korea, Gwangju, Oct 7-10 (2009)
4. Bong Gill Choi, Min Ho Yang, Tae Jung Park, Sang Yup Lee, and Won Hee Hong,. "Electrochemical Biosensor Based on Graphene/Ionic Liquid Composite Electrode for Amperometric Detection of Organophosphate Pesticides", 2009 Annual Fall Meeting of The Polymer Society of Korea, Gwangju, Oct 7-10 (2009)
5. Min Ho Yang, Bong Gill Choi, Tae Jung Park, Sang Yup Lee, and Won Hee Hong. "Peptide wrapped single-walled carbon nanotubes as an ultrathin platform for biosensor", Annual Fall Meeting of The Korean Society of Industrial and Engineering Chemistry, Seoul, Oct 15-16 (2009)
6. Bong Gill Choi, Min Ho Yang, Tae Jung Park, Won Hee Hong, and Sang Yup Lee. "Advanced Electrode Based on Carbon Materials for Biosensor", Annual Fall Meeting of The Korean Society of Industrial and Engineering Chemistry, Seoul, Oct 15-16 (2009)
7. Bong Gill Choi, HoSeok Park, Min Ho Yang, Tae Jung Park, Sang Yup Lee, and Won Hi Hong. "Flexible and conductive films based on graphene/nafion composites for high-performance biosensors", 2009 Fall Symposium of KIChE, Ilsan, Oct 21-23 (2009)
8. Tae Jung Park, Byung-Seon Kong, Min Ho Yang, Nam Su Heo, Hee-Tae Jung, and Sang Yup Lee. "Electrochemical Biosensor for Agrichemical Detection on the Highly Conductive Carbon Nanotube Film and Gold Nanocomplexes", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daejeon, Nov 2-3 (2009)
9. Tae Jung Park, Min Ho Yang, Bong Gill Choi, Won Hi Hong, and Sang Yup Lee. "Electrochemical Biosensor Based on Exfoliated Graphene/Nafion Electrode for Detection of Glucose", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Daejeon, Nov 2-3 (2009)
10. Min Ho Yang, Bong Gill Choi, Tae Jung Park, Won Hi Hong and Sang Yup Lee. "Supramolecular Assembly of Single-Walled Carbon Nanotubes with Peptides towards Amperometric Glucose Biosensor", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Seongnam, Apr 15-16 (2010)
11. Min Ho Yang, Bong Gill Choi, Tae Jung Park, Won Hi Hong and Sang Yup Lee. "Non-covalent Functionalization of Graphene with Ionic Liquids toward Biosensing Application", 2010 Spring Symposium of KIChE, Daegu, Apr 22-23 (2010)
12. Min Ho Yang, Bong Gill Choi, Tae Jung Park, Won Hi Hong and Sang Yup Lee. "Organophosphorus Hydrolase on Graphene-based Electrode for Dectection of Organophosphate Pesticides", Annual Spring Meeting of The Korean Society of Industrial and Engineering Chemistry, Busan, May 13-14 (2010)
13. Tae Jung Park, MinHo Yang, Bong Gill Choi, Won Hi Hong and Sang Yup Lee. "Ionic Liquid-Associated Preparation of Gold Nanoparticle/Graphene Nanohybrids and Their Applications in Glucose Biosensor", Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Incheon, Oct 8-9 (2010)
14. MinHo Yang, Bong Gill Choi, Tae Jung Park, Won Hi Hong and Sang Yup Lee. "Graphene-based electrode utilized with Fusion Proteins for Detection of Organophosphate Pesticides", 2010 Fall Symposium of KIChE, Daejeon, Oct 21-22 (2010)
15. Gyo Hee Kim, MinHo Yang, Bong Gill Choi, Sang Yup Lee, and Won Hi Hong. "Advanced electrochemical glucose biosensor development from self-assembled single-walled carbon nanotubes with peptides ", 2010 Fall Symposium of KIChE, Daejeon, Oct 21-22 (2010)
16. Tae Jung Park, MinHo Yang, Bong Gill Choi, Won Hi Hong, and Sang Yup Lee. "Site-specific immobilization of organophosphrous hydrolase on graphene-based nanohybrids for electrochemical detection of paraoxon", 2011 Spring Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jeju, Apr 14-16 (2011)
17. Bong Gill Choi, Min Ho Yang, Tae Jung Park, and Sang Yup Lee. "Programmable peptide-directed one dimensional array of gold nanoparticles on single-walled carbon nanotubes for biosensor ", 2011 Spring Annual Meeting of Korean Society for Biotechnology and Bioengineering Symposium, Jeju, Apr 14-16 (2011)
18. MinHo Yang, Bong Gill Choi, Tae Jung Park, Yun Suk Huh, Won Hi Hong, and Sang Yup Lee. "Synthesis of ionic liquid-functionalized cobalt oxide for high performance of energy storage" Annual Spring Meeting of The KSIEC, Jeju, May 11-13 (2011)
Min Young Kim
M.S. '11. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Synthetic Biology
2. Education
3/2005 - 2/2009 B.S., Department of Biology Education, Seoul National University, Seoul, Korea
9/2009 - 8/2011 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Kyung Yun Lee
M.S. '12. 2.
Hanwha
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Systems Biology / Biotechnology
Metabolic Engineering
Bioinformatics / Genome Analysis
2. Education
3/2003 – 2/2010 B.S., Biotechnology, Yonsei University, Seoul, Korea
2/2010 - 2/2012 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Experience
8/2010 World Intellectual Property Organization (WIPO) Summer School on Intellectual Property in Washington D.C., United States of America
4. Honors and Awards
2/2004 High Honor Student, Yonsei University
8/2004 Honor Student, Yonsei University
Lee, K.Y., Choi, E.J., Lee, J.W., Jang, Y.S., Lee, S.Y., "Production of Succinic Acid Using Phosphoenolpyruvate Carboxykinase in Escherichia coli" 2010 KSBB Fall Meeting and International Symposium. Songdo Convensia, Incheon, October 7-9 (2010), Excellence Poster Awards.
5. Journal Publication
Lee, K.Y., Park, J.M., Kim, T.Y., Yun, H., and Lee, S.Y. "The genome-scale metabolic network analysis of Zymomonas mobilis ZM4 explains physiological features and suggests ethanol and succinic acid production strategies", Microbial Cell Factories, in press.
6. Conference
International
Lee, K.Y., Choi, E.J., Lee, J.W., Jang, Y.S., Lee, S.Y., "Production of Succinic Acid Using Phosphoenolpyruvate Carboxykinase in Escherichia coli" 2010 KSBB Fall Meeting and International Symposium. Songdo Convensia, Incheon, October 7-9 (2010)
Lee, K.Y., Park, J.M., Kim, T.Y., Yun, H., Lee, S.Y., "In-silico Genome-scale Reconstruction of the Metabolic Network in Zymomonas mobilis ZM4" 2010 KSBB Fall Meeting and International Symposium. Songdo Convensia, Incheon, October 7-9 (2010)
Lee, K.Y., Sohn, S.B., Graf, A.B., Kim, T.Y., Gasser, B., Maurer, M., Ferrer, P., Mattanovich, D., Lee, S.Y., "Simulating Protein Production Using the Genome-scale Metabolic Model of Pichia pastoris" 2010 KSBB Fall Meeting and International Symposium. Songdo Convensia, Incheon, October 7-9 (2010)
Lee, K.Y., Oh, J.E., Park, J.H., Lee, K.H., Lee, S.Y., "Metabolic engineering of Escherichia coli for the Production of L-Isoleucine" 2010 KSBB Fall Meeting and International Symposium. Songdo Convensia, Incheon, October 7-9 (2010)
Lee, K.Y., Yoo, S.M., Kang, T., Yoon, I., Kim, B., Lee, S.Y., "SERS-based Identification of Pathogenic Bacteria Using Patterned Au Particle-on-wire Sensor" 2010 KSBB Fall Meeting and International Symposium. Songdo Convensia, Incheon, October 7-9 (2010)
Lee, K.Y., Kim, H.U., Kim, T.Y., Lee, S.Y., "Systematic Drug Targeting of Microbial Pathogens Using Metabolic Networks" 2010 KSBB Fall Meeting and International Symposium. Songdo Convensia, Incheon, October 7-9 (2010)
Domestic
Lee, K.Y., Park, J.M., Kim, T.Y., Lee, S.Y., "Improved genome-scale simulation through genomic contextand flux-converging patter analyses", The Korean Society for Microbiology and Biotechnology, Kyoyuk munhwa hoekwan, Seoul, June 24-25 (2010)
Lee, K.Y., Shon, S.B., Kim, T.Y., Lee, S.Y., "Reconstruction and analysis of the genome-scale model of the fission yeast Schizosaccharomyces pombe", The Korean Society for Microbiology and Biotechnology, Kyoyuk munhwa hoekwan, Seoul, June 24-25 (2010)
Lee, K.Y., Kim, H.U., Kim, T.Y., Lee, S.Y., "Reconstruction and analysis of genome-scale metabolic network of multi-drug resistant pathogen Acinetobacter baumannii AYE", The Korean Society for Microbiology and Biotechnology, Kyoyuk munhwa hoekwan, Seoul, June 24-25 (2010)
Hye Min Park
M.S. '12. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Synthetic Biology
Biorefinery
Biotechnology
Bioenergy
2. Education
2007.3. - 2010.8. B.S., Herbal Pharmaceutical Engineering, Daegu Haany University, Kyungbuk, Korea
2010.8. ~ 2012.8. M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Experience
2008. 3. - 2010. 2. Herbal Cosmeceutical Material Bank(HCMB), Daegu Haany University, Reseacher
2008. 6. - 2008. 8. Undergraduate research fellowship program (Functional Biomaterial & Proteomics Lab, Daegu university)
4. Honors and Awards
2007. 7 KB Scholarship
2007. 8. ~ 2010. 2. Honor student, Academic Scholarship
2012. 12. Best speaker award. "Systems metabolic engineering of Escherichia coli for the production of cadaverine : A five carbon diamine", The 24th International Symposium on Chemical Engineering (24th ISChE)
Jin Eyun Kim
M.S. '13. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Systems Biology / Biotechnology
Metabolic Engineering
2. Education
2005.3 - 2011.2 B.S , Chemical & Biological Engineering, Korea Univ., Seoul, Korea
2011.2 - 2013.2 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Min Kyung Kim
M.S. '13. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Synthetic Biology
Biotechnology
Genome Analysis
2. Education
3/2006 - 2/2010 B.S., Department of Chemistry, Chonbuk National Univ., Jeonju, Korea
2/2011 – 2/2013 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Chan Woo Song
Ph.D. (M.S. '13. 2.)
GS Caltex
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Systems Biology / Biotechnology
Metabolic Engineering
Bioprocess engineering
Value added chemicals production using bacteria
Development of tools for gene manipulation and pathway optimization
2. Education
3/2005 – 2/2011 B.S., Biotechnology, Yonsei University, Seoul, Korea graduated with the highest honor
2/2011 - 2/2013 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3/2013 - 2/2016 Ph.D., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Publications and Patents
Publications
1. Jang, Y.-S., Kim, B., Shin, J.H., Choi, Y.J., Choi, S., Song, C.W., Lee, J., Park, H.G., Lee, S.Y. "Bio-based production of C2-C6 platform chemicals", 2012, Biotechnol. Bioeng., 109(10): 2437-2459
2. Song, C.W., Kim, D.I., Choi, S., Jang, J.W., and Lee, S.Y., "Metabolic engineering of Escherichia coli for the production of fumaric acid", Biotechnol. Bioeng., 110(7): 2025-2034 (2013. 7) Journal cover paper
3. Song, C.W. and Lee, S.Y., "Rapid one-step inactivation of single or multiple genes in Escherichia coli", Biotechnol. J., 8(7): 776-784 (2013. 7) Journal cover paper
4. Song, C.W., Lee, J., and Lee, S.Y., "Genome engineering and gene expression control for bacterial strain development", Biotechnol. J. 10:48-60 (2015. 1) Journal cover paper
5. Choi, S.*, Song, C.W.*, Shin, J.H., and Lee, S.Y., "Biorefineries for the production of top building block chemicals and their derivatives", Metab. Eng., 28: 223-239 (2015.3) (*Equally contribution)
6. Song, C.W., Lee, J., Ko, Y.-S., and Lee, S.Y. "Metabolic engineering of Escherichia coli for the production of 3-aminopropionic acid", Metab. Eng., 30:121-129 (2015.7)
7. Song, C.W. and Lee, S.Y. "Combining rational metabolic engineering and flux optimization strategies for efficient production of fumaric acid", Appl. Microbiol. Biotechnol., 99(20): 8455-8464 (2015. 10)
8. Song, C.W., Kim, J.W., Cho, I.J., and Lee, S.Y. "Metabolic engineering of Escherichia coli for the production of 3-hydroxypropionic acid and malonic acid through beta-alanine route", ACS Syn. Biol. In press.
Patents - 3건 출원
4. Oral presentations
1. Chan Woo Song, Dong In Kim, Sol Choi, Jae Won Jang, and Sang Yup Lee, "Metabolic Engineering of Escherichia coli for the production of fumaric acid", 2013 KMB’s 40th anniversary 2013 international symposium & annual meeting (Recent breakthroughs in microbial biotechnology: from bench to industry), July 3~5, 2013, Alpensia, Pyeongchang, Korea
2. Chan Woo Song and Sang Yup Lee, "Rapid one-step inactivation of single or multiple genes in Escherichia coli", 2013 KSBB Fall Meeting and International Symposium (Innovative biotechnology for human life and industry), Oct 16~18, 2013, Bexco, Busan, Korea
3. Chan Woo Song and Sang Yup Lee, “Development of rapid one-step inactivation tool and engineering of E. coli to produce fumaric acid”, 2014 International Meeting of the Microbiological Society of Korea, April 30 - May 2, Daegu, Korea
4. Chan Woo Song and Sang Yup Lee, “Production of 3-aminopropionic acid through novel platform route using fumaric acid producing E. coli”, 2015 KIChE spring meeting, April 22-24, 2015, Jeju island, Korea
5. Chan Woo Song and Sang Yup Lee, “Metabolic Engineering of Escherichia coli for the Production of Industrial Platform Chemicals”, 2015 FKMS International meeting, November 5-6, 2015, KINTEX, Korea
5. Experience
2013. 9. - 2013. 12. Teaching assistant, KAIST, Molecular Engineering Laboratory (CBE201)
2014. 3. - 2014. 6. Teaching assistant, KAIST, Chemical and Biomolecular Engineering Laboratory (CBE301)
6. Honors and Awards
Best Student Presentation Award, 2013 Korean Society for Microbiology and Biotechnology Conference (2013. 7. 5)
Best Oral Presentation Award, 2015 International Meeting of the Federation of Korean Microbiological Societies (2015. 11. 6)
Yu Bin Kim
M.S. '13. 8.
Hanwha
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Computational / Systems Biology
Metabolic Flux Analysis
2. Education
3/2005 ~ 2/2011 B.S Chemical & Biomolecular Engineering, Sogang University, Seoul, Korea
2011/2 ~ 8/2018 M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Experience
1/2010 ~ 2/2010 Undergraduate research fellowship program of Postech
(Systems Biology Lab. Prof. Dae Hee Hwang)
Hannah Chung
Ph.D. (M.S. '13. 8.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Synthetic Biology
Metabolic Engineering
2. Education
09.2006 - 02.2011 B.S Chemical & Biomolecular Engineering, KAIST
Won Jun Kim
Ph.D. (M.S. '13. 8.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Bioinformatics/Genome Analysis
Metabolic Engineering
Transcriptome Profiling
Molecular Biology
2. Education
2007. 2.,(B.S.) Dept. of Chemical Engineering, Yonsei university, Seoul,Korea
2009. 8.,(M.S.) Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Min Sung Choi
M.S. '13. 8.
LG Household & Health Care
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
9/2009 ~ 5/2011 B.S. Chemical Engineering, Department of Chemical and Biological Engineering, Illinois Institute of Technology (IIT), Chicago, IL, United States.
3/2005 ~ 8/2010 B.S. Engineering, Department of Chemical Egineering, Hongik University, Seoul, Korea.
3. Achievement
Early graduation at Hongik University (7 semesters) 8/2010
Honor: Magna Cum Laude at IIT 5/2011
Ji Young Kim
M.S. '13. 8.
Celltrion
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interesty
Bioengineering
Synthetic biology
Metabolic engineering
2. Education
9/2005-6/2010 B.S Biochemistry, University of California, San Diego
Jung Eun Yang
Ph.D., Post-doc. (M.S. '13. 8.)
BioProcess Engineering Research Center, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Education
2007.03 – 2011.02 B.S., Polymer Engineering, Suwon University, Korea
2011.09 – 2013.08 M.S., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2013.09 – 2017.02 Ph.D., Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2. Publications
Park, S.J., Kang, K.-H., Lee, H., Park, A.-R., Yang, J.E., Oh, Y.H., Song, B.K., Jegal, J., Lee, S.H., Lee, S.Y., "Propionyl-CoA dependent biosynthesis of 2-hydroxybutyrate containing polyhydroxyalkanoates in metabolically engineered Escherichia coli", J. Biotechnol., 165(2): 93-98 (2013. 5)
Park, S.J., Jang, Y.-A., Lee, H., Park, A.-R., Yang, J.E., Shin, J., Oh, Y.H., Song, B.K., Jegal, J., Lee, S.H., and Lee, S.Y., "Metabolic engineering of Ralstonia eutropha for the biosynthesis of 2-hydroxyacid-containing polyhydroxyalkanoates", Metabolic Eng., 20: 20-28 (2013. 11)
Yang, J.E., Choi, S.Y., Shin, J.H., Park, S.J. and Lee, S.Y., "Microbial production of lactate-containing polyesters", Microbial Biotechnol., 6(6): 621-636 (2013. 11)
Yang, J.E., Choi, Y.J., Lee, S.J., Kang, K.-H., Lee, H., Oh, Y.H., Lee, S.H., Park, S.J., and Lee, S.Y., "Metabolic engineering of Escherichia coli for biosynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) from glucose", Appl. Microbiol. Biotechnol., 98(1): 95-104 (2014.1)
Park, S.J., David, Y., Baylon, M.G., Hong, S.H., Oh, Y.H., Yang, J.E., Choi, S.Y., Lee, S.H., Lee, S.Y., "Development of Metabolic Engineering Strategies for Microbial Platform to Produce Bioplastics", Appl. Chem. Eng., 25(2): 134-141 (2014. 4)
Park, S.J., Jang, Y.-A., Noh, W., Oh, Y.H., Lee, H., David, Y., Baylon, M.G., Shin, J., Yang, J.E., Choi, S.Y., Lee, S.H., Lee, S.Y., "Metabolic engineering of Ralstonia eutropha for the production of polyhydroxyalkanoates from sucrose", Biotechnol. Bioeng., 112:638–643 (2015. 3)
Park, S.J., Shin, J., Yang, J.E., and Lee, S.Y. “Synthetic Biology of Hydrophobic Polymer Production”, Part of the series Springer Protocols Handbooks, 1-11 (2015. 3)
Chung, H., Yang, J.E., Ha, J.Y., Chae, T.U., Shin, J.H., Gustavsson, M., and Lee, S.Y. "Bio-based production of monomers and polymers by metabolically engineered microorganisms", Curr. Opin. Biotechnol., 36: 73-84 (2015. 12)
Chae, C.G., Kim, Y.J., Lee, S.J., Oh, Y.H., Yang, J.E., Joo, J.C., Kang, K.H., Jang, Y.-A., Lee, H., Park, A.-R., Song, B.K., Lee, S.Y., Park, S.J., "Biosynthesis of poly(2-hydroxybutyrate-co-lactate) in metabolically engineered Escherichia coli", Biotechnol. Bioproc. Eng., 21: 169-174 (2016. 1)
Choi, S.Y., Park, S.J., Kim, W.J., Yang, J.E., Lee, H., Shin, J., and Lee, S.Y. "One-step fermentative production of poly(lactate-co-glycolate) from carbohydrates in Escherichia coli", Nature Biotechnol. (2016. 4)
Yang, J.E., Kim, J.W., Oh, Y.H., Choi, S.Y., Lee, H., Park, A.-R., Shin, J., Park, S.J., and Lee,S.Y. "Biosynthesis of poly(2-hydroxyisovalerate-co-lactate) by metabolically engineered Escherichia coli", Biotechnol. J. (2016. 9)
3. Patents
Lee, S.Y. and Yang, J.E" Preparing Method of 4-hydroxyphenyllactic Acid Using Variant Microorganism” Korea patent app. 10-2015-0067345 (2015.05)
4. Honors/ Awards
Best Poster Award, The Rubber Society of Korea (RSK) conference (2010.03)
Honor Student , Suwon University (2011.02)
Outstanding Poster Award, The Feberation of Korean Microbiological Societies (2012.10)
Best Poster Award, The Korean Society for Microbiology and Biotechnology (2012.06)
Silver Prize, Cold Spring Harbor Asia Fellowship Award (2014.12)
Best Poster Award, International Meeting of the Microbiological Society of Korea (2015.04)
Excellent Speaker Award, International Meeting of the Microbiological Society of Korea (2015.04)
5. International conferences
Yang, J.E., Kim, M.K., Park, S.J., Lee, S.H., Song, B.K., Lee, S.Y., "Production of polyhydroxyalkanoates (PHAs) containing 2-hydroxybutyrate (2HB) by metabolic engineered E.coli", Cold Spring Harbor Asia Symposium on Synthetic Biology, November 26 – 30, 2012, Suzhou, China
Yang, J.E., Jung, Y.K., Kim, T.Y., Park, S.J., Lee, S.Y., "Microbial production of lactate-containing polyhydroxyalkanoates (PHAs) using metabolically engineered Escherichia coli", BioBricks Foundation SB6.0: The Sixth International Meeting on Synthetic Biology, July 9-11, 2013, London, UK
Yang, J.E., Choi, Y.J., Lee, S.H., Song, B.K., Park, S.J., Lee, S.Y., "Biosynthesis of Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Metabolically Engineered Escherichia coli", The 4th International Conference on Biobased Polymers (ICBP2013), September 25-28, 2013, HIT (Hanyang Institute of Technology), Hanyang University, Seoul, Korea
Yang, J.E., Choi Y.J., Lee, S.H., Song, B.K., Park, S.J., Lee, S.Y., "Microbial production of poly(3-hydroxybutyrate-co-3-hydroxyvalerate)", Synthetic Biology, Suzhou, China, 1-5, December, 2014
Yang, J. E., Choi, Y. J., Lee, S. H., Song, B. K., Park, S. J., Lee, S. Y., “Bisynthesis of poly(3-hydroxybutyrate-co-3-hydroxyvalerate) in Escherichia coli by a rational metabolic engineering”, Metabolic Engineering Summit, Beijing, China, 30, November-2, December, 2015
Hye Gwon Park
M.S. '13. 8.
LG Chem.
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Synthetic biology
Metabolic engineering
2. Education
2007.03 – 2011.08 B.S Food Engineering, Ewha Womans University
Jae Won Jang
M.S. '14. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic engineering
2. Education
2/2006 ~ 2/2012 B.S Biotechnology, Ajou University, Suwon, Korea
2/2012/ ~ 2/2014 M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Seo Yun Kim
M.S. '14. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic engineering
2. Education
2/2008 ~ 2/2012 B.S Biotechnology, Hankuk University of Foreign Studies(HUFS), Seoul, Korea
2012/8 ~ 8/2014 M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Seungwoo Cheon
Ph.D. (M.S. '15. 8.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 335, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
8/2008 ~ 8/2011 B.S Biological Science, Virginia Polytechnic Institute and State University, Virginia, US.
2012/8 ~ 2015/8 M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2016/8 ~ Present Ph.D Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Ji Yeon Ha
Ph.D. (M.S. '16. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: BioProcess Engineering Research Center KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Synthetic biology
Metabolic Engineering
2. Education
2010/2 - 2014/2 B.S Chemical & Biomolecular Engineering, KAIST
2014/2 ~ 2016/2 M.S Chemical & Biomolecular Engineering, KAIST
2016/2 ~ Present Ph.D Chemical & Biomolecular Engineering, KAIST
Seon Young Park
Ph.D. (M.S. '16. 8.)
Chemical & Biomolecular Engineering, KAIST
Phone : +82-42-350-8816
Fax : +82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST, (373-1, Guseong-Dong) 291, Daehak-ro, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Bioinformatics/Genome Analysis
Metabolic Engineering
Transcriptome Profiling
Molecular Biology
2. Education
2007. 2.,(B.S.) Dept. of Chemical Engineering, Yonsei university, Seoul,Korea
2009. 8.,(M.S.) Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea
Shin Hee Ha
M.S. '17. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic engineering
Synthetic Biology
2. Education
2015. 9 ~ 2017. 8 M.S. Chemical and Biomolecular Engineering, KAIST
2007. 3 ~ 2011. 2 B.S. Life science, Pohang university of science and technology(POSTECH)
Robert Michael Binkley
M.S. '17. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic engineering
Synthetic Biology
Ji Hyeon Hwang
M.S. '18. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Nano-bio technology
Nano material synthesis
2. Education
2011. 3 ~ 2016. 2 B.S. Chemical and Biological Engineering, Korea University, Seoul, Korea
2016. 3 ~ 2018. 2 M.S. Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea
Jiha Kim
M.S. '18. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Synthetic Biology
Biomolecules
2. Education
2007. 3. - 2010. 2. Korea Science Academy (KSA) of KAIST, Busan, Korea Secondary Education in Science
2010. 2. - 2015. 8. B.S. in Chemistry (Minor: Chemical and Biomolecular Engineering), KAIST, Daejeon, Korea
2015.1. - 2015. 5. National University of Singapore(NUS), Singapore Non-graduate Exchange Student, Faculty of Science, Chemistry
2016. 3. - 2018. 2 M.S. Candidate, Chemical and Biomolecular Engineering (Advisor: Prof. Sang Yup Lee), KAIST, Daejeon, Korea
3. Research Experience
2015. 5. - 8. Summer Internship
Synthesis of tert-butyl (3-(7-acetyl-9-(4-(diethylamino)phenyl)-3-oxo-1,3-dihydro-2H-pyrrolo[3,4-b]indolizin-2-yl)propyl)carbamate (Seoul-Fluor 44) by palladium catalyzed C-H activation
Advisor: Prof. Seung Bum, Park / Department of Chemistry, Seoul National University, Seoul, Korea2012. 9. - 2013. 6. Graduation Research and Research Assistant
Bio-inspired Synthesis of Silica Particle and Cell Encapsulation Through Expression of Silicatein-a Protein
Advisor: Prof. Insung S. Choi / Department of Chemistry, KAIST, Daejeon, Korea2012. 7. - 8. Summer Internship
Synthesis of Uniform Gold-Nanorods and Silica Coating on Nanoparticles
Advisor: Yuanzhe Piao / Graduate School of Convergence Science and Technology, Seoul National University, Suwon, Korea2009. 3. - 12. Graduation Research
Analysis on the Component Content of Schisandra chinensis Baillon Depending on its Processing Method
Advisor: Man-Seok, Chun. Ph. D. / KSA, Busan, Korea2009. 3. - 12. High-school Research Program (HRP)
Bioethanol Production from Cellulose by Using Microbes
Advisor: Prof. Jong-In, Han / Department of Civil and Environmental Engineering, KAIST, Daejeon, Korea2008 - 2009 Individual Research
Anaylsis on the Content of Caffeine in Green Tea with Different Extract Condition by Using High Performance Liquid Chromatography-Mass Spectrometry(HPLC-MS)
Advisor: Jinho, Oh. Ph. D. / KSA, Busan, Korea2008 - 2009 Research and Education(R&E) Program in Chemistry
Derivatization of Tryptic Peptides for Signal Enhancement by Using Matrix-Assisted Laser Desorption/Ionization Time-of-Flight Mass Spectrometry
Advisor: Prof. Hie-Joon, Kim / Department of Chemistry, Seoul National University, Seoul, Korea2007 - 2008 Research and Education(R&E) Program in Biology
Novel Mechanism for the Pro-coagulant Activity by Endogenous Molecules in Human Red Blood Cells
Advisor: Prof. Jin-Ho, Chung / College of Pharmacy, Seoul National University, Seoul, Korea
4. Honors and Awards
2015 Exchange Student Scholarship, KAIST For the study at National University of Singapore
2010 - 2015 National Presidential Science Scholarship For the undergraduate study at KAIST
2009. 5. Singapore International Science Challenge (SISC), Merit Award Ministry of Education, Singapore
2009. 3. Got a Scholarship from Busan Savings Bank
2009 Won a Prize at National High School Research Project Presentation Contest (Women into Science and Engineering, WISE)
2008. 3. Got a Scholarship from Kwangsin Oil Corporation
2008. 2. Won a Best Student Prize at Research and Education Program of 2007 (Ministry of Education and Science)
2007. 3. Got a Scholarship from Seojeon Academy
Cindy Pricilia Surya Prabowo
Ph.D. (M.S. '18. 8.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic engineering
Synthetic Biology
2. Education
2012. 9 ~ 2016. 8 B.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2016. 9 ~ 2018. 8 M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2018. 9 ~ 2023. 2 Ph.D. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Chang Dai Gu
Ph.D.(M.S. '19. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Systems and computational biology
Pathophysiology
2. Education
2011. Mar. ~ 2017. Feb. B.S. Biomedical Science, CHA University, Gyeonggi-do, Korea
2017. Feb ~ 2019.Feb. M.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Tae Hee Han
Ph.D. (M.S. '19. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
2010.02 ~ 2013.02 Korea Science Academy of KAIST, Busan, Korea
2013.03 ~ 2017.02 B.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2017.02 ~ 2019.02 M.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Dong In Kim
M.S. '19. 9.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Systems/computational biology
Metabolic engineering
2. Education
2/2008 ~ 2/2012 B.S Chemical & Biomolecular Engineering, Sogang University, Seoul, Korea
2012/2 ~ Present M.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Da Hyeon Park
M.S. '20. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
2010.02 ~ 2013.02 Korea Science Academy of KAIST, Busan, Korea
2013.03 ~ 2018.02 B.S. Chemical and Biological Engineering, Seoul National University, Seoul, South Korea
2013.03 ~ 2018.02 B.S. Biological Sciences, Seoul National University, Seoul, South Korea (Double Major)
2018.02 ~ present M.S. Chemical and Biomolecular Engineering, KAIST, Daejeon, South Korea
Hanwen Xu
Ph.D Candidate (M.S. '21. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8817
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
Sep. 2014 - Jun. 2018 B. Eng. Bioengineering, Shanghai Jiao Tong University, Shanghai, China
Jul. 2017 - Aug. 2017 Visiting Student Researcher, University of Ottawa, Ottawa, Canada
Aug. 2018-Present M.S. Chemical and Biomolecular Engineering, Korea Advanced Institute of Science and Technology
3. AWARDS
Oct. 2016: Gold Award in iGEM 2016 (in Team SJTU-BioX-Shanghai), iGEM Foundation
Seongjin Park
M.S. '21. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Synthetic biology
2. Education
2015. 3 ~ 2019. 2 B.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2019. 2 ~2021.2 M.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Yae Seul Park
M.S. '21. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
2014~2017 | B.S. in Biochemistry, University of Wisonsin-Madison, Madison, WI, USA (Graduated with Distinction)
2019~2021| M.S. in Chemical and Biomolecular Engineering, KAIST, Daejeon, Korea
3. Research Experience
2017 | University of Wisconsin School of Medicine and Public Health | WIMR(Wisconsin Institute of Medical Research) | Department of Human Oncology | Professor Randal Tibbetts
Jeong Eum Park
M.S. '21. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
Feb 2021 - M.S. Chemical and biomolecular engineering (Advisor: Prof. Sang Yup Lee, Ph.D), KAIST, Daejeon, Korea
Feb 2019 - B.S. department of Biotechnology, Yonsei University, Seoul, Korea
Chang Hun Hwang
M.S. '21. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
2014.03 ~ 2019.02 B.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
2019.02 ~ 2021.02 M.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Ji Hye Hyun
M.S. '21. 8.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Nano-bio technology
Nanomaterial synthesis
2. Education
Mar 2018 - Present - M.S. Chemical and biomolecular engineering (Advisor: Sang Yup Lee), KAIST, Daejeon, Korea
May 2017 - B.S. Engineering Chemistry, Stony Brook University, Stony Brook, NY, US
3. Research Experience
May 2017 - Oct 2017 Professor Daniel Raleigh Laboratory, Stony Brook University, Stony Brook, NY
Jan 2017 - May 2017 Professor Benjamin Hsiao Laboratory, Stony Brook University, Stony Brook, NY
4. Honors/ Awards
May 2017 - Summa Cum Laude graduate (Highest University Honor), Stony Brook University
May 2017 - Outstanding Engineering Chemistry Student Award, Stony Brook University
May 2017 - Elected and joined Phi Beta Kappa Honor Society
Dec 2016 - Outstanding Academic Achievement Award, Stony Brook University
May 2016 - Elected and joined Golden Key International Honor Society
Aug 2014 - May 2017 - Dean’s Honor List (Every Semester), Stony Brook University
Gyul Han
M.S. '22. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8817
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Synthetic biology
2. Education
2012.03 ~ 2019.02 B.S. Chemical & Biomolecular Engineering, Yonsei, Seoul, Korea
2019.09 ~ Present M.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Hye Eun Yu
Ph.D. Candidate (M.S. '22. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8817
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
Present - Ph.D. Chemical and biomolecular engineering, KAIST, Daejeon, Korea
Feb 2020 - B.S. Department of Life Science, Ewha Womans University, Seoul, Korea
Su Min Cho
Ph.D. Candidate (M.S. '22. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
2015. 3 ~ 2020. 2 B.S Food Bioscience and Technology, Korea University, Seoul, Korea
2015. 3 ~ 2020. 2 B.S Brain and Cognitive Science, Korea University, Seoul, Korea (Double Major)
2020. 3 ~ Present Ph.D. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Yeah Ji Ahn
M.S. '23. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
Mar 2021 ~ Feb 2023 - M.S. Chemical & Biomolecular Engineering (Advisor: Sang Yup Lee), KAIST, Daejeon, Korea
Aug 2019 ~ Jan 2020 - Exchange student in Life Science Engineering department, EPFL, Switzerland
Mar 2016 ~ Feb 2021 - B.S Biological Sciences (Double major), KAIST, Daejeon, Korea
Mar 2016 ~ Feb 2021 - B.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Research Experience
May 2020 - Jun 2020 KAIST Protein Engineering Laboratory
Jul 2018 - Aug 2018 KAIST Bio Network Analysis Laboratory
4. Honors / Awards
Mar 2018 - Feb 2020 National Science and Engineering Scholarship, Korea Student Aid Foundation (KOSAF)
Alisher Nazarbekov
Ph.D. Candidate (M.S. '23. 8.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
Systems biology / Biotechnology
2. Education
Aug 2023 - Present - Ph.D. Chemical & Biomolecular Engineering (Advisor: Sang Yup Lee, PhD), KAIST, Daejeon, Republic of Korea
Aug 2021 - Aug 2023 - M.S. Chemical & Biomolecular Engineering (Advisor: Sang Yup Lee, PhD), KAIST, Daejeon, Republic of Korea
Aug 2017 - Aug 2021 - B.S. Chemical Engineering, Minor in Biological Science, UNIST, Ulsan, Republic of Korea
3. Research Experience
Jul 2019 - Jun 2021 - Research Assistant, Biochemical Engineering Laboratory (Advisor: Sunghoon Park, PhD), UNIST, Ulsan, Republic of Korea
4. Honors / Awards
Aug 2021 - Magna Cum Laude Graduation Prize, UNIST
Aug 2017 - Aug 2021 - Global UNISTAR Gold Scholarship, UNIST
Jul 2017 - International Biology Olympiad (Bronze), Coventry, United Kingdom
Jul 2016 - International Biology Olympiad (Bronze), Hanoi, Vietnam
Ga Eun Park
M.S. '24. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8817
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Metabolic Engineering
2. Education
2016.03~ 2021.02 B.S. Biological Engineering, Konkuk University, Seoul, Korea
3. Research Experience
Konkuk University, Biomaterial & Biotransformation Laboratory(Advisor : Prof. Yung Hun Yang) (2019.01~2019.02, 2019.09~2019.12)
KIST(Korea Institute of Science and Technology), Theragnosis center(Advisor : Prof. Hak Suk Chung) (2020.01~2020.02)
Gahyeon Ryu
M.S. '24. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8867
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research Interest
Systems and computational biology
2. Education
Aug. 2021 - Present M.S. Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
Mar. 2015 - Aug. 2021 B.S. Biotechnology (Double Major), Korea University, Seoul, Korea
Mar. 2015 - Aug. 2021 B.S. Environmental Science & Ecological Engineering, Korea University, Seoul, Korea
3. Research Experience
Aug. 2019 - Feb. 2020 Lab assistant, Water Quality Laboratory (Advisor: Prof. Jinho Jung), Korea University, Seoul, Korea
May. 2019 - Oct. 2019 Research Scholarship program, Ecological Restoration Laboratory (Advisor: Prof. Yong Sik Ok), Korea University, Seoul, Korea
Sep. 2018 - Jan. 2019 Lab Intern, Water Quality Laboratory (Advisor: Prof. Jinho Jung), Korea University, Seoul, Korea
4. Honors / Awards
Mar. 2015 - Aug. 2020 National Science and Engineering Scholarship, Korea Student Aid Foundation (KOSAF)
Tae Ho Yu
M.S. '24. 2.
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-8867
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research interest
Metabolic engineering
Systems and computational biology
2. Education
Mar. 2022 ~ Present - M.S. Chemical & Biomolecular Engineering (Advisor: Sang Yup Lee), KAIST, Daejeon, Korea
Mar. 2016 ~ Feb. 2022 - B.S. Chemical and biomolecular engineering, KAIST, Daejeon, Korea
3. Research Experience
Aug. 2020 ~ Nov. 2021 - Lab Intern, Metabolic & Biomolecular Engineering National Research Laboratory
Young Min Yun
M.S. (M.S. '24. 2.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research interest
Metabolic engineering
2. Education
Mar 2022 ~ Present - M.S. Chemical and biomolecular engineering (Advisor: Prof. Sang Yup Lee, Ph.D), KAIST, Daejeon, Korea
Mar 2018 ~ Feb 2022 - B.S. Biomedical science and engineering, Konkuk University, Korea
3. Research Experience
Mar 2021 – Konkuk University, Genomics and Genome Engineering Laboratory
Jul 2021 – POSTECH University, Molecular Diagnosis and Synthetic Biology Laboratory
4. Honors/ Awards
Mar 2020 ~ Feb 2022 - National Science and Engineering Scholarship, Korea Student Aid Foundation (KOSAF)
Min Ju Kang
Ph.D. Candidate (M.S. '24. 8.)
Chemical & Biomolecular Engineering, KAIST
Phone :+82-42-350-5970
Fax :+82-42-350-8800
Address: Chemical & Biomolecular Engineering, KAIST(373-1, Guseong-Dong) 291, Gwahangno, Yuseong-Gu, DAEJEON, 305-701, Republic of KOREA
Details
1. Research interest
Metabolic engineering
2. Education
Aug 2022 ~ Present - M.S. Chemical and biomolecular engineering (Advisor: Prof. Sang Yup Lee, Ph.D), KAIST, Daejeon, Korea
Feb 2018 ~ Aug 2022 - B.S Chemical & Biomolecular Engineering, KAIST, Daejeon, Korea
3. Research Experience
Mar 2022 - Jun 2022 KAIST MBEL (Research in Chemical Engineering Undergraduate)
4. Honors/ Awards
Mar 2019 - Feb 2022 미원상사 두명 장학금, 미원상사